BR112015027982A2 - método para a produção de uma proteína recombinante, proteína recombinante, sistema à base de plantas, uso de um sistema à base de plantas, uso da proteína recombinante, uso de um gene de prolil-4-hidroxilase endógeno modulado de physcomitrella patens - Google Patents

método para a produção de uma proteína recombinante, proteína recombinante, sistema à base de plantas, uso de um sistema à base de plantas, uso da proteína recombinante, uso de um gene de prolil-4-hidroxilase endógeno modulado de physcomitrella patens

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Publication number
BR112015027982A2
BR112015027982A2 BR112015027982A BR112015027982A BR112015027982A2 BR 112015027982 A2 BR112015027982 A2 BR 112015027982A2 BR 112015027982 A BR112015027982 A BR 112015027982A BR 112015027982 A BR112015027982 A BR 112015027982A BR 112015027982 A2 BR112015027982 A2 BR 112015027982A2
Authority
BR
Brazil
Prior art keywords
recombinant protein
plant
herbal
producing
herbal system
Prior art date
Application number
BR112015027982A
Other languages
English (en)
Inventor
Decker Eva
Altmann Friedrich
Stadlmann Johannes
Parsons Juliana
Graf Manuela
Reski Ralf
Original Assignee
Baden Wuerttemberg Stiftung Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baden Wuerttemberg Stiftung Gmbh filed Critical Baden Wuerttemberg Stiftung Gmbh
Publication of BR112015027982A2 publication Critical patent/BR112015027982A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/11—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (1.14.11)
    • C12Y114/11002—Procollagen-proline dioxygenase (1.14.11.2), i.e. proline-hydroxylase

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Botany (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)

Abstract

resumo método para a produção de uma proteína recombinante, proteína recombinante, sistema à base de plantas, uso de um sistema à base de plantas, uso da proteína recombinante, uso de um gene de prolil-4-hidroxilase endógeno modulado de physcomitrella patens o campo da invenção se refere a um método para a produção de uma proteína recombinante em um sistema à base de planta que compreende as etapas de fornecer um sistema à base de planta compreendendo uma modulação para um gene endógeno de planta prolil-4-hidroxilase, proporcionando um gene codificando a proteína recombinante no sistema à base de planta, e cultivando o sistema à base de planta para a expressão do gene codificando a proteína recombinante. o campo da invenção se refere ainda a uma proteína recombinante, a qual foi produzida em um sistema à base de planta. um sistema à base de planta e o uso da proteína recombinante são também fornecidos. 1/1
BR112015027982A 2013-05-06 2014-05-05 método para a produção de uma proteína recombinante, proteína recombinante, sistema à base de plantas, uso de um sistema à base de plantas, uso da proteína recombinante, uso de um gene de prolil-4-hidroxilase endógeno modulado de physcomitrella patens BR112015027982A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1308120.3A GB201308120D0 (en) 2013-05-06 2013-05-06 Recombinant protein and method for its production
PCT/EP2014/059132 WO2014180793A1 (en) 2013-05-06 2014-05-05 Modified expression of prolyl-4-hydroxylase in physcoitrella patens

Publications (1)

Publication Number Publication Date
BR112015027982A2 true BR112015027982A2 (pt) 2017-10-17

Family

ID=48627341

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015027982A BR112015027982A2 (pt) 2013-05-06 2014-05-05 método para a produção de uma proteína recombinante, proteína recombinante, sistema à base de plantas, uso de um sistema à base de plantas, uso da proteína recombinante, uso de um gene de prolil-4-hidroxilase endógeno modulado de physcomitrella patens

Country Status (16)

Country Link
US (1) US10174334B2 (pt)
EP (1) EP2994479B1 (pt)
JP (1) JP6588892B2 (pt)
KR (1) KR101906442B1 (pt)
AU (1) AU2014264732B2 (pt)
BR (1) BR112015027982A2 (pt)
CA (1) CA2911083C (pt)
DK (1) DK2994479T3 (pt)
ES (1) ES2744993T3 (pt)
GB (1) GB201308120D0 (pt)
HR (1) HRP20191556T1 (pt)
LT (1) LT2994479T (pt)
PL (1) PL2994479T3 (pt)
PT (1) PT2994479T (pt)
SI (1) SI2994479T1 (pt)
WO (1) WO2014180793A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023513307A (ja) * 2020-02-14 2023-03-30 モダン メドウ，インコーポレイテッド アミノ酸をヒドロキシル化するための単量体タンパク質及び生成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001029242A2 (en) 1999-10-21 2001-04-26 Monsanto Company Post-translational modification of recombinant proteins produced in plants
KR100389141B1 (ko) 2000-05-18 2003-06-25 동아제약 주식회사 인간 에리스로포이에틴을 고효율로 발현하는 재조합세포주 및 이의 제조방법
WO2006035442A2 (en) 2004-09-29 2006-04-06 Collplant Ltd. Collagen producing plants and methods of generating and using same
ATE472605T1 (de) * 2005-07-12 2010-07-15 Greenovation Biotech Gmbh Verbesserungen der proteinproduktion oder in zusammenhang damit

Also Published As

Publication number Publication date
WO2014180793A1 (en) 2014-11-13
ES2744993T3 (es) 2020-02-27
JP2016519136A (ja) 2016-06-30
GB201308120D0 (en) 2013-06-12
DK2994479T3 (da) 2019-09-23
KR20150143593A (ko) 2015-12-23
JP6588892B2 (ja) 2019-10-09
US10174334B2 (en) 2019-01-08
AU2014264732A1 (en) 2015-12-03
EP2994479A1 (en) 2016-03-16
KR101906442B1 (ko) 2018-12-07
HRP20191556T1 (hr) 2019-11-29
AU2014264732B2 (en) 2017-04-13
CA2911083C (en) 2020-09-15
PL2994479T3 (pl) 2020-02-28
US20160208275A1 (en) 2016-07-21
SI2994479T1 (sl) 2019-12-31
PT2994479T (pt) 2019-09-30
EP2994479B1 (en) 2019-06-19
LT2994479T (lt) 2019-10-25
CA2911083A1 (en) 2014-11-13

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