SI2170861T1 - Derivati 4-(n-azacikloalkil) anilidov kot kalijevi kanalski modulatorji - Google Patents
Derivati 4-(n-azacikloalkil) anilidov kot kalijevi kanalski modulatorjiInfo
- Publication number
- SI2170861T1 SI2170861T1 SI200830745T SI200830745T SI2170861T1 SI 2170861 T1 SI2170861 T1 SI 2170861T1 SI 200830745 T SI200830745 T SI 200830745T SI 200830745 T SI200830745 T SI 200830745T SI 2170861 T1 SI2170861 T1 SI 2170861T1
- Authority
- SI
- Slovenia
- Prior art keywords
- azacycloalkyl
- anilides
- derivatives
- potassium channel
- channel modulators
- Prior art date
Links
- 102000004257 Potassium Channel Human genes 0.000 title 1
- 229940051881 anilide analgesics and antipyretics Drugs 0.000 title 1
- 150000003931 anilides Chemical class 0.000 title 1
- 108020001213 potassium channel Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93439607P | 2007-06-13 | 2007-06-13 | |
| US12/138,251 US8367684B2 (en) | 2007-06-13 | 2008-06-12 | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
| EP08771077A EP2170861B1 (en) | 2007-06-13 | 2008-06-13 | Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators |
| PCT/US2008/066984 WO2008157404A2 (en) | 2007-06-13 | 2008-06-13 | Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2170861T1 true SI2170861T1 (sl) | 2012-12-31 |
Family
ID=40137141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200830745T SI2170861T1 (sl) | 2007-06-13 | 2008-06-13 | Derivati 4-(n-azacikloalkil) anilidov kot kalijevi kanalski modulatorji |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8367684B2 (https=) |
| EP (1) | EP2170861B1 (https=) |
| JP (1) | JP2010530002A (https=) |
| KR (1) | KR20100018618A (https=) |
| CN (1) | CN101868451A (https=) |
| AU (1) | AU2008266009B2 (https=) |
| BR (1) | BRPI0812564A2 (https=) |
| CA (1) | CA2689208A1 (https=) |
| DK (1) | DK2170861T3 (https=) |
| ES (1) | ES2392774T3 (https=) |
| HR (1) | HRP20120857T1 (https=) |
| MX (1) | MX2009013581A (https=) |
| PL (1) | PL2170861T3 (https=) |
| PT (1) | PT2170861E (https=) |
| RU (1) | RU2010100893A (https=) |
| SI (1) | SI2170861T1 (https=) |
| TW (1) | TW200914452A (https=) |
| WO (1) | WO2008157404A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8563566B2 (en) * | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
| US7786146B2 (en) * | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
| EP2421863A1 (en) | 2009-04-21 | 2012-02-29 | NeuroSearch AS | Substituted naphthyridine derivatives and their medical use |
| CA2804165C (en) * | 2010-07-08 | 2015-02-24 | Pfizer Inc. | Piperidinyl pyrimidine amides as kv7 potassium channel openers |
| KR20150000900A (ko) | 2012-04-10 | 2015-01-05 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 신규한 1-치환된 인다졸 유도체 |
| CN108250128A (zh) * | 2012-09-27 | 2018-07-06 | 江苏先声药业有限公司 | 作为钾通道调节剂的化合物 |
| US10702057B2 (en) | 2015-07-07 | 2020-07-07 | Colgate-Palmolive Company | Oral care implement and monofilament bristle for use with the same |
| CN110511220B (zh) * | 2018-05-22 | 2022-04-01 | 上海挚盟医药科技有限公司 | 作为钾通道调节剂的对二氨基苯衍生物、其制备方法及其在医药上的应用 |
| CN118451079A (zh) * | 2021-12-31 | 2024-08-06 | 上海翰森生物医药科技有限公司 | 苯并哌啶衍生物调节剂、其制备方法和应用 |
| CN116535353A (zh) * | 2022-01-25 | 2023-08-04 | 上海挚盟医药科技有限公司 | 作为钾通道调节剂的酰胺类化合物及其制备和应用 |
Family Cites Families (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4181803A (en) | 1973-12-14 | 1980-01-01 | Eisai Co., Ltd. | Propiophenone derivatives and preparation thereof |
| DE3337593A1 (de) | 1982-10-27 | 1984-05-03 | Degussa Ag, 6000 Frankfurt | 2-amino-3-acylamino-6-benzylamino-pyridin-derivate mit antiepileptischer wirkung |
| DE3369315D1 (en) | 1982-10-27 | 1987-02-26 | Degussa | Derivatives of 2-amino-3-acylamino-6-benzylamino pyridine with an anti-epileptic activity |
| DE3665538D1 (en) | 1985-01-23 | 1989-10-19 | Asta Pharma Ag | Synergistic combination of flupirtin and non-steroidal anti-phlogistics |
| EP0193056B1 (de) | 1985-02-23 | 1989-06-07 | ASTA Pharma Aktiengesellschaft | Kombination von Flupirtin und anticholinergisch wirkenden Spasmolytika |
| DE3604575A1 (de) | 1985-02-23 | 1986-08-28 | Degussa Ag, 6000 Frankfurt | Kombination von flupirtin und anticholinergisch wirkenden spasmolytika |
| JP2583067B2 (ja) | 1987-08-04 | 1997-02-19 | 住友化学工業株式会社 | モノアゾ化合物およびそれを用いて疎水性繊維材料を染色または捺染する方法 |
| GB8800199D0 (en) | 1988-01-06 | 1988-02-10 | Beecham Group Plc | Pharmaceutical preparation |
| MC2029A1 (fr) | 1988-05-16 | 1990-04-25 | Asta Pharma Ag | (n-heterocyclyl)-3 diamino-2,6 pyridines substituees et leurs n-oxydes,preparation de ces composes et leur application comme medicaments |
| US5629307A (en) | 1989-10-20 | 1997-05-13 | Olney; John W. | Use of ibogaine in reducing excitotoxic brain damage |
| US6004945A (en) | 1990-05-10 | 1999-12-21 | Fukunaga; Atsuo F. | Use of adenosine compounds to relieve pain |
| IN172468B (https=) | 1990-07-14 | 1993-08-14 | Asta Medica Ag | |
| US5643921A (en) | 1990-09-26 | 1997-07-01 | E.R. Squibb & Sons, Inc. | Cardiopulmonary bypass and organ transplant using a potassium channel activator |
| US5234947A (en) | 1991-11-07 | 1993-08-10 | New York University | Potassium channel activating compounds and methods of use thereof |
| DE4200259A1 (de) | 1992-01-08 | 1993-07-15 | Asta Medica Ag | Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung |
| US5262419A (en) | 1992-06-11 | 1993-11-16 | E. R. Squibb & Sons, Inc. | Method for the prophylaxis and/or treatment of ulcerative gastrointestinal conditions using a potassium channel activator |
| CA2115792C (en) | 1993-03-05 | 2005-11-01 | David J. Mayer | Method for the treatment of pain |
| US5428039A (en) | 1994-02-20 | 1995-06-27 | The Center For Innovative Technology | Method for electively achieving reversible hyperpolarized cardiac arrest |
| FI971334A7 (fi) * | 1994-08-03 | 1997-04-01 | Asta Medica Ag | Indoli-, indatsoli-, pyridopyrroli- ja pyridopyratsolijohdannaiset, jo illa on antiastmaattinen, antiallerginen, anti-inflammatorinen ja immu nomoduloiva vaikutus |
| JP4097285B2 (ja) | 1994-09-22 | 2008-06-11 | リチャード・アラン・スミス | 種々の頑固な疾患の治療のための医薬の製造に有用な組成物 |
| US5679706A (en) | 1994-09-30 | 1997-10-21 | Bristol-Myers Squibb Company | Combination of a potassium channel activator and an antiarrhythmic agent |
| EP2301562B1 (en) | 1994-12-12 | 2013-04-17 | Omeros Corporation | Irrigation solution and method for inhibition of pain, inflammation and spasm |
| DE19539861A1 (de) | 1995-10-26 | 1997-04-30 | Asta Medica Ag | Verwendung von 4-Amino-4-(4-fluorbenzylamino)-1-ethoxy-carbonylaminobenzen zur Prophylaxe und Behandlung der Folgen der akuten und chronischen zerebralen Minderdurchblutung sowie neurodegenerativer Erkrankungen |
| DE19701694A1 (de) | 1997-01-20 | 1998-07-23 | Asta Medica Ag | Neue Modifikationen des 2-Amino-4-(4-fluorbenzylamino)-l-ethoxycarbonyl-aminobenzen sowie Verfahren zu ihrer Herstellung |
| IN188411B (https=) * | 1997-03-27 | 2002-09-21 | Yuhan Corp | |
| US5760007A (en) | 1997-07-16 | 1998-06-02 | Ortho Pharmaceutical Corporation | Anticonvulsant derivatives useful in treating neuropathic pain |
| EP1004316B1 (en) | 1997-08-08 | 2005-11-02 | Chugai Seiyaku Kabushiki Kaisha | Therapeutics for diabetic complications |
| US6265417B1 (en) | 1997-12-18 | 2001-07-24 | Abbott Laboratories | Potassium channel openers |
| US6593335B1 (en) | 1997-12-18 | 2003-07-15 | Abbott Laboratories | Potassium channel openers |
| US6211171B1 (en) | 1998-05-19 | 2001-04-03 | Dalhousie University | Use of antidepressants for local analgesia |
| JP3441970B2 (ja) | 1998-06-30 | 2003-09-02 | 株式会社サミー | 豆腐の製造方法及び製造装置 |
| JP2000143510A (ja) | 1998-11-16 | 2000-05-23 | Taisho Pharmaceut Co Ltd | 外用組成物 |
| JP2002542147A (ja) | 1998-12-14 | 2002-12-10 | セレジィ ファーマシューティカルス， インコーポレイテッド | 肛門直腸障害の処置のための組成物および方法 |
| US6281211B1 (en) | 1999-02-04 | 2001-08-28 | Euro-Celtique S.A. | Substituted semicarbazides and the use thereof |
| GB9903476D0 (en) | 1999-02-17 | 1999-04-07 | Zeneca Ltd | Therapeutic agents |
| US6451857B1 (en) | 1999-03-10 | 2002-09-17 | Warner-Lambert Company | Analgesic compositions comprising anti-epileptic compounds and methods of using same |
| AU766648B2 (en) | 1999-03-17 | 2003-10-23 | Axys Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
| AT409083B (de) | 1999-04-01 | 2002-05-27 | Sanochemia Pharmazeutika Ag | Pharmazeutische, tolperison enthaltende zubereitung zur oralen verabreichung |
| US6610324B2 (en) | 1999-04-07 | 2003-08-26 | The Mclean Hospital Corporation | Flupirtine in the treatment of fibromyalgia and related conditions |
| GB9915414D0 (en) | 1999-07-01 | 1999-09-01 | Glaxo Group Ltd | Medical use |
| EP1200073B1 (en) | 1999-07-06 | 2007-01-10 | Eli Lilly And Company | SELECTIVE iGluR 5? RECEPTOR ANTAGONISTS FOR THE TREATMENT OF MIGRAINE |
| US6472165B1 (en) | 1999-08-03 | 2002-10-29 | Arzneimittelwerk Dresden Gmbh | Modulatory binding site in potassium channels for screening and finding new active ingredients |
| NZ516610A (en) | 1999-08-04 | 2004-05-28 | Icagen Inc | Benzanilides as potassium channel openers |
| US6495550B2 (en) | 1999-08-04 | 2002-12-17 | Icagen, Inc. | Pyridine-substituted benzanilides as potassium ion channel openers |
| NZ527771A (en) | 1999-08-04 | 2005-04-29 | Icagen Inc | Methods for treating or preventing anxiety |
| US6117900A (en) | 1999-09-27 | 2000-09-12 | Asta Medica Aktiengesellschaft | Use of retigabine for the treatment of neuropathic pain |
| US6383511B1 (en) | 1999-10-25 | 2002-05-07 | Epicept Corporation | Local prevention or amelioration of pain from surgically closed wounds |
| US6538004B2 (en) | 2000-03-03 | 2003-03-25 | Abbott Laboratories | Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers |
| US20020015730A1 (en) | 2000-03-09 | 2002-02-07 | Torsten Hoffmann | Pharmaceutical formulations and method for making |
| TWI287984B (en) | 2000-10-17 | 2007-10-11 | Wyeth Corp | Pharmaceutical composition for modulating bladder function |
| US6589986B2 (en) | 2000-12-20 | 2003-07-08 | Wyeth | Methods of treating anxiety disorders |
| US6951863B2 (en) * | 2001-02-07 | 2005-10-04 | Ortho-Mcneil Pharmaceutical, Inc. | Pyridoarylphenly oxazolidinone antibacterials, and related compositions and methods |
| US6469042B1 (en) | 2001-02-20 | 2002-10-22 | Bristol-Myers Squibb Company | Fluoro oxindole derivatives as modulators if KCNQ potassium channels |
| AR033095A1 (es) | 2001-04-04 | 2003-12-03 | Wyeth Corp | Metodos para el tratamiento de motilidad gastrica hiperactiva |
| GB0121214D0 (en) | 2001-08-31 | 2001-10-24 | Btg Int Ltd | Synthetic method |
| US6831087B2 (en) * | 2001-11-09 | 2004-12-14 | Hoffmann-La Roche Inc. | Pyridine substituted isoquinoline derivatives |
| KR100875362B1 (ko) * | 2002-02-05 | 2008-12-22 | 아스텔라스세이야쿠 가부시키가이샤 | 2,4,6-트리아미노-1,3,5-트리아진 유도체 |
| WO2003068769A1 (en) * | 2002-02-12 | 2003-08-21 | Pfizer Inc. | Non-peptide compounds affecting the action of gonadotropin-releasing hormone (gnrh) |
| WO2003097586A1 (en) | 2002-05-17 | 2003-11-27 | Janssen Pharmaceutica N.V. | Aminotetralin-derived urea modulators of vanilloid vr1 receptor |
| WO2003106454A1 (en) | 2002-06-12 | 2003-12-24 | Orchid Chemicals & Pharmaceuticals Ltd | 1h-isoquinoline-oxazolidinone derivaties and their use as antibacterial agents |
| AUPS312602A0 (en) | 2002-06-21 | 2002-07-18 | James Cook University | Organ arrest, protection, preservation and recovery |
| US7419981B2 (en) | 2002-08-15 | 2008-09-02 | Pfizer Inc. | Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor |
| EP1581510A4 (en) | 2002-11-22 | 2006-08-30 | Bristol Myers Squibb Co | 1-ARYL-2-HYDROXYETHYLAMIDEALS CALIUM CHANNEL OPENER |
| EP1585522B1 (en) | 2002-12-23 | 2010-11-17 | Icagen, Inc. | Quinazolinones as potassium channel modulators |
| MXPA05006463A (es) | 2002-12-27 | 2005-08-26 | Lundbeck & Co As H | Derivados de 1,2,4-triaminobenceno, utiles para tratar transtornos del sistema nervioso central. |
| WO2004080950A1 (en) | 2003-03-14 | 2004-09-23 | H. Lundbeck A/S | Substituted aniline derivatives |
| BRPI0408437A (pt) | 2003-03-21 | 2006-04-04 | Lundbeck & Co As H | derivados de p-diaminobenzeno substituìdos, composição farmacêutica, e, uso da mesma |
| EP1631546A1 (en) | 2003-04-25 | 2006-03-08 | H. Lundbeck A/S | Sustituted indoline and indole derivatives |
| JP2006528231A (ja) | 2003-05-27 | 2006-12-14 | アルタナ ファルマ アクチエンゲゼルシャフト | プロトンポンプ阻害剤と胃腸運動性を変更する化合物との医薬品組合せ物 |
| US7276608B2 (en) * | 2003-07-11 | 2007-10-02 | Bristol-Myers Squibb Company | Tetrahydroquinoline derivatives as cannabinoid receptor modulators |
| US20050089473A1 (en) | 2003-09-10 | 2005-04-28 | Cedars-Sinai Medical Center | Potassium channel mediated delivery of agents through the blood-brain barrier |
| US20050089559A1 (en) | 2003-10-23 | 2005-04-28 | Istvan Szelenyi | Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains |
| DE10359335A1 (de) | 2003-10-23 | 2005-05-25 | Viatris Gmbh & Co. Kg | Kombinationen aus Kaliumkanalöffnern und Natriumkanalinhibitoren oder Natriumkanal beeinflussenden Wirkstoffen zur Behandlung von Schmerzzuständen |
| ES2235626B1 (es) | 2003-11-10 | 2006-11-01 | Almirall Prodesfarma, S.A. | Formas de administracion masticables, no comprimidas dosificadas individualmente. |
| TW200530235A (en) * | 2003-12-24 | 2005-09-16 | Renovis Inc | Bicycloheteroarylamine compounds as ion channel ligands and uses thereof |
| TWI357901B (en) | 2004-03-12 | 2012-02-11 | Lundbeck & Co As H | Substituted morpholine and thiomorpholine derivati |
| KR20070030196A (ko) | 2004-04-13 | 2007-03-15 | 이카겐, 인코포레이티드 | 칼륨 이온 채널 조절제로서의 폴리시클릭 피리딘 |
| CA2565154A1 (en) | 2004-05-03 | 2005-11-24 | Duke University | Compositions for affecting weight loss |
| KR101042490B1 (ko) * | 2004-07-15 | 2011-06-16 | 니뽄 다바코 산교 가부시키가이샤 | 축합 벤즈아미드 화합물 및 바닐로이드 수용체 1형(ｖｒ1)활성 저해제 |
| UA89503C2 (uk) | 2004-09-13 | 2010-02-10 | Х. Луннбек А/С | Заміщені похідні аніліну |
| CN101083985A (zh) * | 2004-09-21 | 2007-12-05 | 幸讬制药公司 | 用于炎症及免疫相关用途的化合物 |
| CA2589001A1 (en) | 2004-11-19 | 2006-05-26 | Kissei Pharmaceutical Co., Ltd. | Preventive or therapeutic agent for neuropathic pain |
| EP1688141A1 (en) | 2005-01-31 | 2006-08-09 | elbion AG | The use of flupirtine for the treatment of overactive bladder and associated diseases, and for the treatment of irritable bowel syndrome |
| EP1861394A1 (en) | 2005-03-03 | 2007-12-05 | H.Lundbeck A/S | Substituted pyridine derivatives |
| US7683058B2 (en) | 2005-09-09 | 2010-03-23 | H. Lundbeck A/S | Substituted pyrimidine derivatives |
| AU2006306542B2 (en) * | 2005-10-21 | 2012-04-19 | Merck Sharp & Dohme Corp. | Potassium channel inhibitors |
| BRPI0716715B1 (pt) | 2006-08-23 | 2021-07-06 | Xenon Pharmaceuticals, Inc | Derivados de 4-(n-azacicloalquil) anilidas como moduladores de canal de potássio, seus usos, produto, composição, comprimido e cápsula |
| CA2670966A1 (en) | 2006-11-28 | 2008-06-05 | Valeant Pharmaceuticals International | 1,4 diamino bicyclic retigabine analogues as potassium channel modulators |
| US8563566B2 (en) * | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
| US9096518B2 (en) * | 2009-06-22 | 2015-08-04 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
-
2008
- 2008-06-12 US US12/138,251 patent/US8367684B2/en active Active
- 2008-06-13 MX MX2009013581A patent/MX2009013581A/es active IP Right Grant
- 2008-06-13 WO PCT/US2008/066984 patent/WO2008157404A2/en not_active Ceased
- 2008-06-13 BR BRPI0812564-3A2A patent/BRPI0812564A2/pt not_active Application Discontinuation
- 2008-06-13 ES ES08771077T patent/ES2392774T3/es active Active
- 2008-06-13 EP EP08771077A patent/EP2170861B1/en not_active Not-in-force
- 2008-06-13 HR HRP20120857AT patent/HRP20120857T1/hr unknown
- 2008-06-13 AU AU2008266009A patent/AU2008266009B2/en not_active Ceased
- 2008-06-13 DK DK08771077.8T patent/DK2170861T3/da active
- 2008-06-13 KR KR1020107000706A patent/KR20100018618A/ko not_active Withdrawn
- 2008-06-13 JP JP2010512399A patent/JP2010530002A/ja active Pending
- 2008-06-13 TW TW097122339A patent/TW200914452A/zh unknown
- 2008-06-13 SI SI200830745T patent/SI2170861T1/sl unknown
- 2008-06-13 RU RU2010100893/04A patent/RU2010100893A/ru not_active Application Discontinuation
- 2008-06-13 PT PT08771077T patent/PT2170861E/pt unknown
- 2008-06-13 PL PL08771077T patent/PL2170861T3/pl unknown
- 2008-06-13 CA CA002689208A patent/CA2689208A1/en not_active Abandoned
- 2008-06-13 CN CN200880102338A patent/CN101868451A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| TW200914452A (en) | 2009-04-01 |
| US20080318979A1 (en) | 2008-12-25 |
| RU2010100893A (ru) | 2011-07-20 |
| AU2008266009B2 (en) | 2013-06-06 |
| US8367684B2 (en) | 2013-02-05 |
| AU2008266009A1 (en) | 2008-12-24 |
| BRPI0812564A2 (pt) | 2015-02-10 |
| HRP20120857T1 (hr) | 2012-11-30 |
| MX2009013581A (es) | 2010-01-26 |
| PL2170861T3 (pl) | 2013-01-31 |
| CA2689208A1 (en) | 2008-12-24 |
| ES2392774T3 (es) | 2012-12-13 |
| EP2170861B1 (en) | 2012-08-29 |
| JP2010530002A (ja) | 2010-09-02 |
| WO2008157404A2 (en) | 2008-12-24 |
| KR20100018618A (ko) | 2010-02-17 |
| DK2170861T3 (da) | 2012-11-26 |
| CN101868451A (zh) | 2010-10-20 |
| WO2008157404A3 (en) | 2009-02-19 |
| EP2170861A2 (en) | 2010-04-07 |
| PT2170861E (pt) | 2012-09-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA200901977B (en) | Derivatives of 4-(in-azacycloalkyl) anilides as potassium channel modulators | |
| EP2531024A4 (en) | 4- (N-AZACYCLOALKYL) ANILIDE DERIVATIVES AS MODULATORS OF POTASSIUM CHANNELS | |
| SI2170861T1 (sl) | Derivati 4-(n-azacikloalkil) anilidov kot kalijevi kanalski modulatorji | |
| AP2516A (en) | 2-Pyridine carboxamide derivatives as sodium channel modulators | |
| IL200501A0 (en) | Purinyl derivatives and their use as potassium channel modulators | |
| ZA200905796B (en) | Purinyl derivatives and their use as potassium channel modulators | |
| EP2178373A4 (en) | HETEROCYCLES AS COLD CHANNEL MODULATORS | |
| EP2297174A4 (en) | EXCLUSIVE SYNTHESIS OF GALACTOSIDE INHIBITORS | |
| GB0813403D0 (en) | Potassium ion channel modulators & uses thereof | |
| EP2097384A4 (en) | INDOZALYL SULFOMNAMIDE DERIVATIVES USEFUL AS MODULATORS OF GLUCOCORTICOIDS | |
| IL208136A0 (en) | Substituted dihydropyrazolones as inhibitors of hif-prolyl-4-hydroxylases | |
| EP2175728A4 (en) | SODIUM CHANNEL INHIBITORS | |
| CU23861B1 (es) | Nuevo procedimiento de síntesis de agomelatina | |
| IL206044A0 (en) | Isoxazole derivatives as modulators of 11-beta-hydroxysteroid dehydrogenase type 1 | |
| IL199941A (en) | Stable Thyacomycin preparations | |
| PL2129680T3 (pl) | Łączone kompozycje cząsteczek antysensownych o strukturze spinki do włosów oraz sposoby modulacji ekspresji | |
| DK2240154T3 (da) | Kosmetisk sammensætning omfattende glycogentil anvendelse med fløjlsblød virkning | |
| IL200087A0 (en) | Novel crystal of piperacillin sodium | |
| DK2350079T3 (da) | Thiazolylpyrazolopyrimidinforbindelser som syntetiske mellemprodukter og dertil relaterede syntetiske fremgangsmåder | |
| EP2310369A4 (en) | BENZYL OXYANILID DERIVATIVES SUITABLE AS SODIUM CHANNEL MODULATORS | |
| ZA201100141B (en) | Stable crystal modifications of dopc | |
| EP2178529A4 (en) | NEW APPLICATION OF TOPICAL NARCROGEN FOR MODULATION OF NEUROGENIC TREMOR | |
| PL383758A1 (pl) | Nowe zastosowanie undekan-2-onu | |
| PL383759A1 (pl) | Nowe zastosowanie undekan-2-olu | |
| PL383760A1 (pl) | Nowe zastosowanie undekan-2-olu |