SI2590974T1 - Tetrahidro-pirido-pirimidinski derivati - Google Patents
Tetrahidro-pirido-pirimidinski derivatiInfo
- Publication number
- SI2590974T1 SI2590974T1 SI201130220T SI201130220T SI2590974T1 SI 2590974 T1 SI2590974 T1 SI 2590974T1 SI 201130220 T SI201130220 T SI 201130220T SI 201130220 T SI201130220 T SI 201130220T SI 2590974 T1 SI2590974 T1 SI 2590974T1
- Authority
- SI
- Slovenia
- Prior art keywords
- pyrido
- tetrahydro
- pyrimidine derivatives
- pyrimidine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36158910P | 2010-07-06 | 2010-07-06 | |
PCT/EP2011/061393 WO2012004299A1 (en) | 2010-07-06 | 2011-07-06 | Tetrahydro-pyrido-pyrimidine derivatives |
EP11730637.3A EP2590974B1 (en) | 2010-07-06 | 2011-07-06 | Tetrahydro-pyrido-pyrimidine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2590974T1 true SI2590974T1 (sl) | 2014-08-29 |
Family
ID=44532774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201130220T SI2590974T1 (sl) | 2010-07-06 | 2011-07-06 | Tetrahidro-pirido-pirimidinski derivati |
Country Status (39)
Country | Link |
---|---|
US (9) | US8653092B2 (sl) |
EP (1) | EP2590974B1 (sl) |
JP (1) | JP5770842B2 (sl) |
KR (1) | KR101560066B1 (sl) |
CN (1) | CN102971317B (sl) |
AR (3) | AR084970A1 (sl) |
AU (1) | AU2011275777C1 (sl) |
BR (1) | BR112013000275B1 (sl) |
CA (1) | CA2802132C (sl) |
CL (1) | CL2013000033A1 (sl) |
CO (1) | CO6670566A2 (sl) |
CR (1) | CR20130004A (sl) |
DK (1) | DK2590974T3 (sl) |
DO (1) | DOP2013000027A (sl) |
EA (1) | EA024123B1 (sl) |
EC (1) | ECSP13012420A (sl) |
ES (1) | ES2494718T3 (sl) |
GT (1) | GT201300009A (sl) |
HK (1) | HK1179966A1 (sl) |
HR (1) | HRP20140778T1 (sl) |
IL (1) | IL223795A (sl) |
JO (1) | JO2939B1 (sl) |
MA (1) | MA34361B1 (sl) |
MX (1) | MX2012015088A (sl) |
MY (1) | MY166026A (sl) |
NI (1) | NI201300002A (sl) |
NZ (1) | NZ604302A (sl) |
PE (1) | PE20130650A1 (sl) |
PL (1) | PL2590974T3 (sl) |
PT (1) | PT2590974E (sl) |
RS (1) | RS53490B1 (sl) |
SG (1) | SG186187A1 (sl) |
SI (1) | SI2590974T1 (sl) |
TN (1) | TN2012000578A1 (sl) |
TW (1) | TWI534145B (sl) |
UA (1) | UA112517C2 (sl) |
UY (1) | UY33486A (sl) |
WO (1) | WO2012004299A1 (sl) |
ZA (1) | ZA201209117B (sl) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8759362B2 (en) * | 2008-10-24 | 2014-06-24 | Purdue Pharma L.P. | Bicycloheteroaryl compounds and their use as TRPV1 ligands |
UA112517C2 (uk) | 2010-07-06 | 2016-09-26 | Новартіс Аг | Тетрагідропіридопіримідинові похідні |
JO3733B1 (ar) | 2011-04-05 | 2021-01-31 | Bayer Ip Gmbh | استخدام 3,2-دايهيدروايميدازو[1, 2 -c]كوينازولينات مستبدلة |
CN103608349A (zh) | 2011-06-27 | 2014-02-26 | 诺瓦提斯公司 | 四氢-吡啶并-嘧啶衍生物的固体形式和盐 |
EA029473B1 (ru) * | 2011-12-15 | 2018-03-30 | Новартис Аг | Применение ингибиторов pi3k для лечения острой и церебральной малярии |
KR101656592B1 (ko) | 2011-12-22 | 2016-09-23 | 노파르티스 아게 | 디히드로-벤조-옥사진 및 디히드로-피리도-옥사진 유도체 |
EP2916868B1 (en) | 2012-11-08 | 2022-05-11 | Rhizen Pharmaceuticals S.A. | Pharmaceutical compositions containing a pde4 inhibitor and a pi3 delta or dual pi3 delta-gamma kinase inhibitor |
KR20150084992A (ko) * | 2012-11-16 | 2015-07-22 | 머크 샤프 앤드 돔 코포레이션 | 인간 포스파티딜이노시톨 3-키나제 델타의 퓨린 억제제 |
AU2013347538B2 (en) | 2012-11-16 | 2017-04-27 | Merck Sharp & Dohme Corp. | Purine inhibitors of human phosphatidylinositol 3-kinase delta |
EP2742940B1 (en) | 2012-12-13 | 2017-07-26 | IP Gesellschaft für Management mbH | Fumarate salt of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-l-aza-bicyclo-[2.2.2]octane for adminstration once daily, twice daily or thrice daily |
UY35675A (es) | 2013-07-24 | 2015-02-27 | Novartis Ag | Derivados sustituidos de quinazolin-4-ona |
WO2015162584A1 (en) | 2014-04-24 | 2015-10-29 | Novartis Ag | Crystalline forms of the sulfate salt of n-[5-(3-imidazol-1-yl-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide |
GB201506786D0 (en) * | 2015-04-21 | 2015-06-03 | Ucb Biopharma Sprl | Therapeutic use |
JP6462155B2 (ja) * | 2015-05-04 | 2019-01-30 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | B型肝炎ウイルス感染症の治療用のHBsAg(HBV表面抗原)及びHBV DNA産生の阻害剤としてのテトラヒドロピリドピリミジン類及びテトラヒドロピリドピリジン類 |
DK3413894T3 (da) * | 2016-02-10 | 2020-06-15 | Novartis Ag | Anvendelse af inhibitorer af aktiviteten eller funktionen af PI3K til behandling af primært Sjögrens syndrom |
EA201992232A1 (ru) | 2017-03-22 | 2020-05-14 | Новартис Аг | Композиции и способы для иммуноонкологии |
EP3630116B1 (en) | 2017-05-26 | 2024-05-01 | The Board Of Regents Of The University Of Texas System | Tetrahydropyrido[4,3-d]pyrimidine inhibitors of atr kinase |
AU2018301696B8 (en) | 2017-07-13 | 2023-03-23 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of ATR kinase |
US10800774B2 (en) | 2017-08-17 | 2020-10-13 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of ATR kinase |
US10894052B2 (en) | 2018-03-16 | 2021-01-19 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of ATR kinase |
CN114315826B (zh) * | 2021-11-30 | 2023-05-16 | 西安交通大学 | 一种吡啶并嘧啶类化合物及其应用 |
KR20230160977A (ko) | 2022-05-17 | 2023-11-27 | 에이치앤오바이오시스(주) | 항암 치료에 사용되는 5종 이상의 생약 추출물 |
Family Cites Families (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1197466B (de) | 1962-03-22 | 1965-07-29 | Thomae Gmbh Dr K | Verfahren zur Herstellung von neuen 5, 6, 7, 8-Tetrahydropyrido-[4, 3-d]pyrimidinen |
GB1524747A (en) | 1976-05-11 | 1978-09-13 | Ici Ltd | Polypeptide |
PT72878B (en) | 1980-04-24 | 1983-03-29 | Merck & Co Inc | Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents |
DE3372965D1 (en) | 1982-07-23 | 1987-09-17 | Ici Plc | Amide derivatives |
GB8327256D0 (en) | 1983-10-12 | 1983-11-16 | Ici Plc | Steroid derivatives |
US5093330A (en) | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
US5010099A (en) | 1989-08-11 | 1991-04-23 | Harbor Branch Oceanographic Institution, Inc. | Discodermolide compounds, compositions containing same and method of preparation and use |
NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
TW225528B (sl) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
US5300645A (en) | 1993-04-14 | 1994-04-05 | Eli Lilly And Company | Tetrahydro-pyrido-indole |
GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
CA2216796C (en) | 1995-03-30 | 2003-09-02 | Pfizer Inc. | Quinazoline derivatives |
GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
US5843901A (en) | 1995-06-07 | 1998-12-01 | Advanced Research & Technology Institute | LHRH antagonist peptides |
KR100437582B1 (ko) | 1995-07-06 | 2004-12-17 | 노파르티스 아게 | 피롤로피리미딘및그들의제조방법 |
US5760041A (en) | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
CA2249446C (en) | 1996-04-12 | 2008-06-17 | Warner-Lambert Company | Irreversible inhibitors of tyrosine kinases |
ATE308527T1 (de) | 1996-06-24 | 2005-11-15 | Pfizer | Phenylamino-substituierte triicyclische derivate zur behandlung hyperproliferativer krankheiten |
AU716610B2 (en) | 1996-08-30 | 2000-03-02 | Novartis Ag | Method for producing epothilones, and intermediate products obtained during the production process |
DE69724269T2 (de) | 1996-09-06 | 2004-06-09 | Obducat Ab | Verfahren für das anisotrope ätzen von strukturen in leitende materialien |
AU4342997A (en) | 1996-09-13 | 1998-04-02 | Sugen, Inc. | Use of quinazoline derivatives for the manufacture of a medicament in the reatment of hyperproliferative skin disorders |
EP0837063A1 (en) | 1996-10-17 | 1998-04-22 | Pfizer Inc. | 4-Aminoquinazoline derivatives |
EP1367057B1 (de) | 1996-11-18 | 2008-09-17 | Gesellschaft für biotechnologische Forschung mbH (GBF) | Epothilone E und F |
US6441186B1 (en) | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
US5939421A (en) * | 1997-07-01 | 1999-08-17 | Signal Pharmaceuticals, Inc. | Quinazoline analogs and related compounds and methods for treating inflammatory conditions |
CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
GB9721069D0 (en) | 1997-10-03 | 1997-12-03 | Pharmacia & Upjohn Spa | Polymeric derivatives of camptothecin |
US6194181B1 (en) | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
ATE307123T1 (de) | 1998-02-25 | 2005-11-15 | Sloan Kettering Inst Cancer | Synthese von epothilonen, ihren zwischenprodukten und analogen verbindungen |
KR100851418B1 (ko) | 1998-11-20 | 2008-08-08 | 코산 바이오사이언시즈, 인코포레이티드 | 에포틸론 및 에포틸론 유도체의 생산을 위한 재조합 방법 및 물질 |
PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
KR20080014934A (ko) | 2000-11-07 | 2008-02-14 | 노파르티스 아게 | 단백질 키나제 c 억제제로서의 인돌릴말레이미드 유도체 |
AR035885A1 (es) | 2001-05-14 | 2004-07-21 | Novartis Ag | Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica |
GB0119249D0 (en) | 2001-08-07 | 2001-10-03 | Novartis Ag | Organic compounds |
PE20040079A1 (es) | 2002-04-03 | 2004-04-19 | Novartis Ag | Derivados de indolilmaleimida |
JP2006514021A (ja) | 2002-12-09 | 2006-04-27 | ザ・ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システム | Janusチロシンキナーゼ3(Jak3)を選択的に阻害するための方法 |
BR0317749A (pt) | 2002-12-27 | 2005-11-22 | Angeletti P Ist Richerche Bio | Composto, composição farmacêutica, e, uso de um composto |
JP2007524596A (ja) | 2003-02-28 | 2007-08-30 | トランスフォーム・ファーマシューティカルズ・インコーポレイテッド | 共結晶医薬組成物 |
EP1704145B1 (en) | 2004-01-12 | 2012-06-13 | YM BioSciences Australia Pty Ltd | Selective kinase inhibitors |
AU2005206562A1 (en) * | 2004-01-23 | 2005-08-04 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
PL1761528T3 (pl) | 2004-06-11 | 2008-05-30 | Japan Tobacco Inc | Pochodne 5-amino-2,4,7-triokso-3,4,7,8-tetrahydro-2H-pirydo[2,3-D]pirymidyny i związki pokrewne do leczenia raka |
US20060128710A1 (en) | 2004-12-09 | 2006-06-15 | Chih-Hung Lee | Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof |
EP1885369B1 (en) * | 2005-05-04 | 2015-09-23 | Evotec AG | Fused heterocyclic compounds, and compositions and uses thereof |
GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
US8653091B2 (en) * | 2007-04-02 | 2014-02-18 | Evotec Ag | Pyrid-2yl fused heterocyclic compounds, and compositions and uses thereof |
WO2008130481A1 (en) * | 2007-04-17 | 2008-10-30 | Renovis, Inc. | 2-cyanophenyl fused heterocyclic compounds, and compositions and uses thereof |
US20100298289A1 (en) | 2007-10-09 | 2010-11-25 | Ucb Pharma, S.A. | Heterobicyclic compounds as histamine h4-receptor antagonists |
CA2707047C (en) | 2007-12-12 | 2017-11-28 | Rigel Pharmaceuticals, Inc. | Carboxamide, sulfonamide and amine compounds for metabolic disorders |
US8436005B2 (en) | 2008-04-03 | 2013-05-07 | Abbott Laboratories | Macrocyclic pyrimidine derivatives |
WO2010033495A2 (en) | 2008-09-16 | 2010-03-25 | Schering Corporation | Functionally selective azanitrile alpha2c adrenoreceptor agonists |
WO2010048149A2 (en) | 2008-10-20 | 2010-04-29 | Kalypsys, Inc. | Heterocyclic modulators of gpr119 for treatment of disease |
US8546388B2 (en) | 2008-10-24 | 2013-10-01 | Purdue Pharma L.P. | Heterocyclic TRPV1 receptor ligands |
US8759362B2 (en) | 2008-10-24 | 2014-06-24 | Purdue Pharma L.P. | Bicycloheteroaryl compounds and their use as TRPV1 ligands |
JP2010105951A (ja) | 2008-10-29 | 2010-05-13 | Dainippon Sumitomo Pharma Co Ltd | 6−アルキル置換テトラヒドロピリド[4,3−d]ピリミジン誘導体 |
WO2010117425A1 (en) | 2009-03-31 | 2010-10-14 | Biogen Idec Ma Inc. | Certain substituted pyrimidines, pharmaceutical compositions thereof, and methods for their use |
WO2010120991A1 (en) | 2009-04-17 | 2010-10-21 | Wyeth Llc | 5, 6, 7, 8-tetrahydropyrido[4,3-d]pyrimidine compounds, their use as mtor, pi3, and hsmg-1 kinase inhibitors, and their syntheses |
WO2010127212A1 (en) | 2009-04-30 | 2010-11-04 | Forest Laboratories Holdings Limited | Inhibitors of acetyl-coa carboxylase |
US9908884B2 (en) | 2009-05-05 | 2018-03-06 | Dana-Farber Cancer Institute, Inc. | EGFR inhibitors and methods of treating disorders |
US8492392B2 (en) | 2009-05-27 | 2013-07-23 | Merck Sharp & Dohme Corp. | Alkoxy tetrahydro-pyridopyrimidine PDE10 inhibitors |
JP2013032290A (ja) | 2009-11-20 | 2013-02-14 | Dainippon Sumitomo Pharma Co Ltd | 新規縮合ピリミジン誘導体 |
CA2786277A1 (en) | 2010-01-06 | 2011-07-14 | Joseph P. Errico | Methods and compositions of targeted drug development |
SA111320200B1 (ar) | 2010-02-17 | 2014-02-16 | ديبيوفارم اس ايه | مركبات ثنائية الحلقة واستخداماتها كمثبطات c-src/jak مزدوجة |
WO2011103715A1 (en) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Task channel antagonists |
CA2798325A1 (en) | 2010-05-13 | 2011-11-17 | Amgen Inc. | Heteroaryloxyheterocyclyl compounds as pde10 inhibitors |
CA2799579A1 (en) | 2010-05-21 | 2011-11-24 | Intellikine, Inc. | Chemical compounds, compositions and methods for kinase modulation |
UA112517C2 (uk) | 2010-07-06 | 2016-09-26 | Новартіс Аг | Тетрагідропіридопіримідинові похідні |
EA029473B1 (ru) | 2011-12-15 | 2018-03-30 | Новартис Аг | Применение ингибиторов pi3k для лечения острой и церебральной малярии |
-
2011
- 2011-06-07 UA UAA201213598A patent/UA112517C2/uk unknown
- 2011-07-01 US US13/175,050 patent/US8653092B2/en active Active
- 2011-07-04 AR ARP110102390A patent/AR084970A1/es not_active Application Discontinuation
- 2011-07-05 TW TW100123736A patent/TWI534145B/zh active
- 2011-07-05 JO JO2011215A patent/JO2939B1/en active
- 2011-07-06 UY UY0001033486A patent/UY33486A/es active IP Right Grant
- 2011-07-06 SI SI201130220T patent/SI2590974T1/sl unknown
- 2011-07-06 BR BR112013000275-1A patent/BR112013000275B1/pt active IP Right Grant
- 2011-07-06 PE PE2013000017A patent/PE20130650A1/es active IP Right Grant
- 2011-07-06 EP EP11730637.3A patent/EP2590974B1/en active Active
- 2011-07-06 KR KR1020137000230A patent/KR101560066B1/ko active IP Right Grant
- 2011-07-06 ES ES11730637.3T patent/ES2494718T3/es active Active
- 2011-07-06 MX MX2012015088A patent/MX2012015088A/es active IP Right Grant
- 2011-07-06 CN CN201180033521.1A patent/CN102971317B/zh active Active
- 2011-07-06 PL PL11730637T patent/PL2590974T3/pl unknown
- 2011-07-06 PT PT117306373T patent/PT2590974E/pt unknown
- 2011-07-06 SG SG2012089496A patent/SG186187A1/en unknown
- 2011-07-06 WO PCT/EP2011/061393 patent/WO2012004299A1/en active Application Filing
- 2011-07-06 EA EA201291317A patent/EA024123B1/ru not_active IP Right Cessation
- 2011-07-06 NZ NZ604302A patent/NZ604302A/en unknown
- 2011-07-06 MA MA35527A patent/MA34361B1/fr unknown
- 2011-07-06 CA CA2802132A patent/CA2802132C/en active Active
- 2011-07-06 DK DK11730637.3T patent/DK2590974T3/da active
- 2011-07-06 JP JP2013517375A patent/JP5770842B2/ja active Active
- 2011-07-06 AU AU2011275777A patent/AU2011275777C1/en active Active
- 2011-07-06 MY MYPI2012005385A patent/MY166026A/en unknown
- 2011-07-06 RS RS20140427A patent/RS53490B1/en unknown
-
2012
- 2012-12-03 ZA ZA2012/09117A patent/ZA201209117B/en unknown
- 2012-12-06 TN TNP2012000578A patent/TN2012000578A1/en unknown
- 2012-12-20 IL IL223795A patent/IL223795A/en active IP Right Grant
-
2013
- 2013-01-03 CO CO13001273A patent/CO6670566A2/es active IP Right Grant
- 2013-01-04 GT GT201300009A patent/GT201300009A/es unknown
- 2013-01-04 CL CL2013000033A patent/CL2013000033A1/es unknown
- 2013-01-07 NI NI201300002A patent/NI201300002A/es unknown
- 2013-01-07 CR CR20130004A patent/CR20130004A/es unknown
- 2013-02-01 DO DO2013000027A patent/DOP2013000027A/es unknown
- 2013-02-04 EC ECSP13012420 patent/ECSP13012420A/es unknown
- 2013-06-21 HK HK13107261.2A patent/HK1179966A1/xx unknown
-
2014
- 2014-01-09 US US14/151,796 patent/US9499536B2/en active Active
- 2014-08-18 HR HRP20140778AT patent/HRP20140778T1/hr unknown
-
2016
- 2016-10-05 US US15/285,614 patent/US20170022199A1/en not_active Abandoned
-
2017
- 2017-06-05 US US15/613,560 patent/US20170267678A1/en not_active Abandoned
-
2018
- 2018-05-30 US US15/993,051 patent/US20180265509A1/en not_active Abandoned
- 2018-10-17 US US16/163,106 patent/US20190040061A1/en not_active Abandoned
-
2019
- 2019-03-28 US US16/367,525 patent/US20190218217A1/en not_active Abandoned
- 2019-08-07 AR ARP190102244A patent/AR115927A2/es unknown
-
2020
- 2020-05-12 AR ARP200101358A patent/AR118919A2/es unknown
- 2020-06-30 US US16/916,168 patent/US20200392132A1/en not_active Abandoned
-
2021
- 2021-08-11 US US17/399,090 patent/US20220267318A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1182594A1 (en) | N3-substituted-n1-sulfonyl-5-fluoropyrimidinone derivatives n3--n1--5- | |
DK3342786T3 (en) | Anti-dll3-antistof | |
AP3107A (en) | 5-Alkynyl-pyrimidines | |
ZA201209117B (en) | Tetrahydro-pyrido-pyrimidine derivatives | |
EP2640189A4 (en) | 3-deutero-pomalidomide | |
ZA201300032B (en) | Tetrahydrocarboline derivative | |
DK3466977T3 (en) | Anti-vla-4-antistoffer | |
EP2641891A4 (en) | PKC ACTIVATOR- | |
HK1185082A1 (en) | Acylbenzene derivative | |
GB2490849B (en) | Di-aspirin derivatives | |
EP2599775A4 (en) | ETHINYLPYRAZOLDERIVAT | |
HK1174625A1 (en) | Pyrrazolopyridine derivatives | |
HUP1000243A2 (en) | 8-hidroxy-quinoline derivatives | |
ZA201303887B (en) | 2-carboxamide-4-piperazinyl-benzofuran derivative | |
ZA201209248B (en) | Amido-tropane derivatives | |
IL220983A0 (en) | 2-aldoximino-5-fluoropyrimidine derivatives | |
AU4536P (en) | TB01 Tibouchina urvilleana | |
AU4937P (en) | FlatinsulGL Myoporum insulare | |
AU4932P (en) | FlatwaxpinkGL Chamelaucium uncinatum | |
AU4931P (en) | FlatwaxDarkGL Chamelaucium uncinatum | |
AU4822P (en) | FlatwaxwhiteGL Chamelaucium uncinatum | |
AU2010194V (en) | CalpenGL Calothamnus quadrifidus | |
AU2010165V (en) | Silversunrise Conostylis candicans | |
GB201000020D0 (en) | Velcrose |