SI20019A - Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola - Google Patents

Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola Download PDF

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Publication number
SI20019A
SI20019A SI9800196A SI9800196A SI20019A SI 20019 A SI20019 A SI 20019A SI 9800196 A SI9800196 A SI 9800196A SI 9800196 A SI9800196 A SI 9800196A SI 20019 A SI20019 A SI 20019A
Authority
SI
Slovenia
Prior art keywords
methoxy
omeprazole
dimethyl
methyl
pyridyl
Prior art date
Application number
SI9800196A
Other languages
English (en)
Slovenian (sl)
Inventor
MILA� Nata�a HAFNER
Darja Jereb
Original Assignee
LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20432301&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI20019(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. filed Critical LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.
Priority to SI9800196A priority Critical patent/SI20019A/sl
Priority to RU2001103900/04A priority patent/RU2197486C2/ru
Priority to CZ2001123A priority patent/CZ293653B6/cs
Priority to HU0102523A priority patent/HUP0102523A2/hu
Priority to DE69901307T priority patent/DE69901307D1/de
Priority to PCT/SI1999/000020 priority patent/WO2000002876A1/en
Priority to SI9930057T priority patent/SI1095037T2/sl
Priority to NZ509000A priority patent/NZ509000A/en
Priority to PL345543A priority patent/PL202167B1/pl
Priority to AU46714/99A priority patent/AU4671499A/en
Priority to US09/463,651 priority patent/US6268502B1/en
Priority to SK25-2001A priority patent/SK286432B6/sk
Priority to EP99930107A priority patent/EP1095037B2/de
Priority to AT99930107T priority patent/ATE216382T1/de
Publication of SI20019A publication Critical patent/SI20019A/sl
Priority to US09/919,068 priority patent/US20020007069A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B41/00—Formation or introduction of functional groups containing oxygen
    • C07B41/06—Formation or introduction of functional groups containing oxygen of carbonyl groups

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI9800196A 1998-07-13 1998-07-13 Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola SI20019A (sl)

Priority Applications (15)

Application Number Priority Date Filing Date Title
SI9800196A SI20019A (sl) 1998-07-13 1998-07-13 Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola
AT99930107T ATE216382T1 (de) 1998-07-13 1999-07-12 Verfahren zur herstellung von 5-methoxy-2-((4- methoxy-3,5-dimethyl-2-pyrydyl)methyl)sulfinyl- h-benzimidazol
SI9930057T SI1095037T2 (sl) 1998-07-13 1999-07-12 Postopek za pripravo 5-metoksi-2-((4-metoksi-3,5-dimetil-2-piridil)metil)sulfinil-1H- benzimidazola
PL345543A PL202167B1 (pl) 1998-07-13 1999-07-12 Ulepszony sposób wytwarzania 5-metoksy-2-[(4-metoksy-3,5-dimetylo-2-pirydylo)metylo]sulfinylo-1H-benzimidazolu
HU0102523A HUP0102523A2 (hu) 1998-07-13 1999-07-12 Javított eljárás 5-metoxi-2-[(4-metoxi-3,5-dimetil-2-piridil)-metil]-szulfinil-1H-benzimidazol előállítására
DE69901307T DE69901307D1 (de) 1998-07-13 1999-07-12 Verfahren zur herstellung von 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyrydyl)methyl]sulfinyl-1h-benzimidazol
PCT/SI1999/000020 WO2000002876A1 (en) 1998-07-13 1999-07-12 Improved process of synthesis of 5-methoxy- 2-[(4-methoxy- 3,5-dimethyl- 2-pyridyl)methyl]sulfinyl-1h-benzimidazole
RU2001103900/04A RU2197486C2 (ru) 1998-07-13 1999-07-12 Усовершенствованный способ синтеза 5-метокси-2-[(4-метокси-3,5-диметил-2-пиридил)метил]сульфинил-1н-бензимидазола
NZ509000A NZ509000A (en) 1998-07-13 1999-07-12 A process of synthesis of 5-methoxy-2-[(4-methoxy- 3,5-dimethyl- 2-pyridyl)methyl]sulfinyl-1H-benzimidazole using ethyl acetate as a solvent
CZ2001123A CZ293653B6 (cs) 1998-07-13 1999-07-12 Zlepšený způsob syntézy 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl-1H-benzimidazolu
AU46714/99A AU4671499A (en) 1998-07-13 1999-07-12 Improved process of synthesis of 5-methoxy- 2-((4-methoxy- 3,5-dimethyl- 2-pyridyl)methyl)sulfinyl-1h-benzimidazole
US09/463,651 US6268502B1 (en) 1998-07-13 1999-07-12 Process of synthesis of 5-methoxy- 2-[(4-methoxy-3,5-dimethy-2-pyridyl)methyl]sulfiny-1h-benzimidazole
SK25-2001A SK286432B6 (sk) 1998-07-13 1999-07-12 Spôsob syntézy 5-metoxy-2-[(4-metoxy-3,5-dimetyl-2- pyridyl)metyl]sulfinyl-1H-benzimidazolu
EP99930107A EP1095037B2 (de) 1998-07-13 1999-07-12 Verfahren zur herstellung von 5-methoxy-2-¬(4-methoxy-3,5-dimethyl-2-pyrydyl)methyl|sulfinyl-1h-benzimidazol
US09/919,068 US20020007069A1 (en) 1998-07-13 2001-07-30 Process of synthesis of 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl] sulfinyl-1 H-benzimidazole

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI9800196A SI20019A (sl) 1998-07-13 1998-07-13 Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola

Publications (1)

Publication Number Publication Date
SI20019A true SI20019A (sl) 2000-02-29

Family

ID=20432301

Family Applications (2)

Application Number Title Priority Date Filing Date
SI9800196A SI20019A (sl) 1998-07-13 1998-07-13 Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola
SI9930057T SI1095037T2 (sl) 1998-07-13 1999-07-12 Postopek za pripravo 5-metoksi-2-((4-metoksi-3,5-dimetil-2-piridil)metil)sulfinil-1H- benzimidazola

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI9930057T SI1095037T2 (sl) 1998-07-13 1999-07-12 Postopek za pripravo 5-metoksi-2-((4-metoksi-3,5-dimetil-2-piridil)metil)sulfinil-1H- benzimidazola

Country Status (13)

Country Link
US (2) US6268502B1 (de)
EP (1) EP1095037B2 (de)
AT (1) ATE216382T1 (de)
AU (1) AU4671499A (de)
CZ (1) CZ293653B6 (de)
DE (1) DE69901307D1 (de)
HU (1) HUP0102523A2 (de)
NZ (1) NZ509000A (de)
PL (1) PL202167B1 (de)
RU (1) RU2197486C2 (de)
SI (2) SI20019A (de)
SK (1) SK286432B6 (de)
WO (1) WO2000002876A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19951960C2 (de) * 1999-10-28 2002-06-27 Gruenenthal Gmbh Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
CZ20032351A3 (cs) * 2001-02-02 2004-08-18 Tevaápharmaceuticaláindustriesáltd Způsob výroby substituovaných @@}@@pyridylmethylB sulfinyl @�H@benzimidazolů
SI20875A (sl) * 2001-04-25 2002-10-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristalna oblika omeprazola
HU230155B1 (hu) * 2001-07-16 2015-09-28 Janssen Pharmaceutica N.V. Javított eljárás benzimidazol típusú vegyületek előállítására
KR100873419B1 (ko) * 2002-06-18 2008-12-11 페어차일드코리아반도체 주식회사 높은 항복 전압, 낮은 온 저항 및 작은 스위칭 손실을갖는 전력용 반도체 소자
EP1764364A1 (de) * 2002-08-21 2007-03-21 Teva Pharmaceutical Industries Ltd Eine Methode zur Reinigung von Lansoprazol
EP1501824B1 (de) * 2002-08-21 2007-10-10 Teva Pharmaceutical Industries Ltd Verfahren zur aufreinigung von lanzoprazol
SE0203092D0 (en) 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound
EP1743893A1 (de) * 2002-11-18 2007-01-17 Teva Pharmaceutical Industries Ltd. Stabiles Lansoprazol, enthaltend mehr als 500 ppm bis zu 3000 ppm Wasser und mehr als 200 ppm bis zu 5000 ppm Alkohol
AU2003294405A1 (en) * 2002-11-18 2004-06-15 Teva Pharmaceutical Industries Ltd. Stable lansoprazole containing more than 500 ppm, up to about 3,000 ppm water and more than 200 ppm, up to about 5,000 ppm alcohol
CA2515130A1 (en) * 2003-02-05 2004-08-26 Teva Pharmaceutical Industries Ltd. Method of stabilizing lansoprazole
WO2006040635A1 (en) * 2004-10-11 2006-04-20 Ranbaxy Laboratories Limited Processes for the preparation of substituted sulfoxides
EP1801110A1 (de) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Argininsalz des Esomeprazols
RU2339631C1 (ru) * 2007-04-12 2008-11-27 Новосибирский институт органической химии им. Н.Н. Ворожцова СО РАН (НИОХ СО РАН) Способ получения эзомепразола

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
SE9002043D0 (sv) * 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
SE521100C2 (sv) * 1995-12-15 2003-09-30 Astra Ab Förfarande för framställning av en bensimidazolförening
SE510666C2 (sv) * 1996-12-20 1999-06-14 Astra Ab Nya Kristallmodifikationer
UA72748C2 (en) * 1998-11-10 2005-04-15 Astrazeneca Ab A novel crystalline form of omeprazole

Also Published As

Publication number Publication date
ATE216382T1 (de) 2002-05-15
PL202167B1 (pl) 2009-06-30
PL345543A1 (en) 2001-12-17
CZ2001123A3 (en) 2001-05-16
EP1095037A1 (de) 2001-05-02
EP1095037B2 (de) 2007-08-08
SI1095037T2 (sl) 2007-10-31
SK252001A3 (en) 2001-07-10
EP1095037B1 (de) 2002-04-17
US20020007069A1 (en) 2002-01-17
SK286432B6 (sk) 2008-10-07
DE69901307D1 (de) 2002-05-23
WO2000002876A1 (en) 2000-01-20
RU2197486C2 (ru) 2003-01-27
CZ293653B6 (cs) 2004-06-16
NZ509000A (en) 2001-12-21
US6268502B1 (en) 2001-07-31
AU4671499A (en) 2000-02-01
HUP0102523A2 (hu) 2001-11-28
SI1095037T1 (en) 2002-08-31

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Effective date: 20080814