SI2984490T1 - Metode proizvodnje derivatov omega hidroksilirane maščobne kisline - Google Patents

Metode proizvodnje derivatov omega hidroksilirane maščobne kisline

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Publication number
SI2984490T1
SI2984490T1 SI201431627T SI201431627T SI2984490T1 SI 2984490 T1 SI2984490 T1 SI 2984490T1 SI 201431627 T SI201431627 T SI 201431627T SI 201431627 T SI201431627 T SI 201431627T SI 2984490 T1 SI2984490 T1 SI 2984490T1
Authority
SI
Slovenia
Prior art keywords
methods
fatty acid
acid derivatives
hydroxylated fatty
producing omega
Prior art date
Application number
SI201431627T
Other languages
English (en)
Slovenian (sl)
Inventor
Andreas W. Schirmer
Haibo Wang
Cardayre Stephen B. Del
Zhihao Hu
Louis G. Hom
Baolong Zhu
Cindy Chang
Emanuela E. Popova
Original Assignee
Genomatica, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genomatica, Inc. filed Critical Genomatica, Inc.
Publication of SI2984490T1 publication Critical patent/SI2984490T1/sl

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C—CHEMISTRY; METALLURGY
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    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/14—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (1.14.14)
    • C12Y114/14001—Unspecific monooxygenase (1.14.14.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/15—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen (1.14.15)
    • C12Y114/15003—Alkane 1-monooxygenase (1.14.15.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/0102—Diacylglycerol O-acyltransferase (2.3.1.20)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01075—Long-chain-alcohol O-fatty-acyltransferase (2.3.1.75)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01005—Lysophospholipase (3.1.1.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
    • C12Y301/02014—Oleoyl-[acyl-carrier-protein] hydrolase (3.1.2.14), i.e. ACP-thioesterase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
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    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01042—Hexadecanal dehydrogenase (acylating) (1.2.1.42), i.e. fatty acyl-CoA reductase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

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  • Physics & Mathematics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
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SI201431627T 2013-06-14 2014-06-16 Metode proizvodnje derivatov omega hidroksilirane maščobne kisline SI2984490T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361835464P 2013-06-14 2013-06-14
EP14738962.1A EP2984490B1 (en) 2013-06-14 2014-06-16 Methods of producing omega-hydroxylated fatty acid derivatives
PCT/US2014/042594 WO2014201474A1 (en) 2013-06-14 2014-06-16 Methods of producing omega-hydroxylated fatty acid derivatives

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SI2984490T1 true SI2984490T1 (sl) 2020-10-30

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US (3) US10711288B2 (cg-RX-API-DMAC7.html)
EP (2) EP3745133A1 (cg-RX-API-DMAC7.html)
JP (3) JP7004500B2 (cg-RX-API-DMAC7.html)
KR (4) KR20240049856A (cg-RX-API-DMAC7.html)
CN (3) CN118374462A (cg-RX-API-DMAC7.html)
AU (2) AU2014277874B2 (cg-RX-API-DMAC7.html)
BR (2) BR122020002919B1 (cg-RX-API-DMAC7.html)
CA (1) CA2915229A1 (cg-RX-API-DMAC7.html)
MX (2) MX374736B (cg-RX-API-DMAC7.html)
MY (3) MY207701A (cg-RX-API-DMAC7.html)
SI (1) SI2984490T1 (cg-RX-API-DMAC7.html)
WO (1) WO2014201474A1 (cg-RX-API-DMAC7.html)

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KR101903551B1 (ko) 2015-10-27 2018-10-04 한국생명공학연구원 중쇄 디올의 생산 방법
KR101903553B1 (ko) * 2015-10-27 2018-10-04 한국생명공학연구원 중쇄 아미노카르복시산의 생산 방법
WO2017101987A1 (en) * 2015-12-15 2017-06-22 REG Life Sciences, LLC Omega-hydroxylase-related fusion polypeptide variants with improved properties
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KR102677413B1 (ko) 2017-04-03 2024-06-24 게노마티카 인코포레이티드 중쇄 지방산 유도체의 생산을 위해 개선된 활성을 갖는 티오에스테라제 변이체
KR102170282B1 (ko) * 2017-12-15 2020-10-29 건국대학교 산학협력단 α,ω-디올류 생산하는 재조합 미생물 및 α,ω-디올류의 생산방법
TWI701040B (zh) * 2018-03-19 2020-08-11 國立臺灣大學 蛋白質的用途及包含該蛋白質之全細胞催化系統及其應用
EP3792351A4 (en) 2018-04-16 2022-01-19 Korea Research Institute of Bioscience and Biotechnology Method for producing multi-hydroxy derivatives of polyunsaturated fatty acids
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KR102117828B1 (ko) 2018-07-19 2020-06-02 서울대학교산학협력단 레귤론 변이를 통한 지방산 및 지방산 유도체 생산에서 불포화도 감소
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CN111218430B (zh) * 2018-11-26 2022-06-14 中国科学院大连化学物理研究所 一种nadh类似物依赖型的细胞色素p450还原酶及其应用
CN111218485B (zh) * 2018-11-26 2023-01-24 中国科学院大连化学物理研究所 一种生产ω-1-羟基脂肪酸的方法
CN111592996A (zh) * 2019-12-09 2020-08-28 福建省水产研究所（福建水产病害防治中心） 一种芽孢杆菌cqn-2高密度发酵培养方法
WO2022212119A1 (en) * 2021-03-29 2022-10-06 Genomatica, Inc. Production of non-native monounsaturated fatty acids in bacteria
JP2023005283A (ja) * 2021-06-28 2023-01-18 出光興産株式会社 ペプチドタグ付加タンパク質を用いた代謝物生産
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CN114480513A (zh) * 2022-04-01 2022-05-13 北京林业大学 一种基因编辑酵母体外合成麝香酮的方法
CN115537369B (zh) * 2022-11-09 2024-03-01 云南农业大学 2-十二烯二酸促进蒙氏假单胞菌生长和定殖的应用
CN116064362B (zh) * 2022-12-15 2025-10-28 浙江大学 一种利用葡萄糖从头合成12-氨基月桂酸的基因工程菌及其构建和应用
CN116790529B (zh) * 2023-05-24 2025-01-17 天津大学 P450 bm3蛋白突变体及其应用
CN117343970B (zh) * 2023-10-24 2025-01-21 杭州佳嘉乐生物技术有限公司 一种提升植物油脂亲肤感的油脂发酵方法
CN120699859A (zh) * 2024-11-13 2025-09-26 中国科学院深圳先进技术研究院 重组菌及其构建方法和应用
CN120254135B (zh) * 2025-06-04 2025-08-29 中国农业科学院北京畜牧兽医研究所 一种高精度、抗干扰的内毒素分析方法及试剂盒

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