SI2411408T2 - Topna protitelesa "samo s težko verigo" - Google Patents
Topna protitelesa "samo s težko verigo"Info
- Publication number
- SI2411408T2 SI2411408T2 SI201031110T SI201031110T SI2411408T2 SI 2411408 T2 SI2411408 T2 SI 2411408T2 SI 201031110 T SI201031110 T SI 201031110T SI 201031110 T SI201031110 T SI 201031110T SI 2411408 T2 SI2411408 T2 SI 2411408T2
- Authority
- SI
- Slovenia
- Prior art keywords
- antibodies
- soluble
- heavy
- chain
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1018—Orthomyxoviridae, e.g. influenza virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0905023.8A GB0905023D0 (en) | 2009-03-24 | 2009-03-24 | Binding molecules |
PCT/GB2010/000500 WO2010109165A2 (en) | 2009-03-24 | 2010-03-19 | Binding molecules |
EP10711069.4A EP2411408B2 (en) | 2009-03-24 | 2010-03-19 | Soluble "heavy-chain only" antibodies |
Publications (2)
Publication Number | Publication Date |
---|---|
SI2411408T1 SI2411408T1 (sl) | 2016-03-31 |
SI2411408T2 true SI2411408T2 (sl) | 2023-06-30 |
Family
ID=40640054
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201031110T SI2411408T2 (sl) | 2009-03-24 | 2010-03-19 | Topna protitelesa "samo s težko verigo" |
Country Status (24)
Country | Link |
---|---|
US (2) | US8883150B2 (sl) |
EP (1) | EP2411408B2 (sl) |
JP (1) | JP5836927B2 (sl) |
KR (1) | KR20120068757A (sl) |
CN (1) | CN102482342B (sl) |
BR (1) | BRPI1012694A2 (sl) |
CA (1) | CA2756171C (sl) |
CY (1) | CY1117203T1 (sl) |
DK (1) | DK2411408T4 (sl) |
ES (1) | ES2563321T5 (sl) |
FI (1) | FI2411408T4 (sl) |
GB (1) | GB0905023D0 (sl) |
HR (1) | HRP20160158T4 (sl) |
HU (1) | HUE026473T2 (sl) |
MX (1) | MX2011010027A (sl) |
PL (1) | PL2411408T5 (sl) |
PT (1) | PT2411408E (sl) |
RU (1) | RU2528737C2 (sl) |
SG (1) | SG174510A1 (sl) |
SI (1) | SI2411408T2 (sl) |
SM (1) | SMT201600044B (sl) |
TW (1) | TW201040264A (sl) |
WO (1) | WO2010109165A2 (sl) |
ZA (1) | ZA201106983B (sl) |
Families Citing this family (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2311874B1 (en) | 2004-07-22 | 2017-05-31 | Erasmus University Medical Center Rotterdam | Binding molecules |
AU2007219159B8 (en) * | 2006-01-25 | 2012-06-28 | Roger Kingdon Craig | Generation of heavy-chain only antibodies in transgenic animals |
KR101826224B1 (ko) | 2008-09-30 | 2018-02-06 | 아블렉시스, 엘엘씨 | 키메라 항체의 제조를 위한 인간 이외의 포유동물 |
CA2747534C (en) | 2008-12-18 | 2020-08-18 | Erasmus University Medical Center Rotterdam | Non-human transgenic animals expressing humanised antibodies and use therof |
DK2564695T3 (en) | 2009-07-08 | 2015-05-26 | Kymab Ltd | Animal models and therapeutic molecules |
US20120204278A1 (en) | 2009-07-08 | 2012-08-09 | Kymab Limited | Animal models and therapeutic molecules |
US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
MY172472A (en) | 2009-12-10 | 2019-11-26 | Regeneron Pharma | Mice that make heavy chain antibodies |
EP3248462B1 (en) | 2010-03-31 | 2024-03-13 | Ablexis, LLC | Genetic engineering of mice for the production of chimeric antibodies |
SG10201912639SA (en) | 2010-08-02 | 2020-02-27 | Regeneron Pharma | Mice that make binding proteins comprising vl domains |
WO2012104227A1 (en) * | 2011-02-02 | 2012-08-09 | Glaxo Group Limited | Novel antigen binding proteins |
ME02106B (me) | 2011-02-25 | 2015-10-20 | Regeneron Pharma | Miševi sa adam6 |
IL273982B2 (en) | 2011-08-05 | 2023-03-01 | Regeneron Pharma | Humanized mice possess a universal light chain |
WO2013041845A2 (en) | 2011-09-19 | 2013-03-28 | Kymab Limited | Animals, repertoires & methods |
CN107056936B (zh) | 2011-09-19 | 2021-09-03 | 科马布有限公司 | 免疫球蛋白基因多样性的操纵及多抗体治疗剂 |
WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
PT3216871T (pt) | 2011-10-17 | 2022-03-15 | Regeneron Pharma | Ratos com cadeia pesada de imunoglobulina restrita |
GB2496375A (en) | 2011-10-28 | 2013-05-15 | Kymab Ltd | A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof |
GB201122047D0 (en) | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
SG10201913164YA (en) | 2011-12-20 | 2020-03-30 | Regeneron Pharma | Humanized light chain mice |
GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
WO2013144567A1 (en) | 2012-03-28 | 2013-10-03 | Kymab Limited | Transgenic non-human vertebrate for the expression of class - switched, fully human, antibodies |
CA2876172C (en) * | 2012-06-12 | 2021-01-19 | Regeneron Pharmaceuticals, Inc. | Humanized non-human animals with restricted immunoglobulin heavy chain loci |
JP5993102B2 (ja) | 2013-02-20 | 2016-09-14 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | 修飾された免疫グロブリン重鎖配列を有する非ヒト動物 |
EP2967012B1 (en) | 2013-03-14 | 2020-09-16 | Erasmus University Medical Center Rotterdam | Transgenic non-human mammal for antibody production |
US10993420B2 (en) | 2013-03-15 | 2021-05-04 | Erasmus University Medical Center | Production of heavy chain only antibodies in transgenic mammals |
US10119134B2 (en) | 2013-03-15 | 2018-11-06 | Abvitro Llc | Single cell bar-coding for antibody discovery |
US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
GB201316644D0 (en) | 2013-09-19 | 2013-11-06 | Kymab Ltd | Expression vector production & High-Throughput cell screening |
EP3051942B1 (en) | 2013-10-01 | 2020-09-02 | Kymab Limited | Animal models and therapeutic molecules |
JP2017512831A (ja) * | 2014-03-20 | 2017-05-25 | 大塚製薬株式会社 | 置換フェニル−(1,3−ジヒドロ−イソインドール−2−イル)−メタノンを含んでなる医薬処方物 |
JP2017510273A (ja) | 2014-03-21 | 2017-04-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | 異なる結合特性を示すvl抗原結合タンパク質 |
RU2016141307A (ru) | 2014-03-21 | 2018-04-24 | Регенерон Фармасьютикалз, Инк. | Отличные от человека животные, которые вырабатывают однодоменные связывающие белки |
ES2727656T3 (es) | 2014-09-15 | 2019-10-17 | Abvitro Llc | Secuenciación de alto rendimiento de banco de nucleótidos |
EP3209699A1 (en) * | 2014-10-22 | 2017-08-30 | Crescendo Biologics Limited | Vh scaffold |
EP3209776A1 (en) * | 2014-10-22 | 2017-08-30 | Crescendo Biologics Limited | Human vh domain scaffolds |
CN104710528B (zh) * | 2015-03-13 | 2019-02-15 | 西北农林科技大学 | 一种特异性结合PRRS病毒非结构蛋白Nsp9纳米抗体及其应用 |
AU2016232715A1 (en) | 2015-03-19 | 2017-09-28 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
WO2016150845A1 (en) * | 2015-03-20 | 2016-09-29 | Ablynx Nv | Glycosylated immunoglobulin single variable domains |
US20180094243A1 (en) * | 2015-04-03 | 2018-04-05 | Dana-Farber Cancer Institute, Inc. | Composition and methods of genome editing of b-cells |
WO2017020001A2 (en) | 2015-07-29 | 2017-02-02 | Allergan, Inc. | Heavy chain only antibodies to ang-2 |
CA2992788A1 (en) | 2015-08-14 | 2017-02-23 | Allergan, Inc. | Heavy chain only antibodies to pdgf |
WO2017058944A1 (en) | 2015-09-29 | 2017-04-06 | Amgen Inc. | Asgr inhibitors |
CN105777894A (zh) * | 2016-03-12 | 2016-07-20 | 长春力太生物技术有限公司 | 通过转基因啮齿类动物制备人源化驼类单域抗体的方法 |
EP3440194A1 (en) | 2016-04-04 | 2019-02-13 | ETH Zurich | Mammalian cell line for protein production and library generation |
CA3029209A1 (en) | 2016-06-21 | 2017-12-28 | Teneobio, Inc. | Cd3 binding antibodies |
EP3503722A1 (en) | 2016-08-24 | 2019-07-03 | Teneobio, Inc. | Transgenic non-human animals producing modified heavy chain-only antibodies |
IL265321B2 (en) | 2016-09-14 | 2024-01-01 | Teneobio Inc | CD3 binding antibodies |
US10968281B2 (en) * | 2016-10-14 | 2021-04-06 | Institut Curie | Anti-LSP1 antibody |
CN109906030B (zh) * | 2016-11-04 | 2022-03-18 | 安健基因公司 | 用于产生仅重链抗体的经基因修饰的非人动物和方法 |
JP7254699B2 (ja) * | 2016-12-21 | 2023-04-10 | テネオバイオ, インコーポレイテッド | 抗bcma重鎖のみ抗体 |
US11267904B2 (en) * | 2016-12-28 | 2022-03-08 | Sysmex Corporation | Method for controlling affinity of antibody for antigen, antibody whose affinity for antigen has been altered, and its production method |
KR20190104400A (ko) * | 2017-01-19 | 2019-09-09 | 오픈 모노클로날 테크놀로지, 인코포레이티드 | 다중 중쇄 면역글로불린 유전자좌를 갖는 트랜스제닉 설치류 기원의 인간 항체 |
CN117567624A (zh) * | 2017-06-20 | 2024-02-20 | 特纳奥尼股份有限公司 | 仅有重链的抗bcma抗体 |
SG11201912774RA (en) * | 2017-06-20 | 2020-01-30 | Teneobio Inc | Anti-bcma heavy chain-only antibodies |
MX2020002802A (es) | 2017-09-13 | 2020-10-12 | Teneobio Inc | Anticuerpos de cadena pesada que se unen a ectoenzimas. |
PL3710484T3 (pl) * | 2017-12-20 | 2024-03-25 | Harbour Biomed (Shanghai) Co., Ltd | Przeciwciała wiążące ctla-4 i ich zastosowania |
EA202091557A1 (ru) | 2017-12-22 | 2020-11-18 | Тенеобио, Инк. | Антитела, содержащие только тяжелые цепи, которые связываются с cd22 |
US11905327B2 (en) | 2017-12-28 | 2024-02-20 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against TIGIT |
AU2019237926A1 (en) * | 2018-03-21 | 2020-09-24 | Crystal Bioscience Inc. | Transgenic chicken that produces human antibodies |
SG11202006674QA (en) | 2018-03-30 | 2020-08-28 | Nanjing Legend Biotech Co Ltd | Single-domain antibodies against lag-3 and uses thereof |
WO2019241002A1 (en) * | 2018-06-13 | 2019-12-19 | Crystal Bioscience Inc. | Transgenic chicken that makes antibodies with long cdr-h3s stabilized by multiple disulfide bridges and diversified by gene conversion |
KR20210021024A (ko) * | 2018-06-13 | 2021-02-24 | 크리스탈 바이오사이언스 주식회사 | 유전자 변환에 의한 자율 중쇄 가변 도메인의 수정에 의한 항체 생산 |
AU2019305663A1 (en) | 2018-07-20 | 2021-03-11 | TeneoTwo, Inc | Heavy chain antibodies binding to cd19 |
GB2576914A (en) | 2018-09-06 | 2020-03-11 | Kymab Ltd | Antigen-binding molecules comprising unpaired variable domains produced in mammals |
KR20210086651A (ko) | 2018-10-26 | 2021-07-08 | 테네오바이오, 인코포레이티드 | Cd38에 결합하는 중쇄 항체 |
CN113874394B (zh) | 2019-02-20 | 2024-01-19 | 和铂抗体有限公司 | 抗体 |
SG11202111027WA (en) | 2019-04-05 | 2021-11-29 | Teneobio Inc | Heavy chain antibodies binding to psma |
MX2021015045A (es) | 2019-06-07 | 2022-03-17 | Amgen Inc | Construcciones de unión biespecíficas. |
EP3983438A1 (en) | 2019-06-14 | 2022-04-20 | TeneoBio, Inc. | Multispecific heavy chain antibodies binding to cd22 and cd3 |
CA3158579A1 (en) | 2019-12-18 | 2021-06-24 | Pranjali DALVI | Heavy chain antibodies binding to cd38 |
GB202003632D0 (en) | 2020-03-12 | 2020-04-29 | Harbour Antibodies Bv | SARS-Cov-2 (SARS2, COVID-19) antibodies |
CA3214992A1 (en) | 2020-04-29 | 2021-11-04 | Teneobio, Inc. | Multispecific heavy chain antibodies with modified heavy chain constant regions |
CN115894703A (zh) | 2020-04-29 | 2023-04-04 | 特尼奥生物股份有限公司 | 具有经修饰重链恒定区的多特异性重链抗体 |
CA3184351A1 (en) | 2020-06-04 | 2021-12-09 | Amgen Inc. | Bispecific binding constructs |
TWI806088B (zh) | 2020-06-30 | 2023-06-21 | 大陸商和鉑醫藥(上海)有限責任公司 | 具有H2L2與HCAb結構的結合蛋白 |
JP2023530766A (ja) | 2020-06-30 | 2023-07-19 | ハーバー・バイオメド・ユーエス・インコーポレイテッド | 二重特異性抗体及びその用途 |
US20230257473A1 (en) | 2020-06-30 | 2023-08-17 | Teneobio, Inc. | Multi-specific antibodies binding to bcma |
CA3187680A1 (en) | 2020-09-11 | 2022-03-17 | Yashu Liu | Identification and production of antigen-specific antibodies |
GB202017555D0 (en) | 2020-11-06 | 2020-12-23 | Harbour Antibodies Bv | Antibody-conjugated nanoparticles |
TW202233684A (zh) | 2020-11-18 | 2022-09-01 | 美商泰尼歐生物公司 | 結合於葉酸受體α之重鏈抗體 |
CA3203468A1 (en) | 2020-12-03 | 2022-06-09 | Amgen Inc. | Immunoglobuline constructs with multiple binding domains |
US20240050583A1 (en) | 2020-12-08 | 2024-02-15 | Harbour Biomed (Shanghai) Co., Ltd | Protein-drug conjugate and site-specific conjugating method |
EP4258865A1 (en) * | 2020-12-09 | 2023-10-18 | Trianni, Inc. | Heavy chain-only antibodies |
CN116848254A (zh) | 2020-12-16 | 2023-10-03 | 瑞泽恩制药公司 | 表达人源化Fcα受体的小鼠 |
CN117500835A (zh) | 2021-02-25 | 2024-02-02 | 特尼奥生物股份有限公司 | 抗psma抗体及car-t结构 |
KR20230150825A (ko) | 2021-02-26 | 2023-10-31 | 테네오바이오, 인코포레이티드 | 항-muc1-c 항체 및 car-t 구조 |
TW202304994A (zh) | 2021-04-02 | 2023-02-01 | 美商泰尼歐生物公司 | 促效性抗il-2r抗體及使用方法 |
BR112023020450A2 (pt) | 2021-04-06 | 2024-01-23 | Teneobio Inc | Anticorpos anti-cd19 e estruturas car-t |
EP4323403A1 (en) | 2021-04-16 | 2024-02-21 | Teneobio, Inc. | Anti-cd20 antibodies and car-t structures |
WO2022271987A1 (en) | 2021-06-23 | 2022-12-29 | TeneoFour, Inc. | Anti-cd38 antibodies and epitopes of same |
WO2023004197A1 (en) | 2021-07-23 | 2023-01-26 | Teneoten, Inc. | Heavy chain antibodies binding to hepatitis b surface antigen |
GB202112935D0 (en) | 2021-09-10 | 2021-10-27 | Harbour Antibodies Bv | Sars-cov-2 (sars2, covid-19) heavy chain only antibodies |
WO2023036982A1 (en) | 2021-09-10 | 2023-03-16 | Harbour Antibodies Bv | Anti-sars2-s antibodies |
WO2023246578A1 (zh) * | 2022-06-24 | 2023-12-28 | 成都科伦精准生物科技有限公司 | 特异性结合gpc3的嵌合抗原受体及其应用 |
WO2024077044A1 (en) | 2022-10-05 | 2024-04-11 | Amgen Inc. | Combination therapies comprising t-cell redirecting therapies and agonistic anti-il-2r antibodies or fragments thereof |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3333941A1 (de) | 1983-09-20 | 1985-04-04 | Karl Kässbohrer Fahrzeugwerke GmbH, 7900 Ulm | Fraese |
KR0184860B1 (ko) | 1988-11-11 | 1999-04-01 | 메디칼 리써어치 카운실 | 단일영역 리간드와 이를 포함하는 수용체 및 이들의 제조방법과 이용(법) |
US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
US6150584A (en) * | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5843440A (en) | 1990-10-03 | 1998-12-01 | Redcell Canada, Inc. | Cellular and serum protein anchors for modulating pharmacokinetics |
ATE452975T1 (de) | 1992-08-21 | 2010-01-15 | Univ Bruxelles | Immunoglobuline ohne leichte ketten |
ATE461282T1 (de) | 1997-10-27 | 2010-04-15 | Bac Ip Bv | Multivalente antigenbindende proteine |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US20030022240A1 (en) * | 2001-04-17 | 2003-01-30 | Peizhi Luo | Generation and affinity maturation of antibody library in silico |
GB0110029D0 (en) | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
CN100497389C (zh) | 2001-06-13 | 2009-06-10 | 根马布股份公司 | 表皮生长因子受体(egfr)的人单克隆抗体 |
GB0115256D0 (en) | 2001-06-21 | 2001-08-15 | Babraham Inst | Mouse light chain locus |
JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
GB0228210D0 (en) | 2002-12-03 | 2003-01-08 | Babraham Inst | Single chain antibodies |
EP1597280B2 (en) * | 2003-02-26 | 2016-08-24 | Institute for Research in Biomedicine | Monoclonal antibody production by ebv transformation of b cells |
US7785903B2 (en) | 2004-04-09 | 2010-08-31 | Genentech, Inc. | Variable domain library and uses |
EP2311874B1 (en) * | 2004-07-22 | 2017-05-31 | Erasmus University Medical Center Rotterdam | Binding molecules |
AU2005325801A1 (en) * | 2005-01-31 | 2006-08-03 | Ablynx N.V. | Method for generating variable domain sequences of heavy chain antibodies |
RU2433139C2 (ru) * | 2005-05-20 | 2011-11-10 | Аблинкс Н.В. | Nanobodies tm для лечения заболеваний, опосредованных агрегацией |
DE202005011297U1 (de) | 2005-07-18 | 2005-11-03 | Trw Automotive Electronics & Components Gmbh & Co. Kg | Fahrzeug-Haltegriff |
AU2007219159B8 (en) | 2006-01-25 | 2012-06-28 | Roger Kingdon Craig | Generation of heavy-chain only antibodies in transgenic animals |
GB0618345D0 (en) | 2006-09-18 | 2006-10-25 | Univ Erasmus | Binding molecules |
EP2016101A2 (en) | 2006-05-09 | 2009-01-21 | Genentech, Inc. | Binding polypeptides with optimized scaffolds |
ATE537190T1 (de) | 2006-06-02 | 2011-12-15 | Regeneron Pharma | Hochaffine antikörper gegen den humanen il-6- rezeptor |
US7731969B1 (en) * | 2006-12-06 | 2010-06-08 | Neoclone Biotechnology International, Llc | Methods for developing and producing antigen-specific antibody-producing cells |
DK2336329T3 (da) | 2007-06-01 | 2013-01-07 | Omt Inc | Sammensætninger og fremgangsmåder til hæmning af endogene immunglobulingener og til produktion af transgene, humane, idiotypiske antistoffer |
WO2009013620A2 (en) | 2007-06-11 | 2009-01-29 | Erasmus University Medical Center Rotterdam | Homologous recombination |
AU2008295248A1 (en) | 2007-09-07 | 2009-03-12 | Symphogen A/S | Methods for recombinant manufacturing of anti-RSV antibodies |
MY172472A (en) | 2009-12-10 | 2019-11-26 | Regeneron Pharma | Mice that make heavy chain antibodies |
ME02106B (me) | 2011-02-25 | 2015-10-20 | Regeneron Pharma | Miševi sa adam6 |
WO2012122512A1 (en) | 2011-03-10 | 2012-09-13 | Hco Antibody, Inc. | Recombinant production of mixtures of single chain antibodies |
JP6282000B6 (ja) | 2015-06-22 | 2018-06-27 | 株式会社日立国際電気 | 電力増幅装置 |
-
2009
- 2009-03-24 GB GBGB0905023.8A patent/GB0905023D0/en not_active Ceased
-
2010
- 2010-03-19 KR KR1020117025003A patent/KR20120068757A/ko not_active Application Discontinuation
- 2010-03-19 RU RU2011142759/10A patent/RU2528737C2/ru active
- 2010-03-19 HU HUE10711069A patent/HUE026473T2/en unknown
- 2010-03-19 SI SI201031110T patent/SI2411408T2/sl unknown
- 2010-03-19 HR HRP20160158TT patent/HRP20160158T4/hr unknown
- 2010-03-19 WO PCT/GB2010/000500 patent/WO2010109165A2/en active Application Filing
- 2010-03-19 US US13/259,472 patent/US8883150B2/en active Active
- 2010-03-19 CN CN201080023562.8A patent/CN102482342B/zh active Active
- 2010-03-19 CA CA2756171A patent/CA2756171C/en active Active
- 2010-03-19 PT PT107110694T patent/PT2411408E/pt unknown
- 2010-03-19 DK DK10711069.4T patent/DK2411408T4/da active
- 2010-03-19 FI FIEP10711069.4T patent/FI2411408T4/fi active
- 2010-03-19 PL PL10711069.4T patent/PL2411408T5/pl unknown
- 2010-03-19 ES ES10711069T patent/ES2563321T5/es active Active
- 2010-03-19 JP JP2012501368A patent/JP5836927B2/ja active Active
- 2010-03-19 EP EP10711069.4A patent/EP2411408B2/en active Active
- 2010-03-22 MX MX2011010027A patent/MX2011010027A/es not_active Application Discontinuation
- 2010-03-22 SG SG2011068418A patent/SG174510A1/en unknown
- 2010-03-22 BR BRPI1012694A patent/BRPI1012694A2/pt not_active IP Right Cessation
- 2010-03-24 TW TW099108753A patent/TW201040264A/zh unknown
-
2011
- 2011-04-23 ZA ZA2011/06983A patent/ZA201106983B/en unknown
-
2013
- 2013-03-15 US US13/815,812 patent/US9365655B2/en active Active
-
2016
- 2016-02-12 SM SM201600044T patent/SMT201600044B/it unknown
- 2016-02-17 CY CY20161100136T patent/CY1117203T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA201106983B (en) | Soluble "heavy-chain only" antibodies | |
IL214996A0 (en) | Anti-bcma antibodies | |
IL218724A0 (en) | Endoglin antibodies | |
GB0920127D0 (en) | Antibodies | |
GB0909906D0 (en) | Antibodies | |
GB0708002D0 (en) | Antibodies | |
PT3023438T (pt) | Anticorpos anti-gitr | |
ZA201107486B (en) | Anti-tnf-x antibodies and their uses | |
EP2494062A4 (en) | ANTI-GLP-1R ANTIBODIES AND THEIR USES | |
ZA201104545B (en) | Anti-siglec-15 antibody | |
EP2427496A4 (en) | ANTI-VEGF-D ANTIBODIES | |
GB0821100D0 (en) | Antibodies | |
EP2337798A4 (en) | BSA-SPECIFIC ANTIBODIES | |
GB0718737D0 (en) | Antibodies | |
ZA201006099B (en) | Anti-tyrp1 antibodies | |
GB0920324D0 (en) | Antibodies | |
HK1170745A1 (en) | Antibodies against il-17br il-17br | |
ZA201007976B (en) | Anti-pirb antibodies | |
EP2400984A4 (en) | HER2 ANTIBODY COMPOSITIONS | |
GB0818356D0 (en) | Antibodies | |
GB2473934B (en) | Anti-VEEV antibody | |
EP2499256A4 (en) | ANTI-C-MPL ANTIBODIES | |
EP2424892A4 (en) | DC-STAMP ANTIBODY | |
GB0908945D0 (en) | Antibodies | |
GB0724185D0 (en) | Antibodies |