RS57242B1 - [1,2,4]triazolo[4,3-b]piridazini za upotrebu u tretmanu proliferativnih bolesti - Google Patents

[1,2,4]triazolo[4,3-b]piridazini za upotrebu u tretmanu proliferativnih bolesti

Info

Publication number
RS57242B1
RS57242B1 RS20180582A RSP20180582A RS57242B1 RS 57242 B1 RS57242 B1 RS 57242B1 RS 20180582 A RS20180582 A RS 20180582A RS P20180582 A RSP20180582 A RS P20180582A RS 57242 B1 RS57242 B1 RS 57242B1
Authority
RS
Serbia
Prior art keywords
pyridazines
triazolo
treatment
proliferative diseases
proliferative
Prior art date
Application number
RS20180582A
Other languages
English (en)
Inventor
Robert Hugh Bradbury
Alfred Arthur Rabow
Michael James Waring
James Francis Mccabe
Steven Christopher Glossop
Arshed Mahmood
Zoe Ann Cotter
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of RS57242B1 publication Critical patent/RS57242B1/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
    • C07C65/11—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic with carboxyl groups on a condensed ring system containing two rings
    • E—FIXED CONSTRUCTIONS
    • E21—EARTH DRILLING; MINING
    • E21B—EARTH DRILLING, e.g. DEEP DRILLING; OBTAINING OIL, GAS, WATER, SOLUBLE OR MELTABLE MATERIALS OR A SLURRY OF MINERALS FROM WELLS
    • E21B7/00—Special methods or apparatus for drilling
    • E21B7/04—Directional drilling
    • E21B7/06—Deflecting the direction of boreholes
    • E—FIXED CONSTRUCTIONS
    • E21—EARTH DRILLING; MINING
    • E21B—EARTH DRILLING, e.g. DEEP DRILLING; OBTAINING OIL, GAS, WATER, SOLUBLE OR MELTABLE MATERIALS OR A SLURRY OF MINERALS FROM WELLS
    • E21B7/00—Special methods or apparatus for drilling
    • E21B7/04—Directional drilling
    • E21B7/06—Deflecting the direction of boreholes
    • E21B7/062—Deflecting the direction of boreholes the tool shaft rotating inside a non-rotating guide travelling with the shaft
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
RS20180582A 2014-07-28 2015-07-24 [1,2,4]triazolo[4,3-b]piridazini za upotrebu u tretmanu proliferativnih bolesti RS57242B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462029676P 2014-07-28 2014-07-28
PCT/GB2015/052143 WO2016016618A1 (en) 2014-07-28 2015-07-24 [1,2,4]triazolo[4,3-b]pyridazines for use in the treatment of proliferative diseases
EP15744308.6A EP3174881B1 (en) 2014-07-28 2015-07-24 [1,2,4]triazolo[4,3-b]pyridazines for use in the treatment of proliferative diseases

Publications (1)

Publication Number Publication Date
RS57242B1 true RS57242B1 (sr) 2018-07-31

Family

ID=53761420

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20180582A RS57242B1 (sr) 2014-07-28 2015-07-24 [1,2,4]triazolo[4,3-b]piridazini za upotrebu u tretmanu proliferativnih bolesti

Country Status (36)

Country Link
US (5) US9944650B2 (sr)
EP (1) EP3174881B1 (sr)
JP (1) JP6592503B2 (sr)
KR (1) KR20170033427A (sr)
CN (1) CN106536524B (sr)
AP (1) AP2017009700A0 (sr)
AU (1) AU2015295120B2 (sr)
BR (1) BR112017001160A2 (sr)
CA (2) CA3185741A1 (sr)
CL (1) CL2017000223A1 (sr)
CO (1) CO2017001918A2 (sr)
CY (1) CY1120602T1 (sr)
DK (1) DK3174881T3 (sr)
DO (1) DOP2017000018A (sr)
EA (1) EA032654B9 (sr)
ES (1) ES2670444T3 (sr)
GT (1) GT201700016A (sr)
HR (1) HRP20180788T1 (sr)
HU (1) HUE037571T2 (sr)
IL (1) IL250104B (sr)
LT (1) LT3174881T (sr)
MX (1) MX2017001218A (sr)
MY (1) MY187251A (sr)
NI (1) NI201700006A (sr)
NO (2) NO2719005T3 (sr)
PE (1) PE20170527A1 (sr)
PH (1) PH12017500159B1 (sr)
PL (1) PL3174881T3 (sr)
PT (1) PT3174881T (sr)
RS (1) RS57242B1 (sr)
SG (1) SG11201700419SA (sr)
SI (1) SI3174881T1 (sr)
SV (1) SV2017005368A (sr)
TN (1) TN2017000018A1 (sr)
WO (1) WO2016016618A1 (sr)
ZA (1) ZA201701207B (sr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO2719005T3 (sr) * 2014-07-28 2018-01-20
CN110317216A (zh) * 2018-03-28 2019-10-11 首都医科大学 一种三唑并哒嗪类衍生物在医药领域的应用
TWI816880B (zh) * 2018-09-13 2023-10-01 大陸商恒翼生物醫藥（上海）股份有限公司 治療前列腺癌之組合療法
MX2022004555A (es) 2019-10-14 2022-07-21 Astrazeneca Ab Terapia de combinacion para tratar una neoplasia maligna hematologica.
AU2021206140A1 (en) 2020-01-09 2022-08-18 Astrazeneca Ab Combination therapy for treating cancer
CN113143930B (zh) * 2021-04-08 2023-05-30 深圳湾实验室 化合物在制备SARS-Cov-2 E蛋白抑制剂中的用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007065664A2 (en) 2005-12-08 2007-06-14 Novartis Ag Pyrazolo[1,5-a]pyridine-3-carboxylic acids as ephb and vegfr2 kinase inhibitors
GB0525065D0 (en) * 2005-12-08 2006-01-18 Novartis Ag Organic compounds
BRPI0821676A2 (pt) * 2007-12-21 2015-06-16 Astrazeneca Ab Composto, composição farmacêutica, e, processo para a preparação dos compostos.
KR20110113755A (ko) * 2009-02-10 2011-10-18 아스트라제네카 아베 트리아졸로 〔4,3-ｂ〕 피리다진 유도체 및 전립샘암에 대한 이의 용도
AU2010247190A1 (en) * 2009-05-11 2011-11-10 Astrazeneca Ab [1,2,4] triazolo [4,3-b] pyridazines as ligands of the androgen receptor
CA2779355C (en) 2009-11-05 2018-01-16 Glaxosmithkline Llc Benzodiazepine bromodomain inhibitor
EP2721031B1 (en) * 2011-06-17 2016-01-20 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
US9422290B2 (en) 2012-11-13 2016-08-23 Boehringer Ingelheim International Gmbh Triazolopyridazine
NO2719005T3 (sr) * 2014-07-28 2018-01-20

Also Published As

Publication number Publication date
GT201700016A (es) 2018-12-19
DK3174881T3 (en) 2018-06-06
US20210107905A1 (en) 2021-04-15
PH12017500159A1 (en) 2017-07-10
IL250104B (en) 2018-10-31
AP2017009700A0 (en) 2017-01-31
US20230035133A1 (en) 2023-02-02
MY187251A (en) 2021-09-15
US10407432B2 (en) 2019-09-10
HRP20180788T1 (hr) 2018-06-29
US20180230158A1 (en) 2018-08-16
KR20170033427A (ko) 2017-03-24
NO3174881T3 (sr) 2018-08-25
PT3174881T (pt) 2018-05-25
AU2015295120B2 (en) 2018-02-01
US9944650B2 (en) 2018-04-17
AU2015295120A8 (en) 2017-02-09
AU2015295120A1 (en) 2017-02-02
PH12017500159B1 (en) 2017-07-10
IL250104A0 (en) 2017-03-30
TN2017000018A1 (en) 2018-07-04
CA2956421A1 (en) 2016-02-04
CA2956421C (en) 2023-03-14
EP3174881B1 (en) 2018-03-28
CO2017001918A2 (es) 2017-05-10
EP3174881A1 (en) 2017-06-07
EA032654B9 (ru) 2019-07-31
CN106536524B (zh) 2019-11-15
NO2719005T3 (sr) 2018-01-20
JP6592503B2 (ja) 2019-10-16
CN106536524A (zh) 2017-03-22
US11407755B2 (en) 2022-08-09
CL2017000223A1 (es) 2017-08-25
NI201700006A (es) 2017-08-25
SG11201700419SA (en) 2017-02-27
SV2017005368A (es) 2017-05-12
JP2017522338A (ja) 2017-08-10
LT3174881T (lt) 2018-06-11
MX2017001218A (es) 2017-05-01
PE20170527A1 (es) 2017-05-24
US20170210747A1 (en) 2017-07-27
CA3185741A1 (en) 2016-02-04
CY1120602T1 (el) 2019-12-11
ZA201701207B (en) 2018-12-19
EA201790179A1 (ru) 2017-07-31
PL3174881T3 (pl) 2018-08-31
SI3174881T1 (en) 2018-06-29
DOP2017000018A (es) 2017-03-15
EA032654B1 (ru) 2019-06-28
US20200055861A1 (en) 2020-02-20
ES2670444T3 (es) 2018-05-30
HUE037571T2 (hu) 2018-09-28
WO2016016618A1 (en) 2016-02-04
BR112017001160A2 (pt) 2017-11-14
US10766905B2 (en) 2020-09-08

Similar Documents

Publication Publication Date Title
HRP20180697T1 (hr) Spojevi imidazo[4,5-c]kinolin-2-ona i njihova upotreba za liječenje raka
HRP20180876T1 (hr) Adc duokarmicina, namijenjeni upotrebi u liječenju raka mokraćnog mjehura
IL246564A (en) 3-aryl-1-heterocyclic-pyrazolo [4,3- d] pyrimidine derivatives and their use in the treatment of diseases
IL254224B (en) History of 5-alkyl-7-(piperidinyl/morpholinyl)-[4,2,1]triazolo[5,1-a]pyrimidine for use in medical treatment
PT3107914T (pt) Compostos de pirazolo[1,5-a]pirimidina-5,7-diamina como inibidores de cdk e utilização terapêutica dos mesmos
IL252053B2 (en) Converted pyrazolo[1,5-a]pyrimidines and their use in the treatment of medical disorders
HRP20180788T1 (hr) [1,2,4]triazolo[4,3-b]piridazini za uporabu za liječenje proliferativnih bolesti
IL251371A0 (en) Cortexolone 17alpha-benzoate for use in the treatment of tumors
PL3277280T3 (pl) Izomiosmina do zastosowania w leczeniu chorób autoimmunologicznych
HK1225723A1 (zh) 取代的咪唑並[1，2-a]吡啶甲酰胺及其用途
HUE039750T2 (hu) Hidroxi-buspiron mozgászavarok kezelésére
IL246855A0 (en) Materials for use in the treatment of retinitis
SI3452465T1 (sl) Substituirani derivati 2,4-diamino-kinolina za uporabo v zdravljenju proliferativnih bolezni
ZA201704727B (en) New imidazo[1,2-a]quinoxalines and derivates thereof for the treatment of cancer
GB201406986D0 (en) Bicyclic heterocycle compounds and their uses in therapy