SI21164B - Uporaba benzofenantridinskih alkaloidov kot dodatki za krmo in kot zdravila proti vnetju črevesa - Google Patents
Uporaba benzofenantridinskih alkaloidov kot dodatki za krmo in kot zdravila proti vnetju črevesa Download PDFInfo
- Publication number
- SI21164B SI21164B SI200120056A SI200120056A SI21164B SI 21164 B SI21164 B SI 21164B SI 200120056 A SI200120056 A SI 200120056A SI 200120056 A SI200120056 A SI 200120056A SI 21164 B SI21164 B SI 21164B
- Authority
- SI
- Slovenia
- Prior art keywords
- feed
- alkaloids
- benzophenanthridine
- amino acids
- aromatic amino
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims abstract 3
- 229930013930 alkaloid Natural products 0.000 title claims 5
- 239000003674 animal food additive Substances 0.000 title claims 2
- 206010022678 Intestinal infections Diseases 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- 229930015421 benzophenanthridine alkaloid Natural products 0.000 claims abstract 7
- 150000008622 benzophenanthridines Chemical class 0.000 claims abstract 7
- -1 aromatic amino acids Chemical class 0.000 claims abstract 6
- 230000007515 enzymatic degradation Effects 0.000 claims abstract 3
- 241001465754 Metazoa Species 0.000 claims abstract 2
- 239000000463 material Substances 0.000 claims abstract 2
- 102000004169 proteins and genes Human genes 0.000 claims abstract 2
- 108090000623 proteins and genes Proteins 0.000 claims abstract 2
- OWUNMSGLMUPGEZ-UHFFFAOYSA-N benzo[k]phenanthridine Chemical compound C1=CC=CC2=C3C4=CC=CC=C4C=CC3=CN=C21 OWUNMSGLMUPGEZ-UHFFFAOYSA-N 0.000 claims 5
- 241000196324 Embryophyta Species 0.000 claims 3
- 241000218180 Papaveraceae Species 0.000 claims 3
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims 2
- 150000003797 alkaloid derivatives Chemical class 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000037354 amino acid metabolism Effects 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 239000006052 feed supplement Substances 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- ZFRKQXVRDFCRJG-UHFFFAOYSA-N skatole Chemical compound C1=CC=C2C(C)=CNC2=C1 ZFRKQXVRDFCRJG-UHFFFAOYSA-N 0.000 claims 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 235000011941 Tilia x europaea Nutrition 0.000 abstract 1
- 240000008042 Zea mays Species 0.000 abstract 1
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 abstract 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 abstract 1
- 235000013339 cereals Nutrition 0.000 abstract 1
- 235000011868 grain product Nutrition 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000004571 lime Substances 0.000 abstract 1
- 235000009973 maize Nutrition 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 235000021317 phosphate Nutrition 0.000 abstract 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 235000002639 sodium chloride Nutrition 0.000 abstract 1
- 229940088594 vitamin Drugs 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 abstract 1
- 235000013343 vitamin Nutrition 0.000 abstract 1
- 239000011782 vitamin Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- Birds (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Fodder In General (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (7)
1 PATENTNI ZAHTEVKI 1. Uporaba enega ali več benzofenantridinskih alkaloidov ali njihovih derivatov, ali sintetičnih analogov kot dodatki krmi v učinkoviti količini za inhibiranje ali preprečevanje encimatske razgradnje esencialnih aromatskih aminokislin v krmi ali dodatku krmi.
2. Uporaba po zahtevku 1, označena s tem, da benzofenantridinske alkaloide uporabimo v obliki rastlinskega materiala Papaveraceae ali kot njihov ekstrakt, ali v obliki izoliranih alkaloidov, ali alkaloidnih zmesi, ali sintetičnih analogov.
3. Uporaba po zahtevku 1 ali 2, označena s tem, da krma vsebuje esencialne aromatske aminokisline in benzofenantridinske alkaloide.
4. Uporaba po enem od zahtevkov od 1 do 3, označena s tem, da esencialne aromatske aminokisline dodatno dodamo v krmo.
5. Uporaba po enem od prejšnjih zahtevkov, označena s tem, daje količina alkaloidov na tono krme večja od 1 mg.
6. Uporaba benzofenantridinskih alkaloidov ali njihovih derivatov, ali sintetičnih analogov, ali rastlinskih sestavin Papaveraceae, ki vsebujejo benzofenantridinski(e) alkaloid(e), za pripravo krm ali dodatkov krmi za izboljšanje proteinske bilance pri koristnih domačih živalih z inhibiranjem ali preprečevanjem encimatske razgradnje aromatskih aminokislin v prebavnem traktu.
7. Uporaba benzofenantridinskih alkaloidov ali njihovih derivatov, ali sintetičnih analogov, ali rastlinskih sestavin Papaveraceae, ki vsebujejo benzofenantridinski(e) alkaloid(e), za pripravo zdravila proti črevesnim vnetjem, posebno takim, ki jih povzročijo razgradni produkti aminokislinske presnove, kot sta indol in skatol.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0157900A AT500455B1 (de) | 2000-09-15 | 2000-09-15 | Verwendung von benzophenanthridinalkaloiden als futteradditiv |
| PCT/IB2001/002487 WO2002021932A2 (de) | 2000-09-15 | 2001-09-14 | Futtermittel, futterzusatzmittel und heilmittel gegen darmentzündung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI21164A SI21164A (sl) | 2003-10-31 |
| SI21164B true SI21164B (sl) | 2005-10-31 |
Family
ID=3688371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200120056A SI21164B (sl) | 2000-09-15 | 2001-09-14 | Uporaba benzofenantridinskih alkaloidov kot dodatki za krmo in kot zdravila proti vnetju črevesa |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20030190344A1 (sl) |
| EP (1) | EP1317188B2 (sl) |
| JP (1) | JP2004508059A (sl) |
| AT (1) | AT500455B1 (sl) |
| AU (1) | AU2002222354A1 (sl) |
| BG (1) | BG107626A (sl) |
| CA (1) | CA2422250A1 (sl) |
| CZ (1) | CZ299208B6 (sl) |
| DE (1) | DE50104706D1 (sl) |
| EE (1) | EE200300101A (sl) |
| ES (1) | ES2233706T5 (sl) |
| HR (1) | HRP20030193A2 (sl) |
| HU (1) | HUP0302433A3 (sl) |
| NO (1) | NO323687B1 (sl) |
| PL (1) | PL365902A1 (sl) |
| PT (1) | PT1317188E (sl) |
| RO (1) | RO121630B1 (sl) |
| SI (1) | SI21164B (sl) |
| SK (1) | SK285504B6 (sl) |
| WO (1) | WO2002021932A2 (sl) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT500455B1 (de) † | 2000-09-15 | 2007-08-15 | Roth Hermann Dr | Verwendung von benzophenanthridinalkaloiden als futteradditiv |
| AT500589B1 (de) * | 2004-05-19 | 2009-08-15 | Roth Hermann Dr | Alkaloidhaltiges futtermittel bzw. futtermittelzusatz |
| EP1882473A1 (en) * | 2006-07-28 | 2008-01-30 | Indena S.P.A. | Use of anthocyanosides to prepare formulations for the treatment of mucositis induced by antitumoral drugs |
| AT504440B1 (de) * | 2006-11-13 | 2012-03-15 | Neufeld Klaus | Ballaststoff |
| AT506498B1 (de) * | 2008-02-25 | 2011-02-15 | Roth Hermann Dr | Verfahren zur fermentation von biomasse |
| AT509728B1 (de) | 2010-04-15 | 2012-05-15 | Neufeld Klaus | Verwendung eines alkaloidhältigen pflanzenextraktes beziehungsweise pflanzenmaterials als tierfutterzusatz |
| JP5385446B2 (ja) * | 2012-11-12 | 2014-01-08 | 国立大学法人東京海洋大学 | 魚類のタンパク質節約を目的とした飼料 |
| JP6253964B2 (ja) * | 2013-11-29 | 2017-12-27 | 日本ニュートリション株式会社 | 牛乳の乳質改善剤および乳質改善方法 |
| AT515336A1 (de) * | 2014-02-03 | 2015-08-15 | Roth Hermann Dr | Vermeidung oxidativer Prozesse und oxidativem Stress |
| WO2016056520A1 (ja) * | 2014-10-06 | 2016-04-14 | 扶桑化学工業株式会社 | 水中動物用飼料、水中動物用発育向上剤、および、それらを用いた養殖魚の飼育方法 |
| CN104351534B (zh) * | 2014-11-03 | 2017-09-12 | 广东恒兴饲料实业股份有限公司 | 一种陆川猪用促生长饲料添加剂预混料及应用方法 |
| US20170095467A1 (en) * | 2015-10-01 | 2017-04-06 | Rhizofeed, LLC | Encapsulation of isoquinoline alkaloids |
| BR112019000815A2 (pt) * | 2017-04-04 | 2019-11-05 | Roth Hermann | alimento para animais ou suplemento alimentar para animais e método para diminuir a quantidade de proteína que precisa ser alimentada a um animal durante a aplicação de um agonista beta adrenérgico para permitir que o agonista beta adrenérgico se torne fisiologicamente eficaz |
| CN107683970A (zh) * | 2017-09-21 | 2018-02-13 | 香格里拉市利众种植农民专业合作社 | 藏香猪育肥饲料及其制备方法 |
| CN107667969A (zh) * | 2017-10-21 | 2018-02-09 | 赵三存 | 一种提高猪肉瘦肉率的育肥方法 |
| CN107568458A (zh) * | 2017-10-24 | 2018-01-12 | 山西大禹生物工程股份有限公司 | 一种免疫促进饲料添加剂 |
| CN108567059B (zh) * | 2018-05-09 | 2021-09-07 | 湖南弘康生态农业科技发展股份有限公司 | 一种猪饲料及其制备方法 |
| EP3851116A1 (de) * | 2020-01-20 | 2021-07-21 | Phytobiotics Futterzusatzstoffe GmbH | Substanzkombination mit isochinolinalkaloiden und kokzidiostatikum oder kokzidioseimpfmittel |
| CN113480552B (zh) * | 2021-06-04 | 2022-05-10 | 中国农业科学院北京畜牧兽医研究所 | 一种化合物及其在改善动物瘤胃微生物发酵中的用途 |
| EP4241572A1 (de) * | 2022-03-11 | 2023-09-13 | Phytobiotics Futterzusatzstoffe GmbH | Tierfutter oder tierfutterzusatz mit canadin und/oder canadin-derivat |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4335110A (en) * | 1979-08-23 | 1982-06-15 | Orewa Inc. | Pharmaceutical compositions of sanguinaria galangal and zinc chloride |
| AU548560B2 (en) * | 1980-05-20 | 1985-12-19 | Vipont Laboratories Inc. | Benzophenanthridine alkaloids as antimicrobial agents |
| US5175000A (en) † | 1987-06-30 | 1992-12-29 | Vipont Pharmaceutical, Inc. | Free amine benzophenanthridine alkaloid compositions |
| JP2599158B2 (ja) * | 1987-12-26 | 1997-04-09 | 日清製粉株式会社 | 家畜のカンピロバクター・ジェジュニ感染症の予防及び治療剤 |
| JP2578488B2 (ja) * | 1988-03-04 | 1997-02-05 | 協和醗酵工業株式会社 | アミノ酸の製造法 |
| AT403873B (de) * | 1992-02-21 | 1998-06-25 | Neufeld Klaus Dr | Tierfutter zur leistungssteigerung |
| NL1008054C2 (nl) * | 1998-01-16 | 1999-07-19 | Nl Zuivelonderzoek Inst | Werkwijze voor het produceren van alanine, alsmede hierbij toegepaste micro-organismen en recombinant DNA moleculen. |
| AT500455B1 (de) † | 2000-09-15 | 2007-08-15 | Roth Hermann Dr | Verwendung von benzophenanthridinalkaloiden als futteradditiv |
-
2000
- 2000-09-15 AT AT0157900A patent/AT500455B1/de not_active IP Right Cessation
-
2001
- 2001-09-14 WO PCT/IB2001/002487 patent/WO2002021932A2/de not_active Ceased
- 2001-09-14 EE EEP200300101A patent/EE200300101A/xx unknown
- 2001-09-14 EP EP01984622A patent/EP1317188B2/de not_active Expired - Lifetime
- 2001-09-14 RO ROA200300226A patent/RO121630B1/ro unknown
- 2001-09-14 SI SI200120056A patent/SI21164B/sl not_active IP Right Cessation
- 2001-09-14 ES ES01984622T patent/ES2233706T5/es not_active Expired - Lifetime
- 2001-09-14 JP JP2002526198A patent/JP2004508059A/ja active Pending
- 2001-09-14 PT PT01984622T patent/PT1317188E/pt unknown
- 2001-09-14 DE DE50104706T patent/DE50104706D1/de not_active Expired - Lifetime
- 2001-09-14 HU HU0302433A patent/HUP0302433A3/hu unknown
- 2001-09-14 US US10/380,447 patent/US20030190344A1/en not_active Abandoned
- 2001-09-14 PL PL01365902A patent/PL365902A1/xx not_active IP Right Cessation
- 2001-09-14 CA CA002422250A patent/CA2422250A1/en not_active Abandoned
- 2001-09-14 HR HR20030193A patent/HRP20030193A2/hr not_active Application Discontinuation
- 2001-09-14 AU AU2002222354A patent/AU2002222354A1/en not_active Abandoned
- 2001-09-14 SK SK300-2003A patent/SK285504B6/sk unknown
- 2001-09-14 CZ CZ20030714A patent/CZ299208B6/cs not_active IP Right Cessation
-
2003
- 2003-03-11 BG BG107626A patent/BG107626A/bg unknown
- 2003-03-14 NO NO20031196A patent/NO323687B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004508059A (ja) | 2004-03-18 |
| EP1317188B2 (de) | 2008-06-11 |
| AT500455A1 (de) | 2005-12-15 |
| EE200300101A (et) | 2005-02-15 |
| NO20031196D0 (no) | 2003-03-14 |
| PL365902A1 (en) | 2005-01-10 |
| SK3002003A3 (en) | 2003-08-05 |
| BG107626A (bg) | 2003-11-28 |
| WO2002021932A3 (de) | 2002-10-17 |
| US20030190344A1 (en) | 2003-10-09 |
| AU2002222354A1 (en) | 2002-03-26 |
| NO323687B1 (no) | 2007-06-25 |
| DE50104706D1 (de) | 2005-01-05 |
| AT500455B1 (de) | 2007-08-15 |
| SI21164A (sl) | 2003-10-31 |
| ES2233706T5 (es) | 2008-12-01 |
| HUP0302433A2 (hu) | 2003-10-28 |
| SK285504B6 (sk) | 2007-03-01 |
| ES2233706T3 (es) | 2005-06-16 |
| HUP0302433A3 (en) | 2006-02-28 |
| RO121630B1 (ro) | 2008-01-30 |
| CZ299208B6 (cs) | 2008-05-21 |
| HRP20030193A2 (en) | 2005-10-31 |
| CA2422250A1 (en) | 2003-03-14 |
| NO20031196L (no) | 2003-05-15 |
| EP1317188B1 (de) | 2004-12-01 |
| EP1317188A2 (de) | 2003-06-11 |
| WO2002021932A2 (de) | 2002-03-21 |
| PT1317188E (pt) | 2005-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF | Valid on the event date | ||
| OU02 | Decision according to article 73(2) ipa 1992, publication of decision on partial fulfilment of the invention and change of patent claims |
Effective date: 20050824 |
|
| KO00 | Lapse of patent |
Effective date: 20080428 |