SI2796466T1 - Molekule humaniziranih protiteles specifične za il-31 - Google Patents
Molekule humaniziranih protiteles specifične za il-31 Download PDFInfo
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- SI2796466T1 SI2796466T1 SI200831897T SI200831897T SI2796466T1 SI 2796466 T1 SI2796466 T1 SI 2796466T1 SI 200831897 T SI200831897 T SI 200831897T SI 200831897 T SI200831897 T SI 200831897T SI 2796466 T1 SI2796466 T1 SI 2796466T1
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- 101710181613 Interleukin-31 Proteins 0.000 title claims abstract 5
- 239000000427 antigen Substances 0.000 claims 10
- 102000036639 antigens Human genes 0.000 claims 10
- 108091007433 antigens Proteins 0.000 claims 10
- 239000012634 fragment Substances 0.000 claims 10
- 150000001413 amino acids Chemical group 0.000 claims 6
- 201000004624 Dermatitis Diseases 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 208000002874 Acne Vulgaris Diseases 0.000 claims 2
- 201000004384 Alopecia Diseases 0.000 claims 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims 2
- 206010012442 Dermatitis contact Diseases 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 201000009053 Neurodermatitis Diseases 0.000 claims 2
- 206010034277 Pemphigoid Diseases 0.000 claims 2
- 208000003251 Pruritus Diseases 0.000 claims 2
- 206010047642 Vitiligo Diseases 0.000 claims 2
- 206010000496 acne Diseases 0.000 claims 2
- 231100000360 alopecia Toxicity 0.000 claims 2
- 201000008937 atopic dermatitis Diseases 0.000 claims 2
- 208000010668 atopic eczema Diseases 0.000 claims 2
- 208000010247 contact dermatitis Diseases 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 208000017940 prurigo nodularis Diseases 0.000 claims 2
- 201000004700 rosacea Diseases 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- 101001043821 Homo sapiens Interleukin-31 Proteins 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 208000000594 bullous pemphigoid Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102000045345 human IL31 Human genes 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 1
- 238000011577 humanized mouse model Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000000670 limiting effect Effects 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 230000000770 proinflammatory effect Effects 0.000 abstract 1
- 230000001823 pruritic effect Effects 0.000 abstract 1
- 230000001603 reducing effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001136—Cytokines
- A61K39/00114—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (8)
- MOLEKULE HUMANIZIRANIH PROTITELES SPECIFIČNE ZA IL-31 EP 2 796 466 B1 PATENTNI ZAHTEVKI1. Izolirano monoklonsko protitelo ali njegov antigen vezavni fragment, ki se specifično veže na humani IL-31, ki obsega humanizirano variabilno težkoverižno domeno in humanizirano variabilno lahkoverižno domeno, kjer humanizirana variabilna težkoverižna domena obsega CDR1, CDR2 in CDR3, ki sestoji iz aminokislinskega zaporedja SEQ ID NOs: 1, 2 in 3, posamezno, in imajo okvirni predeli FR1, FR2, FR3 in FR4, aminokislinsko zaporedje, ki je vsaj 90% identično aminokislinskemu zaporedju SEQ ID NO: 12 (FR1), SEQ ID NO: 13 (FR2), SEQ ID NO: 14 (FR3) in SEQ ID NO: 15 (FR4); in kjer humanizirana variabilna lahkoverižna domena obsega CDR1, CDR2 in CDR3, ki sestoji iz aminokislinskega zaporedja SEQ ID NOs: 5, 6 in 7, in imajo okvirni predeli FR5, FR6, FR7 in FR8, aminokislinsko zaporedje, ki je vsaj 90% identično aminokislinskemu zaporedju SEQ ID NO: 17 (FR5), SEQ ID NO: 18 (FR6), SEQ ID NO: 19 (FR7) in SEQ ID NO: 20 (FR8); kjer je aminokislinski ostanek na položaju 29 od SEQ ID NO: 12 (FRI) leucin, aminokislinski ostanek na položaju 8 od SEQ ID NO: 14 (FR3) je lizin, aminokislinski ostanek na položaju 32 od SEQ ID NO: 14 (FR3) je fenilalanin in aminokislinski ostanek na položaju 15 od SEQ ID NO: 19 (FR7) je tirozin.
- 2. Izolirani monoklonski antigen-vezavni fragment po zahtevku 1, kjer antigen vezavni fragment nadalje obsega domeno Fc.
- 3. Izolirano monoklonsko protitelo ali njegov antigen vezavni fragment po zahtevku 1 ali 2, kjer protitelo ali antigen vezavni fragment nadalje obsega konstantno težkoverižno domeno imunoglobulina, izbrano izmed skupine, ki jo sestavljajo: a) konstantna domena humanega IgGI; b) konstantna domena humanega lgG2; c) konstantna domena humanega lgG3; in d) konstantna domena humanega lgG4.
- 4. Izolirano monoklonsko protitelo ali njegov antigen vezavni fragment po zahtevku 3, kjer je konstantna težkoverižna domena imunoglobulina konstantna domena humanega lgG4.
- 5. Izolirano monoklonsko protitelo ali njegov antigen vezavni fragment, po zahtevku 4, kjer ima konstantna domena humanega lgG4 serin za proline mutacijo na položaju 241, kot je določeno po Kabatu.
- 6. Uporaba izoliranega monoklonskega protitelesa ali antigen vezavnega fragmenta, po kateremkoli od zahtevkov 1-5, za izdelavo zdravila za zdravljenje atopičnega dermatitisa, dermatitisa, prurigo nodularisa, ekcema, pruritusa, vitiliga, alopecia aerata, akne rozacea, akne vulgaris, bulozni pemfigoid ali kontaktnega dermatitisa.
- 7. Izolirano monoklonsko protitelo ali antigen vezavni fragment, po kateremkoli od zahtevkov 1-5 za uporabo pri zdravljenju atopičnega dermatitisa, dermatitisa, prurigo nodularisa, ekcema, pruritusa, vitiliga, alopecia aerate, akne rozacee, akne vulgaris, buloznega pemfigoida ali kontaktnega dermatitisa.
- 8. Uporaba po zahtevku 6 ali izolirano monoklonsko protitelo ali antigen vezavni fragment, za uporabo po zahtevku 7, v kombinaciji s farmacevtsko sprejemljivim nosilcem.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1236207P | 2007-12-07 | 2007-12-07 | |
| EP14175301.2A EP2796466B1 (en) | 2007-12-07 | 2008-12-08 | Humanized antibody molecules specific for IL-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2796466T1 true SI2796466T1 (sl) | 2018-01-31 |
Family
ID=40347963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200831897T SI2796466T1 (sl) | 2007-12-07 | 2008-12-08 | Molekule humaniziranih protiteles specifične za il-31 |
Country Status (25)
| Country | Link |
|---|---|
| US (8) | US8470979B2 (sl) |
| EP (3) | EP2215120A2 (sl) |
| JP (2) | JP5744522B2 (sl) |
| KR (1) | KR101603109B1 (sl) |
| CN (1) | CN101970488B (sl) |
| AU (1) | AU2008333131B2 (sl) |
| BR (1) | BRPI0820099A2 (sl) |
| CA (1) | CA2708251C (sl) |
| CY (1) | CY1120412T1 (sl) |
| DK (1) | DK2796466T3 (sl) |
| EA (1) | EA020457B1 (sl) |
| ES (2) | ES2570853T3 (sl) |
| HK (2) | HK1154020A1 (sl) |
| HR (1) | HRP20180252T1 (sl) |
| HU (1) | HUE036548T2 (sl) |
| IL (1) | IL206147A (sl) |
| LT (1) | LT2796466T (sl) |
| ME (1) | ME03057B (sl) |
| NO (1) | NO2796466T3 (sl) |
| PL (1) | PL2796466T3 (sl) |
| PT (1) | PT2796466T (sl) |
| RS (1) | RS56930B1 (sl) |
| SI (1) | SI2796466T1 (sl) |
| TR (1) | TR201802202T4 (sl) |
| WO (1) | WO2009071696A2 (sl) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1476541B1 (en) | 2002-01-18 | 2008-07-16 | ZymoGenetics, Inc. | Cytokine (zcytor17 ligand) |
| MX2007009471A (es) * | 2005-02-14 | 2008-02-15 | Zymogenetics Inc | Metodos de tratamiento de enfermedades que son mediadas por las celulas positivas al antigeno del linfocito cutaneo. |
| US20130216542A1 (en) | 2005-05-06 | 2013-08-22 | Zymogenetics, Inc. | Variable region sequences of il-31 monoclonal antibodies and methods of use |
| US8101183B2 (en) | 2005-05-06 | 2012-01-24 | Zymogentics, Inc. | Variable region sequences of IL-31 monoclonal antibodies |
| ES2561628T3 (es) | 2005-05-06 | 2016-02-29 | Zymogenetics, Inc. | Anticuerpos monoclonales IL-31 y métodos de uso |
| WO2007133816A2 (en) | 2006-01-10 | 2007-11-22 | Zymogenetics, Inc. | Methods of treating pain and inflammation in neuronal tissue using il-31ra and osmrb antagonists |
| WO2008028192A2 (en) * | 2006-09-01 | 2008-03-06 | Zymogenetics, Inc. | Variable region sequences of il-31 monoclonal antibodies and methods of use |
| CN101970488B (zh) | 2007-12-07 | 2014-06-18 | 津莫吉尼蒂克斯公司 | 对il-31特异的人源化抗体分子 |
| US8790651B2 (en) | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
| US9603849B2 (en) * | 2012-10-11 | 2017-03-28 | Nerre Therapeutics Limited | Uses of orvepitant |
| CN110511279B (zh) | 2013-05-30 | 2024-03-29 | 基尼克萨制药有限公司 | 制瘤素m受体抗原结合蛋白 |
| AR099625A1 (es) * | 2014-03-21 | 2016-08-03 | Lilly Co Eli | Anticuerpos de il-21 |
| AR102333A1 (es) | 2014-08-19 | 2017-02-22 | Regeneron Pharma | Selectividad eficiente de proteínas recombinadas |
| EP3284480A4 (en) | 2015-04-14 | 2018-12-05 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition for prevention and/or treatment of atopic dermatitis containing il-31 antagonist as active ingredient |
| CN114848823A (zh) | 2015-04-14 | 2022-08-05 | 中外制药株式会社 | 包含il-31拮抗剂作为活性成分的用于预防和/或治疗特应性皮炎的药物组合物 |
| US9862760B2 (en) | 2015-09-16 | 2018-01-09 | Novartis Ag | Polyomavirus neutralizing antibodies |
| US11261462B2 (en) | 2016-01-27 | 2022-03-01 | Just-Evotec Biologics, Inc. | Inducible expression from transposon-based vectors and uses |
| US11098310B2 (en) | 2016-01-27 | 2021-08-24 | Just-Evotec Biologics, Inc. | Expression from transposon-based vectors and uses |
| JP6937309B2 (ja) | 2016-01-27 | 2021-09-22 | ジャスト−エヴォテック バイオロジックス、インコーポレイテッド | ハイブリッドプロモーターおよびその使用 |
| WO2018156180A1 (en) | 2017-02-24 | 2018-08-30 | Kindred Biosciences, Inc. | Anti-il31 antibodies for veterinary use |
| WO2019106578A2 (en) | 2017-12-01 | 2019-06-06 | Novartis Ag | Polyomavirus neutralizing antibodies |
| EP3765500A2 (en) | 2018-03-16 | 2021-01-20 | Zoetis Services LLC | Interleukin-31 monoclonal antibodies for veterinary use |
| WO2019178601A1 (en) | 2018-03-16 | 2019-09-19 | Zoetis Services Llc | Peptide vaccines against interleukin-31 |
| FR3084365B1 (fr) * | 2018-07-27 | 2020-10-23 | Cisbio Bioassays | Anticorps a domaine unique qui se lient a la proteine g alpha |
| WO2021100794A1 (ja) | 2019-11-20 | 2021-05-27 | 中外製薬株式会社 | 抗体含有製剤 |
| WO2022049614A1 (ja) | 2020-09-01 | 2022-03-10 | 中外製薬株式会社 | Ｉｌ－３１アンタゴニストを有効成分として含有する、透析そう痒症の予防用及び／又は治療用医薬組成物 |
| EP4019546A1 (en) * | 2020-12-23 | 2022-06-29 | Numab Therapeutics AG | Antibody variable domains that bind il-31 |
| IL303166A (en) * | 2020-12-23 | 2023-07-01 | Numab Therapeutics AG | Antibody variable domains that bind IL-31 |
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