SI9300624A - Insecticidal 5-substituted-2,4-diaminopyrimidine derivatives - Google Patents
Insecticidal 5-substituted-2,4-diaminopyrimidine derivatives Download PDFInfo
- Publication number
- SI9300624A SI9300624A SI9300624A SI9300624A SI9300624A SI 9300624 A SI9300624 A SI 9300624A SI 9300624 A SI9300624 A SI 9300624A SI 9300624 A SI9300624 A SI 9300624A SI 9300624 A SI9300624 A SI 9300624A
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- SI
- Slovenia
- Prior art keywords
- hydrogen
- lower alkyl
- mol
- phenyl
- substituted
- Prior art date
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- -1 5-substituted-2,4-diaminopyrimidine Chemical class 0.000 title claims abstract description 66
- 230000000749 insecticidal effect Effects 0.000 title claims abstract description 29
- 150000001875 compounds Chemical class 0.000 claims abstract description 205
- 239000000203 mixture Substances 0.000 claims abstract description 100
- 239000001257 hydrogen Substances 0.000 claims abstract description 96
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 96
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 90
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 62
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 50
- 150000002431 hydrogen Chemical class 0.000 claims abstract description 30
- 238000000034 method Methods 0.000 claims description 55
- 241000238631 Hexapoda Species 0.000 claims description 46
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 39
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 38
- 125000001188 haloalkyl group Chemical group 0.000 claims description 21
- 229910052736 halogen Inorganic materials 0.000 claims description 20
- 150000002367 halogens Chemical class 0.000 claims description 19
- 125000003545 alkoxy group Chemical group 0.000 claims description 17
- 125000005843 halogen group Chemical group 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 15
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 14
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 14
- 239000002917 insecticide Substances 0.000 claims description 12
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 11
- 125000001424 substituent group Chemical group 0.000 claims description 11
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 10
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 10
- 125000004385 trihaloalkyl group Chemical group 0.000 claims description 10
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims description 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 9
- 125000001624 naphthyl group Chemical group 0.000 claims description 9
- 229910052720 vanadium Inorganic materials 0.000 claims description 9
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 claims description 8
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 8
- 125000005359 phenoxyalkyl group Chemical group 0.000 claims description 8
- 125000003884 phenylalkyl group Chemical group 0.000 claims description 8
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 5
- 125000005592 polycycloalkyl group Polymers 0.000 claims description 5
- 150000001343 alkyl silanes Chemical class 0.000 claims description 4
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 4
- 125000004438 haloalkoxy group Chemical group 0.000 claims description 4
- 125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 claims description 4
- 150000002989 phenols Chemical class 0.000 claims description 4
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 125000000175 2-thienyl group Chemical class S1C([*])=C([H])C([H])=C1[H] 0.000 claims description 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 2
- 125000004414 alkyl thio group Chemical group 0.000 claims description 2
- 125000002947 alkylene group Chemical group 0.000 claims description 2
- 125000004190 benzothiazol-2-yl group Chemical group [H]C1=C([H])C([H])=C2N=C(*)SC2=C1[H] 0.000 claims description 2
- 125000004441 haloalkylsulfonyl group Chemical group 0.000 claims description 2
- 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 claims description 2
- 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 150000001602 bicycloalkyls Chemical group 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 description 136
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 133
- 238000003786 synthesis reaction Methods 0.000 description 133
- 239000011541 reaction mixture Substances 0.000 description 128
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 108
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 97
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 93
- 239000000543 intermediate Substances 0.000 description 83
- 239000000243 solution Substances 0.000 description 82
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 78
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 70
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 60
- 239000000460 chlorine Substances 0.000 description 57
- 238000012360 testing method Methods 0.000 description 56
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 54
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 51
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 51
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 46
- 239000007787 solid Substances 0.000 description 41
- 239000000706 filtrate Substances 0.000 description 37
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 35
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 34
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 32
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 30
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 30
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 27
- 229910000027 potassium carbonate Inorganic materials 0.000 description 27
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 24
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 24
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 23
- 235000019341 magnesium sulphate Nutrition 0.000 description 23
- 239000000126 substance Substances 0.000 description 23
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 22
- 238000006243 chemical reaction Methods 0.000 description 22
- 239000000047 product Substances 0.000 description 22
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 21
- 239000000284 extract Substances 0.000 description 20
- 229960000789 guanidine hydrochloride Drugs 0.000 description 20
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 20
- 238000010828 elution Methods 0.000 description 19
- 230000012010 growth Effects 0.000 description 19
- 239000003921 oil Substances 0.000 description 19
- 235000019198 oils Nutrition 0.000 description 19
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 18
- 238000010898 silica gel chromatography Methods 0.000 description 18
- 238000001914 filtration Methods 0.000 description 16
- 238000010992 reflux Methods 0.000 description 16
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 15
- 229910052757 nitrogen Inorganic materials 0.000 description 15
- 150000003230 pyrimidines Chemical class 0.000 description 15
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 15
- 238000003756 stirring Methods 0.000 description 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 13
- 239000003054 catalyst Substances 0.000 description 13
- 239000003208 petroleum Substances 0.000 description 13
- 239000012074 organic phase Substances 0.000 description 12
- STIAPHVBRDNOAJ-UHFFFAOYSA-N carbamimidoylazanium;carbonate Chemical compound NC(N)=N.NC(N)=N.OC(O)=O STIAPHVBRDNOAJ-UHFFFAOYSA-N 0.000 description 11
- 235000005911 diet Nutrition 0.000 description 11
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 10
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 10
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 10
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 10
- 239000000843 powder Substances 0.000 description 10
- 238000002360 preparation method Methods 0.000 description 10
- 229920006395 saturated elastomer Polymers 0.000 description 10
- KLFCTZBLVSRWSW-UHFFFAOYSA-N 5-(2-ethylbutoxy)pyrimidine-2,4-diamine Chemical compound CCC(CC)COC1=CN=C(N)N=C1N KLFCTZBLVSRWSW-UHFFFAOYSA-N 0.000 description 9
- 239000000969 carrier Substances 0.000 description 9
- 239000012141 concentrate Substances 0.000 description 9
- 235000008504 concentrate Nutrition 0.000 description 9
- 230000037213 diet Effects 0.000 description 9
- UAOMVDZJSHZZME-UHFFFAOYSA-N diisopropylamine Chemical compound CC(C)NC(C)C UAOMVDZJSHZZME-UHFFFAOYSA-N 0.000 description 9
- 230000009036 growth inhibition Effects 0.000 description 9
- 239000012299 nitrogen atmosphere Substances 0.000 description 9
- HUPVIAINOSTNBJ-HWKANZROSA-N (e)-3-ethoxyprop-2-enenitrile Chemical compound CCO\C=C\C#N HUPVIAINOSTNBJ-HWKANZROSA-N 0.000 description 8
- MIZKXHBNFZFLJP-UHFFFAOYSA-N 3-(3-phenylphenyl)propanenitrile Chemical compound N#CCCC1=CC=CC(C=2C=CC=CC=2)=C1 MIZKXHBNFZFLJP-UHFFFAOYSA-N 0.000 description 8
- 241000196324 Embryophyta Species 0.000 description 8
- 241000256244 Heliothis virescens Species 0.000 description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 8
- FKRCODPIKNYEAC-UHFFFAOYSA-N ethyl propionate Chemical compound CCOC(=O)CC FKRCODPIKNYEAC-UHFFFAOYSA-N 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 239000012071 phase Substances 0.000 description 8
- RFYFPICRESHAJC-UHFFFAOYSA-N 1-(3-iodopropyl)naphthalene Chemical compound C1=CC=C2C(CCCI)=CC=CC2=C1 RFYFPICRESHAJC-UHFFFAOYSA-N 0.000 description 7
- XOMGENVDQWACIS-UHFFFAOYSA-N 5-(1-adamantyl)-6-methylpyrimidine-2,4-diamine Chemical compound CC1=NC(N)=NC(N)=C1C1(C2)CC(C3)CC2CC3C1 XOMGENVDQWACIS-UHFFFAOYSA-N 0.000 description 7
- JUUBFXIMFOJFOF-UHFFFAOYSA-N 5-(4-chloro-3-nitrophenyl)-6-ethylpyrimidine-2,4-diamine Chemical class CCC1=NC(N)=NC(N)=C1C1=CC=C(Cl)C([N+]([O-])=O)=C1 JUUBFXIMFOJFOF-UHFFFAOYSA-N 0.000 description 7
- XUUGUMBZSOOHQO-UHFFFAOYSA-N 6-ethyl-5-[3-[3-(trifluoromethyl)phenyl]butyl]pyrimidine-2,4-diamine Chemical compound CCC1=NC(N)=NC(N)=C1CCC(C)C1=CC=CC(C(F)(F)F)=C1 XUUGUMBZSOOHQO-UHFFFAOYSA-N 0.000 description 7
- YXHKONLOYHBTNS-UHFFFAOYSA-N Diazomethane Chemical compound C=[N+]=[N-] YXHKONLOYHBTNS-UHFFFAOYSA-N 0.000 description 7
- 238000009472 formulation Methods 0.000 description 7
- 238000004817 gas chromatography Methods 0.000 description 7
- 238000002844 melting Methods 0.000 description 7
- YAAWASYJIRZXSZ-UHFFFAOYSA-N pyrimidine-2,4-diamine Chemical class NC1=CC=NC(N)=N1 YAAWASYJIRZXSZ-UHFFFAOYSA-N 0.000 description 7
- 125000000547 substituted alkyl group Chemical group 0.000 description 7
- 239000004094 surface-active agent Substances 0.000 description 7
- HWIKMSXIILZULT-UHFFFAOYSA-N 3-undecylphenol Chemical compound CCCCCCCCCCCC1=CC=CC(O)=C1 HWIKMSXIILZULT-UHFFFAOYSA-N 0.000 description 6
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 6
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 description 6
- 230000002401 inhibitory effect Effects 0.000 description 6
- 230000005764 inhibitory process Effects 0.000 description 6
- 230000008018 melting Effects 0.000 description 6
- HXITXNWTGFUOAU-UHFFFAOYSA-N phenylboronic acid Chemical compound OB(O)C1=CC=CC=C1 HXITXNWTGFUOAU-UHFFFAOYSA-N 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 239000012312 sodium hydride Substances 0.000 description 6
- 229910000104 sodium hydride Inorganic materials 0.000 description 6
- YQGHJCYLMLPCCB-UHFFFAOYSA-N 2,4-diaminopyrimidin-5-ol Chemical compound NC1=NC=C(O)C(N)=N1 YQGHJCYLMLPCCB-UHFFFAOYSA-N 0.000 description 5
- JCUOLNHGQQXLPO-UHFFFAOYSA-N 6-ethyl-5-(3-undecylphenoxy)pyrimidine-2,4-diamine Chemical compound CCCCCCCCCCCC1=CC=CC(OC=2C(=NC(N)=NC=2N)CC)=C1 JCUOLNHGQQXLPO-UHFFFAOYSA-N 0.000 description 5
- RSWHPXKGJFAXFE-UHFFFAOYSA-N 6-methyl-5-(3-phenylpropoxy)pyrimidine-2,4-diamine Chemical compound CC1=NC(N)=NC(N)=C1OCCCC1=CC=CC=C1 RSWHPXKGJFAXFE-UHFFFAOYSA-N 0.000 description 5
- ROOWPYZRTUQRAH-UHFFFAOYSA-N 6-methyl-5-[3-[2-(trifluoromethyl)phenyl]propyl]pyrimidine-2,4-diamine Chemical compound CC1=NC(N)=NC(N)=C1CCCC1=CC=CC=C1C(F)(F)F ROOWPYZRTUQRAH-UHFFFAOYSA-N 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 5
- 239000012359 Methanesulfonyl chloride Substances 0.000 description 5
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 5
- 238000005481 NMR spectroscopy Methods 0.000 description 5
- SMNRFWMNPDABKZ-WVALLCKVSA-N [[(2R,3S,4R,5S)-5-(2,6-dioxo-3H-pyridin-3-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [[[(2R,3S,4S,5R,6R)-4-fluoro-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate Chemical compound OC[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)C2C=CC(=O)NC2=O)[C@H](O)[C@@H](F)[C@@H]1O SMNRFWMNPDABKZ-WVALLCKVSA-N 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- 229940058936 antimalarials diaminopyrimidines Drugs 0.000 description 5
- 125000003118 aryl group Chemical group 0.000 description 5
- 125000004432 carbon atom Chemical group C* 0.000 description 5
- 238000001035 drying Methods 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- 239000008187 granular material Substances 0.000 description 5
- QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 description 5
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 5
- QJPQVXSHYBGQGM-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 QJPQVXSHYBGQGM-UHFFFAOYSA-N 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 239000002244 precipitate Substances 0.000 description 5
- 239000011347 resin Substances 0.000 description 5
- 229920005989 resin Polymers 0.000 description 5
- 239000000741 silica gel Substances 0.000 description 5
- 229910002027 silica gel Inorganic materials 0.000 description 5
- 235000009518 sodium iodide Nutrition 0.000 description 5
- RGYVDOAMWQKART-UHFFFAOYSA-N (2,4-diaminopyrimidin-5-yl) sulfate;hydron Chemical compound NC1=NC=C(OS(O)(=O)=O)C(N)=N1 RGYVDOAMWQKART-UHFFFAOYSA-N 0.000 description 4
- UVLAGCAJWBLZLZ-UHFFFAOYSA-N 1-(3-phenylmethoxyphenyl)undecan-1-ol Chemical compound CCCCCCCCCCC(O)C1=CC=CC(OCC=2C=CC=CC=2)=C1 UVLAGCAJWBLZLZ-UHFFFAOYSA-N 0.000 description 4
- IZYBVBNOENNJNW-UHFFFAOYSA-N 3-methoxy-2-[3-(2,4,5-trichlorophenyl)propyl]pent-2-enenitrile Chemical compound CCC(OC)=C(C#N)CCCC1=CC(Cl)=C(Cl)C=C1Cl IZYBVBNOENNJNW-UHFFFAOYSA-N 0.000 description 4
- KUHYUBLQGOJRNM-UHFFFAOYSA-N 3-oxo-2-[3-(2,4,5-trichlorophenyl)propyl]pentanenitrile Chemical compound CCC(=O)C(C#N)CCCC1=CC(Cl)=C(Cl)C=C1Cl KUHYUBLQGOJRNM-UHFFFAOYSA-N 0.000 description 4
- FBAZXCGPKSJTCE-UHFFFAOYSA-N 5-(3-amino-4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine Chemical compound CCC1=NC(N)=NC(N)=C1C1=CC=C(Cl)C(N)=C1 FBAZXCGPKSJTCE-UHFFFAOYSA-N 0.000 description 4
- FUVWRUJASRBHEK-UHFFFAOYSA-N 5-phenylpyrimidine-2,4-diamine Chemical compound NC1=NC(N)=NC=C1C1=CC=CC=C1 FUVWRUJASRBHEK-UHFFFAOYSA-N 0.000 description 4
- RTSCKDBJHRWMJI-UHFFFAOYSA-N 6-methyl-5-[3-(2-methylphenyl)propyl]pyrimidine-2,4-diamine Chemical compound CC1=CC=CC=C1CCCC1=C(C)N=C(N)N=C1N RTSCKDBJHRWMJI-UHFFFAOYSA-N 0.000 description 4
- YSUHRRLYFRXOEY-UHFFFAOYSA-N 6-methyl-5-[3-(4-methylphenyl)propyl]pyrimidine-2,4-diamine Chemical compound C1=CC(C)=CC=C1CCCC1=C(C)N=C(N)N=C1N YSUHRRLYFRXOEY-UHFFFAOYSA-N 0.000 description 4
- BOQULSHFABJIKN-UHFFFAOYSA-N 6-methyl-5-[3-[2-(trifluoromethyl)phenoxy]propoxy]pyrimidine-2,4-diamine Chemical compound CC1=NC(N)=NC(N)=C1OCCCOC1=CC=CC=C1C(F)(F)F BOQULSHFABJIKN-UHFFFAOYSA-N 0.000 description 4
- KZMGYPLQYOPHEL-UHFFFAOYSA-N Boron trifluoride etherate Chemical compound FB(F)F.CCOCC KZMGYPLQYOPHEL-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 4
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 4
- RFFFKMOABOFIDF-UHFFFAOYSA-N Pentanenitrile Chemical compound CCCCC#N RFFFKMOABOFIDF-UHFFFAOYSA-N 0.000 description 4
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Natural products OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 4
- 208000002474 Tinea Diseases 0.000 description 4
- 241000893966 Trichophyton verrucosum Species 0.000 description 4
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- 238000000354 decomposition reaction Methods 0.000 description 4
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- 235000001508 sulfur Nutrition 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- YJBKVPRVZAQTPY-UHFFFAOYSA-J tetrachlorostannane;dihydrate Chemical compound O.O.Cl[Sn](Cl)(Cl)Cl YJBKVPRVZAQTPY-UHFFFAOYSA-J 0.000 description 1
- 125000004001 thioalkyl group Chemical group 0.000 description 1
- GZNAASVAJNXPPW-UHFFFAOYSA-M tin(4+) chloride dihydrate Chemical compound O.O.[Cl-].[Sn+4] GZNAASVAJNXPPW-UHFFFAOYSA-M 0.000 description 1
- FWPIDFUJEMBDLS-UHFFFAOYSA-L tin(II) chloride dihydrate Substances O.O.Cl[Sn]Cl FWPIDFUJEMBDLS-UHFFFAOYSA-L 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
- KMPQYAYAQWNLME-UHFFFAOYSA-N undecanal Chemical compound CCCCCCCCCCC=O KMPQYAYAQWNLME-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/84—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/18—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/20—N-Aryl derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98508492A | 1992-12-02 | 1992-12-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI9300624A true SI9300624A (en) | 1994-09-30 |
Family
ID=25531185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9300624A SI9300624A (en) | 1992-12-02 | 1993-12-02 | Insecticidal 5-substituted-2,4-diaminopyrimidine derivatives |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US5521192A (de) |
| EP (1) | EP0671881A4 (de) |
| JP (1) | JPH08502998A (de) |
| KR (1) | KR960700005A (de) |
| CN (1) | CN1096156A (de) |
| AP (1) | AP503A (de) |
| AU (1) | AU673222B2 (de) |
| BG (1) | BG99688A (de) |
| BR (1) | BR9307587A (de) |
| CA (1) | CA2150672A1 (de) |
| CO (1) | CO4180491A1 (de) |
| CZ (1) | CZ143295A3 (de) |
| FI (1) | FI952682A (de) |
| HR (1) | HRP931432A2 (de) |
| HU (1) | HUP9501597A2 (de) |
| LT (1) | LT3166B (de) |
| MA (1) | MA23044A1 (de) |
| MX (1) | MX9307471A (de) |
| NO (1) | NO952180L (de) |
| NZ (1) | NZ258722A (de) |
| OA (1) | OA10162A (de) |
| PL (1) | PL309259A1 (de) |
| RU (1) | RU95113597A (de) |
| SI (1) | SI9300624A (de) |
| SK (1) | SK73595A3 (de) |
| TN (1) | TNSN93133A1 (de) |
| TW (1) | TW311911B (de) |
| WO (1) | WO1994012032A1 (de) |
| ZA (1) | ZA938591B (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6893815B1 (en) * | 1997-06-30 | 2005-05-17 | Isis Pharmaceuticals, Inc. | Nucleobase heterocyclic combinatorialization |
| AU2001280445A1 (en) * | 2000-06-23 | 2002-01-08 | Vanderbilt University | Novel chain-breaking antioxidants |
| ES2255624T3 (es) * | 2001-08-15 | 2006-07-01 | E. I. Du Pont De Nemours And Company | Aril amidas sustituidas con grupos orto-heterociclicos para el control de plagas de invertebrados. |
| CN1717391A (zh) * | 2002-10-21 | 2006-01-04 | 希龙公司 | 糖元合成酶激酶3的抑制剂 |
| US20050070712A1 (en) * | 2003-09-26 | 2005-03-31 | Christi Kosogof | Pyrimidine derivatives as ghrelin receptor modulators |
| US20050171132A1 (en) * | 2003-09-26 | 2005-08-04 | Zhili Xin | Diaminopyrimidine derivatives as selective growth hormone secrectgogue receptor (GHS-R) antagonists |
| DE102004003428A1 (de) * | 2004-01-23 | 2005-08-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue langwirksame Beta-2-Agonisten, und deren Verwendung als Arzneimittel |
| US20080176744A1 (en) * | 2005-03-10 | 2008-07-24 | Basf Aktiengesellschaft | Use of 4-Aminopyrimidines for Controlling Harmful Fungi, Novel 4-Aminopyrimidines, Processes for Their Preparation and Compositions Comprising Them |
| US8367669B2 (en) * | 2005-06-15 | 2013-02-05 | Vanderbilt University | Inhibitors of hemeprotein-catalyzed lipid peroxidation |
| US9133212B1 (en) | 2005-06-15 | 2015-09-15 | Vanderbilt University | Inhibitors of hemeprotein-catalyzed lipid peroxidation |
| EP2532240A3 (de) * | 2007-04-03 | 2013-03-13 | E. I. du Pont de Nemours and Company | Substituierte Benzenfungizide |
| EP2194985B1 (de) * | 2007-10-08 | 2019-02-20 | MMV Medicines for Malaria Venture | Antimalaria-verbindungen mit flexiblen seitenketten |
| US8110608B2 (en) | 2008-06-05 | 2012-02-07 | Ecolab Usa Inc. | Solid form sodium lauryl sulfate (SLS) pesticide composition |
| US20120065067A1 (en) * | 2010-09-14 | 2012-03-15 | The Regents Of The University Of California | Pamoic acid blocks ethylene signaling |
| US8968757B2 (en) | 2010-10-12 | 2015-03-03 | Ecolab Usa Inc. | Highly wettable, water dispersible, granules including two pesticides |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1229413A (de) * | 1967-06-14 | 1971-04-21 | ||
| JPS4829228A (de) * | 1971-08-21 | 1973-04-18 | ||
| GB1546937A (en) * | 1976-07-29 | 1979-05-31 | Beecham Group Ltd | 2,4-diaminopyrimidine derivatives |
| DE2720771C3 (de) * | 1977-05-09 | 1979-11-29 | Ludwig Heumann & Co Gmbh, 8500 Nuernberg | 2,4-Diamino-5-(33-dimethoxy-4thioalkyl-benzyD-pyrimidine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| GB2086386B (en) * | 1980-10-27 | 1984-01-18 | May & Baker Ltd | Pyrimidine derivatives |
| US4438267A (en) * | 1980-11-11 | 1984-03-20 | Daluge Susan M | Monoheteroring compounds and their use |
| PH20344A (en) * | 1981-01-29 | 1986-12-04 | Sankyo Co | Aminopyrimidine derivatives, processes for their preparation, and fungicidal, insecticidal and acaricidal compositions containing them |
| DE3669315D1 (de) * | 1985-03-14 | 1990-04-12 | Sankyo Co | Phenoxyalkylaminopyrimidinderivate, deren herstellung und diese enthaltende insektizide und akarizide zusammensetzungen. |
| US4783468A (en) * | 1986-04-30 | 1988-11-08 | Ciba-Geigy Corporation | Insecticidal 5-pyrimidine carbonitriles |
| US4895849A (en) * | 1986-10-08 | 1990-01-23 | Ube Industries, Ltd. | Aralkylaminopyrimidine compounds which are useful as for producing thereof and insecticides |
| HU199683B (en) * | 1987-07-22 | 1990-03-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing pharmaceutical compositions analgesic, antiphlogistic, antipyretic, antianginic and/or antioxidative activity |
| JPH0720943B2 (ja) * | 1988-08-19 | 1995-03-08 | 宇部興産株式会社 | アミノピリミジン誘導体、その製法及び殺虫・殺菌剤 |
-
1992
- 1992-11-18 RU RU95113597/04A patent/RU95113597A/ru unknown
-
1993
- 1993-11-17 ZA ZA938591A patent/ZA938591B/xx unknown
- 1993-11-18 EP EP94902306A patent/EP0671881A4/de not_active Withdrawn
- 1993-11-18 AU AU56716/94A patent/AU673222B2/en not_active Ceased
- 1993-11-18 CZ CZ951432A patent/CZ143295A3/cs unknown
- 1993-11-18 PL PL93309259A patent/PL309259A1/xx unknown
- 1993-11-18 WO PCT/US1993/011240 patent/WO1994012032A1/en not_active Application Discontinuation
- 1993-11-18 CA CA002150672A patent/CA2150672A1/en not_active Abandoned
- 1993-11-18 BR BR9307587-1A patent/BR9307587A/pt not_active Application Discontinuation
- 1993-11-18 JP JP6513259A patent/JPH08502998A/ja active Pending
- 1993-11-18 HU HU9501597A patent/HUP9501597A2/hu unknown
- 1993-11-18 NZ NZ258722A patent/NZ258722A/en unknown
- 1993-11-18 SK SK735-95A patent/SK73595A3/sk unknown
- 1993-11-18 KR KR1019950702250A patent/KR960700005A/ko not_active Application Discontinuation
- 1993-11-24 HR HR931432A patent/HRP931432A2/hr not_active Application Discontinuation
- 1993-11-26 CO CO93420258A patent/CO4180491A1/es unknown
- 1993-11-29 MX MX9307471A patent/MX9307471A/es unknown
- 1993-11-30 MA MA23352A patent/MA23044A1/fr unknown
- 1993-12-01 AP APAP/P/1993/000595A patent/AP503A/en active
- 1993-12-01 LT LTIP1510A patent/LT3166B/lt not_active IP Right Cessation
- 1993-12-02 CN CN93120401A patent/CN1096156A/zh active Pending
- 1993-12-02 TW TW082110271A patent/TW311911B/zh active
- 1993-12-02 SI SI9300624A patent/SI9300624A/sl unknown
- 1993-12-02 TN TNTNSN93133A patent/TNSN93133A1/fr unknown
-
1994
- 1994-05-03 US US08/237,481 patent/US5521192A/en not_active Expired - Fee Related
-
1995
- 1995-05-22 US US08/446,354 patent/US5587379A/en not_active Expired - Fee Related
- 1995-05-31 BG BG99688A patent/BG99688A/xx unknown
- 1995-06-01 NO NO952180A patent/NO952180L/no unknown
- 1995-06-01 FI FI952682A patent/FI952682A/fi unknown
- 1995-06-02 OA OA60670A patent/OA10162A/en unknown
- 1995-11-08 US US08/555,249 patent/US5627189A/en not_active Expired - Fee Related
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