SI3174881T1 - (1,2,4) triazolo (4,3-B) pyridazines for use in the treatment of proliferative diseases - Google Patents
(1,2,4) triazolo (4,3-B) pyridazines for use in the treatment of proliferative diseases Download PDFInfo
- Publication number
- SI3174881T1 SI3174881T1 SI201530257T SI201530257T SI3174881T1 SI 3174881 T1 SI3174881 T1 SI 3174881T1 SI 201530257 T SI201530257 T SI 201530257T SI 201530257 T SI201530257 T SI 201530257T SI 3174881 T1 SI3174881 T1 SI 3174881T1
- Authority
- SI
- Slovenia
- Prior art keywords
- pharmaceutically acceptable
- compound
- acceptable salt
- triazolo
- compound according
- Prior art date
Links
- YRACHDVMKITFAZ-UHFFFAOYSA-N [1,2,4]triazolo[4,3-b]pyridazine Chemical class C1=CC=NN2C=NN=C21 YRACHDVMKITFAZ-UHFFFAOYSA-N 0.000 title claims 2
- 201000010099 disease Diseases 0.000 title claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims 2
- 230000002062 proliferating effect Effects 0.000 title claims 2
- 150000001875 compounds Chemical class 0.000 claims abstract 19
- 150000003839 salts Chemical class 0.000 claims abstract 12
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 3
- KAUQJMHLAFIZDU-UHFFFAOYSA-N 6-Hydroxy-2-naphthoic acid Chemical compound C1=C(O)C=CC2=CC(C(=O)O)=CC=C21 KAUQJMHLAFIZDU-UHFFFAOYSA-N 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 238000000634 powder X-ray diffraction Methods 0.000 claims 2
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- RSMYFSPOTCDHHJ-GOSISDBHSA-N (3R)-4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]-1,3-dimethylpiperazin-2-one Chemical compound COC1=NN=C2N1N=C(C=C2)N1CCC(CC1)C1=CC=C(OCCN2[C@@H](C(N(CC2)C)=O)C)C=C1 RSMYFSPOTCDHHJ-GOSISDBHSA-N 0.000 claims 1
- PRSHWIPDPJVWMF-LJQANCHMSA-N (3R)-4-[3-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]propyl]-1,3-dimethylpiperazin-2-one Chemical compound COC1=NN=C2N1N=C(C=C2)N1CCC(CC1)C1=CC=C(OCCCN2[C@@H](C(N(CC2)C)=O)C)C=C1 PRSHWIPDPJVWMF-LJQANCHMSA-N 0.000 claims 1
- MBUCDQZCQATXCS-XJDOXCRVSA-N 1-[(3S)-4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]-3,5-dimethylpiperazin-1-yl]ethanone Chemical compound COC1=NN=C2N1N=C(C=C2)N1CCC(CC1)C1=CC=C(OCCN2[C@H](CN(CC2C)C(C)=O)C)C=C1 MBUCDQZCQATXCS-XJDOXCRVSA-N 0.000 claims 1
- UUPJLLSFIGCOCD-OYRHEFFESA-N 1-[(3S,5R)-4-[3-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]propyl]-3,5-dimethylpiperazin-1-yl]ethanone Chemical compound COC1=NN=C2N1N=C(C=C2)N1CCC(CC1)C1=CC=C(OCCCN2[C@@H](CN(C[C@@H]2C)C(C)=O)C)C=C1 UUPJLLSFIGCOCD-OYRHEFFESA-N 0.000 claims 1
- MBUCDQZCQATXCS-UHFFFAOYSA-N 1-[4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]-3,5-dimethylpiperazin-1-yl]ethanone Chemical compound COC1=NN=C2N1N=C(C=C2)N1CCC(CC1)C1=CC=C(OCCN2C(CN(CC2C)C(C)=O)C)C=C1 MBUCDQZCQATXCS-UHFFFAOYSA-N 0.000 claims 1
- SJJCQDRGABAVBB-UHFFFAOYSA-N 1-hydroxy-2-naphthoic acid Chemical compound C1=CC=CC2=C(O)C(C(=O)O)=CC=C21 SJJCQDRGABAVBB-UHFFFAOYSA-N 0.000 claims 1
- -1 3- (4- (1- (3-methoxy- [1,2,4] triazolo [4,3-b] pyridazin-6-yl) piperidin-4- yl) phenoxy) propyl Chemical group 0.000 claims 1
- RSMYFSPOTCDHHJ-UHFFFAOYSA-N 4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]-1,3-dimethylpiperazin-2-one Chemical compound COC1=NN=C2N1N=C(C=C2)N1CCC(CC1)C1=CC=C(OCCN2C(C(N(CC2)C)=O)C)C=C1 RSMYFSPOTCDHHJ-UHFFFAOYSA-N 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 101100314454 Caenorhabditis elegans tra-1 gene Proteins 0.000 claims 1
- 229940126062 Compound A Drugs 0.000 claims 1
- 229910016523 CuKa Inorganic materials 0.000 claims 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000003445 large cell neuroendocrine carcinoma Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 230000002611 ovarian Effects 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 239000003139 biocide Substances 0.000 abstract 1
- 230000022534 cell killing Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
- C07C65/11—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic with carboxyl groups on a condensed ring system containing two rings
-
- E—FIXED CONSTRUCTIONS
- E21—EARTH OR ROCK DRILLING; MINING
- E21B—EARTH OR ROCK DRILLING; OBTAINING OIL, GAS, WATER, SOLUBLE OR MELTABLE MATERIALS OR A SLURRY OF MINERALS FROM WELLS
- E21B7/00—Special methods or apparatus for drilling
- E21B7/04—Directional drilling
- E21B7/06—Deflecting the direction of boreholes
-
- E—FIXED CONSTRUCTIONS
- E21—EARTH OR ROCK DRILLING; MINING
- E21B—EARTH OR ROCK DRILLING; OBTAINING OIL, GAS, WATER, SOLUBLE OR MELTABLE MATERIALS OR A SLURRY OF MINERALS FROM WELLS
- E21B7/00—Special methods or apparatus for drilling
- E21B7/04—Directional drilling
- E21B7/06—Deflecting the direction of boreholes
- E21B7/062—Deflecting the direction of boreholes the tool shaft rotating inside a non-rotating guide travelling with the shaft
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mining & Mineral Resources (AREA)
- Geology (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Geochemistry & Mineralogy (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Fluid Mechanics (AREA)
- Environmental & Geological Engineering (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462029676P | 2014-07-28 | 2014-07-28 | |
| PCT/GB2015/052143 WO2016016618A1 (en) | 2014-07-28 | 2015-07-24 | [1,2,4]triazolo[4,3-b]pyridazines for use in the treatment of proliferative diseases |
| EP15744308.6A EP3174881B1 (en) | 2014-07-28 | 2015-07-24 | [1,2,4]triazolo[4,3-b]pyridazines for use in the treatment of proliferative diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3174881T1 true SI3174881T1 (en) | 2018-06-29 |
Family
ID=53761420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201530257T SI3174881T1 (en) | 2014-07-28 | 2015-07-24 | (1,2,4) triazolo (4,3-B) pyridazines for use in the treatment of proliferative diseases |
Country Status (37)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO2719005T3 (OSRAM) * | 2014-07-28 | 2018-01-20 | ||
| CN110317216A (zh) * | 2018-03-28 | 2019-10-11 | 首都医科大学 | 一种三唑并哒嗪类衍生物在医药领域的应用 |
| TWI816880B (zh) * | 2018-09-13 | 2023-10-01 | 大陸商恒翼生物醫藥（上海）股份有限公司 | 治療前列腺癌之組合療法 |
| US20230029336A1 (en) | 2019-10-14 | 2023-01-26 | Astrazeneca Ab | Combination Therapy for Treating a Hematological Malignancy |
| EP4087572A1 (en) | 2020-01-09 | 2022-11-16 | AstraZeneca AB | Combination therapy for treating cancer |
| CN113143930B (zh) * | 2021-04-08 | 2023-05-30 | 深圳湾实验室 | 化合物在制备SARS-Cov-2 E蛋白抑制剂中的用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0525065D0 (en) * | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
| WO2007065664A2 (en) | 2005-12-08 | 2007-06-14 | Novartis Ag | Pyrazolo[1,5-a]pyridine-3-carboxylic acids as ephb and vegfr2 kinase inhibitors |
| PE20091157A1 (es) * | 2007-12-21 | 2009-09-03 | Astrazeneca Ab | Derivados biciclicos para usar en el tratamiento de afecciones asociadas con el receptor de androgeno - 155 |
| CN102388048B (zh) * | 2009-02-10 | 2014-07-30 | 阿斯利康(瑞典)有限公司 | 三唑并[4，3-b]哒嗪衍生物及其用于前列腺癌的用途 |
| EA201101604A1 (ru) * | 2009-05-11 | 2012-05-30 | Астразенека Аб | [1,2,4]триазоло[4,3-b]пиридазины в качестве лигандов андрогенового рецептора |
| DK2722334T3 (en) | 2009-11-05 | 2016-03-07 | Glaxosmithkline Llc | benzodiazepine bromdomæneinhibitor |
| WO2012174487A2 (en) * | 2011-06-17 | 2012-12-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| US9422290B2 (en) | 2012-11-13 | 2016-08-23 | Boehringer Ingelheim International Gmbh | Triazolopyridazine |
| NO2719005T3 (OSRAM) * | 2014-07-28 | 2018-01-20 |
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2012
- 2012-05-17 NO NO12797323A patent/NO2719005T3/no unknown
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2015
- 2015-07-24 PL PL15744308T patent/PL3174881T3/pl unknown
- 2015-07-24 HU HUE15744308A patent/HUE037571T2/hu unknown
- 2015-07-24 WO PCT/GB2015/052143 patent/WO2016016618A1/en not_active Ceased
- 2015-07-24 EA EA201790179A patent/EA032654B9/ru unknown
- 2015-07-24 NO NO15744308A patent/NO3174881T3/no unknown
- 2015-07-24 JP JP2017504710A patent/JP6592503B2/ja not_active Expired - Fee Related
- 2015-07-24 US US15/329,274 patent/US9944650B2/en active Active
- 2015-07-24 RS RS20180582A patent/RS57242B1/sr unknown
- 2015-07-24 SM SM20180260T patent/SMT201800260T1/it unknown
- 2015-07-24 SI SI201530257T patent/SI3174881T1/en unknown
- 2015-07-24 DK DK15744308.6T patent/DK3174881T3/en active
- 2015-07-24 CA CA2956421A patent/CA2956421C/en active Active
- 2015-07-24 ES ES15744308.6T patent/ES2670444T3/es active Active
- 2015-07-24 MX MX2017001218A patent/MX374539B/es active IP Right Grant
- 2015-07-24 EP EP15744308.6A patent/EP3174881B1/en active Active
- 2015-07-24 PE PE2017000095A patent/PE20170527A1/es unknown
- 2015-07-24 TN TN2017000018A patent/TN2017000018A1/en unknown
- 2015-07-24 CA CA3185741A patent/CA3185741A1/en active Pending
- 2015-07-24 MY MYPI2017700325A patent/MY187251A/en unknown
- 2015-07-24 CN CN201580039278.2A patent/CN106536524B/zh not_active Expired - Fee Related
- 2015-07-24 PT PT157443086T patent/PT3174881T/pt unknown
- 2015-07-24 AU AU2015295120A patent/AU2015295120B2/en not_active Ceased
- 2015-07-24 KR KR1020177005146A patent/KR20170033427A/ko not_active Ceased
- 2015-07-24 HR HRP20180788TT patent/HRP20180788T1/hr unknown
- 2015-07-24 AP AP2017009700A patent/AP2017009700A0/en unknown
- 2015-07-24 BR BR112017001160A patent/BR112017001160A2/pt active Search and Examination
- 2015-07-24 SG SG11201700419SA patent/SG11201700419SA/en unknown
- 2015-07-24 LT LTEP15744308.6T patent/LT3174881T/lt unknown
-
2017
- 2017-01-15 IL IL250104A patent/IL250104B/en active IP Right Grant
- 2017-01-18 DO DO2017000018A patent/DOP2017000018A/es unknown
- 2017-01-26 CL CL2017000223A patent/CL2017000223A1/es unknown
- 2017-01-26 PH PH12017500159A patent/PH12017500159B1/en unknown
- 2017-01-27 NI NI201700006A patent/NI201700006A/es unknown
- 2017-01-27 SV SV2017005368A patent/SV2017005368A/es unknown
- 2017-01-27 GT GT201700016A patent/GT201700016A/es unknown
- 2017-02-17 ZA ZA2017/01207A patent/ZA201701207B/en unknown
- 2017-02-27 CO CONC2017/0001918A patent/CO2017001918A2/es unknown
-
2018
- 2018-04-11 US US15/950,443 patent/US10407432B2/en not_active Expired - Fee Related
- 2018-05-18 CY CY181100512T patent/CY1120602T1/el unknown
-
2019
- 2019-08-01 US US16/528,738 patent/US10766905B2/en not_active Expired - Fee Related
-
2020
- 2020-07-16 US US16/930,911 patent/US11407755B2/en active Active
-
2022
- 2022-06-29 US US17/853,737 patent/US20230035133A1/en not_active Abandoned
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