SI2542228T1 - Pulzirajoče sproščanje zdravila - Google Patents

Pulzirajoče sproščanje zdravila Download PDF

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SI2542228T1
SI2542228T1 SI201131426T SI201131426T SI2542228T1 SI 2542228 T1 SI2542228 T1 SI 2542228T1 SI 201131426 T SI201131426 T SI 201131426T SI 201131426 T SI201131426 T SI 201131426T SI 2542228 T1 SI2542228 T1 SI 2542228T1
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disease
syndrome
diseases
acid
active agent
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Alexander Mullen
Howard Stevens
Sarah Eccleston
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University Of Strathclyde
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/288—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • General Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (9)

  1. •· · ·· ···· ··· ·· PULZIRAJOČE SPROŠČANJE ZDRAVILA PATENTNI ZAHTEVKI
    1. Stisnjena-prevlečena tabletna formulacija, za zakasnelo, ki mu sledi pulzirajoče sproščanje aktivnega sredstva, tableta vsebuje (a) jedro, ki vsebuje aktivno sredstvo(a) skupaj z ekscipientom(i); in (b) sloj z zadržanim sproščanjem, ki obdaja jedro in obsega vosek in nizko substituirano hidroksipropil celulozo (L-HPC), ki je večinoma vlaknata in ima povprečno velikost delcev 55 pm, vsebnost hidroksipropila okoli 11% in molekulsko maso okoli 130.000, v razmerju od 40:60 do 60:40 m/m; pri čemer sloj z zakasnelim sproščanje zakasnelo sprošča aktivno sredstvo znotraj jedra od 1,5 do 8 ur po dajanje tablete subjektu in nato se pojavi pulzirajoče sproščanje aktivnega sredstva iz jedra, tako da se vsaj 70% aktivno sredstvo v jedru sprosti znotraj 5-80 min.
  2. 2. Stisnjena-prevlečena tableta po katerem koli predhodnem zahtevku, ki vsebuje eno ali več naslednjih aktivnih sredstev: Gastro zdravila Antacidi - aluminijev hidroksid, magnezij karbonat, magnezijev trisilikat, hidrotalcit, simetikon alginati, Antispazmodiki - atropinijev sulfat, dicikloverin ·· · ·· ···· ··* hidroklorid, hioscin butilbromin, propantelin bromid, alverin citrat, mebeverin hidroklorid, Motiliteti stimulansi - metoklorpramid, domperidon H2 - Antagonisti receptorjev - Cimetidin, famotidinnizatidin, ranitidin Antimuskarini - pirenzepin Kelati - trikalijev dicitratibismutat, sukralfat, Prostaglandinski analogi-misoprostol Aminosalicilati - balsazid natrij, mesalazin, olsalazin, sulfasalazin Kortikosteroidi - beklometazon dipropionat, budenozid, hidrokortizon, pednizolon Vpliv na imunski odziv - ciklosporin, merkaptopurin, metotreksat, adalimumab, infliksimab Stimulantni odvajala - bisakodil, dantron, dokusat, natrijev pikosulfat, Zdravila, ki vplivajo na biološko sestavo in pretok -ursodeoksiholna kislina Sekceptorji žolčnih kislin - kolestiramin, oksifenciklimin, Camylofin, Mebeverin, Trimebutin, Rociverin, Dicikloverin, Diheksiverin, Difemerin, piperidolatni benzilon, mepenzolat, Pipenzolat, glikopironij, oksifenonij, Pentienat, Metantelin, Propantelin, Otilonijev bromid, tridiheksetil, izopropamid, Heksociklium, Poldin, Bevonium, ## · · · ···· Difemanil, Tiemonijev jodid, Prifinium bromid, Timepidium bromid, Fenpiverinium Papaverin, Drotaverin, Moksaverin 5-HT3 Antagonisti (kot so Alosetron, Cilansetron), 5-HT4 agonisti (kot so Mosaprid, Prukaloprid, Tegaserod) Fenpipran, diizopromin, Klorbenzoksamin, Pinaverij, Fenoverin, Idanpramin, proksazol, alverin, trepibuton, Izometepten, karoverin, floroglucinol, silikoni, Trimetildifenilpropilamin Atropin, Hiosciamin Skopolamin (kot Butilskopolamin, Metilskopolamin), metilatropin, Fentonium, Cimetropium bromid predvsem antagonisti dopamina, kot sta metoklopramid/bromoprid, Kleboprid, Domperidon, in Alizaprid, 5-HT4 agonisti, kot so Cinitaprid in Cisaprid, Inhibitorji protonske črpalke Omeprazol, lansoprazol, pantoprazol, esomeprazol, rabeprazol natrij, opioidi in in opioidni receptorski antagonisti, kot so kodein, morfin, loperamid, difenoksilat, metilnaltreksonijev bromid Analgetik Acetaminofen Diklofenak Diflunisal Etodolak fenoprofen Flurbiprofen Ibuprofen Indometacin Ketoprofen Ketorolac Meklofenamat Mefenaminska kislina Meloksikam Nabumeton Naproksen oksaprozin fenilbutazon piroksikam ·· · ·· **·· ·· ·* Sulindak Tolmetin Celekoksib Buprenorfin Butorfanol kodein Hidrokodon Hidromorfon Levorfanol Meperidin metadon Morfinski nalbufin oksikodonski oksimorfon Pentazocin, Propoksifen Tramadol kodein Zdravila za spanje Hipnotiki - Nitrazepam, Flurazepam, Loprazolam, Lormetazepam, Temazepam, Zaleplon, Zolpidem, Zopiklon, Kloralni hidrat, trikolofos, klometiazol, Ouazepam, triazolam Estazolam Klonazepam, Alprazolam, Eszopiklon, Rozerem, Trazodon, Amitriptilin doksepin, benzodiazepin zdravila, melatonin, difenhidramin in zdravilna zelišča kot je Valerian Kardiovaskularna zdravila Srčni glikozidi - Digoksin, digitoksin, Inhibitorji fosfodiesteraze - enoksimon, milrinon Tiazidi in sorodni diuretiki - bendroflumetiazid, klortalidon, ciklopentiazid, inapamid, metolazon, ksipamid Diuretiki - furosemid, bumetanid, torasemid, Diuretiki, ki varčujejo s kalijem, in aldosteron antagonisti - amilorid hidroklorid, triamteren, vveplerenon, spironolakton, Osmotski diuretiki - manitol •· · ······ · · · · · Zdravila za aritmije - adenozin, amiodaron hidroklorid, dizopiramid, flekainid acetat, propafenon hidroklorid, lidokain hidroklorid, Beta adrenoreceptorski blokatorji - propanalol, atenolol, acebutolol, bisprolol fumarat, karvedilol, celiprolol, esmolol, lebatolol, metoprolol tartrat, nadolol, nebivolol, oksprenolol, pindolol, solatol, timolol, Hipertenzija - ambrisentan, bosentan, diazoksid, hidralazin, iloprost, minoksidil, sildenafil, sitaksentan, natrijev nitroprusid, klonidin, metildopa, moksonidin, gvanetidin monosulfat, doksazosin, indoramin, prazosin, terazosin, fenoksibenzamin, fentolamin mesilat, Zdravila, ki vplivajo na sistem renin-angiotenzin -Kaptropril, Cilazapril, Enalapril Maleat, Fosinopril, Imidapril, Lisinopril, Moeksipril, Perindopril Erbumin, Ouinapril, Ramipril, Trandolapril, Candesartan Cileksetil, Eprosartan, Irbesartan, Losartan, Olmesartan Medoksomil, Telmisartan, Valsartan, Aliskiren. Nitrati, blokatorji kalcijevih kanalčkov in antiangin zdravila - gliceril trinitrat, Izosorbid Dinitrat, Izosorbid mononitrat, amlodipin, Diltiazem, Felodipin, Isradipin, Lacidipin, Lerkanidipin, nikardipin, Nifedipin, Nimodipin, · « ·♦ ···· «t» » * Verapamil, Ivabradin, Nikorandil, Ranolazin, Periferni vazodilatatorji in sorodna zdravila -Ciiostazol, Inositol nikotinat, Moksisilit, Naftidrofuril Oksalat, Pentoksifilin, Simpatomimetiki - dopamin, dopeksamin, Ephedrine, metaraminol, noradrenalin kislina Tartrat, Norefidrin Bitartrat, Fenilfidrin, Antikoagulanti in protamin - heparin, bemiparin, Dalteparin, Enoksaparin, Tinzaparin, Danaparoid, Bivalirudin, Lepirudin, Epoprostenol, Fondaprinuks, VVarfarin, Acenokumarol, Fenindion, Dabigatran eteksilat, Rivaroksaban, Protamin sulfat, Antitrombocitna zdravila - Abciksimab, Aspirin, Klopidogrel, Dipiridamol, Eptifibatid, Prasugrel, Tirofiban, Fibrinolitična in antifibrinolitična zdravila - Alteplaza, Reteplaza, streptokinaza, tenekteplaza, urokinaza, Etamsilat, traneksamična kislina, Zdravila za uravnavanje lipidov - atorvastatin, fluvastatin, Pravastatin, Rosuvastatin, Simvastatin, Colesevam, Colestiramin, Colestipol, Ezetimib, Bezafibrat, Ciprofibrat, Fenofibrat, Gemfibrozil, Acipmoks, Nikotinska kislina, spojine omega tri maščobnih kislin, etanolamin »' · « * V w m — w — Oleat, natrijev tetradecil Sulfat. Zdravila CNS - Benperidol, klorpromazin, flupentiksol, Haloperidol, levomepromazin, periciazin, Perfenazin, pimozid, prokloroperazin, Promazin, Sulpirid, Trifluoperazin, Zuklopentiksol, amisulprid, aripiprazol, klozapin, Olanzapin, paliperidon, kvetiapin, Riperidon, sertindol, zotepin, flupentiksol, Flufenazin, olanzapin-embonat, pipotiazin Palmitat, Risperidon, Zuklopentiksol Dekanoat, karbamazepin, valproat, Valproična kislina, litijev karbonat, litijev citrat, amitriptilin, Klomipramin, Dosulepin, Imipramin, Lofepramin, Nortriptilin, Trimipramin, mianserin, trazodon, fenelzin, Izokarboksazid, tranilcipromin, moklobemid, Citalopram, Escitalopram, fluoksetin, fluvoksamin, paroksetin, Sertralin, Agomelatin, Duloksetin, Flupentiksol, Mirtazapin, Reboksetin, Tritofan, Venflaksin, Atomoksetin, Deksametamin, Metilfenidat, modafinil, eslikarbazepin, Okarbazepen, etosuksimid, gabapentin, Pregabalin, lakozamid, lamotrigin, levetiracetam, Fenobarbital, primidon, fenitoin, Rufinamid, Tiagabin, Topiramat, Vigabatrin, ·· · ·· ···· Zonisamid, ropinirol, Rotigotin, Co-Beneldopa, Levodopa, Co-Careldopa, Rasagilin, Selegilin, entakapon, tolkapon, amantidin, Orfenadrin, Prociklidin, Triheksifenidil, Haloperidol, Piracetam, Riluzol, Tetrabenazin, Acamprosat, Disulfiram, Bupropion, Varenicilin, buprenorfin, lofeksidin, Donepezil, Galantamin, Memantin, Rivastigimin. Anti-infektivni - Benzilpenicilin, fenoksimetilpenicilin, Flukloksacilin, Temocilin, Amoksicilin, Ampicilin, Co-Amoksiklav, Co-Fluampicil, Piperacilin, Ticarcillin, Pivmecillinam, Cefalosporini, Cefaklor, cefadroksil, cefaleksin, cefiksem, Cefotaksim, cefradin, ceftazidim, cefuroksim, Ertapenem, Imipenem, Meropenem, Aztreonam, Tetraciklin, Demeklociklin, Doksociklin, Limeciklin, Minociklin, Oksitetraciklin, Tigeciklin, Gentamicin, Amikacin, Neomicin, Tobramicin, Eritromicin, Azitromicin, Klaritromicin, telitromicin, klindamicin, Kloramfenikol, fusidinska kislina, vankomicin, Teikoplanin, Daptomicin, Linezolid, kinupristin, Colistin, ko-trimoksazol, sulpadiazin, trimetoprim Kapreomicin, cikloserin, etambutol, Izoniazid, pirazinamid, rifabutin, rifampicin, Streptomicin, Dapson, klofazimin, ·· · ...... Metronidazol, tinidazol, ciproflaksakin, levoflaksacin, Moksifloksacin, nalidiksična kislina, norflakin, Orflaksacin, nitrofurantoin, metanamin Hipurat, Amfotericin, Anidulafungin, Kaspofungin, flukonazol, flucitozin, griseofluvin, Itrakonzol, ketokonazol, mikafungin, Nistatin, Posakonazol, Terbinafin, Vorikonazol, Abakavir, Didanozin, Emtricitabin, Lamivudin, Stavudin, Tenofovir Dizoproksil, Zidovudin, Atazanavir, Darunavir, Fosamprenavir, Indinavir, Lopinair, Nelfinavir, Ritonavir, Sakinavir, Tipranavir, Efavirenz, Etravirin, Nevarapin, Enfuvirtid, Maravirok, Raltegravir, Aciklovir, Famciklovir, Inozin Pranobeks, Valaciklovir, Cidofovir, Gangciklovir, Foskarnet, Valgangciklovir, Adefovir Dipivoksil, entekavir, telbivudin, Amantadin, Oseltamivir, Zanamivir, Palivizumab, Ribavirin, Artemeter, klorokin, MeflokinPrimakin, Proguanil, Pirimetamin, Kinin, doksiciklin, dioksanid Furoat, Metronidazol, Tinidazol, Mepakrinnatrij Stiboglukonat, Atovakon, Pentamidin Izetionat, Mebendazol, Piperazin, Drugo: benztropiprociklidin biperiden, amantadin Bromokriptin Pergolid Entakapon Tolkapon Selegelin Pramipeksol, budesonid, .. · ..... formoterol, kvetiapin fumarat, olanzapin, pioglitazon, montelukast, zoledromska kislina, valsartan, latanoprost, irbesartan, klopidogrel, Atomoksetin, deksamfetamin, metilfenidat, Modafinil, Bleomicin, Daktinomicin, Daunorubicin, Idarubicin, mitomicin, mitoksantron, Azacitidin, Kapecitabin, Cladribin, Clofarabin, citarabin, fludarabin, flurouracil, Gemcitabin, merkaptopurin, metotreksat, Nelarabin, pemetreksed Raltitreksed, tiogvanin, Apomorfin, Betametazon, Kortizon, Deflazakort, deksametazon, hidrokortizon, Metilprednizolon, Prednizolon, Triamcinolon, Ciklosporin, sirolimus, takrolimus, interferon Alfa, Interferon Beta.
  3. 3. Stisnjena-prevlečena tableta po zahtevku 2 za uporabo pri metodi zdravljenja ene ali več izmed naslednje bolezni ali stanj: Bolezni centralnega živčnega sistema, npr. Neurogenske bolečine, kapi, demence, Alzheimerjeve bolezni, Parkinsonove bolezni, nevronske degeneracije, meningitisa, poškodbe hrbtenjače, cerebralnega vazospazema, amiotrofične lateralne skleroze Kardiovaskularne bolezni, hipertenzije, ateroskleroze, angine, arterijske obstrukcije, periferne «« · arterijske bolezni, miokardne patologije, aritmije, Akutnega miokardnega infarkta, angine, Kardiomiopatije, kongestivnega srčnega popuščanja, koronarne arterijske bolezni (CAD), bolezni karotidne arterije, Endokarditisa, hiperholesterolemije, hiperlipidemije, Periferne arterijske bolezni (PAD) Genitourinarnih motenj; erektilne disfunkcije, Bolezni urinarnih organov benigne hipertrofije prostate (BPH), renalne tubularne acidoze, diabetične nefropatije, glomerulonefritisa, glomeruloskleroze, okužba sečil, fekalna inkontinenca očesne bolezni Glavkoma, blefartitisa, očesne hipertenzije, retinopatije, konjunktivitisa, skleritisa, retinitisa, keratitisa, razjede roženice, iritisa, korioretinalega vnetja, makularnega edema, kserofalmije pljučne bolezni astme, pljučne hipertenzije, akutnega respiratornega distresnega sindroma, KOPB, emfizma, pljučnice, tuberkuloze, bronhitisa, akutnega bronhitisa, bronhiektazije, Bronhiolitisa, bronhopulmonalne displazije, Bisinoze, kokcidioidomikoze (Cocci), cistične Fibroze, gripe, raka pljuč, mezotelioma Bolezni presnove; Hiperkalciurije, hiperglikemije, Hiperinsulinemične hipoglikemije, hiperinzulinizma, Hiperlizinurije, hipoglikemije Eksokrine in Endokrine; Addisonove bolezni, hipoalosteronizma, • · kušingovega sindroma, diabetesa, Goitre, hipertiroidizma, hipotiroidizma, Tiroiditisa, pankreatitisa Jetrnih motenj, hepatitisa, nealkoholne maščobne bolezni jeter, ciroze, raka jeter, primarnega skierozirajočega holangitisa, primarne ciroze žolča, Budd-Chiarijevega sindroma, Avtoimunske in vnetne bolezni, multiple skleroze revmatoidnega artritisa, psoriaze, diabetesa, sarkoidoze, Addisonove bolezni, Alopecia areata, Amiotrofične lateralne skleroze, Ankilozirajočega spondilitisa, poliartikularnega artritisa, Atopične alergije, topičnega dermatitisa, avtoimunskega hepatitisa, celiaklije, bolezni Chagas, celiaklije, Cogan sindroma, kronove bolezni, Cushingovega sindroma, diabetesa mellitusa tipa 1, endometrioze, eozinofilnega fasciitisa, fibromialgije/ fibromiozitisa, Gastritisa, glomerulonefritisa, Gravesove bolezeni. Guillain-Barrejevega sindroma (GBS), Hashimotovega encefalitisa, Hashimotovega tiroiditisa, hemolitične anemije, idiopatske bolezni Vnetne demielinizirajoče bolezni, Idiopatske pljučne fibroze, intersticijskega cistitisa, Juvenilnega idiopatskega artritisa, Juvenilnega revmatoidnega artritisa, Kavvasakijeve bolezni, Lichen sclerosus, Lupus eritematozus, Menierjeve bolezni, ·« · ---- Miastenija gravis, miozitisa, narkolepsije, Pernicious anemije, Perivenskega encefalomielitisa, Polymyalgia rheumatica, Primarne biliarne ciroze, psoriatičnega artritisa, Reiterjevega sindroma, Revmatoidne vročice, sarkoidoze, shizofrenije, SjOgrenovega sindroma, spondiloartropatije, ulcerativnega Kolitisa Bolezni mišično-skeletnega sistema: osteoartritisa, osteoporoze, Osteonekroze, artritisa, Pagetove bolezni Bursitisa, kostohondritisa, Tendonitisa Motnje kože; Akne, alopecija, kandidiaze, celuliltisa, dermatitisa, ekcema, bulosa epidermolize, eritrasma, herpesa, erizipel, folikulitisa, impetigo, ringvvorm, scabies, Tinea, trihomikoze Motnje ENT; Otitis, sinusitis, laringitis, faringitis, menerejeva bolezen, labirintitis, Drugo: akutne in kronične bolečine, virusne okužbe, raka, mastoiditisa, mrzlice, Otitis media, rinitisa, sinusitisa, sialadenitisa, retrofaringealnega Abcesa, Tonsilofargitisa, gastrointestinalne motnje Sindrom razdražljivega črevesja, nekrotizirajočega enterolititisa, Ne-ulkusna dispepsija, kronične črevesne pseudo-obstrukcije, funkcionalne dispepsije, kolonskega pseudo-obstruiodioduodenogastričnega refluksa, gastroezofagealne refluksne bolezni, vnetje ileusa, * 4 9 gastropareze, zgage, zaprtja - (npr. zaprtje, povezano z uporabo zdravil kot so opioidi), kolorektalnega raka, polipov kolona, divertikulitisa, kolorektalnega raka, Barretts Ezofagus, krvavitve v prebavnem traktu celiaklije, polipov kolona, Zaprtja, kronove bolezni, sindroma cikličnega bruhanja, Odloženega želodčnega praznjenja (gastropareza), Diareje, divertikuloze, razjed dvanajstnika, Fekalne inkontinence, žolčnih kamnov, plina v prebavnem traktu, gastritisa, bolezni gastroezofagealnega refluksa, zgage, Hiatalne hernije, hemoromatoze, Hemorhoidov, Hiatalne Hernije, Hirschsprungsove Bolezni, prebavnih motenj, dimeljske kile, Laktozne intolerance, peptičnih ulkusov, polipov, Porfirije, primarne biliarne ciroze, primarnega sklerozirajočega holangitisa, proktitisa, hitrega praznjenja želodca, sindrom kratkega črevesa, razjed na želodcu, Ulceroznega kolitisa, ulkusov, Whipplove bolezni.
  4. 4. Stisnjena-prevlečena tableta po zahtevku 1, kjer je aktivno sredstvo je namenjeno za zdravljenje vzdrževanja spanja nespečnosti je po izbiri pomirjevalo ali hipnotik, kot so zolpidem, zaleplon ali zopiklon.
  5. 5. Tableta po katerem koli od predhodnih zahtevkov, kjer je vosek čebelji vosek, karnuba vosek, mikrokristaliničen vosek, hidrogenirano ricinusovo olje ali glicerilni ester.
  6. 6. Tableta po zahtevku 5, kjer je glicerilni ester glicerol behenat.
  7. 7. Tableta po katerem koli od predhodnih zahtevkov, kjer sta vosek in L-HPC prisotna v razmerju 45:55 do 55:45 m/m.
  8. 8. Tableta po katerem koli od predhodnih zahtevkov, ki nadalje obsega dodatno prevleko, pri čemer je prevleka odvisna od pH, neodvisna od pH, estetska ali funkcionalna.
  9. 9. Stisnjena prevlečena tableta po katerem koli od predhodnih zahtevkov kjer je aktivno sredstvo sedativno ali hipnotično sredstvo.
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