SI2379084T1 - Modulation of factor expression 11 - Google Patents

Modulation of factor expression 11 Download PDF

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Publication number
SI2379084T1
SI2379084T1 SI200931777T SI200931777T SI2379084T1 SI 2379084 T1 SI2379084 T1 SI 2379084T1 SI 200931777 T SI200931777 T SI 200931777T SI 200931777 T SI200931777 T SI 200931777T SI 2379084 T1 SI2379084 T1 SI 2379084T1
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SI
Slovenia
Prior art keywords
segment
compound
modified oligonucleotide
modified
wing
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SI200931777T
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English (en)
Slovenian (sl)
Inventor
Susan M. Freier
Brett P. Monia
Hong Zhang
Chenguang Zhao
Jeffrey R. Crosby
Andrew M. Siwkowski
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Ionis Pharmaceuticals, Inc.
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Application filed by Ionis Pharmaceuticals, Inc. filed Critical Ionis Pharmaceuticals, Inc.
Publication of SI2379084T1 publication Critical patent/SI2379084T1/en

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • A61K31/365—Lactones
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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SI200931777T 2008-10-15 2009-10-15 Modulation of factor expression 11 SI2379084T1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10577208P 2008-10-15 2008-10-15
US17446109P 2009-04-30 2009-04-30
EP09821293.9A EP2379084B1 (en) 2008-10-15 2009-10-15 Modulation of factor 11 expression
PCT/US2009/060922 WO2010045509A2 (en) 2008-10-15 2009-10-15 Modulation of factor 11 expression

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SI2379084T1 true SI2379084T1 (en) 2018-04-30

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SI200931777T SI2379084T1 (en) 2008-10-15 2009-10-15 Modulation of factor expression 11

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US (7) US8334372B2 (enExample)
EP (2) EP3335715A3 (enExample)
JP (4) JP5809058B2 (enExample)
KR (2) KR101773551B1 (enExample)
CN (4) CN104212799B (enExample)
AU (2) AU2009305636A1 (enExample)
BR (1) BRPI0920263B1 (enExample)
CA (2) CA2966011C (enExample)
CY (1) CY1119909T1 (enExample)
DK (1) DK2379084T3 (enExample)
ES (1) ES2657679T3 (enExample)
HR (1) HRP20171969T1 (enExample)
HU (1) HUE035888T2 (enExample)
IL (2) IL212267A (enExample)
LT (1) LT2379084T (enExample)
MX (1) MX2011004097A (enExample)
NO (1) NO2379084T3 (enExample)
NZ (2) NZ603603A (enExample)
PL (1) PL2379084T3 (enExample)
PT (1) PT2379084T (enExample)
RU (2) RU2535964C2 (enExample)
SI (1) SI2379084T1 (enExample)
WO (1) WO2010045509A2 (enExample)

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DK2379084T3 (en) 2008-10-15 2018-01-22 Ionis Pharmaceuticals Inc MODULATION OF FACTOR 11 EXPRESSION
CA2758927A1 (en) * 2009-04-15 2010-10-21 Isis Pharmaceuticals, Inc. Modulation of inflammatory responses by factor xi
US9150864B2 (en) * 2010-11-08 2015-10-06 Isis Pharmaceuticals, Inc. Methods for modulating factor 12 expression
SI3505528T1 (sl) 2011-04-21 2021-04-30 Glaxo Group Limited Modulacija izražanja virusa hepatitisa B (HBV)
TW201303013A (zh) * 2011-04-21 2013-01-16 Isis Pharmaceuticals Inc Ｂ型肝炎病毒（ｈｂｖ）表現之調節
WO2012170947A2 (en) 2011-06-10 2012-12-13 Isis Pharmaceuticals, Inc. Methods for modulating factor 12 expression
AU2012327227A1 (en) * 2011-11-07 2013-05-23 Isis Pharmaceuticals, Inc. Administration of Factor XI antisense oligonucleotides
US10502737B2 (en) 2012-05-25 2019-12-10 The University Of Vermont And State Agriculture College Anti-thrombotic compositions and methods for assaying platelet reactivity and treatment selection
PL2992098T3 (pl) 2013-05-01 2019-09-30 Ionis Pharmaceuticals, Inc. Kompozycje i sposoby modulowania ekspresji hbv i ttr
ES2812099T3 (es) 2014-05-01 2021-03-16 Ionis Pharmaceuticals Inc Composiciones y métodos para modular la expresión del receptor de la hormona del crecimiento
US10570169B2 (en) 2014-05-22 2020-02-25 Ionis Pharmaceuticals, Inc. Conjugated antisense compounds and their use
US9771417B2 (en) 2014-08-07 2017-09-26 Novartis Ag Angiopoietin-like 4 antibodies and methods of use
US9988443B2 (en) 2014-08-07 2018-06-05 Novartis Ag Angiopoetin-like 4 (ANGPTL4) antibodies and methods of use
JOP20200312A1 (ar) 2015-06-26 2017-06-16 Novartis Ag الأجسام المضادة للعامل xi وطرق الاستخدام
TW201802121A (zh) 2016-05-25 2018-01-16 諾華公司 抗因子XI/XIa抗體之逆轉結合劑及其用途
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WO2019105418A1 (zh) 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 双链寡核苷酸、含双链寡核苷酸的组合物与缀合物及制备方法和用途
WO2019105437A1 (zh) 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
WO2019105419A1 (zh) 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
WO2019105414A1 (zh) 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
KR102617947B1 (ko) 2017-12-29 2023-12-27 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 접합체와 제조 및 그 용도
KR20210005100A (ko) * 2018-04-20 2021-01-13 더 유니버시티 오브 버몬트 앤드 스테이트 애그리컬쳐 칼리지 선택된 환자에서 심혈관 질환을 치료하기 위한 조성물 및 방법
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