WO2011018246A3 - Controlled release paliperidone composition - Google Patents
Controlled release paliperidone composition Download PDFInfo
- Publication number
- WO2011018246A3 WO2011018246A3 PCT/EP2010/005211 EP2010005211W WO2011018246A3 WO 2011018246 A3 WO2011018246 A3 WO 2011018246A3 EP 2010005211 W EP2010005211 W EP 2010005211W WO 2011018246 A3 WO2011018246 A3 WO 2011018246A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- controlled release
- paliperidone
- independently
- pharmaceutically acceptable
- acceptable salt
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
Abstract
The present invention relates to A controlled-release pharmaceutical tablet, comprising: (a) an inner hydrogel tablet core comprising paliperidone or a pharmaceutically acceptable salt thereof and a pH-independently gelling polymer; and (b) an outer hydrogel layer surrounding said inner tablet core comprising a pH-independently gelling polymer; wherein said outer layer does not contain paliperidone or a pharmaceutically acceptable salt thereof, to a method of making such tablets and for use in medicine.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23355109P | 2009-08-13 | 2009-08-13 | |
US61/233,551 | 2009-08-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011018246A2 WO2011018246A2 (en) | 2011-02-17 |
WO2011018246A3 true WO2011018246A3 (en) | 2011-04-21 |
Family
ID=43569173
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2010/005211 WO2011018246A2 (en) | 2009-08-13 | 2010-08-11 | Controlled release paliperidone composition |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2011018246A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9271939B2 (en) | 2010-03-15 | 2016-03-01 | Inventia Healthcare Private Limited | Stabilized prolonged release pharmaceutical composition comprising atypical antipsychotic |
CN110251475B (en) * | 2019-07-25 | 2021-07-16 | 沈阳信康药物研究有限公司 | Paliperidone tablet and preparation method thereof |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5158952A (en) * | 1988-11-07 | 1992-10-27 | Janssen Pharmaceutica N.V. | 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use |
WO2004010981A1 (en) * | 2002-07-29 | 2004-02-05 | Alza Corporation | Methods and dosage forms for controlled delivery of paliperidone |
WO2009025859A1 (en) * | 2007-08-21 | 2009-02-26 | Teva Pharmaceutical Industries Ltd. | Paliperidone sustained release formulation |
WO2009109993A1 (en) * | 2008-02-04 | 2009-09-11 | Torrent Pharmaceuticals Ltd. | Extended release dosage form of paliperidone |
WO2010009900A1 (en) * | 2008-07-25 | 2010-01-28 | Krka, D.D. Novo Mesto | Paliperidone composition comprising solid matrix particles |
WO2010044097A2 (en) * | 2008-09-15 | 2010-04-22 | Intas Pharmaceuticals Limited | Novel dosage form of paliperidone and process for preparing the same |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2000786C (en) | 1988-11-07 | 1999-01-26 | Cornelus G. M. Janssen | 3-piperidinyl-1,2-benzisoxazoles |
MX2007001563A (en) | 2004-08-04 | 2008-03-05 | Johnson & Johnson | Sustained drug release composition demonstrating an ascending zero order release pattern, methods of manufacturing such a composition. |
WO2006085856A1 (en) | 2005-02-04 | 2006-08-17 | Alza Corporation | Methods and dosage forms for reducing side effects of benzisozazole derivatives |
US20070190137A1 (en) | 2005-10-07 | 2007-08-16 | Reyes Iran | Osmotic dosage form with controlled release and fast release aspects |
US20070166381A1 (en) | 2006-01-06 | 2007-07-19 | Iran Reyes | Osmotic dosage form with controlled release and fast release aspects |
JP2009524685A (en) | 2006-08-14 | 2009-07-02 | テバ ファーマシューティカル インダストリーズ リミティド | Crystal form of 9-hydroxy-risperidone (paliperidone) |
-
2010
- 2010-08-11 WO PCT/EP2010/005211 patent/WO2011018246A2/en active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5158952A (en) * | 1988-11-07 | 1992-10-27 | Janssen Pharmaceutica N.V. | 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use |
WO2004010981A1 (en) * | 2002-07-29 | 2004-02-05 | Alza Corporation | Methods and dosage forms for controlled delivery of paliperidone |
WO2009025859A1 (en) * | 2007-08-21 | 2009-02-26 | Teva Pharmaceutical Industries Ltd. | Paliperidone sustained release formulation |
WO2009109993A1 (en) * | 2008-02-04 | 2009-09-11 | Torrent Pharmaceuticals Ltd. | Extended release dosage form of paliperidone |
WO2010009900A1 (en) * | 2008-07-25 | 2010-01-28 | Krka, D.D. Novo Mesto | Paliperidone composition comprising solid matrix particles |
WO2010044097A2 (en) * | 2008-09-15 | 2010-04-22 | Intas Pharmaceuticals Limited | Novel dosage form of paliperidone and process for preparing the same |
Also Published As
Publication number | Publication date |
---|---|
WO2011018246A2 (en) | 2011-02-17 |
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