SI2994479T1 - Modificirano izražanje prolil-4-hidroksilaze v Physcoitrella patens - Google Patents

Modificirano izražanje prolil-4-hidroksilaze v Physcoitrella patens

Info

Publication number
SI2994479T1
SI2994479T1 SI201431350T SI201431350T SI2994479T1 SI 2994479 T1 SI2994479 T1 SI 2994479T1 SI 201431350 T SI201431350 T SI 201431350T SI 201431350 T SI201431350 T SI 201431350T SI 2994479 T1 SI2994479 T1 SI 2994479T1
Authority
SI
Slovenia
Prior art keywords
physcoitrella
patens
prolyl
hydroxylase
modified expression
Prior art date
Application number
SI201431350T
Other languages
English (en)
Inventor
Ralf Reski
Juliana Parsons
Friedrich Altmann
Manuela Graf
Eva Decker
Johannes Stadlmann
Original Assignee
Albert-Ludwigs-Universitaet Freiburg
Universitaet Fuer Bodenkultur Wien
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albert-Ludwigs-Universitaet Freiburg, Universitaet Fuer Bodenkultur Wien filed Critical Albert-Ludwigs-Universitaet Freiburg
Publication of SI2994479T1 publication Critical patent/SI2994479T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/11—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (1.14.11)
    • C12Y114/11002—Procollagen-proline dioxygenase (1.14.11.2), i.e. proline-hydroxylase

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Botany (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI201431350T 2013-05-06 2014-05-05 Modificirano izražanje prolil-4-hidroksilaze v Physcoitrella patens SI2994479T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1308120.3A GB201308120D0 (en) 2013-05-06 2013-05-06 Recombinant protein and method for its production
PCT/EP2014/059132 WO2014180793A1 (en) 2013-05-06 2014-05-05 Modified expression of prolyl-4-hydroxylase in physcoitrella patens
EP14720988.6A EP2994479B1 (en) 2013-05-06 2014-05-05 Modified expression of prolyl-4-hydroxylase in physcoitrella patens

Publications (1)

Publication Number Publication Date
SI2994479T1 true SI2994479T1 (sl) 2019-12-31

Family

ID=48627341

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201431350T SI2994479T1 (sl) 2013-05-06 2014-05-05 Modificirano izražanje prolil-4-hidroksilaze v Physcoitrella patens

Country Status (16)

Country Link
US (1) US10174334B2 (sl)
EP (1) EP2994479B1 (sl)
JP (1) JP6588892B2 (sl)
KR (1) KR101906442B1 (sl)
AU (1) AU2014264732B2 (sl)
BR (1) BR112015027982A2 (sl)
CA (1) CA2911083C (sl)
DK (1) DK2994479T3 (sl)
ES (1) ES2744993T3 (sl)
GB (1) GB201308120D0 (sl)
HR (1) HRP20191556T1 (sl)
LT (1) LT2994479T (sl)
PL (1) PL2994479T3 (sl)
PT (1) PT2994479T (sl)
SI (1) SI2994479T1 (sl)
WO (1) WO2014180793A1 (sl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115003803A (zh) * 2020-02-14 2022-09-02 现代牧场股份有限公司 用于羟基化氨基酸的单体蛋白质和产品

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1224309A2 (en) 1999-10-21 2002-07-24 Monsanto Company Post-translational modification of recombinant proteins produced in plants
KR100389141B1 (ko) 2000-05-18 2003-06-25 동아제약 주식회사 인간 에리스로포이에틴을 고효율로 발현하는 재조합세포주 및 이의 제조방법
ATE479762T1 (de) 2004-09-29 2010-09-15 Collplant Ltd Kollagenproduzierende pflanzen sowie verfahren zu deren erzeugung und verwendung
AU2006268851B2 (en) * 2005-07-12 2011-06-30 Greenovation Biotech Gmbh Improvements in or relating to protein production

Also Published As

Publication number Publication date
GB201308120D0 (en) 2013-06-12
EP2994479A1 (en) 2016-03-16
HRP20191556T1 (hr) 2019-11-29
JP6588892B2 (ja) 2019-10-09
EP2994479B1 (en) 2019-06-19
ES2744993T3 (es) 2020-02-27
CA2911083C (en) 2020-09-15
CA2911083A1 (en) 2014-11-13
DK2994479T3 (da) 2019-09-23
KR20150143593A (ko) 2015-12-23
US20160208275A1 (en) 2016-07-21
LT2994479T (lt) 2019-10-25
PL2994479T3 (pl) 2020-02-28
AU2014264732B2 (en) 2017-04-13
PT2994479T (pt) 2019-09-30
JP2016519136A (ja) 2016-06-30
AU2014264732A1 (en) 2015-12-03
KR101906442B1 (ko) 2018-12-07
WO2014180793A1 (en) 2014-11-13
BR112015027982A2 (pt) 2017-10-17
US10174334B2 (en) 2019-01-08

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