SI1791533T1 - Transdermalni terapevtski sistem z adhezivno plastjo, postopek za silikoniziranje hrbtne plasti sistema in uporaba hrbtne plasti - Google Patents

Transdermalni terapevtski sistem z adhezivno plastjo, postopek za silikoniziranje hrbtne plasti sistema in uporaba hrbtne plasti

Info

Publication number
SI1791533T1
SI1791533T1 SI200531700T SI200531700T SI1791533T1 SI 1791533 T1 SI1791533 T1 SI 1791533T1 SI 200531700 T SI200531700 T SI 200531700T SI 200531700 T SI200531700 T SI 200531700T SI 1791533 T1 SI1791533 T1 SI 1791533T1
Authority
SI
Slovenia
Prior art keywords
back layer
siliconizing
transdermal therapeutic
layer
adhesive layer
Prior art date
Application number
SI200531700T
Other languages
English (en)
Slovenian (sl)
Inventor
Walter Muller
Johannes Leonhard
Original Assignee
Lts Lohmann Therapie-Systeme Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lts Lohmann Therapie-Systeme Ag filed Critical Lts Lohmann Therapie-Systeme Ag
Publication of SI1791533T1 publication Critical patent/SI1791533T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/023—Adhesive bandages or dressings wound covering film layers without a fluid retention layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer
    • A61F13/0253—Adhesive bandages or dressings characterised by the skin-adhering layer characterized by the adhesive material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/34—Silicon-containing compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
SI200531700T 2004-09-13 2005-09-06 Transdermalni terapevtski sistem z adhezivno plastjo, postopek za silikoniziranje hrbtne plasti sistema in uporaba hrbtne plasti SI1791533T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004044578A DE102004044578A1 (de) 2004-09-13 2004-09-13 Transdermales therapeutisches System mit einer Haftschicht, Verfahren zum Silikonisieren einer Rückschicht des Systems und Verwendung der Rückschicht
PCT/EP2005/009547 WO2006029740A2 (de) 2004-09-13 2005-09-06 Transdermales therapeutisches system mit einer haftschicht, verfahren zum silikonisieren einer rückschicht des systems und verwendung der rückschicht
EP05777179A EP1791533B1 (de) 2004-09-13 2005-09-06 Transdermales therapeutisches system mit einer haftschicht, verfahren zum silikonisieren einer rückschicht des systems und verwendung der rückschicht

Publications (1)

Publication Number Publication Date
SI1791533T1 true SI1791533T1 (sl) 2013-05-31

Family

ID=35911201

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200531700T SI1791533T1 (sl) 2004-09-13 2005-09-06 Transdermalni terapevtski sistem z adhezivno plastjo, postopek za silikoniziranje hrbtne plasti sistema in uporaba hrbtne plasti
SI200532168T SI2529732T1 (sl) 2004-09-13 2005-09-06 Transdermalni terapevtski sistem z adhezivno plastjo, postopek za silikoniziranje hrbtne plasti sistema in uporaba hrbtne plasti

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200532168T SI2529732T1 (sl) 2004-09-13 2005-09-06 Transdermalni terapevtski sistem z adhezivno plastjo, postopek za silikoniziranje hrbtne plasti sistema in uporaba hrbtne plasti

Country Status (25)

Country Link
US (2) US9226903B2 (enExample)
EP (2) EP1791533B1 (enExample)
JP (1) JP4921371B2 (enExample)
KR (1) KR101297903B1 (enExample)
CN (2) CN101018545A (enExample)
AR (1) AR050621A1 (enExample)
AU (1) AU2005284436B2 (enExample)
BR (1) BRPI0515270B8 (enExample)
CA (1) CA2578534C (enExample)
CY (2) CY1113997T1 (enExample)
DE (1) DE102004044578A1 (enExample)
DK (2) DK2529732T3 (enExample)
ES (2) ES2634439T3 (enExample)
IL (1) IL181337A (enExample)
LT (1) LT2529732T (enExample)
MX (1) MX2007002966A (enExample)
NZ (1) NZ553485A (enExample)
PH (1) PH12012501165A1 (enExample)
PL (2) PL2529732T3 (enExample)
PT (2) PT1791533E (enExample)
RU (1) RU2398567C2 (enExample)
SI (2) SI1791533T1 (enExample)
TW (1) TWI383811B (enExample)
WO (1) WO2006029740A2 (enExample)
ZA (1) ZA200701138B (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070191815A1 (en) 2004-09-13 2007-08-16 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
US8518926B2 (en) * 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
US20070259930A1 (en) * 2006-04-10 2007-11-08 Knopp Neurosciences, Inc. Compositions and methods of using r(+) pramipexole
CN102160865A (zh) 2006-05-16 2011-08-24 诺普神经科学股份有限公司 R(+)和s(-)普拉克索的组合物以及使用该组合物的方法
US8524695B2 (en) * 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
US8519148B2 (en) 2007-03-14 2013-08-27 Knopp Neurosciences, Inc. Synthesis of chirally purified substituted benzothiazole diamines
JP2012500283A (ja) 2008-08-19 2012-01-05 ノップ ニューロサイエンシーズ、インク． （ｒ）−プラミペキソールを使用した組成物並びにその方法
AU2010262970A1 (en) * 2009-06-19 2012-01-12 Knopp Neurosciences, Inc. Compositions and methods for treating amyotrophic lateral sclerosis
US20130017259A1 (en) 2011-07-06 2013-01-17 The Parkinson's Institute Compositions and Methods for Treatment of Symptoms in Parkinson's Disease Patients
WO2013096816A1 (en) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
KR101850161B1 (ko) 2012-05-17 2018-04-19 도레이첨단소재 주식회사 경피흡수제에 적합하게 사용될 수 있는 릴리즈 라이너 및 그 제조방법
US10105487B2 (en) 2013-01-24 2018-10-23 Chrono Therapeutics Inc. Optimized bio-synchronous bioactive agent delivery system
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
RS67279B1 (sr) 2013-07-12 2025-10-31 Areteia Therapeutics Inc Lečenje povišenih nivoa eozinofila i/ili bazofila
EP3033081B1 (en) 2013-08-13 2021-05-12 Knopp Biosciences LLC Compositions and methods for treating chronic urticaria
ES2813674T3 (es) 2013-08-13 2021-03-24 Knopp Biosciences Llc Composiciones y métodos para el tratamiento de trastornos de células plasmáticas y trastornos prolinfocíticos de células b
JP2016537039A (ja) * 2013-09-24 2016-12-01 ゾディアック コーティング 医療用接着性材料の製造方法
EP2921184A1 (de) * 2014-03-19 2015-09-23 LTS LOHMANN Therapie-Systeme AG Überpflaster mit verbesserter Verträglichkeit und einer langen Haftungsdauer und Verfahren zu seiner Herstellung
JP2018511355A (ja) 2015-01-28 2018-04-26 クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 薬剤送達方法及びシステム
AU2016228779A1 (en) 2015-03-12 2017-09-07 Chrono Therapeutics Inc. Craving input and support system
WO2018129304A1 (en) 2017-01-06 2018-07-12 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
AU2019279884B2 (en) 2018-05-29 2025-01-30 Morningside Venture Investments Limited Drug delivery methods and systems
JP2022507660A (ja) 2018-11-16 2022-01-18 モーニングサイド ベンチャー インベストメンツ リミテッド 温度によって調節される経皮薬剤送達システム

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3131734A1 (de) * 1981-08-11 1983-02-24 Bayer Ag, 5090 Leverkusen Hitzehaertbare organopolysiloxan-mischungen
US4806341A (en) * 1985-02-25 1989-02-21 Rutgers, The State University Of New Jersey Transdermal absorption dosage unit for narcotic analgesics and antagonists and process for administration
FR2619388A1 (fr) * 1987-08-14 1989-02-17 Rhone Poulenc Chimie Article stratifie souple pour adhesif de transfert
DE19738643C2 (de) * 1997-09-04 2001-10-04 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit dem Wirkstoff Scopolaminbase und Verfahren zu seiner Herstellung
ATE242301T1 (de) * 1997-09-16 2003-06-15 Teijin Ltd Gelartiges druckempfindliches klebemittel, klebstoff und medizinische klebrige zusammensetzung welche dieses enthält
CA2374930C (en) * 1999-07-02 2008-08-05 Lts Lohmann Therapie-Systeme Ag Microreservoir system based on polysiloxanes and ambiphilic solvents
US6261595B1 (en) 2000-02-29 2001-07-17 Zars, Inc. Transdermal drug patch with attached pocket for controlled heating device
DE10015783C2 (de) * 2000-03-30 2003-12-04 Lohmann Therapie Syst Lts Transdermales therapeutisches System zur Abgabe von Lerisetron und seine Verwendung
US6488599B2 (en) * 2000-06-06 2002-12-03 Lifetime Products, Inc. System and method for basketball goal height adjustment
GB0017468D0 (en) * 2000-07-18 2000-08-30 Dow Corning Silicone release coating compositions
DE10060550C1 (de) 2000-12-06 2002-04-18 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit dem Wirkstoff Oxybutynin und Verfahren zur Herstellung Oxybutynin enthaltender Wirkstoffschichten
US20030224090A1 (en) * 2002-02-11 2003-12-04 Edizone, Lc Snacks of orally soluble edible films
ITRM20020378A1 (it) 2002-07-15 2004-01-15 Euro 3 S R L Dispositivo iniettore ipodermico attivabile.
JP2006517124A (ja) * 2003-02-07 2006-07-20 エルテーエス ローマン テラピー−ジステーメ アーゲー 活性物質の浸透を促進するために熱を用いるのに適した経皮治療システム及びその使用
EP1613297B1 (en) 2003-04-14 2007-06-06 LTS Lohmann Therapie-Systeme AG Therapeutic patch with polysiloxane matrix comprising capsaicin
US7407709B2 (en) * 2003-12-22 2008-08-05 3M Innovative Properties Company Silicone pressure sensitive adhesive and articles
CN1918256B (zh) * 2003-12-23 2011-11-16 Ge拜尔硅股份有限公司 具有改进的表面性质的可固化硅氧烷组合物
US20050282977A1 (en) * 2004-06-17 2005-12-22 Emil Stempel Cross-linked gel and pressure sensitive adhesive blend, and skin-attachable products using the same

Also Published As

Publication number Publication date
BRPI0515270B1 (pt) 2018-11-06
US9226903B2 (en) 2016-01-05
PL2529732T3 (pl) 2017-12-29
DK1791533T3 (da) 2013-06-10
BRPI0515270B8 (pt) 2021-07-27
CY1113997T1 (el) 2016-07-27
ES2634439T3 (es) 2017-09-27
CN101018545A (zh) 2007-08-15
JP2008512411A (ja) 2008-04-24
WO2006029740A3 (de) 2006-06-22
AR050621A1 (es) 2006-11-08
SI2529732T1 (sl) 2017-10-30
DE102004044578A1 (de) 2006-03-30
EP2529732A1 (de) 2012-12-05
PT2529732T (pt) 2017-07-17
PL1791533T3 (pl) 2013-08-30
CA2578534A1 (en) 2006-03-23
AU2005284436B2 (en) 2011-02-17
PT1791533E (pt) 2013-05-07
US20080026043A1 (en) 2008-01-31
EP1791533A2 (de) 2007-06-06
AU2005284436A1 (en) 2006-03-23
PH12012501165A1 (en) 2013-09-02
MX2007002966A (es) 2007-04-27
TW200621319A (en) 2006-07-01
ES2406958T3 (es) 2013-06-10
RU2398567C2 (ru) 2010-09-10
CN102755305A (zh) 2012-10-31
BRPI0515270A (pt) 2008-07-15
TWI383811B (zh) 2013-02-01
RU2007113674A (ru) 2008-10-27
KR101297903B1 (ko) 2013-08-22
IL181337A0 (en) 2007-07-04
EP1791533B1 (de) 2013-03-06
LT2529732T (lt) 2017-09-11
EP2529732B1 (de) 2017-06-21
DK2529732T3 (en) 2017-09-18
CA2578534C (en) 2013-03-19
CY1120228T1 (el) 2018-12-12
WO2006029740A2 (de) 2006-03-23
KR20070053244A (ko) 2007-05-23
ZA200701138B (en) 2008-08-27
US10034841B2 (en) 2018-07-31
US20160074336A1 (en) 2016-03-17
IL181337A (en) 2014-09-30
NZ553485A (en) 2010-06-25
JP4921371B2 (ja) 2012-04-25

Similar Documents

Publication Publication Date Title
ZA200701138B (en) Transdermal therapeutic system comprising an adhesive layer method for siliconizing the back layer of the system and use of said back layer
IL179643A0 (en) Medical adhesive and methods of tissue adhesion
IL179515A0 (en) Method of administering and using vegf inhibitors for the treatment of human cancer
IL181892A0 (en) Method and system for combined ultrasound treatment
EP2091588A4 (en) CARDIAL DEVICE AND USE METHOD THEREFOR
IL190332A0 (en) Human antibodies against il13 and therapeutic uses
EP1734866A4 (en) ULTRASONIC INTRACAVITARY MEDICAL SYSTEM AND METHOD THEREOF
GB0821524D0 (en) Lumen-traveling biological interface device and method of use
EP1758532A4 (en) TOPICAL PREPARATION AND METHOD FOR TRANSDERMAL DELIVERY AND LOCATION OF THERAPEUTIC AGENTS
EP1789114A4 (en) CURVED CATHETER TERMINAL AND APPLICATION METHOD THEREFOR
GB0614886D0 (en) Pharmaceutical composition and method of the transdermal delivery of magnesium
EP1797186A4 (en) EXPRESSION SYSTEM, COMPONENTS OF THIS EXPRESSION SYSTEM, AND METHODS OF USE
EP1796676A4 (en) TRANSDERMALE ADMINISTRATION OF PHYCOTOXINES
DK1848415T3 (da) Kombinationsterapi med glatirameracetat og rasagilin til behandling af multipel sklerose
EP1838288A4 (en) THERAPEUTIC MATERIALS AND METHODS
EP1736173A4 (en) MEANS FOR THE TREATMENT OF TISSUE DAMAGE AND THERAPEUTIC PROCEDURE
IL192932A0 (en) Medical adhesive and methods of tissue adhesion
EP1939262A4 (en) FASTENING METHOD AND ADHESIVE ADHESIVE FOR USE IN FASTENING
IL179675A0 (en) System and method for transdermal delivery of an anticoagulant
IL178970A0 (en) Haplotype markers and methods of using the same to determine response to treatment
IL170045A (en) Transdermal therapeutic system suitable for heat application for promoting the permeation of active substances and the use thereof
ZA200802541B (en) Human antibodies against IL13 and therapeutic uses
HK1102911A (en) Lipid-extracted therapeutic vaccine and method of use
SE0403168D0 (sv) Reference system for stereotactic procedings and method for use of the reference system
GB0400131D0 (en) Method for applying activator/accelerator for use with cyanoacrylate adhesive