SI9520094B - N-substituirani 3-azabiciklo/3.2.0/ heptanski derivati uporabni kot nevroleptiki - Google Patents
N-substituirani 3-azabiciklo/3.2.0/ heptanski derivati uporabni kot nevroleptiki Download PDFInfo
- Publication number
- SI9520094B SI9520094B SI9520094A SI9520094A SI9520094B SI 9520094 B SI9520094 B SI 9520094B SI 9520094 A SI9520094 A SI 9520094A SI 9520094 A SI9520094 A SI 9520094A SI 9520094 B SI9520094 B SI 9520094B
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- Prior art keywords
- formula
- azabicyclo
- group
- hydroxyl
- amino
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (3)
1 Patentni zahtevki 1. N-substituiran 3-azabiciklo[3.2.0]heptanski derivat s formulo I
N—(CH2)2. R2,
Ά kjer je R1 nafitil, ki je mono- ali disubstituiran z atomi halogenov, je R2 vodik, hidroksil, Ci-C4-alkil ali Ci-C4-alkoksi ali je skupaj s sosednjim ogljikovim atomom C=0 ali C=S, sta X in Y ogljikova atoma, CH, CH2, NH ali Ci-C4-alkil-N skupine ali dušikova atoma, je Z CO je A vodik, hidroksil, amino, merkapto, Ci-C4-alkilamino, di-CrC4- alkilamino, Ci-C4-alkiltio ali CrC4-alkoksi, ali je skupaj s sosednjim ogljikovim atomom C=0, ali je A C3-C4-alkilenska skupina, ki je vezana na Y in lahko vsebuje eno ali dve ne-kumulativni dvojni vezi in v kateri je lahko ena CH ali CH2 skupina nadomeščena z dušikovim ali žveplovim atomom ali NH ah N-CH3 skupino, in kjer je lahko obroč monosubstituiran bodisi s fluorovim ali klorovim atomom ali z metilom, metoksi, nitro ali amino, ali je v primeru benzenskega obroča le-ta lahko mono-, di- ali trisubstituiran s 2 fluorovimi ali klorovimi atomi ali merilno, trifluorometilno, nitro, hidroksilno, metoksi, amino, monometil- ali dimetilamino skupino, in njegove soli s fiziološko sprejemljivimi kislinami.
2. Spojine s formulo I po zahtevku 1, označene s tem, da jih uporabimo za zdravljenje psihoz.
3. Postopek za pripravo spojin s formulo I, kot so zahtevane v zahtevku 1, ki obsega presnovo spojine s formulo II
Z' (Π) Λ kjer imajo n, R , X, Y, Z in A zgoraj navedene pomene in je Nu nukleofugna odhodna skupina, s 3-azabiciklo[3.2.0]heptanskim derivatom s formulo III
kjer ima R1 zgoraj navedene pomene, in pretvorbo nastale spojine, v danem primeru, v sol s fiziološko sprejemljivo kislino.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4427648A DE4427648A1 (de) | 1994-08-04 | 1994-08-04 | N-Stubstituierte 3-Azabicyclo[3,2,0,]heptan-Derivate, ihre Herstellung und Verwendung |
| PCT/EP1995/002893 WO1996004272A1 (de) | 1994-08-04 | 1995-07-21 | N-substituierte 3-azabicyclo(3.2.0)heptan-derivate als neuroleptika |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI9520094A SI9520094A (en) | 1997-08-31 |
| SI9520094B true SI9520094B (sl) | 2002-02-28 |
Family
ID=6524944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9520094A SI9520094B (sl) | 1994-08-04 | 1995-07-21 | N-substituirani 3-azabiciklo/3.2.0/ heptanski derivati uporabni kot nevroleptiki |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6028073A (sl) |
| EP (1) | EP0775135B1 (sl) |
| JP (1) | JPH10503503A (sl) |
| CN (1) | CN1066145C (sl) |
| AT (1) | ATE242236T1 (sl) |
| AU (1) | AU696230B2 (sl) |
| BG (1) | BG63633B1 (sl) |
| CA (1) | CA2196809A1 (sl) |
| CZ (1) | CZ287862B6 (sl) |
| DE (2) | DE4427648A1 (sl) |
| DK (1) | DK0775135T3 (sl) |
| ES (1) | ES2201111T3 (sl) |
| FI (1) | FI970448A (sl) |
| HR (1) | HRP950438A2 (sl) |
| HU (1) | HUT77772A (sl) |
| MX (1) | MX9700807A (sl) |
| NO (1) | NO312243B1 (sl) |
| NZ (1) | NZ290426A (sl) |
| PL (1) | PL183526B1 (sl) |
| PT (1) | PT775135E (sl) |
| RU (1) | RU2163604C2 (sl) |
| SI (1) | SI9520094B (sl) |
| UA (1) | UA44903C2 (sl) |
| WO (1) | WO1996004272A1 (sl) |
| ZA (1) | ZA956477B (sl) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6458821B1 (en) * | 1998-08-12 | 2002-10-01 | Abbott Laboratories | N-substituted azabicycloheptane derivatives, production and use thereof |
| DE19836404A1 (de) * | 1998-08-12 | 2000-02-17 | Basf Ag | N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
| DE19836406A1 (de) * | 1998-08-12 | 2000-02-17 | Basf Ag | N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
| DE19848521A1 (de) * | 1998-10-21 | 2000-04-27 | Basf Ag | Verfahren zur Herstellung von (+)-exo-6-Phenyl-3-azabicyclo-[3.2.0]heptanen |
| DE19854147A1 (de) * | 1998-11-24 | 2000-05-25 | Basf Ag | Verwendung von N-substituierten Azabicycloalkan-Derivaten zur Verwendung bei der Bekämpfung der Cocainsucht |
| JP4754570B2 (ja) * | 2004-10-14 | 2011-08-24 | アボット ゲーエムベーハー ウント カンパニー カーゲー | ドーパミンｄ３受容体の調節に応答する障害の治療に好適なアザビシクロヘプチル化合物 |
| US10233191B2 (en) | 2013-07-10 | 2019-03-19 | Vertex Pharmaceuticals Incorporated | Fused piperidine amides as modulators of ion channels |
| CR20160578A (es) * | 2014-06-26 | 2017-02-21 | Hoffmann La Roche | Derivados de indolin-2-ona o pirrolo-piridin-2-ona |
| CN108349944B (zh) | 2015-11-06 | 2021-03-30 | 豪夫迈·罗氏有限公司 | 二氢吲哚-2-酮衍生物 |
| WO2017076932A1 (en) | 2015-11-06 | 2017-05-11 | F. Hoffmann-La Roche Ag | Indolin-2-one derivatives useful in the treatment of cns diseases |
| EP3371169B1 (en) | 2015-11-06 | 2019-07-17 | H. Hoffnabb-La Roche Ag | Indolin-2-one derivatives for use in the treatment of cns and related disorders |
| CN108137561B (zh) | 2015-11-06 | 2021-03-26 | 豪夫迈·罗氏有限公司 | 二氢吲哚-2-酮衍生物 |
| WO2020239073A1 (zh) * | 2019-05-30 | 2020-12-03 | 中国科学院上海药物研究所 | 一种并环化合物、其制备方法和用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4243287A1 (de) * | 1992-06-19 | 1993-12-23 | Basf Ag | N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
| DE4341402A1 (de) * | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
-
1994
- 1994-08-04 DE DE4427648A patent/DE4427648A1/de not_active Withdrawn
-
1995
- 1995-07-21 SI SI9520094A patent/SI9520094B/sl unknown
- 1995-07-21 AU AU31162/95A patent/AU696230B2/en not_active Ceased
- 1995-07-21 AT AT95926970T patent/ATE242236T1/de not_active IP Right Cessation
- 1995-07-21 JP JP8506146A patent/JPH10503503A/ja not_active Ceased
- 1995-07-21 ES ES95926970T patent/ES2201111T3/es not_active Expired - Lifetime
- 1995-07-21 CN CN95194835A patent/CN1066145C/zh not_active Expired - Fee Related
- 1995-07-21 MX MX9700807A patent/MX9700807A/es unknown
- 1995-07-21 HU HU9700329A patent/HUT77772A/hu unknown
- 1995-07-21 UA UA97030904A patent/UA44903C2/uk unknown
- 1995-07-21 WO PCT/EP1995/002893 patent/WO1996004272A1/de active IP Right Grant
- 1995-07-21 PL PL95318460A patent/PL183526B1/pl unknown
- 1995-07-21 EP EP95926970A patent/EP0775135B1/de not_active Expired - Lifetime
- 1995-07-21 PT PT95926970T patent/PT775135E/pt unknown
- 1995-07-21 US US08/776,577 patent/US6028073A/en not_active Expired - Lifetime
- 1995-07-21 CZ CZ1997310A patent/CZ287862B6/cs not_active IP Right Cessation
- 1995-07-21 DK DK95926970T patent/DK0775135T3/da active
- 1995-07-21 RU RU97103198/04A patent/RU2163604C2/ru not_active IP Right Cessation
- 1995-07-21 NZ NZ290426A patent/NZ290426A/en unknown
- 1995-07-21 CA CA002196809A patent/CA2196809A1/en not_active Abandoned
- 1995-07-21 DE DE59510713T patent/DE59510713D1/de not_active Expired - Fee Related
- 1995-08-03 ZA ZA9506477A patent/ZA956477B/xx unknown
- 1995-08-04 HR HRP4427648.6A patent/HRP950438A2/hr not_active Application Discontinuation
-
1997
- 1997-02-03 FI FI970448A patent/FI970448A/fi unknown
- 1997-02-03 NO NO19970473A patent/NO312243B1/no not_active IP Right Cessation
- 1997-02-12 BG BG101220A patent/BG63633B1/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX9700807A (es) | 1997-05-31 |
| FI970448A0 (fi) | 1997-02-03 |
| FI970448A (fi) | 1997-04-03 |
| WO1996004272A1 (de) | 1996-02-15 |
| JPH10503503A (ja) | 1998-03-31 |
| CN1156454A (zh) | 1997-08-06 |
| HRP950438A2 (en) | 1997-10-31 |
| UA44903C2 (uk) | 2002-03-15 |
| RU2163604C2 (ru) | 2001-02-27 |
| NO970473L (no) | 1997-04-01 |
| NO970473D0 (no) | 1997-02-03 |
| ATE242236T1 (de) | 2003-06-15 |
| EP0775135B1 (de) | 2003-06-04 |
| PL318460A1 (en) | 1997-06-09 |
| PL183526B1 (pl) | 2002-06-28 |
| ZA956477B (en) | 1997-02-03 |
| CN1066145C (zh) | 2001-05-23 |
| NZ290426A (en) | 1998-02-26 |
| NO312243B1 (no) | 2002-04-15 |
| US6028073A (en) | 2000-02-22 |
| AU3116295A (en) | 1996-03-04 |
| DE59510713D1 (de) | 2003-07-10 |
| BG63633B1 (bg) | 2002-07-31 |
| PT775135E (pt) | 2003-10-31 |
| CZ287862B6 (en) | 2001-02-14 |
| BG101220A (en) | 1997-08-29 |
| CZ31097A3 (en) | 1997-10-15 |
| ES2201111T3 (es) | 2004-03-16 |
| SI9520094A (en) | 1997-08-31 |
| EP0775135A1 (de) | 1997-05-28 |
| CA2196809A1 (en) | 1996-02-15 |
| AU696230B2 (en) | 1998-09-03 |
| DE4427648A1 (de) | 1996-02-08 |
| HUT77772A (hu) | 1998-08-28 |
| DK0775135T3 (da) | 2003-09-29 |
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