SI2086945T1 - Novi postopek za pripravo statinov in njihovih farmacevtsko sprejemljivih soli - Google Patents
Novi postopek za pripravo statinov in njihovih farmacevtsko sprejemljivih soliInfo
- Publication number
- SI2086945T1 SI2086945T1 SI200731763A SI200731763A SI2086945T1 SI 2086945 T1 SI2086945 T1 SI 2086945T1 SI 200731763 A SI200731763 A SI 200731763A SI 200731763 A SI200731763 A SI 200731763A SI 2086945 T1 SI2086945 T1 SI 2086945T1
- Authority
- SI
- Slovenia
- Prior art keywords
- statins
- preparation
- pharmaceutically acceptable
- acceptable salts
- novel process
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1864CH2006 | 2006-10-09 | ||
PCT/IN2007/000459 WO2008044243A2 (en) | 2006-10-09 | 2007-10-05 | Novel process for the preparation of statins and their pharmaceutically acceptable salts thereof |
EP07859598.0A EP2086945B1 (en) | 2006-10-09 | 2007-10-05 | Novel process for the preparation of statins and their pharmaceutically acceptable salts thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2086945T1 true SI2086945T1 (sl) | 2016-05-31 |
Family
ID=39283273
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200731763A SI2086945T1 (sl) | 2006-10-09 | 2007-10-05 | Novi postopek za pripravo statinov in njihovih farmacevtsko sprejemljivih soli |
Country Status (6)
Country | Link |
---|---|
US (1) | US8404841B2 (sl) |
EP (1) | EP2086945B1 (sl) |
ES (1) | ES2567171T3 (sl) |
HU (1) | HUE028475T2 (sl) |
SI (1) | SI2086945T1 (sl) |
WO (1) | WO2008044243A2 (sl) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7851624B2 (en) | 2003-12-24 | 2010-12-14 | Teva Pharamaceutical Industries Ltd. | Triol form of rosuvastatin and synthesis of rosuvastatin |
US8455640B2 (en) | 2006-05-03 | 2013-06-04 | Msn Laboratories Limited | Process for statins and its pharmaceutically acceptable salts thereof |
US7994178B2 (en) | 2006-09-18 | 2011-08-09 | Teva Pharmaceutical Industries, Ltd. | Crystalline rosuvastatin calcium and compositions thereof for treatment of hyperlipidaemia |
EP2086945B1 (en) | 2006-10-09 | 2016-01-06 | MSN Laboratories Private Limited | Novel process for the preparation of statins and their pharmaceutically acceptable salts thereof |
EP2079712A2 (en) | 2006-10-31 | 2009-07-22 | Aurobindo Pharma Limited | An improved process for preparing rosuvastatin calcium |
AU2008212622B2 (en) | 2007-02-08 | 2011-01-27 | Aurobindo Pharma Limited | An improved process for preparation of rosuvastatin calcium |
KR20090018964A (ko) | 2007-04-18 | 2009-02-24 | 테바 파마슈티컬 인더스트리즈 리미티드 | Hmg-coa 환원 효소 억제제의 중간체의 제조 방법 |
WO2009009153A1 (en) | 2007-07-12 | 2009-01-15 | Teva Pharmaceutical Industries Ltd. | Purification of rosuvastatin intermediate by thin film evaporation and chemical method |
SI2387566T1 (sl) * | 2009-01-14 | 2014-07-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Postopek za pripravo rosuvastatina |
EA021942B1 (ru) | 2009-01-15 | 2015-10-30 | Эгиш Дьёдьсердьяр Зрт. | Способ изготовления солей розувастатина |
EP2387561A4 (en) * | 2009-01-19 | 2012-07-25 | Msn Lab Ltd | IMPROVED PROCESS FOR THE PREPARATION OF HIGH-PURITY (3R, 5S) -7-β-CYCLOPROPYL-4- (4-FLUOROPHENYL) QUINOLIN-3-YL-3,5-DIHYDROXY-6 (E) -HEPTENOIC ACID, INCLUDING ITS PHARMACEUTICALLY ACCEPTABLE SALTS |
WO2011086584A2 (en) * | 2010-01-18 | 2011-07-21 | Msn Laboratories Limited | Improved process for the preparation of amide intermediates and their use thereof |
WO2011104725A2 (en) | 2010-02-23 | 2011-09-01 | Cadila Healthcare Limited | Hmg-coa reductase inhibitors and process for the preparation thereof |
AU2011243948B2 (en) | 2010-04-23 | 2014-07-17 | Sun Pharmaceutical Industries Limited | Novel intermediates for the preparation of HMG-CoA reductase inhibitors |
EP2588474A4 (en) * | 2010-07-01 | 2014-07-23 | Yuhan Corp | PROCESS FOR PREPARING HMG-COA REDUCTASE INHIBITORS AND INTERMEDIATES THEREOF |
WO2012011129A2 (en) * | 2010-07-22 | 2012-01-26 | Msn Laboratories Limited | Novel polymorph of bis[(e)-7-[4-(4-fluorophenyl)-6-iso-propyl-2-[methyl (methylsulfonyl)amino]pyrimidin-5-yl](3r,5s)-3,5-dihydroxyhept-6-enoic acid] calcium salt |
HU229260B1 (en) | 2010-11-29 | 2013-10-28 | Egis Gyogyszergyar Nyrt | Process for preparation of rosuvastatin salts |
HU230987B1 (hu) | 2010-11-29 | 2019-08-28 | Egis Gyógyszergyár Nyrt. | Eljárás nagy tisztaságú gyógyszeripari intermedierek előállítására |
MX357470B (es) | 2011-01-18 | 2018-07-11 | Dsm Sinochem Pharm Nl Bv | Procedimiento para la preparación de estatinas en presencia de base. |
WO2014045294A1 (en) * | 2012-09-20 | 2014-03-27 | Inogent Laboratories Private Limited | A novel process for the preparation of rosuvastatin calcium using novel intermediates |
WO2015037018A1 (en) * | 2013-09-14 | 2015-03-19 | Ind-Swift Laboratories Limited | Process for the preparation of rosuvastatin via novel intermediates |
CN103804414B (zh) * | 2014-03-07 | 2016-04-13 | 凯莱英医药集团(天津)股份有限公司 | 用于制备瑞舒伐他汀钙的中间体化合物以及由其制备瑞舒伐他汀钙的方法 |
CN105153039B (zh) * | 2015-07-17 | 2018-01-12 | 江西富祥药业股份有限公司 | 一种瑞舒伐他汀钙中间体杂质的制备方法 |
CN111454216B (zh) * | 2019-10-21 | 2021-06-29 | 山东理工职业学院 | HMG-CoA还原酶抑制剂及其中间体的制备方法 |
CN112375102B (zh) * | 2020-10-23 | 2022-05-20 | 郑州大学 | 一种可见光催化膦酰化咪唑并吡啶类化合物的制备方法 |
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CZ299215B6 (cs) | 2005-06-29 | 2008-05-21 | Zentiva, A. S. | Zpusob výroby hemivápenaté soli (E)-7-[4-(4-fluorofenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl] (3R,5S)-3,5-dihydroxy-6-heptenovékyseliny |
EP1883634A2 (en) | 2005-09-13 | 2008-02-06 | Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság | Process for preparing simvastatin and intermediates thereof |
KR101019450B1 (ko) | 2005-10-03 | 2011-03-07 | 테바 파마슈티컬 인더스트리즈 리미티드 | 로수바스타틴의 부분입체 이성질체 정제 |
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US20100274014A1 (en) | 2006-01-30 | 2010-10-28 | Cadila Healthcare Limited | Process for manufacturing rosuvastatin potassium and crystalline and amorphous forms thereof |
CN1821242B (zh) | 2006-02-16 | 2012-03-07 | 亚邦化工集团有限公司 | 制备二羟基酸HMG-CoA还原酶抑制剂的新方法 |
US8455640B2 (en) | 2006-05-03 | 2013-06-04 | Msn Laboratories Limited | Process for statins and its pharmaceutically acceptable salts thereof |
WO2007132482A2 (en) * | 2006-05-17 | 2007-11-22 | Manne Satyanarayana Reddy | Novel process for the preparation of pitavastatin and its pharmaceutically acceptable salts |
EP2086945B1 (en) | 2006-10-09 | 2016-01-06 | MSN Laboratories Private Limited | Novel process for the preparation of statins and their pharmaceutically acceptable salts thereof |
CN101386592B (zh) | 2008-10-30 | 2010-08-18 | 上海交通大学 | 利用不对称氢化制备匹伐他汀钙原料药的方法 |
-
2007
- 2007-10-05 EP EP07859598.0A patent/EP2086945B1/en not_active Not-in-force
- 2007-10-05 ES ES07859598.0T patent/ES2567171T3/es active Active
- 2007-10-05 US US12/531,386 patent/US8404841B2/en not_active Expired - Fee Related
- 2007-10-05 HU HUE07859598A patent/HUE028475T2/en unknown
- 2007-10-05 SI SI200731763A patent/SI2086945T1/sl unknown
- 2007-10-05 WO PCT/IN2007/000459 patent/WO2008044243A2/en active Search and Examination
Also Published As
Publication number | Publication date |
---|---|
WO2008044243A9 (en) | 2008-11-13 |
EP2086945B1 (en) | 2016-01-06 |
HUE028475T2 (en) | 2016-12-28 |
US8404841B2 (en) | 2013-03-26 |
WO2008044243A3 (en) | 2010-02-11 |
EP2086945A2 (en) | 2009-08-12 |
EP2086945A4 (en) | 2010-12-29 |
ES2567171T3 (es) | 2016-04-20 |
US20100056783A1 (en) | 2010-03-04 |
WO2008044243A2 (en) | 2008-04-17 |
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