AU2015295120B2 - [1,2,4]triazolo[4,3-b]pyridazines for use in the treatment of proliferative diseases - Google Patents
[1,2,4]triazolo[4,3-b]pyridazines for use in the treatment of proliferative diseases Download PDFInfo
- Publication number
- AU2015295120B2 AU2015295120B2 AU2015295120A AU2015295120A AU2015295120B2 AU 2015295120 B2 AU2015295120 B2 AU 2015295120B2 AU 2015295120 A AU2015295120 A AU 2015295120A AU 2015295120 A AU2015295120 A AU 2015295120A AU 2015295120 B2 AU2015295120 B2 AU 2015295120B2
- Authority
- AU
- Australia
- Prior art keywords
- compound
- crystal
- hydroxy
- pct
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 C*(C)(C)Oc1ccc(C2CCC(CCc3n[n]4c(O*)nnc4cc3)CC2)cc1 Chemical compound C*(C)(C)Oc1ccc(C2CCC(CCc3n[n]4c(O*)nnc4cc3)CC2)cc1 0.000 description 1
- QXCLEBUFOPBPLU-GOSISDBHSA-N C[C@H]1N(CCCOc2ccc(C(CC3)CCN3c3n[n]4c(OC)nnc4cc3)cc2)CCNC1=O Chemical compound C[C@H]1N(CCCOc2ccc(C(CC3)CCN3c3n[n]4c(OC)nnc4cc3)cc2)CCNC1=O QXCLEBUFOPBPLU-GOSISDBHSA-N 0.000 description 1
- GPTVZBKGRRMLBG-BGYRXZFFSA-N C[C@H]1N(CCCOc2ccc(C(CC3)CCN3c3n[n]4c(OC)nnc4cc3)cc2)[C@@H](C)CNC1 Chemical compound C[C@H]1N(CCCOc2ccc(C(CC3)CCN3c3n[n]4c(OC)nnc4cc3)cc2)[C@@H](C)CNC1 GPTVZBKGRRMLBG-BGYRXZFFSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
- C07C65/11—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic with carboxyl groups on a condensed ring system containing two rings
-
- E—FIXED CONSTRUCTIONS
- E21—EARTH OR ROCK DRILLING; MINING
- E21B—EARTH OR ROCK DRILLING; OBTAINING OIL, GAS, WATER, SOLUBLE OR MELTABLE MATERIALS OR A SLURRY OF MINERALS FROM WELLS
- E21B7/00—Special methods or apparatus for drilling
- E21B7/04—Directional drilling
- E21B7/06—Deflecting the direction of boreholes
-
- E—FIXED CONSTRUCTIONS
- E21—EARTH OR ROCK DRILLING; MINING
- E21B—EARTH OR ROCK DRILLING; OBTAINING OIL, GAS, WATER, SOLUBLE OR MELTABLE MATERIALS OR A SLURRY OF MINERALS FROM WELLS
- E21B7/00—Special methods or apparatus for drilling
- E21B7/04—Directional drilling
- E21B7/06—Deflecting the direction of boreholes
- E21B7/062—Deflecting the direction of boreholes the tool shaft rotating inside a non-rotating guide travelling with the shaft
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mining & Mineral Resources (AREA)
- Geology (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Geochemistry & Mineralogy (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Fluid Mechanics (AREA)
- Environmental & Geological Engineering (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462029676P | 2014-07-28 | 2014-07-28 | |
| US62/029,676 | 2014-07-28 | ||
| PCT/GB2015/052143 WO2016016618A1 (en) | 2014-07-28 | 2015-07-24 | [1,2,4]triazolo[4,3-b]pyridazines for use in the treatment of proliferative diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2015295120A1 AU2015295120A1 (en) | 2017-02-02 |
| AU2015295120A8 AU2015295120A8 (en) | 2017-02-09 |
| AU2015295120B2 true AU2015295120B2 (en) | 2018-02-01 |
Family
ID=53761420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015295120A Ceased AU2015295120B2 (en) | 2014-07-28 | 2015-07-24 | [1,2,4]triazolo[4,3-b]pyridazines for use in the treatment of proliferative diseases |
Country Status (37)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO2719005T3 (OSRAM) * | 2014-07-28 | 2018-01-20 | ||
| CN110317216A (zh) * | 2018-03-28 | 2019-10-11 | 首都医科大学 | 一种三唑并哒嗪类衍生物在医药领域的应用 |
| TWI816880B (zh) * | 2018-09-13 | 2023-10-01 | 大陸商恒翼生物醫藥（上海）股份有限公司 | 治療前列腺癌之組合療法 |
| BR112022007210A2 (pt) | 2019-10-14 | 2022-07-05 | Astrazeneca Ab | Terapia de combinação para tratar malignidade hematológica |
| IL294399A (en) | 2020-01-09 | 2022-08-01 | Astrazeneca Ab | Combination therapy for treating cancer |
| CN113143930B (zh) * | 2021-04-08 | 2023-05-30 | 深圳湾实验室 | 化合物在制备SARS-Cov-2 E蛋白抑制剂中的用途 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010092371A1 (en) * | 2009-02-10 | 2010-08-19 | Astrazeneca Ab | Triazolo [4,3-b] pyridazine derivatives and their uses for prostate cancer |
| WO2010131022A1 (en) * | 2009-05-11 | 2010-11-18 | Astrazeneca Ab | [1,2,4] triazolo [4,3-b] pyridazines as ligands of the androgen receptor |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0525065D0 (en) * | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
| RU2008127263A (ru) | 2005-12-08 | 2010-01-20 | Новартис АГ (CH) | ПИРАЗОЛ [1,5-a] ПИРИДИН-3-КАРБОНОВЫЕ КИСЛОТЫ В КАЧЕСТВЕ ИНГИБИТОРОВ EphB-И VEGFR2-КИНАЗЫ |
| CN101952286A (zh) | 2007-12-21 | 2011-01-19 | 阿斯利康(瑞典)有限公司 | 用于治疗和雄激素受体有关的病症的双环衍生物 |
| RS53179B (sr) | 2009-11-05 | 2014-06-30 | Glaxosmithkline Llc | Benzodiazepinski inhibitor bromodomena |
| US9328117B2 (en) * | 2011-06-17 | 2016-05-03 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| US9422290B2 (en) * | 2012-11-13 | 2016-08-23 | Boehringer Ingelheim International Gmbh | Triazolopyridazine |
| NO2719005T3 (OSRAM) * | 2014-07-28 | 2018-01-20 |
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2012
- 2012-05-17 NO NO12797323A patent/NO2719005T3/no unknown
-
2015
- 2015-07-24 MY MYPI2017700325A patent/MY187251A/en unknown
- 2015-07-24 DK DK15744308.6T patent/DK3174881T3/en active
- 2015-07-24 SG SG11201700419SA patent/SG11201700419SA/en unknown
- 2015-07-24 SM SM20180260T patent/SMT201800260T1/it unknown
- 2015-07-24 BR BR112017001160A patent/BR112017001160A2/pt active Search and Examination
- 2015-07-24 AU AU2015295120A patent/AU2015295120B2/en not_active Ceased
- 2015-07-24 CA CA3185741A patent/CA3185741A1/en active Pending
- 2015-07-24 EA EA201790179A patent/EA032654B9/ru unknown
- 2015-07-24 NO NO15744308A patent/NO3174881T3/no unknown
- 2015-07-24 CN CN201580039278.2A patent/CN106536524B/zh not_active Expired - Fee Related
- 2015-07-24 RS RS20180582A patent/RS57242B1/sr unknown
- 2015-07-24 EP EP15744308.6A patent/EP3174881B1/en active Active
- 2015-07-24 SI SI201530257T patent/SI3174881T1/en unknown
- 2015-07-24 PL PL15744308T patent/PL3174881T3/pl unknown
- 2015-07-24 PE PE2017000095A patent/PE20170527A1/es unknown
- 2015-07-24 MX MX2017001218A patent/MX374539B/es active IP Right Grant
- 2015-07-24 HU HUE15744308A patent/HUE037571T2/hu unknown
- 2015-07-24 PT PT157443086T patent/PT3174881T/pt unknown
- 2015-07-24 AP AP2017009700A patent/AP2017009700A0/en unknown
- 2015-07-24 KR KR1020177005146A patent/KR20170033427A/ko not_active Ceased
- 2015-07-24 CA CA2956421A patent/CA2956421C/en active Active
- 2015-07-24 WO PCT/GB2015/052143 patent/WO2016016618A1/en not_active Ceased
- 2015-07-24 HR HRP20180788TT patent/HRP20180788T1/hr unknown
- 2015-07-24 US US15/329,274 patent/US9944650B2/en active Active
- 2015-07-24 TN TN2017000018A patent/TN2017000018A1/en unknown
- 2015-07-24 ES ES15744308.6T patent/ES2670444T3/es active Active
- 2015-07-24 JP JP2017504710A patent/JP6592503B2/ja not_active Expired - Fee Related
- 2015-07-24 LT LTEP15744308.6T patent/LT3174881T/lt unknown
-
2017
- 2017-01-15 IL IL250104A patent/IL250104B/en active IP Right Grant
- 2017-01-18 DO DO2017000018A patent/DOP2017000018A/es unknown
- 2017-01-26 PH PH12017500159A patent/PH12017500159B1/en unknown
- 2017-01-26 CL CL2017000223A patent/CL2017000223A1/es unknown
- 2017-01-27 GT GT201700016A patent/GT201700016A/es unknown
- 2017-01-27 NI NI201700006A patent/NI201700006A/es unknown
- 2017-01-27 SV SV2017005368A patent/SV2017005368A/es unknown
- 2017-02-17 ZA ZA2017/01207A patent/ZA201701207B/en unknown
- 2017-02-27 CO CONC2017/0001918A patent/CO2017001918A2/es unknown
-
2018
- 2018-04-11 US US15/950,443 patent/US10407432B2/en not_active Expired - Fee Related
- 2018-05-18 CY CY181100512T patent/CY1120602T1/el unknown
-
2019
- 2019-08-01 US US16/528,738 patent/US10766905B2/en not_active Expired - Fee Related
-
2020
- 2020-07-16 US US16/930,911 patent/US11407755B2/en active Active
-
2022
- 2022-06-29 US US17/853,737 patent/US20230035133A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010092371A1 (en) * | 2009-02-10 | 2010-08-19 | Astrazeneca Ab | Triazolo [4,3-b] pyridazine derivatives and their uses for prostate cancer |
| WO2010131022A1 (en) * | 2009-05-11 | 2010-11-18 | Astrazeneca Ab | [1,2,4] triazolo [4,3-b] pyridazines as ligands of the androgen receptor |
Non-Patent Citations (2)
| Title |
|---|
| BRADBURY ROBERT H ET AL, "Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, vol. 23, no. 7, pages 1945 - 1948 * |
| JADAV PRADIP ET AL, "Design, synthesis and biological evaluation of novel aminomethyl-piperidones based DPP-IV inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, vol. 24, no. 8, pages 1918 - 1922 * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TH | Corrigenda |
Free format text: IN VOL 31 , NO 4 , PAGE(S) 533 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME ASTRAZENECA AB, APPLICATION NO. 2015295120, UNDER INID (54) CORRECT THE TITLE TO READ (1,2,4)TRIAZOLO(4,3-B)PYRIDAZINES FOR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES |
|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |