PL2721012T3 - Pochodne kwasu bicyklo[3.1.0]heksano-2,6-dikarboksylowego jako agoniści receptora mglu2 - Google Patents
Pochodne kwasu bicyklo[3.1.0]heksano-2,6-dikarboksylowego jako agoniści receptora mglu2Info
- Publication number
- PL2721012T3 PL2721012T3 PL12729769T PL12729769T PL2721012T3 PL 2721012 T3 PL2721012 T3 PL 2721012T3 PL 12729769 T PL12729769 T PL 12729769T PL 12729769 T PL12729769 T PL 12729769T PL 2721012 T3 PL2721012 T3 PL 2721012T3
- Authority
- PL
- Poland
- Prior art keywords
- bicyclo
- hexane
- dicarboxylic acid
- acid derivatives
- receptor agonist
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11382208 | 2011-06-17 | ||
| US201161522791P | 2011-08-12 | 2011-08-12 | |
| EP12729769.5A EP2721012B1 (en) | 2011-06-17 | 2012-06-07 | Bicyclo(3.1.0)hexane-2,6-dicarboxylic acid derivatives as mglu2 receptor agonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2721012T3 true PL2721012T3 (pl) | 2017-05-31 |
Family
ID=47357416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12729769T PL2721012T3 (pl) | 2011-06-17 | 2012-06-07 | Pochodne kwasu bicyklo[3.1.0]heksano-2,6-dikarboksylowego jako agoniści receptora mglu2 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9296710B2 (pl) |
| EP (1) | EP2721012B1 (pl) |
| JP (1) | JP5945592B2 (pl) |
| KR (1) | KR101598679B1 (pl) |
| CN (1) | CN103596933B (pl) |
| AU (1) | AU2012271024B2 (pl) |
| BR (1) | BR112013031928B1 (pl) |
| CA (1) | CA2836485C (pl) |
| CY (1) | CY1117682T1 (pl) |
| DK (1) | DK2721012T3 (pl) |
| EA (1) | EA023553B1 (pl) |
| ES (1) | ES2587204T3 (pl) |
| HR (1) | HRP20160676T1 (pl) |
| HU (1) | HUE030171T2 (pl) |
| MX (1) | MX2013014802A (pl) |
| PL (1) | PL2721012T3 (pl) |
| PT (1) | PT2721012T (pl) |
| RS (1) | RS54888B1 (pl) |
| SI (1) | SI2721012T1 (pl) |
| WO (1) | WO2012173850A1 (pl) |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993006127A1 (en) | 1991-09-17 | 1993-04-01 | Warner-Lambert Company | Novel amino acid prodrug renin inhibitors |
| US5576323A (en) | 1993-12-03 | 1996-11-19 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| US5849525A (en) | 1994-03-09 | 1998-12-15 | Brigham And Women's Hospital, Inc. | Compositions corresponding to a proton-coupled peptide transporter and methods of making and using same |
| GB9605429D0 (en) | 1995-11-16 | 1996-05-15 | Lilly Co Eli | Excitatory amino acid receptor antagonists |
| US5688826A (en) | 1995-11-16 | 1997-11-18 | Eli Lilly And Company | Excitatory amino acid derivatives |
| KR19990067598A (ko) | 1995-11-16 | 1999-08-25 | 피터 지. 스트링거 | 여기성 아미노산 유도체 |
| US5952294A (en) | 1996-07-31 | 1999-09-14 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Peptidyl prodrugs and methods of making and using the same |
| ZA983930B (en) | 1997-05-14 | 1999-11-08 | Lilly Co Eli | Excitatory amino acid receptor modulators. |
| AU734812B2 (en) | 1998-01-28 | 2001-06-21 | Taisho Pharmaceutical Co., Ltd. | Fluorine-containing amino acid derivatives |
| CA2341865C (en) | 1998-08-31 | 2006-01-17 | Taisho Pharmaceutical Co., Ltd. | 6-fluorobicyclo[3.1.0]hexane derivatives |
| US6716452B1 (en) | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US6770676B2 (en) | 2000-06-28 | 2004-08-03 | Taisho Pharmaceutical Co., Ltd. | Dicarboxylic acid derivatives |
| WO2002055485A1 (en) | 2001-01-11 | 2002-07-18 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
| HUP0400620A3 (en) | 2001-01-11 | 2012-09-28 | Lilly Co Eli | Prodrugs of excitatory amino acids and pharmaceutical compositions containing them and process for preparation the compounds |
| WO2002068380A1 (en) * | 2001-02-22 | 2002-09-06 | Eli Lilly And Company | Synthetic excitatory amino acids |
| BR0210391A (pt) | 2001-06-12 | 2004-06-15 | Elan Pharm Inc | Composto, métodos de tratar um paciente que tenha ou de prevenir um paciente de contrair uma doença ou condição e de preparar um composto, e, uso de um composto |
| KR20090031962A (ko) | 2001-12-27 | 2009-03-30 | 다이쇼 세이야꾸 가부시끼가이샤 | 6-플루오로비시클로[3.1.0]헥산 유도체 |
| US20050192273A1 (en) | 2002-04-03 | 2005-09-01 | Johnson Bryan G. | Therapy for psychoses combining an atypical antipsychotic and an mglu2/3 receptor agonist |
| AU2003218063A1 (en) | 2002-04-03 | 2003-10-20 | Eli Lilly And Company | Therapy for psychoses combining an atypical antipsychotic and an mglu2/3 receptor agonist |
| BR0311558A (pt) | 2002-06-11 | 2007-04-27 | Lilly Co Eli | composto ou sal farmaceuticamente aceitável do mesmo, processo para preparar o mesmo, métodos para afetar os receptores de glutamato metabotrópicos ligados a camp, para administrar uma quantidade eficaz de um composto e para tratar um distúrbio neurológico e psiquiátrico em um paciente, e, formulação farmacêutica |
| CN101362793A (zh) * | 2002-06-11 | 2009-02-11 | 伊莱利利公司 | 兴奋性氨基酸前药 |
| CN100582087C (zh) * | 2003-06-26 | 2010-01-20 | 大正制药株式会社 | 2-氨基-双环[3.1.0]己烷-2,6-二甲酸酯衍生物 |
| US7381746B2 (en) * | 2003-06-26 | 2008-06-03 | Taisho Pharmaceutical Co., Ltd. | 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative |
| HUE033352T2 (en) * | 2009-11-18 | 2017-11-28 | Suven Life Sciences Ltd | Bicyclic compounds as alpha4-beta2 nicotinic acetylcholine receptor ligands |
| AR079343A1 (es) | 2009-12-21 | 2012-01-18 | Lilly Co Eli | Compuesto de acido 2-amino-4-(4h-1,2,4-triazol-3-ilsulfanil)biciclo[3.1.0]hexano-2,6-dicarboxilico, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar un trastorno psiquiatrico |
-
2012
- 2012-06-07 EA EA201391700A patent/EA023553B1/ru not_active IP Right Cessation
- 2012-06-07 BR BR112013031928-3A patent/BR112013031928B1/pt active IP Right Grant
- 2012-06-07 CN CN201280029080.2A patent/CN103596933B/zh active Active
- 2012-06-07 EP EP12729769.5A patent/EP2721012B1/en active Active
- 2012-06-07 RS RS20160491A patent/RS54888B1/sr unknown
- 2012-06-07 US US14/123,768 patent/US9296710B2/en active Active
- 2012-06-07 KR KR1020137033028A patent/KR101598679B1/ko active IP Right Grant
- 2012-06-07 ES ES12729769.5T patent/ES2587204T3/es active Active
- 2012-06-07 JP JP2014515878A patent/JP5945592B2/ja active Active
- 2012-06-07 AU AU2012271024A patent/AU2012271024B2/en active Active
- 2012-06-07 PT PT127297695T patent/PT2721012T/pt unknown
- 2012-06-07 SI SI201230569A patent/SI2721012T1/sl unknown
- 2012-06-07 PL PL12729769T patent/PL2721012T3/pl unknown
- 2012-06-07 WO PCT/US2012/041229 patent/WO2012173850A1/en active Application Filing
- 2012-06-07 MX MX2013014802A patent/MX2013014802A/es active IP Right Grant
- 2012-06-07 DK DK12729769.5T patent/DK2721012T3/en active
- 2012-06-07 HU HUE12729769A patent/HUE030171T2/en unknown
- 2012-06-07 CA CA2836485A patent/CA2836485C/en active Active
-
2016
- 2016-06-14 HR HRP20160676TT patent/HRP20160676T1/hr unknown
- 2016-06-24 CY CY20161100570T patent/CY1117682T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20160676T1 (hr) | 2016-07-15 |
| CA2836485A1 (en) | 2012-12-20 |
| CN103596933B (zh) | 2016-03-23 |
| KR101598679B1 (ko) | 2016-02-29 |
| HUE030171T2 (en) | 2017-05-29 |
| AU2012271024A1 (en) | 2013-11-21 |
| BR112013031928A2 (pt) | 2016-12-13 |
| BR112013031928B1 (pt) | 2022-05-24 |
| PT2721012T (pt) | 2016-07-27 |
| CA2836485C (en) | 2016-12-13 |
| EA023553B1 (ru) | 2016-06-30 |
| JP5945592B2 (ja) | 2016-07-05 |
| EP2721012B1 (en) | 2016-05-25 |
| SI2721012T1 (sl) | 2016-08-31 |
| US20140113944A1 (en) | 2014-04-24 |
| CY1117682T1 (el) | 2017-05-17 |
| JP2014517035A (ja) | 2014-07-17 |
| CN103596933A (zh) | 2014-02-19 |
| EP2721012A1 (en) | 2014-04-23 |
| WO2012173850A1 (en) | 2012-12-20 |
| AU2012271024B2 (en) | 2015-07-09 |
| EA201391700A1 (ru) | 2014-04-30 |
| MX2013014802A (es) | 2014-01-24 |
| RS54888B1 (sr) | 2016-10-31 |
| ES2587204T3 (es) | 2016-10-21 |
| US9296710B2 (en) | 2016-03-29 |
| DK2721012T3 (en) | 2016-08-15 |
| KR20140009568A (ko) | 2014-01-22 |
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