SI2721012T1 - Derivati biciklo(3.1.0)heksan-2,6-dikarboksilne kisline kot agonisti mglu2 receptorja - Google Patents
Derivati biciklo(3.1.0)heksan-2,6-dikarboksilne kisline kot agonisti mglu2 receptorjaInfo
- Publication number
- SI2721012T1 SI2721012T1 SI201230569A SI201230569A SI2721012T1 SI 2721012 T1 SI2721012 T1 SI 2721012T1 SI 201230569 A SI201230569 A SI 201230569A SI 201230569 A SI201230569 A SI 201230569A SI 2721012 T1 SI2721012 T1 SI 2721012T1
- Authority
- SI
- Slovenia
- Prior art keywords
- bicyclo
- hexane
- dicarboxylic acid
- acid derivatives
- receptor agonist
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11382208 | 2011-06-17 | ||
| US201161522791P | 2011-08-12 | 2011-08-12 | |
| EP12729769.5A EP2721012B1 (en) | 2011-06-17 | 2012-06-07 | Bicyclo(3.1.0)hexane-2,6-dicarboxylic acid derivatives as mglu2 receptor agonist |
| PCT/US2012/041229 WO2012173850A1 (en) | 2011-06-17 | 2012-06-07 | Bicyclo (3.1.0) hexane- 2, 6 -dicarboxylic acid derivatives as mglu2 receptor agonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2721012T1 true SI2721012T1 (sl) | 2016-08-31 |
Family
ID=47357416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201230569A SI2721012T1 (sl) | 2011-06-17 | 2012-06-07 | Derivati biciklo(3.1.0)heksan-2,6-dikarboksilne kisline kot agonisti mglu2 receptorja |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9296710B2 (sl) |
| EP (1) | EP2721012B1 (sl) |
| JP (1) | JP5945592B2 (sl) |
| KR (1) | KR101598679B1 (sl) |
| CN (1) | CN103596933B (sl) |
| AU (1) | AU2012271024B2 (sl) |
| BR (1) | BR112013031928B1 (sl) |
| CA (1) | CA2836485C (sl) |
| CY (1) | CY1117682T1 (sl) |
| DK (1) | DK2721012T3 (sl) |
| EA (1) | EA023553B1 (sl) |
| ES (1) | ES2587204T3 (sl) |
| HR (1) | HRP20160676T1 (sl) |
| HU (1) | HUE030171T2 (sl) |
| MX (1) | MX2013014802A (sl) |
| PL (1) | PL2721012T3 (sl) |
| PT (1) | PT2721012T (sl) |
| RS (1) | RS54888B1 (sl) |
| SI (1) | SI2721012T1 (sl) |
| WO (1) | WO2012173850A1 (sl) |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993006127A1 (en) | 1991-09-17 | 1993-04-01 | Warner-Lambert Company | Novel amino acid prodrug renin inhibitors |
| US5576323A (en) | 1993-12-03 | 1996-11-19 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| US5849525A (en) | 1994-03-09 | 1998-12-15 | Brigham And Women's Hospital, Inc. | Compositions corresponding to a proton-coupled peptide transporter and methods of making and using same |
| TR199800877T2 (xx) | 1995-11-16 | 1998-09-21 | Eli Lilly And Company | Uyar�c� amino asit t�revleri. |
| US5688826A (en) | 1995-11-16 | 1997-11-18 | Eli Lilly And Company | Excitatory amino acid derivatives |
| GB9605429D0 (en) * | 1995-11-16 | 1996-05-15 | Lilly Co Eli | Excitatory amino acid receptor antagonists |
| US5952294A (en) | 1996-07-31 | 1999-09-14 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Peptidyl prodrugs and methods of making and using the same |
| ZA983930B (en) * | 1997-05-14 | 1999-11-08 | Lilly Co Eli | Excitatory amino acid receptor modulators. |
| ES2191412T3 (es) | 1998-01-28 | 2003-09-01 | Taisho Pharmaceutical Co Ltd | Derivados de aminoacidos que contienen fluor. |
| ATE269293T1 (de) | 1998-08-31 | 2004-07-15 | Taisho Pharmaceutical Co Ltd | 6-fluoro(3.1.0)hexan-derivate |
| US6716452B1 (en) | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| CA2411059A1 (en) | 2000-06-28 | 2002-12-06 | Taisho Pharmaceutical Co., Ltd. | Novel dicarboxylic acid derivatives |
| WO2002055485A1 (en) | 2001-01-11 | 2002-07-18 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
| IL156364A0 (en) | 2001-01-11 | 2004-01-04 | Lilly Co Eli | Prodrugs of excitatory amino acids |
| WO2002068380A1 (en) * | 2001-02-22 | 2002-09-06 | Eli Lilly And Company | Synthetic excitatory amino acids |
| WO2002100399A1 (en) | 2001-06-12 | 2002-12-19 | Elan Pharmaceuticals, Inc. | Macrocycles useful in the treatment of alzheimer's disease |
| AU2002359923B2 (en) | 2001-12-27 | 2007-12-20 | Taisho Pharmaceutical Co., Ltd. | 6-fluorobicyclo[3.1.0]hexane derivatives |
| US20050192273A1 (en) | 2002-04-03 | 2005-09-01 | Johnson Bryan G. | Therapy for psychoses combining an atypical antipsychotic and an mglu2/3 receptor agonist |
| JP2005528378A (ja) | 2002-04-03 | 2005-09-22 | イーライ・リリー・アンド・カンパニー | 非定型抗精神病薬およびｍＧＬＵ２／３受容体アゴニストを組み合わせた精神病治療 |
| CN101362793A (zh) * | 2002-06-11 | 2009-02-11 | 伊莱利利公司 | 兴奋性氨基酸前药 |
| PT1517915E (pt) * | 2002-06-11 | 2009-04-09 | Lilly Co Eli | Pró-drogas de amino ácidos de excitação |
| ES2355144T3 (es) * | 2003-06-26 | 2011-03-23 | Taisho Pharmaceutical Co., Ltd. | Derivado de éster 2-aminobiciclo 3.1.0 hexano-2,6-dicarboxílico. |
| WO2005000790A1 (ja) * | 2003-06-26 | 2005-01-06 | Taisho Pharmaceutical Co., Ltd. | ２－アミノビシクロ[３．１．０]ヘキサン－２，６－ジカルボン酸誘導体 |
| PL2513085T3 (pl) * | 2009-11-18 | 2017-09-29 | Suven Life Sciences Limited | Związki dwupierścieniowe jako ligandy receptora nikotynowego alfa4beta2 acetylocholiny |
| JO2978B1 (en) | 2009-12-21 | 2016-03-15 | ايلي ليلي اند كومباني | MGLU2 aids |
-
2012
- 2012-06-07 PT PT127297695T patent/PT2721012T/pt unknown
- 2012-06-07 CA CA2836485A patent/CA2836485C/en active Active
- 2012-06-07 SI SI201230569A patent/SI2721012T1/sl unknown
- 2012-06-07 EA EA201391700A patent/EA023553B1/ru not_active IP Right Cessation
- 2012-06-07 ES ES12729769.5T patent/ES2587204T3/es active Active
- 2012-06-07 MX MX2013014802A patent/MX2013014802A/es active IP Right Grant
- 2012-06-07 EP EP12729769.5A patent/EP2721012B1/en active Active
- 2012-06-07 KR KR1020137033028A patent/KR101598679B1/ko active IP Right Grant
- 2012-06-07 WO PCT/US2012/041229 patent/WO2012173850A1/en active Application Filing
- 2012-06-07 JP JP2014515878A patent/JP5945592B2/ja active Active
- 2012-06-07 AU AU2012271024A patent/AU2012271024B2/en active Active
- 2012-06-07 HU HUE12729769A patent/HUE030171T2/en unknown
- 2012-06-07 DK DK12729769.5T patent/DK2721012T3/en active
- 2012-06-07 RS RS20160491A patent/RS54888B1/sr unknown
- 2012-06-07 US US14/123,768 patent/US9296710B2/en active Active
- 2012-06-07 PL PL12729769T patent/PL2721012T3/pl unknown
- 2012-06-07 CN CN201280029080.2A patent/CN103596933B/zh active Active
- 2012-06-07 BR BR112013031928-3A patent/BR112013031928B1/pt active IP Right Grant
-
2016
- 2016-06-14 HR HRP20160676TT patent/HRP20160676T1/hr unknown
- 2016-06-24 CY CY20161100570T patent/CY1117682T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA201391700A1 (ru) | 2014-04-30 |
| US20140113944A1 (en) | 2014-04-24 |
| HRP20160676T1 (hr) | 2016-07-15 |
| EP2721012B1 (en) | 2016-05-25 |
| CN103596933A (zh) | 2014-02-19 |
| US9296710B2 (en) | 2016-03-29 |
| CY1117682T1 (el) | 2017-05-17 |
| RS54888B1 (sr) | 2016-10-31 |
| HUE030171T2 (en) | 2017-05-29 |
| JP2014517035A (ja) | 2014-07-17 |
| WO2012173850A1 (en) | 2012-12-20 |
| CA2836485C (en) | 2016-12-13 |
| AU2012271024B2 (en) | 2015-07-09 |
| PT2721012T (pt) | 2016-07-27 |
| AU2012271024A1 (en) | 2013-11-21 |
| DK2721012T3 (en) | 2016-08-15 |
| PL2721012T3 (pl) | 2017-05-31 |
| BR112013031928A2 (pt) | 2016-12-13 |
| EA023553B1 (ru) | 2016-06-30 |
| KR101598679B1 (ko) | 2016-02-29 |
| JP5945592B2 (ja) | 2016-07-05 |
| EP2721012A1 (en) | 2014-04-23 |
| BR112013031928B1 (pt) | 2022-05-24 |
| CN103596933B (zh) | 2016-03-23 |
| ES2587204T3 (es) | 2016-10-21 |
| KR20140009568A (ko) | 2014-01-22 |
| MX2013014802A (es) | 2014-01-24 |
| CA2836485A1 (en) | 2012-12-20 |
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