SI9011872B - Postopek za proizvodnjo optično aktivnega 2-(tetrahidropiran-2-iloksi)-1-propanol, nov intermediat uporabljen pri tem postopku, ter njegova priprava - Google Patents
Postopek za proizvodnjo optično aktivnega 2-(tetrahidropiran-2-iloksi)-1-propanol, nov intermediat uporabljen pri tem postopku, ter njegova priprava Download PDFInfo
- Publication number
- SI9011872B SI9011872B SI9011872A SI9011872A SI9011872B SI 9011872 B SI9011872 B SI 9011872B SI 9011872 A SI9011872 A SI 9011872A SI 9011872 A SI9011872 A SI 9011872A SI 9011872 B SI9011872 B SI 9011872B
- Authority
- SI
- Slovenia
- Prior art keywords
- optically active
- propanol
- yloxy
- formula
- organic solvent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Claims (4)
1 PATENTNI ZAHTEVKI 1. Postopek za proizvodnjo optično aktivnega izomera 2-(tetrahidropiran-2-iloksi)-l-propanola, prikazanega s formulo (I):
označen s tem, da obsega reakcijo optično aktivnega izomera l-aciloksi-2-propanola, prikazanega s formulo (II): OH OCOR (Π) kjer je R z nitro ali halogenom substituirana ali nesubstituirana fenilna skupina, s 3,4-dihidro-2H-piranom, da dobimo optično aktiven izomer l-aciloksi-2-(tetrahidropiran-2-iloksi)propana, prikazanega s formulo (III):
OCOR (III) L kjer ima R zgoraj definirani pomen, in s hidrolizo spojine (III), da odstranimo acilno skupino.
2. Postopek po zahtevku 1, označen s tem, da je navedeni aktivni izomer l-aciloksi-2-propanola prikazan s formulo (II) tak, ki se ga da dobiti z reakcijo optično aktivnega izomera 1,2-propandiola s kislinskim halidom, prikazanim s formulo (V) RCOX (V) kjer je X atom halogena in ima R pri zahtevku 1 navedeni pomen.
3. Postopek po zahtevku 1, označen s tem, da kot R izberemo fenilno, p-nitrofenilno, m-nitrofenilno ali o-nitrofenilno skupino, 2,4-dinitrofenilno, 2,6-dinitrofenilno, 3,4-dinitrofenilno, 3,5-dinitrofenilno, p-bromofenilno, m-bromofenilno, o-bromofenilno, p-jodofenilno, m-jodofenilno, o-jodofenilno, p-klorofenilno, m-klorofenilno in o-klorofenilno skupino.
4. Postopek po zahtevku 3, označen s tem, da je R p-nitrofenilna skupina ali p-bromofenilna skupina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26103189 | 1989-10-05 | ||
| YU187290A YU47868B (sh) | 1989-10-05 | 1990-10-03 | Postupak za proizvodnju optički aktivnog izomera 2-(tetrahidropiran-2-iloksi)-1-propanola |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI9011872A SI9011872A (en) | 1997-08-31 |
| SI9011872B true SI9011872B (sl) | 1999-04-30 |
Family
ID=17356091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9011872A SI9011872B (sl) | 1989-10-05 | 1990-10-03 | Postopek za proizvodnjo optično aktivnega 2-(tetrahidropiran-2-iloksi)-1-propanol, nov intermediat uporabljen pri tem postopku, ter njegova priprava |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5128489A (sl) |
| EP (1) | EP0421774B1 (sl) |
| JP (1) | JP2684237B2 (sl) |
| KR (1) | KR0162079B1 (sl) |
| AT (1) | ATE107297T1 (sl) |
| DE (1) | DE69009925T2 (sl) |
| DK (1) | DK0421774T3 (sl) |
| ES (1) | ES2058811T3 (sl) |
| HR (1) | HRP921076B1 (sl) |
| IE (1) | IE65561B1 (sl) |
| PL (1) | PL164173B1 (sl) |
| SI (1) | SI9011872B (sl) |
| YU (1) | YU47868B (sl) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5686095A (en) * | 1995-10-23 | 1997-11-11 | Price, Jr.; Francis W. | Method of treating canker sores |
| US20040030160A1 (en) * | 1999-12-24 | 2004-02-12 | Kunihiko Sakano | Process for preparation of tetrahydropyranyoxyamines |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3989728A (en) * | 1975-02-12 | 1976-11-02 | The Procter & Gamble Company | Process for synthesizing specific complete mixed polyol esters |
| IE75342B1 (en) * | 1987-12-25 | 1997-08-27 | Daiichi Seiyaku Co | Propoxybenzene derivatives and process for preparing the same |
| JPH0322090A (ja) * | 1989-06-19 | 1991-01-30 | Nec Corp | 画像処理装置 |
-
1990
- 1990-10-02 IE IE352590A patent/IE65561B1/en not_active IP Right Cessation
- 1990-10-03 SI SI9011872A patent/SI9011872B/sl not_active IP Right Cessation
- 1990-10-03 JP JP2265701A patent/JP2684237B2/ja not_active Expired - Fee Related
- 1990-10-03 YU YU187290A patent/YU47868B/sh unknown
- 1990-10-04 EP EP90310848A patent/EP0421774B1/en not_active Expired - Lifetime
- 1990-10-04 DK DK90310848.8T patent/DK0421774T3/da active
- 1990-10-04 DE DE69009925T patent/DE69009925T2/de not_active Expired - Lifetime
- 1990-10-04 US US07/592,752 patent/US5128489A/en not_active Expired - Lifetime
- 1990-10-04 AT AT90310848T patent/ATE107297T1/de not_active IP Right Cessation
- 1990-10-04 ES ES90310848T patent/ES2058811T3/es not_active Expired - Lifetime
- 1990-10-05 KR KR1019900015784A patent/KR0162079B1/ko not_active IP Right Cessation
- 1990-10-05 PL PL90287202A patent/PL164173B1/pl not_active IP Right Cessation
-
1992
- 1992-10-16 HR HRP-1872/90A patent/HRP921076B1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SI9011872A (en) | 1997-08-31 |
| EP0421774A2 (en) | 1991-04-10 |
| ATE107297T1 (de) | 1994-07-15 |
| IE903525A1 (en) | 1991-04-10 |
| IE65561B1 (en) | 1995-11-01 |
| JP2684237B2 (ja) | 1997-12-03 |
| DE69009925T2 (de) | 1995-01-05 |
| HRP921076A2 (en) | 1995-12-31 |
| YU47868B (sh) | 1996-02-19 |
| HRP921076B1 (en) | 1999-02-28 |
| DK0421774T3 (da) | 1994-09-19 |
| KR0162079B1 (ko) | 1998-12-01 |
| JPH03204873A (ja) | 1991-09-06 |
| ES2058811T3 (es) | 1994-11-01 |
| DE69009925D1 (de) | 1994-07-21 |
| US5128489A (en) | 1992-07-07 |
| KR910007906A (ko) | 1991-05-30 |
| EP0421774B1 (en) | 1994-06-15 |
| EP0421774A3 (en) | 1991-10-02 |
| YU187290A (sh) | 1992-09-07 |
| PL164173B1 (pl) | 1994-06-30 |
| PL287202A1 (en) | 1991-07-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF | Valid on the event date | ||
| KO00 | Lapse of patent |
Effective date: 20050722 |