SI9300591A - Water soluble camptothecin derivatives - Google Patents
Water soluble camptothecin derivatives Download PDFInfo
- Publication number
- SI9300591A SI9300591A SI9300591A SI9300591A SI9300591A SI 9300591 A SI9300591 A SI 9300591A SI 9300591 A SI9300591 A SI 9300591A SI 9300591 A SI9300591 A SI 9300591A SI 9300591 A SI9300591 A SI 9300591A
- Authority
- SI
- Slovenia
- Prior art keywords
- camptothecin
- ethylenedioxy
- compound
- formula
- methylenedioxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97536392A | 1992-11-12 | 1992-11-12 | |
US97536492A | 1992-11-12 | 1992-11-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
SI9300591A true SI9300591A (en) | 1994-06-30 |
Family
ID=27130580
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9300591A SI9300591A (en) | 1992-11-12 | 1993-11-11 | Water soluble camptothecin derivatives |
Country Status (12)
Country | Link |
---|---|
US (1) | US6100273A (ja) |
EP (1) | EP0673380A1 (ja) |
JP (1) | JPH08503221A (ja) |
CN (1) | CN1091742A (ja) |
AP (1) | AP9300587A0 (ja) |
AU (1) | AU5604594A (ja) |
CA (1) | CA2148819A1 (ja) |
IS (1) | IS4092A (ja) |
MX (1) | MX9307011A (ja) |
MY (1) | MY109296A (ja) |
SI (1) | SI9300591A (ja) |
WO (1) | WO1994011377A2 (ja) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AP9300587A0 (en) * | 1992-11-12 | 1995-05-05 | Glaxo Inc | Water soluble camptothecin derivatives. |
US5491237A (en) * | 1994-05-03 | 1996-02-13 | Glaxo Wellcome Inc. | Intermediates in pharmaceutical camptothecin preparation |
IT1269862B (it) * | 1994-05-30 | 1997-04-15 | Indena Spa | Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono |
US5496952A (en) * | 1995-02-07 | 1996-03-05 | North Carolina State University | Method of making asymmetric DE ring intermediates for the synthesis of camptothecin and camptothecin analogs |
JPH08333370A (ja) * | 1995-06-08 | 1996-12-17 | Kyorin Pharmaceut Co Ltd | 水に可溶な新規フルオロエチルカンプトテシン誘導体、及びその製造方法 |
US6559309B2 (en) | 1996-11-01 | 2003-05-06 | Osi Pharmaceuticals, Inc. | Preparation of a camptothecin derivative by intramolecular cyclisation |
US6207673B1 (en) | 1997-03-12 | 2001-03-27 | The University Of North Carolina At Chapel Hill | Covalent conjugates of topoisomerase I and topoisomerase II inhibitors |
EP2266607A3 (en) | 1999-10-01 | 2011-04-20 | Immunogen, Inc. | Immunoconjugates for treating cancer |
US6288072B1 (en) * | 1999-12-29 | 2001-09-11 | Monroe E. Wall | Camptothecin β-alanine esters with topoisomerase I inhibition |
AU2001243515A1 (en) * | 2000-03-08 | 2001-09-17 | Rhode Island Hospital, A Lifespan Partner | Combination drug therapy |
US6825206B1 (en) * | 2000-11-16 | 2004-11-30 | Research Triangle Institute | Camptothecin compounds with a thioether group |
US6593334B1 (en) | 2002-05-02 | 2003-07-15 | The University Of North Carolina At Chapel Hill | Camptothecin-taxoid conjugates as antimitotic and antitumor agents |
US20040204435A1 (en) * | 2003-04-09 | 2004-10-14 | Joachim Liehr | Alternating treatment with topoisomerase I and topoisomerase II inhibitors |
US20080058411A1 (en) | 2004-02-18 | 2008-03-06 | Gpc Biotech Ag | Methods For Treating Resistant Or Refractory Tumors |
EP2027853A3 (en) | 2004-06-18 | 2011-01-05 | Agennix USA Inc. | Kinase inhibitors for treating cancers |
UY30915A1 (es) * | 2007-02-16 | 2008-09-02 | Smithkline Beecham Corp | Método de tratamiento de canceres |
US20110129550A1 (en) * | 2007-02-16 | 2011-06-02 | Connie Erickson-Miller | Cancer treatment method |
US20110160130A1 (en) * | 2007-02-16 | 2011-06-30 | Connie Erickson-Miller | Cancer treatment method |
MX2010003881A (es) * | 2007-10-09 | 2010-07-28 | Univ Pennsylvania | El agonista del receptor de trombopoyetina (tpora) destruye las celulas de leucemia mieloide aguda de humano. |
US8722886B1 (en) * | 2012-11-13 | 2014-05-13 | Bionumerik Pharmaceuticals, Inc. | Methods for the total chemical synthesis of enantiomerically-pure 7-(2′-trimethylsilyl)ethyl camptothecin |
CA3045752A1 (en) | 2016-12-01 | 2018-06-07 | Glaxosmithkline Intellectual Property Development Limited | Methods of treating cancer |
EP3725798A4 (en) * | 2017-12-15 | 2021-11-10 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | BIOACTIVE CONJUGATE, METHOD FOR ITS MANUFACTURING AND USES |
CN110590796B (zh) * | 2018-06-12 | 2022-07-15 | 青岛海洋生物医药研究院股份有限公司 | 喜树碱衍生物及其制备方法和应用 |
WO2021018941A1 (en) | 2019-07-31 | 2021-02-04 | Glaxosmithkline Intellectual Property Development Limited | Methods of treating cancer |
US20230158154A1 (en) * | 2021-11-09 | 2023-05-25 | Tubulis Gmbh | Conjugates comprising a phosphorus (v) and a camptothecin moiety |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4399282A (en) * | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
US4399276A (en) * | 1981-01-09 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | 7-Substituted camptothecin derivatives |
JPS6019790A (ja) * | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
US4894456A (en) * | 1987-03-31 | 1990-01-16 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
US4943579A (en) * | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
JPH0615547B2 (ja) * | 1988-01-20 | 1994-03-02 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
HU213136B (en) * | 1990-08-14 | 1997-02-28 | Kyorin Seiyaku Kk | Process for producing fluoroethyl camptothecin derivatives and pharmaceutical compositions containing them |
ES2137932T3 (es) * | 1990-09-28 | 2000-01-01 | Smithkline Beecham Corp | Procedimiento para la preparacion de analogos de camptotecina solubles en agua, asi como los compuestos 10-hidroxi-11-alcoxi-6-camptotecina. |
US5126351A (en) * | 1991-01-24 | 1992-06-30 | Glaxo Inc. | Antitumor compounds |
DE69209969T2 (de) * | 1991-10-29 | 1996-09-12 | Glaxo Wellcome Inc | Wasserlösliche Camptothecinderivate |
US5559235A (en) * | 1991-10-29 | 1996-09-24 | Glaxo Wellcome Inc. | Water soluble camptothecin derivatives |
CA2087898A1 (en) * | 1992-01-24 | 1993-07-25 | Hiroshi Akimoto | Condensed heterocyclic compounds, their production and use |
US5342947A (en) * | 1992-10-09 | 1994-08-30 | Glaxo Inc. | Preparation of water soluble camptothecin derivatives |
AP9300587A0 (en) * | 1992-11-12 | 1995-05-05 | Glaxo Inc | Water soluble camptothecin derivatives. |
-
1993
- 1993-11-05 AP APAP/P/1993/000587A patent/AP9300587A0/en unknown
- 1993-11-08 IS IS4092A patent/IS4092A/is unknown
- 1993-11-09 MY MYPI93002349A patent/MY109296A/en unknown
- 1993-11-10 MX MX9307011A patent/MX9307011A/es unknown
- 1993-11-10 WO PCT/US1993/010987 patent/WO1994011377A2/en not_active Application Discontinuation
- 1993-11-10 JP JP6512398A patent/JPH08503221A/ja active Pending
- 1993-11-10 AU AU56045/94A patent/AU5604594A/en not_active Abandoned
- 1993-11-10 CA CA002148819A patent/CA2148819A1/en not_active Abandoned
- 1993-11-10 EP EP94901461A patent/EP0673380A1/en not_active Withdrawn
- 1993-11-11 SI SI9300591A patent/SI9300591A/sl unknown
- 1993-11-11 CN CN93114372A patent/CN1091742A/zh active Pending
-
1997
- 1997-11-24 US US08/977,217 patent/US6100273A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
MY109296A (en) | 1996-12-31 |
CA2148819A1 (en) | 1994-05-26 |
WO1994011377A2 (en) | 1994-05-26 |
AU5604594A (en) | 1994-06-08 |
MX9307011A (es) | 1994-05-31 |
JPH08503221A (ja) | 1996-04-09 |
IS4092A (is) | 1994-05-13 |
CN1091742A (zh) | 1994-09-07 |
WO1994011377A3 (en) | 1994-08-04 |
US6100273A (en) | 2000-08-08 |
AP9300587A0 (en) | 1995-05-05 |
EP0673380A1 (en) | 1995-09-27 |
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