LT3134410T - Pereinamojo receptoriaus potencialo a1 jonų kanalo slopinimas - Google Patents

Pereinamojo receptoriaus potencialo a1 jonų kanalo slopinimas

Info

Publication number
LT3134410T
LT3134410T LTEP15722319.9T LT15722319T LT3134410T LT 3134410 T LT3134410 T LT 3134410T LT 15722319 T LT15722319 T LT 15722319T LT 3134410 T LT3134410 T LT 3134410T
Authority
LT
Lithuania
Prior art keywords
inhibiting
ion channel
transient receptor
receptor potential
transient
Prior art date
Application number
LTEP15722319.9T
Other languages
English (en)
Inventor
Blaise Lippa
Qingyi Li
Iwona WRONA
Andrew Jackson
Christopher Liu
Guohua LIANG
Matthew Baevsky
Richard Earl
Lisa McQUEEN
Jared Smit
Brett Cowans
Xinyuan Wu
Bertrand Chenard
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of LT3134410T publication Critical patent/LT3134410T/lt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Discharging, Photosensitive Material Shape In Electrophotography (AREA)
  • Electrotherapy Devices (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
LTEP15722319.9T 2014-04-23 2015-04-23 Pereinamojo receptoriaus potencialo a1 jonų kanalo slopinimas LT3134410T (lt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461983223P 2014-04-23 2014-04-23
US201461987272P 2014-05-01 2014-05-01
PCT/US2015/027353 WO2015164643A1 (en) 2014-04-23 2015-04-23 Inhibiting the transient receptor potential a1 ion channel

Publications (1)

Publication Number Publication Date
LT3134410T true LT3134410T (lt) 2021-04-26

Family

ID=53175632

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP15722319.9T LT3134410T (lt) 2014-04-23 2015-04-23 Pereinamojo receptoriaus potencialo a1 jonų kanalo slopinimas

Country Status (18)

Country Link
US (2) US20170050966A1 (lt)
EP (1) EP3134410B1 (lt)
JP (1) JP6557680B2 (lt)
CN (1) CN106573934B (lt)
AU (1) AU2015252007B2 (lt)
CA (1) CA2945789C (lt)
CY (1) CY1124243T1 (lt)
DK (1) DK3134410T3 (lt)
ES (1) ES2865173T3 (lt)
HR (1) HRP20210613T1 (lt)
HU (1) HUE054066T2 (lt)
LT (1) LT3134410T (lt)
PL (1) PL3134410T3 (lt)
PT (1) PT3134410T (lt)
RS (1) RS61715B1 (lt)
SI (1) SI3134410T1 (lt)
TW (1) TWI676626B (lt)
WO (1) WO2015164643A1 (lt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015317332B2 (en) 2014-09-19 2019-07-18 Eli Lilly And Company Inhibiting the transient receptor potential A1 ion channel
EP3554500A1 (en) * 2016-12-16 2019-10-23 Galderma Research & Development Trpa1 antagonists for use in the treatment of atopic dermatitis
UA124793C2 (uk) * 2017-07-11 2021-11-17 Берінґер Інґельгайм Інтернаціональ Ґмбг Заміщені похідні ксантину
CN111655693B (zh) 2018-01-31 2023-03-28 伊莱利利公司 抑制瞬时型感受器电位a1离子通道
KR20210119376A (ko) * 2018-10-23 2021-10-05 조지 에드워드 호아그 폐를 치료하기 위한 조성물 및 방법
FR3114235A1 (fr) 2020-09-18 2022-03-25 Université Grenoble Alpes Inhibition du canal trpa1 astrocytaire comme nouvelle cible therapeutique neuroprotectrice dans les phases prodromales de la maladie d’alzheimer
IT202100015098A1 (it) 2021-06-09 2022-12-09 Flonext S R L Composto antagonista del canale trpa1 per uso in patologie degenerative della retina
WO2023133502A1 (en) * 2022-01-07 2023-07-13 The Johns Hopkins University Treatment and prevention of trigeminal neuralgia
CN114671876B (zh) * 2022-04-27 2023-10-03 成都施贝康生物医药科技有限公司 新型茶碱类化合物、异构体或盐及其制备方法和用途
CN114656473B (zh) * 2022-04-27 2023-09-29 成都施贝康生物医药科技有限公司 吡咯并嘧啶类化合物、异构体或盐及其制备方法和用途
CN114656480B (zh) * 2022-04-27 2024-01-26 成都施贝康生物医药科技有限公司 噻吩并嘧啶类化合物、异构体或盐及其制备方法和用途
CN114656472B (zh) * 2022-04-27 2023-07-04 成都施贝康生物医药科技有限公司 吡唑并嘧啶类化合物、异构体或盐及其制备方法和用途
CN114671875A (zh) * 2022-04-27 2022-06-28 成都施贝康生物医药科技有限公司 新型二氢嘧啶类化合物、异构体或盐及其制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI423819B (zh) 2005-12-22 2014-01-21 Hydra Biosciences Inc 用於調節trpa1功能之化合物
DK2170309T3 (en) * 2007-06-22 2017-01-09 Hydra Biosciences Inc Dioxo-2,6, -2,3-dihydro-1H-purine compounds useful in the treatment of diseases related to activity of TRPA1 channel
WO2009140517A1 (en) * 2008-05-14 2009-11-19 Hydra Biosciences, Inc. Compounds and compositions for treating chemical warfare agent-induced injuries
WO2010036821A1 (en) * 2008-09-24 2010-04-01 Hydra Biosciences, Inc. Methods and compositions for treating respiratory disorders
EP2742048B1 (en) * 2011-08-09 2016-04-27 Hydra Biosciences, Inc. Inhibiting transient receptor potential ion channel trpa1
WO2014113671A1 (en) * 2013-01-18 2014-07-24 Cubist Pharmaceuticals, Inc. Inhibiting the transient receptor potential a1 ion channel
GB201309333D0 (en) * 2013-05-23 2013-07-10 Agency Science Tech & Res Purine diones as WNT pathway modulators
AU2015317332B2 (en) * 2014-09-19 2019-07-18 Eli Lilly And Company Inhibiting the transient receptor potential A1 ion channel
BR112017017052A2 (pt) * 2015-02-15 2018-04-10 F. Hoffmann-La Roche Ag derivados de 1-(het)arilsulfonil-(pirrolidina ou piperidina)-2-carboxamida e seu uso como antagonistas de trpa1

Also Published As

Publication number Publication date
TW201625618A (zh) 2016-07-16
TWI676626B (zh) 2019-11-11
PT3134410T (pt) 2021-04-22
CY1124243T1 (el) 2022-07-22
EP3134410A1 (en) 2017-03-01
SI3134410T1 (sl) 2021-04-30
AU2015252007A1 (en) 2016-10-13
ES2865173T3 (es) 2021-10-15
DK3134410T3 (da) 2021-04-26
JP6557680B2 (ja) 2019-08-07
EP3134410B1 (en) 2021-03-10
WO2015164643A1 (en) 2015-10-29
CA2945789A1 (en) 2015-10-29
HRP20210613T1 (hr) 2021-05-28
RS61715B1 (sr) 2021-05-31
JP2017516763A (ja) 2017-06-22
CN106573934A (zh) 2017-04-19
US20180230149A1 (en) 2018-08-16
AU2015252007B2 (en) 2019-08-22
US10428072B2 (en) 2019-10-01
PL3134410T3 (pl) 2021-07-12
US20170050966A1 (en) 2017-02-23
HUE054066T2 (hu) 2021-08-30
CA2945789C (en) 2022-08-30
CN106573934B (zh) 2019-10-11

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