CA1211643A - Synergic growth-promoting feed supplement composition for farm animals - Google Patents
Synergic growth-promoting feed supplement composition for farm animalsInfo
- Publication number
- CA1211643A CA1211643A CA000452370A CA452370A CA1211643A CA 1211643 A CA1211643 A CA 1211643A CA 000452370 A CA000452370 A CA 000452370A CA 452370 A CA452370 A CA 452370A CA 1211643 A CA1211643 A CA 1211643A
- Authority
- CA
- Canada
- Prior art keywords
- composition
- feed
- component
- cyadox
- farm animals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
ABSTRACT OF THE DISCLOSURE:
The present invention relates to a synergic growth-promoting feed supplement composition for farm animals which contains 2-formylquinoxaline-1,4-dioxide cyanoacetylhydrazone, which has the generic designation cyadox, in combination with antibiotics and/or sulfonamides. These substances were sur-prisingly found to enhance synergically the favorable effect of cyadox on the animal growth promotion and feed utilisation as well as on the suppression of pathogenic microorganisms.
The feed supplement composition according to the invention is advantageously used in the form of additives to feed-stuffs and feed mixtures for farm animals such as, e.g., pigs, calves and poultry. In comparison with cyadox alone, the composition ensures substantially more efficient increase in live-weight gains, suppression of microbial infections, improvement of the health of animals and reduction of losses by early mortality; especially remarkable effects are obtained by the use of the composition and of supplemented feed compris-ing same in large-scale breeding conditions.
The present invention relates to a synergic growth-promoting feed supplement composition for farm animals which contains 2-formylquinoxaline-1,4-dioxide cyanoacetylhydrazone, which has the generic designation cyadox, in combination with antibiotics and/or sulfonamides. These substances were sur-prisingly found to enhance synergically the favorable effect of cyadox on the animal growth promotion and feed utilisation as well as on the suppression of pathogenic microorganisms.
The feed supplement composition according to the invention is advantageously used in the form of additives to feed-stuffs and feed mixtures for farm animals such as, e.g., pigs, calves and poultry. In comparison with cyadox alone, the composition ensures substantially more efficient increase in live-weight gains, suppression of microbial infections, improvement of the health of animals and reduction of losses by early mortality; especially remarkable effects are obtained by the use of the composition and of supplemented feed compris-ing same in large-scale breeding conditions.
Description
~lZ~ 3 The present invention relates to a synergic growth-promoting feed supplement composition for farm animals that may consist essentially of an effective amount of 2-formyl-quinoxaline-1,4-dioxide cyanoacetylhydrazone, which has the generlc designation cyadox, in combination with c~rtain additional biologically active substances. The invention also relates to the use of this feed supplement composition and of supplemented feed mixtures comprising the same in feeding farm animals such as, e.g., pigs, calves and poultry.
1~ The composition of the invention can be used for increasing of liveweight gains, enhancing of the feedstuff utilisation and for the prevention or treatment of microbial and other infections.
The present invention, in particular, provides a synergic growth~promoting feed supplement composition suitable for farm animals, comprising an effective amount of 2-formyl-quinoxaline-1,4-dioxide cyanoacetylhydrazone and a component selected from the group consisting of an antibiotic component a sulfonamide component and mixtures ther~of. The composition ~0 may, if desired additionally include common auxiliaries and carriers; ie biologically acceptable carriers etcO
The present invention also provides a growth-promoting feed mixture, suitable for farm animals, comprising a (i) a feedstuff 2S (ii) 20 to 500 grams per ton of feed mixture of
1~ The composition of the invention can be used for increasing of liveweight gains, enhancing of the feedstuff utilisation and for the prevention or treatment of microbial and other infections.
The present invention, in particular, provides a synergic growth~promoting feed supplement composition suitable for farm animals, comprising an effective amount of 2-formyl-quinoxaline-1,4-dioxide cyanoacetylhydrazone and a component selected from the group consisting of an antibiotic component a sulfonamide component and mixtures ther~of. The composition ~0 may, if desired additionally include common auxiliaries and carriers; ie biologically acceptable carriers etcO
The present invention also provides a growth-promoting feed mixture, suitable for farm animals, comprising a (i) a feedstuff 2S (ii) 20 to 500 grams per ton of feed mixture of
2-formylquinoxaline-1,~-dioxide cyanoacetyl-hydrazone and (iii) 20 to 500 grams per ton of feed mixture of a component selected from the group consisting of an antibiotic component, a sulfonamide component and mixtures thereof The feed mixture can make use of any common feedstuffs and can include common auxiliairiesand carriers.
~l2~643 The feed supplement composition of the p~esent invention can be advantageously used for increasing liveweight gains, enhancing the feed utilisation, suppression of microbial infectionsl improving the general health state of farm animals and reduction of lo~;ses by early mortality, especially in large-scale breeding~ conditio~ns.
It is kno~ from literature /CS 195 508, ~E 2 829 580, US 4 225 604/ that cyadox efficiently promotes the growth of farm animals and suppresses both gram-positive and gram-negative microorganisms; it also has markedly pronouncedcoccidiostatic propert.ies. Advantageously, the compound is almosk nontoxic: in rats, its L~50 is as high as 15 g/kg p.o.
The mentioned favorable effects of cyadox on the growth and health o~ farm anin~als have recently been found to increase surprisingly by its combination with antibiotics and/or sulfonamides, even those which per se elicit little or no growth promotion. The observed increase in activity is substantially higherthan _t could have been predicted on the basis of known properties of the components. The desirable effects of cyadox alone are markedly promoted in the above mentioned combination since the additional components contribute synergically to the growth stimulation as well as to the suppression of pathogenic microorganisms by said compound.
This synergism, similarly as the unexpected slight toxicity and improved stability of cyadox, belongs to extraordinary characteristics of the substance.
This synergic effect occurs in combination of cyadox with quite a number of antibiotics such as, e.g., tylosin, bacitracin, oxytetracycline, chlortetracycline, virginiamycin, spectinomycin, flavomycin, thiamulin or apramycin, and sulfonamides such as, e.g., phthalazole or sulfadimidine Thus, for example, when test groups of early weaned piglets were treated, in parallel experiments under otherwise identical conditions, respectively with cyadox alone, tylosin alone -- ~2~i43 and with a combination of both, at the same dosage level of 1~0 mg per kg of feed mixture, the liveweight gains as well as the feedstuff utilisation in the group treated with the ~ombination proved to be substantiall~ higher than the sum of these effects of the individual components dosaged separately.
Also, when pigs in t:he starting period of fattening, of approx.
50 ~g weight, were fed a mixture supplemented with cyadox and/ox phthalazole in equal llD0 mg per kg doses of either substance applied individuall1y or in combination, the re-spective effects of administering the combination as comparedwith the untreated control group were substantially higher than the sum of the effects of the individual dosage. This clearly indicates synergism, which could not have been ex-pected on the basis of the available data.
The feed supplement composition according to the invention contains the antibiotic and/or sulfonamide component in a suitable dosage form such as, e.g., the cor-responding acidic, basic or amphoteric substance, an acid addition salt, a base addition salt, a complex sal~ or a metal chelate. The antibiotic can also be present as a dried fermentation medium or an antibiotic-containing mycelium previously separated therefrom. Thus, the term tylosin designates the base or the corresponding quantity of an acid addition salt such as, e~g., hydrochloride, sulphate, phosphate or tartrate, or a dried tylosin-containing mycelium.
The term bacitracin stands for this substance as such or its complex compounds with metals such as e.g., Zn-bacitracin.
Due to the extremely low toxicity of cyadox and of antibiot~cs and sulfonamides including those listed herein above, the administration of the feed supplement composition does not involve any hazard of injurious effects even on un-intentional overdosaging of the supplemented fead mixture.
Also, its use as a veterinary medicament in convenient doses is xeliably free of any risk.
~2~ 43 The synergic growth-promoting feed supplemen~
composition according to the present invention may contain cyadox and the antibiotic ancl/or sulfonamide component in any practical proportion of quantities such as within a range of 1 : 10 to 10 : 1. For enc;uring balanced effects and potent synergism, h~wever, a harmonic ratio of approx. 1 : 1 is as a rule preferable. The composition may contain both an antibiotic and a sulfonamide. In Eormulating of supplemented feed mixtures, the composition is advantageously added, in the form of a premix to nutritionally balanced feed mixtures with a required content of essential biologically active substances /biofactors/, in aL quantity xanging substantially ~rom 20 to 500 grams of each per ton of feed. Also, the principal components of the composition may be adjusted into a convenient veterinary medicament form and dosaged eac~ at a level ranging from approx. 1 to 100 mg. per kg of liveweight daily.
The dispensing forms suitable for the application of the oomposition may be solid or liquid such as, e.g., granulations, capsules, pills, oral pastes, suspensions and the like. They may contain compatible solvents or diluents, carriers of organic or inorganic origin such as, e.g., ground limestone, kaolin, talc, starch, sugar, cellulose, crushed plant residues or similar substrates used in formulating of veterinary dosage forms, as well as usual excipients /auxiliaries/ and, if required, other biologically active components. Among said excipients there should be particularly emphasized the addition of suitable surface-active substances such as cationactive, anionactive and nonionogenous tensides or tenside mixtur~s with good wetting and dispersing or emulsifying properties. These tenside substances, advantageously chosen from among a large amount of commercial products, may also form a part of the premixes, feed supplements and feed mixtures. The tensides are admixed preferably in a ~uantity ranging f~om approx. 0.5 to 10.0 ~g per ton of ~eed.
Said dispensing forms of the composition are manu-factured similarly as common veterinary medicament forms, biofactor concentrates, premixes, feed supplements or supple-mented feed mixtures by any of the known methods, predominantly by mixing or grinding of the active constituents with the other components such as, e.g., solvents, carriers and tensides.
The feed supplement composition according to the invention promotes the growth of farm animals in a substantial-ly higher degree than its individual components and signifi-cantly enhances the feedstuff utilisation. In addition to this, the composition can advantageously be used for the prevention and treatment of systemic diseases of farm animals, especially of diarrhoeic diseases such as enterites and salmonelloses as well as of coccidiosis. This feed supplement composition also improves the general health of farm animals, diminishes the losses by their early mortality and so increases the efficiency of farm animal breeding, particularly of large-scale breeding of pigs, cattle and poultry.
The following examples illustrate the utility and effects of the invention, but are in no respect limitative as to the scope thereof. - The percentual values sofar in-~icated herein below represent percents by weight.
Example 1:
Early weaned piglets, crossbreds of the large white x landrasse, born within an interval of 6 days, were transfer-red from the delivery station to the experimental ~iostation on the fifth day after weaning. The animals were divided into groups of 8 to 12 and each group was placed into a separate box; the boxes were provided with grate floors and heated through wooden floorings. After an adaptation period of additional 7 days the experiment was started. Over the entire te~t period of 4 weeks, all groups under test were fed a commercial feed mixture COS-2 designed for feeding of early ~Z~ 3 weaned piglets. The feed mixture was supplemented, by admixture of the respective premix, a~ follows:
Group I - /reference group/ mixture alone II - cyadox, 100 ppm /100 mg per kg of the mixture/
III - feed-grade tylosin, 100 ppm of pure base IV - cyadox and feed-grade tylosin, 100 ppm of each.
The animals were weighed individually at the start and at the end /on the 28th day/ of the experiment. The feed consumption per group was followed daily and the feed utilisation rate was calculated. Also, general health of the animals was examined daily. The test results are summarized in the fol-lowing Table I.
Table I
Group I II III IV
Substance reference cyadox tylosin cyadox /100/
/dosage, ppm/ /0/ ~100/ /100/+tylosin /100/
Number of animals 12 12 11 5 x 8 Initial weight 10.30 10.28 9.13 7.10 x, kg Weight gain index 100.0 109.8 125.9 150.6 %
Feed utilisation x 2.0 1.99 1.90 1.61 /consumption per gain unit/
Feed utilisation lOl~.0 99.5 92.2 84.3 %
index ~-0.5J /-7.8/ /-15.7/
Similar results were obtained with the use of tylosin, b~acitracin, chlortetracycline and oxytetracycline together with cyadox for supplementing of feed mixtures fed to pigs, calves and broilers.
Example 2:
In a pig fattening station there was observed the ~2~43 occurrence of diarrhoea with bleeding in 5 to 15% of the BU x PC + L race starter pigs, approx. 50 kg liveweight, placed in boxes each for 10 to 15 animals. The disease was diagnosticized histolotically and microbiologically; the disease originator was identiiied as Vibrio coli.
The test pigs were clivided into 4 groups and fed a commercial SOL feed mixture, which was supplemented by premixes as ollows:
Group I - /reference group/ mixture alone II - phthala~zole, 100 ppm III - cyadox, 100 ppm IV - cyadox and phthalazole, 100 ppm of each.
Said biologically active substances were administered for 14 days. After that time, groups III /cyadox/ and IV /cyadox +
phthalazole/ had no case of diarrhoea with bleeding /100 therapeutical efficiency/ whereas in groups I /reference/
and II /phthalazole alon~/ the disease was still observed in 20 to 30% of the animals. At the end of the e~periment, altogether 20 pigs from the latter two groups tl5 from group I and 5 from group II/ ha~ to be sent to emergency slaughter because of bad state. The test results are summarized in the subsequent Table II.
Similar results were obtained with the use of phthalazole and sulfadimidine together with cyadox for sup-plementing of feed mixtures fed to pigs, calves and broilers.
. ~
~Z~ 3 " o CO
~r ~ ~ ~ ~ ~
H X-- 1~ r^l n ~D _I ~ ~
~0 X N q~ ~ a~ O _I N
H ~ O --I ~1 i.~ 10 ~1 N r-l ~_ N O ~r O ~n t'J O
H O N _I Il~ n ~r O
~ OD ~r u~
S~ ^ ~ . o al o~ ~ o QJo I~ ,1 L~ u~ ~ O
~ .Y ~
.~ ~ ~ ~ lX ~
.,1 _ ~ ~ ~ ~ ~rl U~ ~1 0~ 3 ,~) .to~ ~:: ~
H ~.~j O 0 ~3 . H ~ 3 ~) O ~:
Q O~ ~ ~X ~X ,~: IX "IX X
E-~ t!) U~--~1 Z ~ a) H I X 14 E~ 1 1 ~ H
~l2~643 The feed supplement composition of the p~esent invention can be advantageously used for increasing liveweight gains, enhancing the feed utilisation, suppression of microbial infectionsl improving the general health state of farm animals and reduction of lo~;ses by early mortality, especially in large-scale breeding~ conditio~ns.
It is kno~ from literature /CS 195 508, ~E 2 829 580, US 4 225 604/ that cyadox efficiently promotes the growth of farm animals and suppresses both gram-positive and gram-negative microorganisms; it also has markedly pronouncedcoccidiostatic propert.ies. Advantageously, the compound is almosk nontoxic: in rats, its L~50 is as high as 15 g/kg p.o.
The mentioned favorable effects of cyadox on the growth and health o~ farm anin~als have recently been found to increase surprisingly by its combination with antibiotics and/or sulfonamides, even those which per se elicit little or no growth promotion. The observed increase in activity is substantially higherthan _t could have been predicted on the basis of known properties of the components. The desirable effects of cyadox alone are markedly promoted in the above mentioned combination since the additional components contribute synergically to the growth stimulation as well as to the suppression of pathogenic microorganisms by said compound.
This synergism, similarly as the unexpected slight toxicity and improved stability of cyadox, belongs to extraordinary characteristics of the substance.
This synergic effect occurs in combination of cyadox with quite a number of antibiotics such as, e.g., tylosin, bacitracin, oxytetracycline, chlortetracycline, virginiamycin, spectinomycin, flavomycin, thiamulin or apramycin, and sulfonamides such as, e.g., phthalazole or sulfadimidine Thus, for example, when test groups of early weaned piglets were treated, in parallel experiments under otherwise identical conditions, respectively with cyadox alone, tylosin alone -- ~2~i43 and with a combination of both, at the same dosage level of 1~0 mg per kg of feed mixture, the liveweight gains as well as the feedstuff utilisation in the group treated with the ~ombination proved to be substantiall~ higher than the sum of these effects of the individual components dosaged separately.
Also, when pigs in t:he starting period of fattening, of approx.
50 ~g weight, were fed a mixture supplemented with cyadox and/ox phthalazole in equal llD0 mg per kg doses of either substance applied individuall1y or in combination, the re-spective effects of administering the combination as comparedwith the untreated control group were substantially higher than the sum of the effects of the individual dosage. This clearly indicates synergism, which could not have been ex-pected on the basis of the available data.
The feed supplement composition according to the invention contains the antibiotic and/or sulfonamide component in a suitable dosage form such as, e.g., the cor-responding acidic, basic or amphoteric substance, an acid addition salt, a base addition salt, a complex sal~ or a metal chelate. The antibiotic can also be present as a dried fermentation medium or an antibiotic-containing mycelium previously separated therefrom. Thus, the term tylosin designates the base or the corresponding quantity of an acid addition salt such as, e~g., hydrochloride, sulphate, phosphate or tartrate, or a dried tylosin-containing mycelium.
The term bacitracin stands for this substance as such or its complex compounds with metals such as e.g., Zn-bacitracin.
Due to the extremely low toxicity of cyadox and of antibiot~cs and sulfonamides including those listed herein above, the administration of the feed supplement composition does not involve any hazard of injurious effects even on un-intentional overdosaging of the supplemented fead mixture.
Also, its use as a veterinary medicament in convenient doses is xeliably free of any risk.
~2~ 43 The synergic growth-promoting feed supplemen~
composition according to the present invention may contain cyadox and the antibiotic ancl/or sulfonamide component in any practical proportion of quantities such as within a range of 1 : 10 to 10 : 1. For enc;uring balanced effects and potent synergism, h~wever, a harmonic ratio of approx. 1 : 1 is as a rule preferable. The composition may contain both an antibiotic and a sulfonamide. In Eormulating of supplemented feed mixtures, the composition is advantageously added, in the form of a premix to nutritionally balanced feed mixtures with a required content of essential biologically active substances /biofactors/, in aL quantity xanging substantially ~rom 20 to 500 grams of each per ton of feed. Also, the principal components of the composition may be adjusted into a convenient veterinary medicament form and dosaged eac~ at a level ranging from approx. 1 to 100 mg. per kg of liveweight daily.
The dispensing forms suitable for the application of the oomposition may be solid or liquid such as, e.g., granulations, capsules, pills, oral pastes, suspensions and the like. They may contain compatible solvents or diluents, carriers of organic or inorganic origin such as, e.g., ground limestone, kaolin, talc, starch, sugar, cellulose, crushed plant residues or similar substrates used in formulating of veterinary dosage forms, as well as usual excipients /auxiliaries/ and, if required, other biologically active components. Among said excipients there should be particularly emphasized the addition of suitable surface-active substances such as cationactive, anionactive and nonionogenous tensides or tenside mixtur~s with good wetting and dispersing or emulsifying properties. These tenside substances, advantageously chosen from among a large amount of commercial products, may also form a part of the premixes, feed supplements and feed mixtures. The tensides are admixed preferably in a ~uantity ranging f~om approx. 0.5 to 10.0 ~g per ton of ~eed.
Said dispensing forms of the composition are manu-factured similarly as common veterinary medicament forms, biofactor concentrates, premixes, feed supplements or supple-mented feed mixtures by any of the known methods, predominantly by mixing or grinding of the active constituents with the other components such as, e.g., solvents, carriers and tensides.
The feed supplement composition according to the invention promotes the growth of farm animals in a substantial-ly higher degree than its individual components and signifi-cantly enhances the feedstuff utilisation. In addition to this, the composition can advantageously be used for the prevention and treatment of systemic diseases of farm animals, especially of diarrhoeic diseases such as enterites and salmonelloses as well as of coccidiosis. This feed supplement composition also improves the general health of farm animals, diminishes the losses by their early mortality and so increases the efficiency of farm animal breeding, particularly of large-scale breeding of pigs, cattle and poultry.
The following examples illustrate the utility and effects of the invention, but are in no respect limitative as to the scope thereof. - The percentual values sofar in-~icated herein below represent percents by weight.
Example 1:
Early weaned piglets, crossbreds of the large white x landrasse, born within an interval of 6 days, were transfer-red from the delivery station to the experimental ~iostation on the fifth day after weaning. The animals were divided into groups of 8 to 12 and each group was placed into a separate box; the boxes were provided with grate floors and heated through wooden floorings. After an adaptation period of additional 7 days the experiment was started. Over the entire te~t period of 4 weeks, all groups under test were fed a commercial feed mixture COS-2 designed for feeding of early ~Z~ 3 weaned piglets. The feed mixture was supplemented, by admixture of the respective premix, a~ follows:
Group I - /reference group/ mixture alone II - cyadox, 100 ppm /100 mg per kg of the mixture/
III - feed-grade tylosin, 100 ppm of pure base IV - cyadox and feed-grade tylosin, 100 ppm of each.
The animals were weighed individually at the start and at the end /on the 28th day/ of the experiment. The feed consumption per group was followed daily and the feed utilisation rate was calculated. Also, general health of the animals was examined daily. The test results are summarized in the fol-lowing Table I.
Table I
Group I II III IV
Substance reference cyadox tylosin cyadox /100/
/dosage, ppm/ /0/ ~100/ /100/+tylosin /100/
Number of animals 12 12 11 5 x 8 Initial weight 10.30 10.28 9.13 7.10 x, kg Weight gain index 100.0 109.8 125.9 150.6 %
Feed utilisation x 2.0 1.99 1.90 1.61 /consumption per gain unit/
Feed utilisation lOl~.0 99.5 92.2 84.3 %
index ~-0.5J /-7.8/ /-15.7/
Similar results were obtained with the use of tylosin, b~acitracin, chlortetracycline and oxytetracycline together with cyadox for supplementing of feed mixtures fed to pigs, calves and broilers.
Example 2:
In a pig fattening station there was observed the ~2~43 occurrence of diarrhoea with bleeding in 5 to 15% of the BU x PC + L race starter pigs, approx. 50 kg liveweight, placed in boxes each for 10 to 15 animals. The disease was diagnosticized histolotically and microbiologically; the disease originator was identiiied as Vibrio coli.
The test pigs were clivided into 4 groups and fed a commercial SOL feed mixture, which was supplemented by premixes as ollows:
Group I - /reference group/ mixture alone II - phthala~zole, 100 ppm III - cyadox, 100 ppm IV - cyadox and phthalazole, 100 ppm of each.
Said biologically active substances were administered for 14 days. After that time, groups III /cyadox/ and IV /cyadox +
phthalazole/ had no case of diarrhoea with bleeding /100 therapeutical efficiency/ whereas in groups I /reference/
and II /phthalazole alon~/ the disease was still observed in 20 to 30% of the animals. At the end of the e~periment, altogether 20 pigs from the latter two groups tl5 from group I and 5 from group II/ ha~ to be sent to emergency slaughter because of bad state. The test results are summarized in the subsequent Table II.
Similar results were obtained with the use of phthalazole and sulfadimidine together with cyadox for sup-plementing of feed mixtures fed to pigs, calves and broilers.
. ~
~Z~ 3 " o CO
~r ~ ~ ~ ~ ~
H X-- 1~ r^l n ~D _I ~ ~
~0 X N q~ ~ a~ O _I N
H ~ O --I ~1 i.~ 10 ~1 N r-l ~_ N O ~r O ~n t'J O
H O N _I Il~ n ~r O
~ OD ~r u~
S~ ^ ~ . o al o~ ~ o QJo I~ ,1 L~ u~ ~ O
~ .Y ~
.~ ~ ~ ~ lX ~
.,1 _ ~ ~ ~ ~ ~rl U~ ~1 0~ 3 ,~) .to~ ~:: ~
H ~.~j O 0 ~3 . H ~ 3 ~) O ~:
Q O~ ~ ~X ~X ,~: IX "IX X
E-~ t!) U~--~1 Z ~ a) H I X 14 E~ 1 1 ~ H
Claims (9)
1. A synergic growth-promoting feed supplement composition, suitable for farm animals, comprising an effect-ive amount of 2-formylquinoxaline-1,4-dioxide cyanoacetyl-hydrazone and a component selected from the group consisting of an antibiotic component, a sulfonamide component and mixtures thereof.
2. A composition is defined in claim 1, wherein said composition additionally includes a biologically ac-ceptable carrier.
3. A composition as defined in claim 1, comprising at least one antibiotic component selected from tylosin, bacitracin, chlortetracycline, oxytetracycline, virginiamycin, spectinomycin, flavomycin, thiamulin and apramycin.
4. A composition as defined in claim 1, comprising at least one sulfonamide component selected from phthalazole and sulfadimidine.
5. A composition as defined in claim 1, wherein said antibiotic component is selected from tylosin, bacitracin, chlortetracycline, oxytetracycline, virginiamycin, spectinomycin, flavomycin, thiamulin and apramycin and said sulfonamide component is selected from phthalazole and sulfadimidine.
6. A composition as defined in claim 1, comprising said 2-formylquinoxaline-1,4-dioxide cyanoacetylhydrazone together with at least one substance selected from tylosin, bacitracin, chlortetracycline, oxytetracycline and phthalazole.
7 . A composition as defined in claim 1, wherein said component is in a form selected from the respective acidic, basic and amphoteric compounds, an acid addition salt, a. base addition salt, a complex salt, a metal chelate, a dried fermentation medium and an antibiotic-containing mycelium previously separated therefrom.
8. A growth-promoting feed mixture, suitable for farm animals, comprising a (i) a feedstuff (ii) 20 to 500 grams per ton of feed mixture of 2-formylquinoxaline-1,4-dioxide cyanoacethyl-hydxazone and (iii) 20 to 500 grams per ton of feed mixture of a component selected from the group consisting of an antibiotic component, a sulfonamide component and mixtures thereof.
9. A feed mixture of claim 6, comprising a physiologically harmless tenside in an amount ranging from 0.5 to 10.0 kilograms per ton of feed mixture.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000452370A CA1211643A (en) | 1984-04-19 | 1984-04-19 | Synergic growth-promoting feed supplement composition for farm animals |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000452370A CA1211643A (en) | 1984-04-19 | 1984-04-19 | Synergic growth-promoting feed supplement composition for farm animals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1211643A true CA1211643A (en) | 1986-09-23 |
Family
ID=4127692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000452370A Expired CA1211643A (en) | 1984-04-19 | 1984-04-19 | Synergic growth-promoting feed supplement composition for farm animals |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA1211643A (en) |
-
1984
- 1984-04-19 CA CA000452370A patent/CA1211643A/en not_active Expired
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