SI2170767T1 - Postopek za pripravo aluminijevega fosfata - Google Patents
Postopek za pripravo aluminijevega fosfata Download PDFInfo
- Publication number
- SI2170767T1 SI2170767T1 SI200831901T SI200831901T SI2170767T1 SI 2170767 T1 SI2170767 T1 SI 2170767T1 SI 200831901 T SI200831901 T SI 200831901T SI 200831901 T SI200831901 T SI 200831901T SI 2170767 T1 SI2170767 T1 SI 2170767T1
- Authority
- SI
- Slovenia
- Prior art keywords
- aluminum phosphate
- range
- solution
- aluminum
- process according
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/36—Aluminium phosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Fertilizers (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
Claims (15)
1. Postopek za pripravo aluminijevega fosfata, ki obsega: mešanje raztopine aluminijevega klorida in raztopine tribazičnega natrijevega fosfata, da nastane suspenzija aluminijevega fosfata in supernatant, pri čemer se raztopina tribazičnega natrijevega fosfata dodaja v raztopino aluminijevega klorida, dokler ni pH v območju od 5,0 do 5,4; posedanje suspenzije aluminijevega fosfata, da nastane oborina aluminijevega fosfata, pri čemer se korak posedanja izvaja pri temperaturi v območju od 50 °C do 70 °C v obdobju od 2 dni do 5 dni; odstranitev supernatanta; steriliziranje oborine aluminijevega fosfata, pri čemer korak steriliziranja obsega segrevanje oborine aluminijevega fosfata na temperaturo nad 110 °C; in naravnanje pH oborine aluminijevega fosfata, da je v območju od 5,6 do 6,0; pri čemer po koraku naravnanja pH oborina aluminijevega fosfata vključuje delce z velikostno porazdelitvijo, ki ima D [v, 0,5] v območju od 3,0 pm do 9,0 pm; in pri čemer se koraki mešanja, posedanja, odstranitve, steriliziranja in naravnanja izvajajo v zaprtem sistemu.
2. Postopek po zahtevku 1, pri čemer se raztopina tribazičnega natrijevega fosfata dodaja v raztopino aluminijevega klorida, dokler ni pH v območju od 5,1 do 5,3.
3. Postopek po zahtevku 1 ali zahtevku 2, pri čemer se korak mešanja izvaja pri temperaturi v območju od 20 °C do 30 °C.
4. Postopek po zahtevku 3, pri čemer se korak mešanja izvaja pri temperaturi 25 °C.
5. Postopek po katerem koli od zahtevkov od 1 do 4, pri čemer korak mešanja obsega mešanje raztopine aluminijevega klorida in raztopine tribazičnega natrijevega fosfata z impelerjem, ki se vrti od 150 vrt/min do 350 vrt/min.
6. Postopek po katerem koli od zahtevkov od 1 do 4, pri čemer korak mešanja obsega mešanje raztopine aluminijevega klorida in raztopine tribazičnega natrijevega fosfata z impelerjem, ki se vrti od 200 vrt/min do 300 vrt/min.
7. Postopek po katerem koli od zahtevkov od 1 do 4, pri čemer korak mešanja obsega mešanje raztopine aluminijevega klorida in raztopine tribazičnega natrijevega fosfata z impelerjem, ki se vrti 250 vrt/min.
8. Postopek po katerem koli od zahtevkov od 1 do 7, pri čemer se korak posedanja izvaja pri temperaturi v območju od 55 °C do 65 °C.
9. Postopek po katerem koli od zahtevkov od 1 do 7, pri čemer se korak posedanja izvaja pri temperaturi 60 °C.
10. Postopek po katerem koli od zahtevkov od 1 do 9, pri čemer se korak posedanja izvaja v trajanju med 3 dnevi in 4 dnevi.
11. Postopek po katerem koli od zahtevkov od 1 do 10, pri čemer korak odstranitve obsega odstranitev supernatanta s potopno cevko.
12. Postopek po katerem koli od zahtevkov od 1 do 11, pri čemer korak steriliziranja obsega segrevanje oborine aluminijevega fosfata na temperaturo nad 121 °C.
13. Postopek po katerem koli od zahtevkov od 1 do 12, pri čemer se pH oborine aluminijevega fosfata naravna tako, da je v območju od 5,8 do 6,0.
14. Postopek po zahtevku 13, pri čemer se pH naravna tako, da je v območju od 5,9 do 6,0.
15. Postopek po katerem koli od zahtevkov od 1 do 14, pri čemer je koncentracija aluminijevega fosfata po koraku mešanja v območju od 9,0 do 16,5 mg/ml.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95895807P | 2007-07-10 | 2007-07-10 | |
| US12/169,665 US8540955B2 (en) | 2007-07-10 | 2008-07-09 | Process for producing aluminum phosphate |
| PCT/US2008/069584 WO2009009629A1 (en) | 2007-07-10 | 2008-07-10 | Process for producing aluminum phosphate |
| EP08772497.7A EP2170767B1 (en) | 2007-07-10 | 2008-07-10 | Process for producing aluminum phosphate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2170767T1 true SI2170767T1 (sl) | 2018-02-28 |
Family
ID=39941489
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200832095T SI3301074T1 (sl) | 2007-07-10 | 2008-07-10 | Postopek za proizvajanje aluminijevega fosfata |
| SI200831901T SI2170767T1 (sl) | 2007-07-10 | 2008-07-10 | Postopek za pripravo aluminijevega fosfata |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200832095T SI3301074T1 (sl) | 2007-07-10 | 2008-07-10 | Postopek za proizvajanje aluminijevega fosfata |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8540955B2 (sl) |
| EP (2) | EP2170767B1 (sl) |
| JP (1) | JP5620265B2 (sl) |
| KR (1) | KR101387142B1 (sl) |
| CN (1) | CN101730660B (sl) |
| AU (1) | AU2008275081B2 (sl) |
| BR (1) | BRPI0814557B1 (sl) |
| CA (1) | CA2692750C (sl) |
| DK (2) | DK3301074T3 (sl) |
| ES (2) | ES2753776T3 (sl) |
| HK (1) | HK1145168A1 (sl) |
| HU (2) | HUE045705T2 (sl) |
| MX (1) | MX2010000228A (sl) |
| PL (2) | PL2170767T3 (sl) |
| PT (2) | PT2170767T (sl) |
| RU (1) | RU2480403C2 (sl) |
| SI (2) | SI3301074T1 (sl) |
| WO (1) | WO2009009629A1 (sl) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102032002B1 (ko) * | 2011-11-23 | 2019-10-14 | 머크 샤프 앤드 돔 코포레이션 | 알루미늄 히드록시포스페이트 아주반트의 제조 방법 |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| US9611147B2 (en) * | 2012-04-16 | 2017-04-04 | Bunge Amorphic Solutions Llc | Aluminum phosphates, compositions comprising aluminum phosphate, and methods for making the same |
| CN105492021B (zh) | 2013-09-08 | 2018-12-04 | 辉瑞公司 | 脑膜炎奈瑟氏球菌组合物及其方法 |
| CN103787296B (zh) * | 2014-01-23 | 2015-09-23 | 苏州大学 | 一种圆片状磷酸铝及其制备方法 |
| CN103804941B (zh) * | 2014-01-23 | 2016-01-27 | 苏州大学 | 一种圆片磷酸铝/热固性树脂复合材料及其制备方法 |
| WO2016132294A1 (en) | 2015-02-19 | 2016-08-25 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| EP3307315B1 (en) * | 2015-06-12 | 2021-01-27 | Biological E Limited | Method for preparation of aluminium phosphate gel for application in vaccine formulations |
| US10245581B2 (en) * | 2015-11-30 | 2019-04-02 | Indian Oil Corporation Limited | Composition and process for preparation of attrition resistant additive suitable for cracking hydrocarbon feed |
| US11197921B2 (en) | 2017-01-31 | 2021-12-14 | Merck Sharp & Dohme Corp. | Methods for making polysaccharide-protein conjugates |
| IL303108B1 (en) | 2017-01-31 | 2024-03-01 | Pfizer | NEISSERIA MENINGITIDIS preparations and methods therefor |
| US11090374B2 (en) | 2017-02-24 | 2021-08-17 | Merck Sharp & Dohme Corp. | Enhancing immunogenicity of Streptococcus pneumoniae polysaccharide-protein conjugates |
| KR20200051005A (ko) | 2017-09-07 | 2020-05-12 | 머크 샤프 앤드 돔 코포레이션 | 폐렴구균 폴리사카라이드 및 면역원성 폴리사카라이드-담체 단백질 접합체에서의 그의 용도 |
| BR112020004471A8 (pt) | 2017-09-07 | 2022-11-01 | Merck Sharp & Dohme | Polissacarídeos pneumocócicos e uso dos mesmos em conjugados imunogênicos polissacarídeo-proteína carreadora |
| CN111683678B (zh) | 2017-12-06 | 2024-01-26 | 默沙东有限责任公司 | 包含肺炎链球菌多糖蛋白缀合物的组合物及其使用方法 |
| KR20210002641A (ko) | 2018-04-30 | 2021-01-08 | 머크 샤프 앤드 돔 코포레이션 | 디메틸술폭시드 중의 동결건조된 돌연변이체 디프테리아 독소의 균질 용액을 제공하는 방법 |
| KR20210005158A (ko) | 2018-04-30 | 2021-01-13 | 머크 샤프 앤드 돔 코포레이션 | 스트렙토코쿠스 뉴모니아에 피막 폴리사카라이드 담체 단백질 접합체를 제조하는 방법 |
| CN109432418A (zh) * | 2018-11-01 | 2019-03-08 | 大连理工大学 | 一种等电点可控的磷酸铝纳米佐剂及其制备方法 |
| CA3123414A1 (en) | 2018-12-19 | 2020-06-25 | Merck Sharp & Dohme Corp. | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| CA3129425A1 (en) | 2019-02-11 | 2020-08-20 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| US20220401544A1 (en) | 2019-09-27 | 2022-12-22 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1963307A (en) * | 1933-10-09 | 1934-06-19 | King H Mclaurin | Apparatus for stripping ingot molds |
| US2668776A (en) * | 1950-03-18 | 1954-02-09 | New Jersey Zinc Co | Titanium dioxide pigment and method of preparing |
| GB777018A (en) | 1955-05-02 | 1957-06-12 | Parke Davis & Co | Poliomyelitis vaccine products and methods for preparing the same |
| US3078215A (en) | 1959-12-22 | 1963-02-19 | Glaxo Group Ltd | Process for the purification and concentration of poliomyelitis vaccine |
| GB962182A (en) | 1962-05-01 | 1964-07-01 | Setso Higashi | Improved metal phosphates and method of making same |
| US4168772A (en) * | 1974-10-01 | 1979-09-25 | General Battery Corporation | Apparatus and method for stacking battery plates and separators |
| RU2149138C1 (ru) * | 1998-06-08 | 2000-05-20 | Государственное унитарное предприятие "Иммунопрепарат" | Способ получения геля фосфата алюминия |
-
2008
- 2008-07-09 US US12/169,665 patent/US8540955B2/en active Active
- 2008-07-10 SI SI200832095T patent/SI3301074T1/sl unknown
- 2008-07-10 ES ES17198364T patent/ES2753776T3/es active Active
- 2008-07-10 WO PCT/US2008/069584 patent/WO2009009629A1/en active Application Filing
- 2008-07-10 ES ES08772497.7T patent/ES2655456T3/es active Active
- 2008-07-10 JP JP2010516234A patent/JP5620265B2/ja active Active
- 2008-07-10 BR BRPI0814557A patent/BRPI0814557B1/pt active IP Right Grant
- 2008-07-10 EP EP08772497.7A patent/EP2170767B1/en active Active
- 2008-07-10 RU RU2010100670/05A patent/RU2480403C2/ru active
- 2008-07-10 HU HUE17198364A patent/HUE045705T2/hu unknown
- 2008-07-10 PT PT87724977T patent/PT2170767T/pt unknown
- 2008-07-10 MX MX2010000228A patent/MX2010000228A/es active IP Right Grant
- 2008-07-10 DK DK17198364T patent/DK3301074T3/da active
- 2008-07-10 CA CA2692750A patent/CA2692750C/en active Active
- 2008-07-10 AU AU2008275081A patent/AU2008275081B2/en active Active
- 2008-07-10 HU HUE08772497A patent/HUE036201T2/hu unknown
- 2008-07-10 EP EP17198364.6A patent/EP3301074B1/en active Active
- 2008-07-10 PT PT171983646T patent/PT3301074T/pt unknown
- 2008-07-10 SI SI200831901T patent/SI2170767T1/sl unknown
- 2008-07-10 CN CN2008800240135A patent/CN101730660B/zh active Active
- 2008-07-10 DK DK08772497.7T patent/DK2170767T3/da active
- 2008-07-10 PL PL08772497T patent/PL2170767T3/pl unknown
- 2008-07-10 KR KR1020107002744A patent/KR101387142B1/ko active IP Right Grant
- 2008-07-10 PL PL17198364T patent/PL3301074T3/pl unknown
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2010
- 2010-12-02 HK HK10111220.7A patent/HK1145168A1/xx not_active IP Right Cessation
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