DE69302991D1 - Aryl und Hetaryl annelierte 2,4-Diazocine als anti-arryhthmische Wirkstoffe - Google Patents

Aryl und Hetaryl annelierte 2,4-Diazocine als anti-arryhthmische Wirkstoffe

Info

Publication number
DE69302991D1
DE69302991D1 DE69302991T DE69302991T DE69302991D1 DE 69302991 D1 DE69302991 D1 DE 69302991D1 DE 69302991 T DE69302991 T DE 69302991T DE 69302991 T DE69302991 T DE 69302991T DE 69302991 D1 DE69302991 D1 DE 69302991D1
Authority
DE
Germany
Prior art keywords
aryl
hetaryl
alkyl
fused
aralkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69302991T
Other languages
English (en)
Inventor
Robert Ed Johnson
Donald Charles Schlegel
Alan Mark Ezrin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Winthrop Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Winthrop Inc filed Critical Sterling Winthrop Inc
Application granted granted Critical
Publication of DE69302991D1 publication Critical patent/DE69302991D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D245/06—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69302991T 1992-11-10 1993-11-06 Aryl und Hetaryl annelierte 2,4-Diazocine als anti-arryhthmische Wirkstoffe Expired - Lifetime DE69302991D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97439692A 1992-11-10 1992-11-10
US2192693A 1993-02-24 1993-02-24

Publications (1)

Publication Number Publication Date
DE69302991D1 true DE69302991D1 (de) 1996-07-11

Family

ID=26695257

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69302991T Expired - Lifetime DE69302991D1 (de) 1992-11-10 1993-11-06 Aryl und Hetaryl annelierte 2,4-Diazocine als anti-arryhthmische Wirkstoffe

Country Status (15)

Country Link
EP (1) EP0597540B1 (de)
JP (1) JPH06220025A (de)
AT (1) ATE138916T1 (de)
AU (1) AU4472093A (de)
CA (1) CA2104060A1 (de)
CZ (1) CZ237393A3 (de)
DE (1) DE69302991D1 (de)
FI (1) FI934895A (de)
HU (1) HUT67281A (de)
IL (1) IL107519A0 (de)
MX (1) MX9305312A (de)
NO (1) NO934058D0 (de)
NZ (1) NZ248414A (de)
SK (1) SK124593A3 (de)
TW (1) TW245714B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1940828B1 (de) 2005-10-27 2010-08-18 Schering Corporation Heterozyklische aspartyl-proteasehemmer
JP5529131B2 (ja) * 2008-08-13 2014-06-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング キマーゼ阻害薬
US20130116241A1 (en) * 2011-11-09 2013-05-09 Abbvie Inc. Novel inhibitor compounds of phosphodiesterase type 10a
KR101991429B1 (ko) 2014-12-19 2019-06-20 주식회사 엘지화학 새로운 화합물 및 이를 이용한 고분자 전해질막
CN113840820B (zh) * 2019-05-29 2024-05-03 St制药株式会社 酞嗪酮化合物及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH527828A (de) * 1967-04-13 1972-09-15 Ciba Geigy Ag Verfahren zur Herstellung von 2,4-Benzdiazepinen
US3696093A (en) * 1970-09-30 1972-10-03 Ciba Geigy Corp 2,4-benzodiazepines
NZ232396A (en) * 1989-02-10 1991-07-26 Merrell Dow Pharma 2-(diphenylalkylamino) -1,3 nn heterocyclic compounds and pharmaceutical compositions
US5032598A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents
US5215989A (en) * 1989-12-08 1993-06-01 Merck & Co., Inc. Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents
TW245719B (de) * 1990-09-10 1995-04-21 Sterling Winthrop Inc

Also Published As

Publication number Publication date
EP0597540A1 (de) 1994-05-18
TW245714B (de) 1995-04-21
MX9305312A (es) 1995-01-31
NO934058L (de) 1994-05-11
JPH06220025A (ja) 1994-08-09
FI934895A (fi) 1994-05-11
CZ237393A3 (en) 1996-08-14
ATE138916T1 (de) 1996-06-15
HU9303135D0 (en) 1994-02-28
SK124593A3 (en) 1994-08-10
CA2104060A1 (en) 1994-05-11
NO934058D0 (no) 1993-11-09
IL107519A0 (en) 1994-02-27
HUT67281A (en) 1995-03-28
FI934895A0 (fi) 1993-11-05
AU4472093A (en) 1994-05-26
EP0597540B1 (de) 1996-06-05
NZ248414A (en) 1995-02-24

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Legal Events

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