SK124593A3 - Aryl-condensed and heteroaryl-condensed 2,4-diazepine and 2,4-diazocine anti-arrhythmic agents - Google Patents

Aryl-condensed and heteroaryl-condensed 2,4-diazepine and 2,4-diazocine anti-arrhythmic agents Download PDF

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Publication number
SK124593A3
SK124593A3 SK1245-93A SK124593A SK124593A3 SK 124593 A3 SK124593 A3 SK 124593A3 SK 124593 A SK124593 A SK 124593A SK 124593 A3 SK124593 A3 SK 124593A3
Authority
SK
Slovakia
Prior art keywords
alkyl
phenyl
hydrogen
alkylsulfonamido
alkoxy
Prior art date
Application number
SK1245-93A
Other languages
English (en)
Slovak (sk)
Inventor
Robert E Johnson
Donald C Schlegel
Alan M Ezrin
Original Assignee
Sterling Winthrop Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Winthrop Inc filed Critical Sterling Winthrop Inc
Publication of SK124593A3 publication Critical patent/SK124593A3/sk

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D245/00Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/04Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D245/06Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SK1245-93A 1992-11-10 1993-11-08 Aryl-condensed and heteroaryl-condensed 2,4-diazepine and 2,4-diazocine anti-arrhythmic agents SK124593A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97439692A 1992-11-10 1992-11-10
US2192693A 1993-02-24 1993-02-24

Publications (1)

Publication Number Publication Date
SK124593A3 true SK124593A3 (en) 1994-08-10

Family

ID=26695257

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1245-93A SK124593A3 (en) 1992-11-10 1993-11-08 Aryl-condensed and heteroaryl-condensed 2,4-diazepine and 2,4-diazocine anti-arrhythmic agents

Country Status (15)

Country Link
EP (1) EP0597540B1 (fr)
JP (1) JPH06220025A (fr)
AT (1) ATE138916T1 (fr)
AU (1) AU4472093A (fr)
CA (1) CA2104060A1 (fr)
CZ (1) CZ237393A3 (fr)
DE (1) DE69302991D1 (fr)
FI (1) FI934895A (fr)
HU (1) HUT67281A (fr)
IL (1) IL107519A0 (fr)
MX (1) MX9305312A (fr)
NO (1) NO934058D0 (fr)
NZ (1) NZ248414A (fr)
SK (1) SK124593A3 (fr)
TW (1) TW245714B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1940828B1 (fr) 2005-10-27 2010-08-18 Schering Corporation Inhibiteurs heterocycliques d'aspartyle protease
JP5529131B2 (ja) * 2008-08-13 2014-06-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング キマーゼ阻害薬
US20130116241A1 (en) * 2011-11-09 2013-05-09 Abbvie Inc. Novel inhibitor compounds of phosphodiesterase type 10a
KR101991429B1 (ko) 2014-12-19 2019-06-20 주식회사 엘지화학 새로운 화합물 및 이를 이용한 고분자 전해질막
CN113840820B (zh) * 2019-05-29 2024-05-03 St制药株式会社 酞嗪酮化合物及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH527828A (de) * 1967-04-13 1972-09-15 Ciba Geigy Ag Verfahren zur Herstellung von 2,4-Benzdiazepinen
US3696093A (en) * 1970-09-30 1972-10-03 Ciba Geigy Corp 2,4-benzodiazepines
NZ232396A (en) * 1989-02-10 1991-07-26 Merrell Dow Pharma 2-(diphenylalkylamino) -1,3 nn heterocyclic compounds and pharmaceutical compositions
US5032598A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents
US5215989A (en) * 1989-12-08 1993-06-01 Merck & Co., Inc. Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents
TW245719B (fr) * 1990-09-10 1995-04-21 Sterling Winthrop Inc

Also Published As

Publication number Publication date
EP0597540A1 (fr) 1994-05-18
TW245714B (fr) 1995-04-21
MX9305312A (es) 1995-01-31
NO934058L (fr) 1994-05-11
JPH06220025A (ja) 1994-08-09
FI934895A (fi) 1994-05-11
CZ237393A3 (en) 1996-08-14
ATE138916T1 (de) 1996-06-15
DE69302991D1 (de) 1996-07-11
HU9303135D0 (en) 1994-02-28
CA2104060A1 (fr) 1994-05-11
NO934058D0 (no) 1993-11-09
IL107519A0 (en) 1994-02-27
HUT67281A (en) 1995-03-28
FI934895A0 (fi) 1993-11-05
AU4472093A (en) 1994-05-26
EP0597540B1 (fr) 1996-06-05
NZ248414A (en) 1995-02-24

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