SI3176255T1 - Uporaba iz adipoznega tkiva pridobljenih stromalnih matičnih celic v zdravljenju fistule - Google Patents

Uporaba iz adipoznega tkiva pridobljenih stromalnih matičnih celic v zdravljenju fistule

Info

Publication number
SI3176255T1
SI3176255T1 SI200632296T SI200632296T SI3176255T1 SI 3176255 T1 SI3176255 T1 SI 3176255T1 SI 200632296 T SI200632296 T SI 200632296T SI 200632296 T SI200632296 T SI 200632296T SI 3176255 T1 SI3176255 T1 SI 3176255T1
Authority
SI
Slovenia
Prior art keywords
stem cells
adipose tissue
derived stromal
stromal stem
treating fistula
Prior art date
Application number
SI200632296T
Other languages
English (en)
Slovenian (sl)
Inventor
Miguel Maria Gema Fernandez
De La Pena Manuel Angel Gonzalez
Castro Rosa Ana Garcia
Arranz Mariano Garcia
Olmo Damian Garcia
Original Assignee
Tigenix, S.A.U.
Universidad Autonoma De Madrid
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37116048&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI3176255(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tigenix, S.A.U., Universidad Autonoma De Madrid filed Critical Tigenix, S.A.U.
Publication of SI3176255T1 publication Critical patent/SI3176255T1/sl

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  • Developmental Biology & Embryology (AREA)
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SI200632296T 2005-06-24 2006-05-16 Uporaba iz adipoznega tkiva pridobljenih stromalnih matičnih celic v zdravljenju fistule SI3176255T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/167,061 US20060045872A1 (en) 2004-08-25 2005-06-24 Use of adipose tissue-derived stromal stem cells in treating fistula
EP17150455.8A EP3176255B1 (en) 2005-06-24 2006-05-16 Use of adipose tissue-derived stromal stem cells in treating fistula

Publications (1)

Publication Number Publication Date
SI3176255T1 true SI3176255T1 (sl) 2019-01-31

Family

ID=37116048

Family Applications (3)

Application Number Title Priority Date Filing Date
SI200632296T SI3176255T1 (sl) 2005-06-24 2006-05-16 Uporaba iz adipoznega tkiva pridobljenih stromalnih matičnih celic v zdravljenju fistule
SI200631939T SI2292737T2 (sl) 2005-06-24 2006-05-16 Uporaba stromalnih matičnih celic, izvirajočih iz adipoznega tkiva, pri zdravljenju fistule
SI200632229T SI2944688T1 (en) 2005-06-24 2006-05-16 Use of stromal stem cells derived from fat tissues in the treatment of fistula

Family Applications After (2)

Application Number Title Priority Date Filing Date
SI200631939T SI2292737T2 (sl) 2005-06-24 2006-05-16 Uporaba stromalnih matičnih celic, izvirajočih iz adipoznega tkiva, pri zdravljenju fistule
SI200632229T SI2944688T1 (en) 2005-06-24 2006-05-16 Use of stromal stem cells derived from fat tissues in the treatment of fistula

Country Status (23)

Country Link
US (10) US20060045872A1 (cg-RX-API-DMAC7.html)
EP (7) EP1899458A2 (cg-RX-API-DMAC7.html)
JP (5) JP2008546397A (cg-RX-API-DMAC7.html)
KR (1) KR20080036588A (cg-RX-API-DMAC7.html)
CN (2) CN103143055A (cg-RX-API-DMAC7.html)
AU (1) AU2006261383B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0613811B8 (cg-RX-API-DMAC7.html)
CA (1) CA2613457C (cg-RX-API-DMAC7.html)
CY (3) CY1116764T1 (cg-RX-API-DMAC7.html)
DK (4) DK2944688T3 (cg-RX-API-DMAC7.html)
ES (6) ES2538657T5 (cg-RX-API-DMAC7.html)
HU (3) HUE025338T2 (cg-RX-API-DMAC7.html)
IL (1) IL188378A (cg-RX-API-DMAC7.html)
LT (3) LT2944688T (cg-RX-API-DMAC7.html)
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Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7803787B2 (en) * 2002-10-16 2010-09-28 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage by transmucosal administration
US8455458B2 (en) 2002-10-16 2013-06-04 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage
US20060045872A1 (en) * 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
AU2006244479B2 (en) 2005-05-05 2012-08-09 Nyse Group, Inc. Unpriced order auction and routing
US20070027543A1 (en) * 2005-08-01 2007-02-01 Gimble Jeffrey M Use of adipose tissue-derived stromal cells in spinal fusion
ES2589311T5 (es) 2005-09-23 2020-02-14 Tigenix S A U Poblaciones de células que tienen actividad inmunorreguladora, método de aislamiento y usos
US20100322906A1 (en) * 2005-10-05 2010-12-23 Osaka University Method for Obtaining Pancreatic Endocrine Cells From Adipose Tissue-Origin Cells
CA2630452C (en) * 2005-12-02 2011-02-22 Cook Incorporated Devices, systems, and methods for occluding a defect
US20090209031A1 (en) * 2006-01-26 2009-08-20 Tyco Healthcare Group Lp Medical device package
EP1984488B1 (en) * 2006-01-30 2017-12-27 University Of Virginia Patent Foundation Methods of preparing and characterizing mesenchymal stem cell aggregates and uses thereof
US20070224173A1 (en) * 2006-03-21 2007-09-27 Koullick Edouard A Nonexpansion Protocol for Autologous Cell-Based Therapies
US8021882B2 (en) * 2006-08-24 2011-09-20 Johnstone Brian H Production of neural protective and regenerative factors from stem cells and treatment of nervous system conditions therewith
WO2008060374A2 (en) * 2006-10-06 2008-05-22 University Of Virginia Patent Foundation Methods and compositions useful for diabetic wound healing
KR20080103637A (ko) 2007-05-25 2008-11-28 주식회사 알앤엘바이오 지방유래 줄기세포를 함유하는 사지말단부 허혈성 질환의세포치료용 조성물
US9186375B2 (en) 2007-06-21 2015-11-17 Arthrodynamic Technologies, Animal Health Division, Inc. Glycosaminoglycan compositions in combination with stem cells
AU2014227541B2 (en) * 2007-09-19 2015-10-01 Pluristem Ltd. Methods of Treating Inflammatory Colon Diseases
CN102123717A (zh) * 2008-05-27 2011-07-13 普拉里斯坦有限公司 治疗炎性结肠疾病的方法
WO2009152084A2 (en) * 2008-06-11 2009-12-17 Cell4Vet Llc Adipose tissue-derived stem cells for veterinary use
WO2010008815A1 (en) * 2008-06-24 2010-01-21 Bioactive Surgical, Inc. Surgical sutures incorporated with stem cells or other bioactive materials
US20100098739A1 (en) * 2008-10-20 2010-04-22 University Of Virginia Patent Foundation Compositions and methods for modular soft tissue repair
US20100112696A1 (en) * 2008-11-03 2010-05-06 Baxter International Inc. Apparatus And Methods For Processing Tissue To Release Cells
US8309343B2 (en) 2008-12-01 2012-11-13 Baxter International Inc. Apparatus and method for processing biological material
WO2010126194A1 (ko) * 2009-04-28 2010-11-04 (주) 안트로젠 누공 치료를 위한 자가 및 동종의 지방 유래 스트로마 줄기세포 조성물
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9669200B2 (en) 2010-08-06 2017-06-06 Boston Scientific Scimed, Inc. Systems and methods for the treatment of pelvic disorders including magnetic particulates
EP4663241A2 (en) 2010-10-08 2025-12-17 Mesoblast International Sàrl Enhanced msc preparations
US9180172B2 (en) 2010-12-15 2015-11-10 Ams Research Corporation Treatment of Peyronies disease
US8979797B2 (en) 2010-12-16 2015-03-17 Ams Research Corporation High pressure delivery system and method for treating pelvic disorder using large molecule therapeutics
EP2663316A2 (en) 2011-01-12 2013-11-20 TiGenix, S.A.U. Adipose-derived mesenchymal stem cells for intralymphatic administration in autoimmune and inflammatory diseases
EP2683813A1 (en) * 2011-03-11 2014-01-15 TiGenix, S.A.U. Cell populations having immunoregulatory activity, method for isolation and uses
US8834928B1 (en) 2011-05-16 2014-09-16 Musculoskeletal Transplant Foundation Tissue-derived tissugenic implants, and methods of fabricating and using same
CL2011001904A1 (es) * 2011-08-08 2012-03-09 Univ Pontificia Catolica Chile Formulacion farmaceutica que comprende celulas madres mesenquimales vivas suspendidas en un vehiculo farmaceuticamente aceptable, sistema de aplicacion topica en aerosol que las comprende; y su uso para tratar heridas.
US20130072903A1 (en) * 2011-09-20 2013-03-21 John Chapman Adipose Tissue Graft for Wound Healing
GB201202319D0 (en) * 2012-02-10 2012-03-28 Orbsen Therapeutics Ltd Stromal stem cells
US20140024011A1 (en) * 2012-07-23 2014-01-23 AdiCyte, Inc. Method for Preparing Adipose Tissue
EP2908871B1 (en) * 2012-10-18 2018-08-08 Mayo Foundation For Medical Education And Research Techniques for treatment of abscesses
WO2014186854A1 (pt) * 2013-05-24 2014-11-27 Universidade Estadual De Campinas - Unicamp Processo de obtenção de fio de sutura enriquecido com celulas-tronco, fios obtidos, kit de sutura e seus usos
US20150037436A1 (en) 2013-07-30 2015-02-05 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US20170327584A1 (en) * 2014-11-26 2017-11-16 Millennium Pharmaceuticals, Inc. Vedolizumab for the Treatment of Fistulizing Crohn's Disease
RU2588835C1 (ru) * 2014-11-27 2016-07-10 Олег Германович Макеев Способ терапии повреждений кожи и биотрансплантат для его осуществления
US10531957B2 (en) 2015-05-21 2020-01-14 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
ES2807897T3 (es) 2015-10-23 2021-02-24 Rigshospitalet Terapia con células madre basada en células madre procedentes de tejido adiposo
GB201604304D0 (en) 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
WO2018011192A1 (en) * 2016-07-12 2018-01-18 Centre National De La Recherche Scientifique Compositions useful for mucosal healing
IT201700043316A1 (it) * 2017-04-20 2018-10-20 Lipogems Int S P A Drug delivery system
JP6999918B2 (ja) * 2017-08-21 2022-02-04 学校法人慶應義塾 血小板表面抗原と間葉系細胞表面抗原を共発現する血小板様細胞を含む創傷治癒促進剤
CN112004923A (zh) 2017-11-22 2020-11-27 迈索布拉斯特国际有限公司 细胞组合物及治疗方法
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections
CN111840645B (zh) * 2020-07-29 2022-04-01 沈阳细胞治疗工程技术研发中心有限公司 一种瘘洞修补制剂及其制备方法
US20240042100A1 (en) * 2020-12-24 2024-02-08 Rokit Healthcare Inc. Method of manufacturing a tissue regeneration patch
CN114949361A (zh) * 2021-12-31 2022-08-30 浙江金时代生物技术有限公司 一种用于子宫内膜修复的聚乳酸-羟基乙酸共聚物支架与人脐带间充质干细胞复合物的制备方法
WO2024227193A2 (en) * 2023-04-28 2024-10-31 Angiocrine Bioscience, Inc. Endothelial cells for treatment of gastrointestinal fistula

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4298002A (en) 1979-09-10 1981-11-03 National Patent Development Corporation Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5143842A (en) 1988-11-01 1992-09-01 The University Of Colorado Foundation, Inc. Media for normal human muscle satellite cells
US5145770A (en) * 1990-06-04 1992-09-08 Biosurface Technology, Inc. Cryopreservation of cultured epithelial sheets
US5149543A (en) 1990-10-05 1992-09-22 Massachusetts Institute Of Technology Ionically cross-linked polymeric microcapsules
US5733542A (en) 1990-11-16 1998-03-31 Haynesworth; Stephen E. Enhancing bone marrow engraftment using MSCS
US6010696A (en) * 1990-11-16 2000-01-04 Osiris Therapeutics, Inc. Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5624105A (en) 1992-10-10 1997-04-29 Hemscheidt Fahrwerktechnik Gmbh & Co. Hydropneumatic suspension system
JPH09502421A (ja) 1992-12-02 1997-03-11 シエル・インターナシヨナル・リサーチ・マートシヤツピイ・ベー・ブイ アゾキシシアノベンゼン誘導体
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
WO1995002698A1 (en) 1993-07-12 1995-01-26 Life Technologies, Inc. Composition and methods for transfecting eukaryotic cells
US6174333B1 (en) * 1994-06-06 2001-01-16 Osiris Therapeutics, Inc. Biomatrix for soft tissue regeneration using mesenchymal stem cells
DK0952792T3 (da) * 1994-06-06 2003-12-08 Osiris Therapeutics Inc Biomatrix til vævsregeneration
US6051429A (en) 1995-06-07 2000-04-18 Life Technologies, Inc. Peptide-enhanced cationic lipid transfections
AU723163B2 (en) 1995-06-07 2000-08-17 Tekmira Pharmaceuticals Corporation Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
CA2227584A1 (en) 1995-08-04 1997-02-20 The General Hospital Corporation Transgenic swine and swine cells having human hla genes
US5744335A (en) 1995-09-19 1998-04-28 Mirus Corporation Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein
US5705308A (en) 1996-09-30 1998-01-06 Eastman Kodak Company Infrared-sensitive, negative-working diazonaphthoquinone imaging composition and element
AU6242298A (en) * 1997-01-17 1998-08-07 Celadon Science, Llc Methods for promoting healing of corneal resurfacing wounds
EP1036163B1 (en) 1997-12-02 2010-08-18 Artecel Sciences, Inc. Differentiation of adipose stromal cells into osteoblasts and uses thereof
IL137614A0 (en) 1998-02-04 2001-07-24 Gen Hospital Corp An inhibitor of a costimulatory pathway and hematopoietic stem cells for promoting graft acceptance
US6368636B1 (en) 1998-03-18 2002-04-09 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
US9585916B2 (en) 1999-03-26 2017-03-07 Northern Therapeutics Inc. Cell based therapy for the pulmonary system
AU2999199A (en) 1998-04-03 1999-10-25 Osiris Therapeutics, Inc. Mesenchymal stem cells as immunosuppressants
US6546105B1 (en) 1998-10-30 2003-04-08 Matsushita Electric Industrial Co., Ltd. Sound image localization device and sound image localization method
KR100968164B1 (ko) * 1999-03-10 2010-07-06 더 리전츠 오브 더 유니버시티 오브 캘리포니아 지방 유래 간세포 및 격자
US20030082152A1 (en) 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
US20050153442A1 (en) * 1999-03-10 2005-07-14 Adam Katz Adipose-derived stem cells and lattices
US6777231B1 (en) 1999-03-10 2004-08-17 The Regents Of The University Of California Adipose-derived stem cells and lattices
WO2000073418A2 (en) * 1999-05-28 2000-12-07 Pacgen Technologies Llc A method of using autologous fibroblasts to promote healing of wounds and fistulas
US7670628B2 (en) 1999-07-07 2010-03-02 Angioblast Systems, Inc. Mesenchymal precursor cell
US6555374B1 (en) 1999-08-19 2003-04-29 Artecel Sciences, Inc. Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof
US7078232B2 (en) * 1999-08-19 2006-07-18 Artecel, Inc. Adipose tissue-derived adult stem or stromal cells for the repair of articular cartilage fractures and uses thereof
CN100475953C (zh) 1999-12-06 2009-04-08 通用医疗公司 胰腺干细胞
EP1372398B1 (en) 2001-02-23 2013-07-10 The University of Pittsburgh Rapid preparation of stem cell matrices for use in tissue and organ treatement and repair
US20030054331A1 (en) 2001-09-14 2003-03-20 Stemsource, Inc. Preservation of non embryonic cells from non hematopoietic tissues
MXPA04004310A (es) 2001-11-09 2005-03-31 Artecel Sciences Inc Metodos y composiciones para el uso de celulas estromales para soportar celulas madre embrionarias y adultas.
CN1617735A (zh) * 2001-12-04 2005-05-18 克里斯托弗·J·伍尔弗顿 贮存稳定性纤维蛋白密封剂
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
JP2005517441A (ja) * 2002-02-19 2005-06-16 メディポスト・カンパニー・リミテッド 臍帯血由来の間葉幹細胞・前駆細胞の分離培養方法及び間葉組織への分化誘導方法
US7282222B2 (en) 2002-03-15 2007-10-16 The United States Of America As Represented By The Department Of Veterans Affairs Methods and compositions for directing cells to target organs
WO2003106493A1 (en) * 2002-06-14 2003-12-24 Dyax Corporation Protein analysis
CA2489212C (en) 2002-06-14 2012-08-14 Cartela Ab Marker for stem cells and its use
US20040101959A1 (en) * 2002-11-21 2004-05-27 Olga Marko Treatment of tissue with undifferentiated mesenchymal cells
JP2004190976A (ja) * 2002-12-12 2004-07-08 Sony Corp 熱輸送装置及び電子デバイス
NZ566132A (en) * 2003-02-13 2009-09-25 Anthrogenesis Corp Use of umbilical cord blood to treat inflammation, ParkinsonÆs disease or diabetes
US8603462B2 (en) 2003-04-01 2013-12-10 University Of Utah Research Foundation Stem-cell, precursor cell, or target cell-based treatment of multi-organ failure and renal dysfunction
ES2265199B1 (es) 2003-06-12 2008-02-01 Cellerix, S.L. Celulas madre adultas multipotentes procedentes de condrocitos desdiferenciados y sus aplicaciones.
PL1641914T3 (pl) 2003-06-27 2017-01-31 DePuy Synthes Products, Inc. Komórki pochodzące z poporodowej tkanki łożyska oraz sposoby uzyskiwania i zastosowania tych komórek
US7645229B2 (en) * 2003-09-26 2010-01-12 Armstrong David N Instrument and method for endoscopic visualization and treatment of anorectal fistula
JP4749331B2 (ja) 2003-10-07 2011-08-17 株式会社バイオマスター 脂肪由来前駆細胞の細胞分化
CN1871343B (zh) 2003-11-04 2013-06-26 株式会社宝玛斯特 从脂肪组织制备干细胞的方法和系统
EP1699523A4 (en) 2003-12-24 2008-05-21 Univ Columbia GENERATION OF A BIOLOGICAL ATRIOVENTRICULAR BYPASS FOR COMPENSATING AN ATRIOVENTRICULAR BLOCK
US20080095749A1 (en) 2004-03-22 2008-04-24 Sudeepta Aggarwal Mesenchymal stem cells and uses therefor
AU2005227295A1 (en) 2004-03-22 2005-10-06 Osiris Therapeutics, Inc. Mesenchymal stem cells and uses therefor
RU2252252C1 (ru) 2004-04-09 2005-05-20 Тепляшин Александр Сергеевич Способ выделения мезенхимальных стволовых клеток
ES2264862B8 (es) 2004-08-25 2017-01-20 Cellerix, S.L. Biomaterial para sutura.
US20060045872A1 (en) 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
ES2313805B1 (es) 2004-10-04 2009-12-23 Cellerix, S.L. Identificacion y aislamiento de celulas multipotentes de tejido mesenquimal no osteocondral.
WO2006029347A2 (en) 2004-09-03 2006-03-16 University Of Maryland, Baltimore Integrin cd18 is a novel stromal stem cell marker and functions to promote osteogenesis
WO2006110582A1 (en) 2005-04-08 2006-10-19 Xcyte Therapies, Inc. Compositions and methods for the treatment of burns and sepsis
ES2589311T5 (es) 2005-09-23 2020-02-14 Tigenix S A U Poblaciones de células que tienen actividad inmunorreguladora, método de aislamiento y usos
EP1795588A1 (en) 2005-12-07 2007-06-13 Cellerix, S.L. Use of adipose tissue derived mesenchymal stem cells for the treatment of graft versus host disease
WO2008036374A2 (en) 2006-09-21 2008-03-27 Medistem Laboratories, Inc. Allogeneic stem cell transplants in non-conditioned recipients
JPWO2009031606A1 (ja) 2007-09-07 2010-12-16 日本ケミカルリサーチ株式会社 関節炎治療及び予防剤
PT2200622E (pt) 2007-09-19 2012-11-06 Pluristem Ltd Células aderentes provenientes de tecido adiposo ou placentário e respetiva utilização terapêutica
JP5539886B2 (ja) 2007-10-17 2014-07-02 ティクセル Ｔｒ１細胞、間葉系幹細胞およびその使用
GB0814249D0 (en) 2008-08-04 2008-09-10 Cellerix Sa Uses of mesenchymal stem cells
ES2345867B1 (es) 2009-04-03 2011-07-28 Fundacion Instituto Mediterraneo Para La Biotecnologia Y La Investigacion Sanitaria (Imabis) Celulas madre multipotentes derivadas de estroma de mesenterio.
WO2010126194A1 (ko) 2009-04-28 2010-11-04 (주) 안트로젠 누공 치료를 위한 자가 및 동종의 지방 유래 스트로마 줄기세포 조성물
EP2451943B1 (en) 2009-07-09 2016-11-23 TiGenix, S.A.U. Methods and compositions for use in cellular therapies
EP2663316A2 (en) 2011-01-12 2013-11-20 TiGenix, S.A.U. Adipose-derived mesenchymal stem cells for intralymphatic administration in autoimmune and inflammatory diseases
EP2683813A1 (en) 2011-03-11 2014-01-15 TiGenix, S.A.U. Cell populations having immunoregulatory activity, method for isolation and uses
US20140134140A1 (en) 2012-11-09 2014-05-15 Case Western Reserve University Mesenchymal stem cell compositions for the treatment of microbial infections
EP3581932A1 (en) 2013-03-15 2019-12-18 TiGenix, S.A.U. Lymphocyte biomarkers for determining the clinical response to cell therapy
EP3013943B1 (en) 2013-06-25 2019-04-10 TiGenix, S.A.U. Cell populations having immunoregulatory activity, methods for the preparation and uses thereof
GB201604304D0 (en) 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease

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