SG11201506284RA - Method of producing microparticles - Google Patents

Method of producing microparticles

Info

Publication number
SG11201506284RA
SG11201506284RA SG11201506284RA SG11201506284RA SG11201506284RA SG 11201506284R A SG11201506284R A SG 11201506284RA SG 11201506284R A SG11201506284R A SG 11201506284RA SG 11201506284R A SG11201506284R A SG 11201506284RA SG 11201506284R A SG11201506284R A SG 11201506284RA
Authority
SG
Singapore
Prior art keywords
method
producing microparticles
microparticles
producing
Prior art date
Application number
SG11201506284RA
Inventor
John Sinden
Lara Stevanato
Randolph Corteling
Original Assignee
Reneuron Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GBGB1302468.2A priority Critical patent/GB201302468D0/en
Priority to GB201317888A priority patent/GB201317888D0/en
Application filed by Reneuron Ltd filed Critical Reneuron Ltd
Priority to PCT/GB2014/050412 priority patent/WO2014125277A1/en
Publication of SG11201506284RA publication Critical patent/SG11201506284RA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0623Stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0647Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/90Serum-free medium, which may still contain naturally-sourced components
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/148Transforming growth factor alpha [TGF-a]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/15Transforming growth factor beta (TGF-β)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/24Interferons [IFN]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/25Tumour necrosing factors [TNF]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/08Coculture with; Conditioned medium produced by cells of the nervous system
    • C12N2502/088Coculture with; Conditioned medium produced by cells of the nervous system neural stem cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/11Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/1171Haematopoietic stem cells
SG11201506284RA 2013-02-12 2014-02-12 Method of producing microparticles SG11201506284RA (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GBGB1302468.2A GB201302468D0 (en) 2013-02-12 2013-02-12 Stem cell product
GB201317888A GB201317888D0 (en) 2013-10-09 2013-10-09 Method and product
PCT/GB2014/050412 WO2014125277A1 (en) 2013-02-12 2014-02-12 Method of producing microparticles

Publications (1)

Publication Number Publication Date
SG11201506284RA true SG11201506284RA (en) 2015-09-29

Family

ID=50236210

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201506284RA SG11201506284RA (en) 2013-02-12 2014-02-12 Method of producing microparticles

Country Status (8)

Country Link
US (1) US20160002597A1 (en)
EP (1) EP2956147A1 (en)
JP (1) JP2016507550A (en)
CN (1) CN105142646A (en)
AU (1) AU2014217615B2 (en)
CA (1) CA2900897A1 (en)
SG (1) SG11201506284RA (en)
WO (1) WO2014125277A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150059168A (en) * 2012-07-19 2015-05-29 레뉴런 리미티드 Stem cell microparticles
GB201317887D0 (en) 2013-10-09 2013-11-20 Reneuron Ltd Product
CA2949083A1 (en) * 2014-05-18 2015-11-26 Children's Medical Center Corporation Methods and compositions relating to exosomes
US10240127B2 (en) 2014-07-03 2019-03-26 ReCyte Therapeutics, Inc. Exosomes from clonal progenitor cells
US20160158291A1 (en) * 2014-12-03 2016-06-09 Capricor, Inc. Processes for producing stable exosome formulations
CA2981277A1 (en) * 2015-03-30 2016-10-06 Ajinomoto Co., Inc. Human serum albumin-containing culture medium for growth of neural stem cells
US20180116956A1 (en) * 2015-04-02 2018-05-03 Stegi-Ra Trust Composition for use in treating celiac disease
EP3347810A1 (en) * 2015-09-10 2018-07-18 Google LLC Playing spherical video on a limited bandwidth connection
US20180161377A1 (en) * 2016-12-09 2018-06-14 Neoneuron Llc Method of treating neurological disorders with stem cell therapy
CN107349220A (en) * 2017-07-26 2017-11-17 深圳市泰华细胞工程有限公司 A kind of preparation comprising fibroblast excretion body and application thereof
GB201716408D0 (en) * 2017-10-06 2017-11-22 Reneuron Ltd Stem cell microparticles for cancer therapy
WO2019169380A1 (en) * 2018-03-02 2019-09-06 The Regents Of The University Of California Stem cell-derived exosomes for the treatment of corneal scarring

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5851832A (en) 1991-07-08 1998-12-22 Neurospheres, Ltd. In vitro growth and proliferation of multipotent neural stem cells and their progeny
US5753506A (en) 1996-05-23 1998-05-19 Cns Stem Cell Technology, Inc. Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
US5968829A (en) 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
DK1144671T3 (en) 1999-02-12 2008-03-17 Stemcells California Inc Enriched central nervous system cell populations
US6468794B1 (en) 1999-02-12 2002-10-22 Stemcells, Inc. Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
US8147824B2 (en) 1999-08-05 2012-04-03 Athersys, Inc. Immunomodulatory properties of multipotent adult progenitor cells and uses thereof
AU3499801A (en) 2000-02-11 2001-08-20 Schepens Eye Res Inst Isolation and transplantation of retinal stem cells
CA2609260A1 (en) * 2004-06-02 2005-12-22 Sourcepharm, Inc. Rna-containing microvesicles and methods therefor
AU2005252434B2 (en) 2004-06-09 2011-11-24 The University Court Of The University Of Edinburgh Neural stem cells
KR20160028498A (en) 2004-09-24 2016-03-11 메소블라스트, 아이엔씨. Method of enhancing proliferation and/or survival of mesenchymal precursor cells (mpc)
EP1645626B1 (en) 2004-09-30 2007-09-12 Reneuron Limited Cell line
PL2441461T3 (en) 2005-11-07 2014-11-28 Pecora & Co Llc Compositions and methods of vascular injury repair
EP2240189B1 (en) * 2008-01-04 2015-12-30 Lydac Neuroscience Limited Microvesicles
EP2254586B1 (en) 2008-02-22 2015-04-08 Agency For Science, Technology And Research (A*star) Mesenchymal stem cell particles
ES2729557T3 (en) 2008-05-28 2019-11-04 Univ Ramot Mesenchymal stem cells for the treatment of CNS diseases
WO2010039241A1 (en) 2008-09-30 2010-04-08 University Of Louisville Research Foundation, Inc. Methods for isolating very small embryonic-like (vsel) stem cells
EP3187581A1 (en) 2008-12-23 2017-07-05 BOCO Silicon Valley, Inc. Target populations of oligodendrocyte precursor cells and methods of making and using same
SG2014010698A (en) * 2009-11-02 2014-05-29 Agency Science Tech & Res Methods of monitoring cellular states
WO2011062244A1 (en) * 2009-11-18 2011-05-26 Kuroda Masahiko Carrier, method for producing same, and applications of same
US9297007B2 (en) * 2010-05-28 2016-03-29 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg miRNAs involved in the blood brain barrier function
GB201011589D0 (en) 2010-07-09 2010-08-25 Reneuron Ltd Therapeutic cells
US9427450B2 (en) 2012-01-31 2016-08-30 Xon Cells, Inc. Therapeutic immune modulation by stem cell secreted exosomes
AU2013245406B2 (en) * 2012-04-03 2017-07-20 Reneuron Limited Stem cell microparticles
KR20150059168A (en) * 2012-07-19 2015-05-29 레뉴런 리미티드 Stem cell microparticles

Also Published As

Publication number Publication date
CA2900897A1 (en) 2014-08-21
JP2016507550A (en) 2016-03-10
AU2014217615B2 (en) 2018-11-15
AU2014217615A1 (en) 2015-08-20
WO2014125277A1 (en) 2014-08-21
EP2956147A1 (en) 2015-12-23
CN105142646A (en) 2015-12-09
US20160002597A1 (en) 2016-01-07

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