SI3313845T1 - Konjugati spremenjenih protiteles cisteina - Google Patents
Konjugati spremenjenih protiteles cisteinaInfo
- Publication number
- SI3313845T1 SI3313845T1 SI201630977T SI201630977T SI3313845T1 SI 3313845 T1 SI3313845 T1 SI 3313845T1 SI 201630977 T SI201630977 T SI 201630977T SI 201630977 T SI201630977 T SI 201630977T SI 3313845 T1 SI3313845 T1 SI 3313845T1
- Authority
- SI
- Slovenia
- Prior art keywords
- conjugates
- cysteine engineered
- engineered antibodies
- antibodies
- cysteine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562186254P | 2015-06-29 | 2015-06-29 | |
US201662338245P | 2016-05-18 | 2016-05-18 | |
PCT/US2016/039796 WO2017004025A1 (en) | 2015-06-29 | 2016-06-28 | Conjugates of cysteine engineered antibodies |
EP16738322.3A EP3313845B1 (en) | 2015-06-29 | 2016-06-28 | Conjugates of cysteine engineered antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
SI3313845T1 true SI3313845T1 (sl) | 2021-01-29 |
Family
ID=56409216
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201630977T SI3313845T1 (sl) | 2015-06-29 | 2016-06-28 | Konjugati spremenjenih protiteles cisteina |
Country Status (24)
Country | Link |
---|---|
US (2) | US10898579B2 (sl) |
EP (2) | EP3769787A1 (sl) |
JP (4) | JP6843080B2 (sl) |
KR (1) | KR20180021176A (sl) |
CN (2) | CN113769108A (sl) |
AR (1) | AR106013A1 (sl) |
AU (2) | AU2016285929B2 (sl) |
CA (1) | CA2988806A1 (sl) |
CY (1) | CY1123606T1 (sl) |
DK (1) | DK3313845T3 (sl) |
ES (1) | ES2832527T3 (sl) |
HK (1) | HK1254782A1 (sl) |
HR (1) | HRP20201790T1 (sl) |
HU (1) | HUE052616T2 (sl) |
LT (1) | LT3313845T (sl) |
MA (1) | MA42250B1 (sl) |
MD (1) | MD3313845T2 (sl) |
PL (1) | PL3313845T3 (sl) |
PT (1) | PT3313845T (sl) |
RS (1) | RS61050B1 (sl) |
RU (1) | RU2733740C2 (sl) |
SI (1) | SI3313845T1 (sl) |
TW (2) | TW202146057A (sl) |
WO (1) | WO2017004025A1 (sl) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2016285552B2 (en) | 2015-06-29 | 2022-10-13 | Immunogen, Inc. | Anti-CD123 antibodies and conjugates and derivatives thereof |
US20170189548A1 (en) * | 2015-11-25 | 2017-07-06 | Immunogen, Inc. | Pharmaceutical formulations and methods of use thereof |
CA3044391A1 (en) | 2016-11-23 | 2018-05-31 | Immunogen, Inc. | Selective sulfonation of benzodiazepine derivatives |
HRP20220550T1 (hr) | 2016-12-23 | 2022-06-10 | Immunogen, Inc. | Imunokonjugati koji ciljaju adam9 i postupci njihove uporabe |
WO2018183494A1 (en) | 2017-03-31 | 2018-10-04 | Immunogen, Inc. | Cd19-targeting antibody-drug conjugates |
TWI826393B (zh) * | 2017-09-22 | 2023-12-21 | 美商免疫遺傳股份有限公司 | 使用陽離子交換層析法分離三輕鏈抗體 |
CN111164208B (zh) | 2017-09-29 | 2023-08-04 | 第一三共株式会社 | 抗体-吡咯并苯并二氮杂卓衍生物偶联物 |
TW202029980A (zh) | 2018-10-26 | 2020-08-16 | 美商免疫遺傳股份有限公司 | E p C A M 抗體、可活化抗體及免疫偶聯物以及其用途 |
AU2019370291A1 (en) | 2018-10-30 | 2021-05-20 | Immunogen, Inc. | Methods of treatment using anti-CD123 immunoconjugates |
JP7437395B2 (ja) | 2018-11-12 | 2024-02-22 | イミュノジェン・インコーポレーテッド | 細胞傷害性ベンゾジアゼピン誘導体の調製方法 |
KR20210091711A (ko) | 2018-11-14 | 2021-07-22 | 다이이찌 산쿄 가부시키가이샤 | 항 cdh6 항체-피롤로벤조디아제핀 유도체 컨쥬게이트 |
CA3133802A1 (en) * | 2019-03-21 | 2020-09-24 | Immunogen, Inc. | Methods of preparing cell-binding agent-drug conjugates |
CN113631190A (zh) | 2019-03-25 | 2021-11-09 | 第一三共株式会社 | 抗her2抗体-吡咯并苯并二氮杂卓衍生物偶联物 |
WO2020196474A1 (ja) | 2019-03-25 | 2020-10-01 | 第一三共株式会社 | 抗体-ピロロベンゾジアゼピン誘導体コンジュゲート |
JPWO2020196712A1 (sl) | 2019-03-27 | 2020-10-01 | ||
AU2020265225A1 (en) | 2019-04-29 | 2021-10-28 | Immunogen, Inc. | Therapeutic combinations comprising anti-CD123 immunoconjugates |
WO2022050300A1 (ja) | 2020-09-02 | 2022-03-10 | 第一三共株式会社 | 新規エンド-β-N-アセチルグルコサミニダーゼ |
TW202237135A (zh) | 2021-01-13 | 2022-10-01 | 紀念斯隆凱特琳癌症中心 | 抗體-吡咯并苯并二氮呯衍生物結合物 |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
ES2149768T3 (es) | 1992-03-25 | 2000-11-16 | Immunogen Inc | Conjugados de agentes enlazantes de celulas derivados de cc-1065. |
GB9422383D0 (en) * | 1994-11-05 | 1995-01-04 | Wellcome Found | Antibodies |
NZ517772A (en) | 1999-11-24 | 2004-03-26 | Immunogen Inc | Cytotoxic agents comprising taxanes and their therapeutic use |
US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
US6716821B2 (en) | 2001-12-21 | 2004-04-06 | Immunogen Inc. | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same |
US6756397B2 (en) | 2002-04-05 | 2004-06-29 | Immunogen, Inc. | Prodrugs of CC-1065 analogs |
CN100522955C (zh) | 2002-08-02 | 2009-08-05 | 伊缪诺金公司 | 含有新型强效紫杉烷的细胞毒性剂及其治疗用途 |
JP2006500364A (ja) | 2002-08-16 | 2006-01-05 | イムノージェン インコーポレーテッド | 高い反応性と溶解度を有する架橋剤および小分子薬物の標的化送達用コンジュゲートの調製におけるそれらの使用 |
BR0316101A (pt) | 2002-11-07 | 2005-09-27 | Immunogen Inc | Anticorpos anticd33 e processo para tratamento de leucemia melóide aguda usando os mesmos |
US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
CA2558399C (en) | 2004-03-02 | 2015-05-19 | Seattle Genetics, Inc. | Partially loaded antibodies and methods of their conjugation |
CN102973947A (zh) | 2004-06-01 | 2013-03-20 | 健泰科生物技术公司 | 抗体-药物偶联物和方法 |
CA2580141C (en) | 2004-09-23 | 2013-12-10 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
EP1817341A2 (en) | 2004-11-29 | 2007-08-15 | Seattle Genetics, Inc. | Engineered antibodies and immunoconjugates |
US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
KR101328756B1 (ko) | 2006-05-30 | 2013-11-18 | 제넨테크, 인크. | 항체 및 면역접합체 및 이들의 용도 |
MX2009010282A (es) | 2007-03-29 | 2009-10-12 | Genmab As | Anticuerpos biespecificos y metodos para su produccion. |
MX2010011807A (es) | 2008-04-30 | 2011-03-04 | Immunogen Inc | Entrelazadores y sus usos. |
UA108598C2 (xx) | 2008-04-30 | 2015-05-25 | Високоефективні кон'югати та гідрофільні зшиваючі агенти (лінкери) | |
WO2010091150A1 (en) * | 2009-02-05 | 2010-08-12 | Immunogen, Inc. | Novel benzodiazepine derivatives |
US8431416B2 (en) * | 2009-04-01 | 2013-04-30 | Becton, Dickinson And Company | Reactive heterocycle-substituted 7-hydroxycoumarins and their conjugates |
CA2766405A1 (en) | 2009-06-22 | 2011-01-13 | Medimmune, Llc | Engineered fc regions for site-specific conjugation |
WO2011092838A1 (ja) | 2010-01-29 | 2011-08-04 | 株式会社フォーサイド・ドット・コム | コンテンツ共有システム、およびコンテンツ共有方法 |
TWI504408B (zh) | 2010-02-24 | 2015-10-21 | Immunogen Inc | 葉酸受體1抗體類和免疫共軛物類及彼等之用途 |
KR101764572B1 (ko) | 2010-03-12 | 2017-08-03 | 이뮤노젠 아이엔씨 | Cd37―결합 분자 및 이의 면역접합체 |
KR102152109B1 (ko) | 2010-04-20 | 2020-09-07 | 젠맵 에이/에스 | 이종이량체 항체 fc-함유 단백질 및 그의 생산 방법 |
AU2011320314B2 (en) | 2010-10-29 | 2015-08-06 | Immunogen, Inc. | Novel EGFR-binding molecules and immunoconjugates thereof |
EP2632947A4 (en) | 2010-10-29 | 2015-03-18 | Immunogen Inc | NON-ANTAGONIST MOLECULES BINDING TO THE EGF RECEPTOR AND IMMUNOCONJUGATES THEREOF |
EP3053600B1 (en) * | 2011-02-15 | 2020-01-29 | ImmunoGen, Inc. | Cytotoxic benzodiazepine derivatives |
JP6494533B2 (ja) * | 2013-02-28 | 2019-04-03 | イミュノジェン・インコーポレーテッド | 細胞結合剤及び細胞毒性剤としてのマイタンシノイドを含む複合体 |
WO2014134457A2 (en) | 2013-02-28 | 2014-09-04 | Immunogen, Inc. | Conjugates comprising cell-binding agents and cytotoxic agents |
JP6423804B2 (ja) | 2013-02-28 | 2018-11-14 | イミュノジェン・インコーポレーテッド | 細胞結合剤及び細胞毒性剤を含む複合体 |
WO2015157595A1 (en) * | 2014-04-11 | 2015-10-15 | Medimmune, Llc | Conjugated compounds comprising cysteine-engineered antibodies |
RU2017101681A (ru) * | 2014-06-20 | 2018-07-20 | Биоэллаенс К.В. | Конъюгаты анти-cd22 антитело - лекарственное средство и способы их применения |
JP2017525755A (ja) * | 2014-06-20 | 2017-09-07 | アブジェノミクス インターナショナル インコーポレイテッド.Abgenomics International Inc. | Her2抗体−薬物抱合体 |
US9950077B2 (en) * | 2014-06-20 | 2018-04-24 | Bioalliance C.V. | Anti-folate receptor alpha (FRA) antibody-drug conjugates and methods of using thereof |
CN109147874A (zh) | 2014-09-02 | 2019-01-04 | 伊缪诺金公司 | 用于配制抗体药物缀合物组合物的方法 |
MA41645A (fr) | 2015-03-04 | 2018-01-09 | Abbvie Stemcentrx Llc | Anticorps issus de génie génétique spécifiques au site et méthodes d'utilisation |
AU2016285552B2 (en) | 2015-06-29 | 2022-10-13 | Immunogen, Inc. | Anti-CD123 antibodies and conjugates and derivatives thereof |
-
2016
- 2016-06-28 ES ES16738322T patent/ES2832527T3/es active Active
- 2016-06-28 KR KR1020187002729A patent/KR20180021176A/ko not_active Application Discontinuation
- 2016-06-28 CN CN202111168673.4A patent/CN113769108A/zh active Pending
- 2016-06-28 PT PT167383223T patent/PT3313845T/pt unknown
- 2016-06-28 MA MA42250A patent/MA42250B1/fr unknown
- 2016-06-28 RS RS20201354A patent/RS61050B1/sr unknown
- 2016-06-28 SI SI201630977T patent/SI3313845T1/sl unknown
- 2016-06-28 PL PL16738322T patent/PL3313845T3/pl unknown
- 2016-06-28 HU HUE16738322A patent/HUE052616T2/hu unknown
- 2016-06-28 MD MDE20180452T patent/MD3313845T2/ro unknown
- 2016-06-28 JP JP2017568292A patent/JP6843080B2/ja active Active
- 2016-06-28 CN CN201680038492.0A patent/CN107708810B/zh active Active
- 2016-06-28 EP EP20182141.0A patent/EP3769787A1/en active Pending
- 2016-06-28 EP EP16738322.3A patent/EP3313845B1/en active Active
- 2016-06-28 WO PCT/US2016/039796 patent/WO2017004025A1/en active Application Filing
- 2016-06-28 CA CA2988806A patent/CA2988806A1/en active Pending
- 2016-06-28 LT LTEP16738322.3T patent/LT3313845T/lt unknown
- 2016-06-28 US US15/195,269 patent/US10898579B2/en active Active
- 2016-06-28 AU AU2016285929A patent/AU2016285929B2/en active Active
- 2016-06-28 RU RU2017144859A patent/RU2733740C2/ru active
- 2016-06-28 DK DK16738322.3T patent/DK3313845T3/da active
- 2016-06-29 TW TW110132303A patent/TW202146057A/zh unknown
- 2016-06-29 AR ARP160101972A patent/AR106013A1/es unknown
- 2016-06-29 TW TW105120514A patent/TWI740833B/zh active
-
2018
- 2018-10-30 HK HK18113828.1A patent/HK1254782A1/zh unknown
-
2020
- 2020-09-08 US US17/014,404 patent/US20210085800A1/en active Pending
- 2020-11-09 HR HRP20201790TT patent/HRP20201790T1/hr unknown
- 2020-11-10 CY CY20201101058T patent/CY1123606T1/el unknown
-
2021
- 2021-02-19 JP JP2021025322A patent/JP2021088581A/ja active Pending
-
2022
- 2022-03-31 AU AU2022202208A patent/AU2022202208A1/en active Pending
- 2022-08-15 JP JP2022129205A patent/JP7441281B2/ja active Active
-
2024
- 2024-02-16 JP JP2024021646A patent/JP2024067036A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1254782A1 (zh) | 半胱氨酸工程化抗體的結合物 | |
HK1243103A1 (zh) | 半胱氨酸改造抗體和綴合物 | |
HK1253507A1 (zh) | 抗 ror1 抗體 | |
HK1254836A1 (zh) | 抗-ror1抗體 | |
IL290457A (en) | Antibodies and their conjugates | |
HK1256116A1 (zh) | 抗lag-3抗體 | |
GB201521393D0 (en) | Antibodies | |
GB201521391D0 (en) | Antibodies | |
HK1246804A1 (zh) | Tau結合抗體 | |
GB201521382D0 (en) | Antibodies | |
IL253633B (en) | Anti-transthyretin antibodies | |
IL255323A0 (en) | Anti-fcrn antibodies | |
HK1255056A1 (zh) | 抗cd115抗體 | |
HK1243429A1 (zh) | 抗前-s1 hbv抗體 | |
PL3250593T3 (pl) | Przeciwciała przeciwko transtyretynie | |
GB201509907D0 (en) | Antibodies | |
GB201620828D0 (en) | Compositions of antibody construct-agonist conjugates and methods thereof | |
GB201522394D0 (en) | Antibodies | |
GB201503438D0 (en) | Antibodies | |
IL284022A (en) | Anti-transthyretin antibodies | |
GB201517852D0 (en) | Novel compounds and conjugates | |
GB201518728D0 (en) | Antibodies | |
GB201515570D0 (en) | Anti-LAG-3 antibodies | |
GB201515572D0 (en) | Anti-LAG-3 antibodies | |
GB201514425D0 (en) | Antibodies |