SI3134410T1 - Inhibicija trpa1 ionskih kanalčkov - Google Patents

Inhibicija trpa1 ionskih kanalčkov

Info

Publication number
SI3134410T1
SI3134410T1 SI201531549T SI201531549T SI3134410T1 SI 3134410 T1 SI3134410 T1 SI 3134410T1 SI 201531549 T SI201531549 T SI 201531549T SI 201531549 T SI201531549 T SI 201531549T SI 3134410 T1 SI3134410 T1 SI 3134410T1
Authority
SI
Slovenia
Prior art keywords
inhibiting
ion channel
transient receptor
receptor potential
transient
Prior art date
Application number
SI201531549T
Other languages
English (en)
Inventor
Blaise S. Lippa
Qingyi Li
Iwona Wrona
Andrew J. Jackson
Christopher M. Liu
Guohua Liang
Matthew F. Baevsky
Richard Alan Earl
Lisa Mcqueen
Jared Smit
Brett Cowans
Xinyuan Wu
Bertrand L. Chenard
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of SI3134410T1 publication Critical patent/SI3134410T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
  • Discharging, Photosensitive Material Shape In Electrophotography (AREA)
  • Electrotherapy Devices (AREA)
SI201531549T 2014-04-23 2015-04-23 Inhibicija trpa1 ionskih kanalčkov SI3134410T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201461983223P 2014-04-23 2014-04-23
US201461987272P 2014-05-01 2014-05-01
EP15722319.9A EP3134410B1 (en) 2014-04-23 2015-04-23 Inhibiting the transient receptor potential a1 ion channel
PCT/US2015/027353 WO2015164643A1 (en) 2014-04-23 2015-04-23 Inhibiting the transient receptor potential a1 ion channel

Publications (1)

Publication Number Publication Date
SI3134410T1 true SI3134410T1 (sl) 2021-04-30

Family

ID=53175632

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201531549T SI3134410T1 (sl) 2014-04-23 2015-04-23 Inhibicija trpa1 ionskih kanalčkov

Country Status (18)

Country Link
US (2) US20170050966A1 (sl)
EP (1) EP3134410B1 (sl)
JP (1) JP6557680B2 (sl)
CN (1) CN106573934B (sl)
AU (1) AU2015252007B2 (sl)
CA (1) CA2945789C (sl)
CY (1) CY1124243T1 (sl)
DK (1) DK3134410T3 (sl)
ES (1) ES2865173T3 (sl)
HR (1) HRP20210613T1 (sl)
HU (1) HUE054066T2 (sl)
LT (1) LT3134410T (sl)
PL (1) PL3134410T3 (sl)
PT (1) PT3134410T (sl)
RS (1) RS61715B1 (sl)
SI (1) SI3134410T1 (sl)
TW (1) TWI676626B (sl)
WO (1) WO2015164643A1 (sl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2788395T3 (es) 2014-09-19 2020-10-21 Lilly Co Eli Inhibición del canal iónico del receptor de potencial transitorio A1
WO2018109155A1 (en) * 2016-12-16 2018-06-21 Galderma Research & Development Trpa1 antagonists for use in the treatment of atopic dermatitis
KR20200030048A (ko) * 2017-07-11 2020-03-19 베링거 인겔하임 인터내셔날 게엠베하 신규한 치환된 크산틴 유도체
EP3746445A1 (en) 2018-01-31 2020-12-09 Eli Lilly And Company Inhibiting the transient receptor potential a1 ion channel
BR112021007692A2 (pt) * 2018-10-23 2021-08-10 George Edward Hoag composição e método para tratar os pulmões
FR3114235A1 (fr) 2020-09-18 2022-03-25 Université Grenoble Alpes Inhibition du canal trpa1 astrocytaire comme nouvelle cible therapeutique neuroprotectrice dans les phases prodromales de la maladie d’alzheimer
IT202100015098A1 (it) 2021-06-09 2022-12-09 Flonext S R L Composto antagonista del canale trpa1 per uso in patologie degenerative della retina
WO2023133502A1 (en) * 2022-01-07 2023-07-13 The Johns Hopkins University Treatment and prevention of trigeminal neuralgia
CN114656480B (zh) * 2022-04-27 2024-01-26 成都施贝康生物医药科技有限公司 噻吩并嘧啶类化合物、异构体或盐及其制备方法和用途
CN114671876B (zh) * 2022-04-27 2023-10-03 成都施贝康生物医药科技有限公司 新型茶碱类化合物、异构体或盐及其制备方法和用途
CN114671875A (zh) * 2022-04-27 2022-06-28 成都施贝康生物医药科技有限公司 新型二氢嘧啶类化合物、异构体或盐及其制备方法和用途
CN114656472B (zh) * 2022-04-27 2023-07-04 成都施贝康生物医药科技有限公司 吡唑并嘧啶类化合物、异构体或盐及其制备方法和用途
CN114656473B (zh) * 2022-04-27 2023-09-29 成都施贝康生物医药科技有限公司 吡咯并嘧啶类化合物、异构体或盐及其制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2634152A1 (en) 2005-12-22 2007-06-28 Hydra Biosciences, Inc. Trpa1 inhibitors for treating pain
SI3184527T1 (sl) * 2007-06-22 2020-03-31 Eli Lilly And Company Spojine 2,6-diokso,-2,3-dihidro-1H-purina uporabne za zdravljenje stanj povezanih z aktivnostjo TRPA1 kanala
WO2009140517A1 (en) * 2008-05-14 2009-11-19 Hydra Biosciences, Inc. Compounds and compositions for treating chemical warfare agent-induced injuries
WO2010036821A1 (en) * 2008-09-24 2010-04-01 Hydra Biosciences, Inc. Methods and compositions for treating respiratory disorders
AU2012294300A1 (en) * 2011-08-09 2014-03-20 Hydra Biosciences, Inc. Inhibiting transient receptor potential ion channel TRPA1
TW201441225A (zh) * 2013-01-18 2014-11-01 Cubist Pharm Inc 瞬時受體電位ａ１離子通道之抑制
GB201309333D0 (en) * 2013-05-23 2013-07-10 Agency Science Tech & Res Purine diones as WNT pathway modulators
ES2788395T3 (es) * 2014-09-19 2020-10-21 Lilly Co Eli Inhibición del canal iónico del receptor de potencial transitorio A1
JP6700291B2 (ja) * 2015-02-15 2020-05-27 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ １−（ｈｅｔ）アリールスルホニル−（ピロリジン又はピペリジン）−２−カルボキサミド誘導体、及びｔｒｐａ１拮抗薬としてのそれらの使用

Also Published As

Publication number Publication date
WO2015164643A1 (en) 2015-10-29
CA2945789A1 (en) 2015-10-29
EP3134410A1 (en) 2017-03-01
AU2015252007B2 (en) 2019-08-22
TWI676626B (zh) 2019-11-11
CA2945789C (en) 2022-08-30
JP6557680B2 (ja) 2019-08-07
CY1124243T1 (el) 2022-07-22
AU2015252007A1 (en) 2016-10-13
HRP20210613T1 (hr) 2021-05-28
RS61715B1 (sr) 2021-05-31
TW201625618A (zh) 2016-07-16
US10428072B2 (en) 2019-10-01
JP2017516763A (ja) 2017-06-22
US20170050966A1 (en) 2017-02-23
HUE054066T2 (hu) 2021-08-30
US20180230149A1 (en) 2018-08-16
CN106573934A (zh) 2017-04-19
PL3134410T3 (pl) 2021-07-12
CN106573934B (zh) 2019-10-11
DK3134410T3 (da) 2021-04-26
PT3134410T (pt) 2021-04-22
ES2865173T3 (es) 2021-10-15
EP3134410B1 (en) 2021-03-10
LT3134410T (lt) 2021-04-26

Similar Documents

Publication Publication Date Title
DK3478217T3 (en) Historisk scanningsreference for intraorale scanninger
RS60192B1 (sr) Inhibicija jonskog kanala a1 za prolazni receptorski potencijal
GB201518778D0 (en) Access point
RS61715B1 (sr) Inhibicija jonskog kanala tranzitornog receptorskog potencijala a1
GB201514875D0 (en) Receptor
HK1252163A1 (zh) 受體
EP3437669C0 (en) PERCUTANEOUS SYSTEM
GB201621889D0 (en) Cell
GB201610515D0 (en) Cell
HK1247061A1 (zh) 改進的垂直滑動衣物懸掛裝置
HUE060833T2 (hu) Lerakószerkezet
EP2945947A4 (en) ION CHANNEL INHIBITION WITH TRANSIENT RECEIVER POTENTIAL A1
GB201603372D0 (en) Cell
GB201508085D0 (en) Reference voltages
DK3449331T3 (en) Indretning til at styre fluidstrømning
GB201609604D0 (en) Cell
GB201617716D0 (en) Cell
ZA201801983B (en) Heterophasic composition
GB2549493B (en) Channel system
ZA201800978B (en) Baffle structure for channel
GB201401475D0 (en) Installation
GB201712093D0 (en) Not known
GB201612360D0 (en) Improved shattaf
GB201604283D0 (en) Improved structure
GB201518538D0 (en) Envelopes