JP2008512411A - 接着剤層を含む経皮治療システム、このシステムの支持層をシリコン処理する方法およびこの支持層の使用 - Google Patents
接着剤層を含む経皮治療システム、このシステムの支持層をシリコン処理する方法およびこの支持層の使用 Download PDFInfo
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Classifications
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- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Abstract
【選択図】 図1
Description
Claims (15)
- 支持体層(1)と、支持体層(1)と接触していて、シリコーン接着剤を含むポリマー層(2)と、ポリマー層(2)と接触する取り外し可能な保護層(3)とを含み、支持体層(1)の接触面がシリコン処理によって得た接着剤層(4)を備えている経皮治療システム(5)。
- 接着剤層(4)がオルガノポリシロキサン層である、請求項1に記載の経皮治療システム。
- 接着剤層(4)がビニル基を含有するオルガノシロキサン類とSi−H基を含有するオルガノポリシロキサン類とを含む、請求項1に記載の経皮治療システム。
- 支持体層(1)が、ポリエステル類(特にポリエチレン・テレフタレート)、ポリプロピレン、ポリエチレン、ポリウレタン、ポリエステルと組み合わせたエチレン酢酸ビニル層、ポリ塩化ビニリデン、ポリアラミド類およびエチレン−(メタ)アクリレート・コポリマーからなる群から選択されるポリマーフィルム材である、請求項1に記載の経皮治療システム。
- 支持体層(1)が、エチルセルロース、酢酸セルロース、セロハン、紙、金属−ポリマー複合材およびエチレン−酢酸ビニル・コポリマーからなる群から選択される材料から構成される、請求項1に記載の経皮治療システム。
- ポリマー層(2)が、シリコーン・ポリマーおよび樹脂をベースとしたシリコーン接着剤を含む、請求項1に記載の経皮治療システム。
- シリコーン接着剤が、ポリシロキサン類およびポリシロキサン混合物類からなる群から選択される、請求項1に記載の経皮治療システム。
- ポリマー層(2)が、両親和性溶媒の溶液中にある活性医薬成分のためのマイクロ・リザーバを含む、請求項1に記載の経皮治療システム。
- 両親和性溶媒が、1,3―ブタンジオール、ジエチレングリコール・モノエチル・エーテル、ジエチレングリコール・ジメチル・エーテル、ジプロピレングリコール、プロピレングリコール、テトラヒドロフルフリルアルコール、ジエチレングリコールモノブチルエーテル、トリエチレングリコールおよびジエチレングリコールのカルボン酸エステル類、ポリオキシエチレン化した6〜18個の炭素原子を持つ脂肪アルコール類、ならびにこれらの混合物からなる群から選択される、請求項1に記載の経皮治療システム。
- 経皮治療システムで使用される支持体層を製造する方法であって、マイクロ・リザーバを備えているポリマー層と接触させようとしている支持体層の表面をシリコン処理することを含む方法。
- ビニル基を含有するオルガノポリシロキサン類および官能性Si−H基を含有するオルガノポリシロキサン類が混合され、触媒の存在下で支持体層の表面がこの混合物でコーティングされる、請求項10に記載の方法。
- 支持体層上にしっかり固定したオルガノポリシロキサン層が形成されるまで支持体層のコーティング表面を熱処理する、請求項11に記載の方法。
- 経皮治療システムにおけるシリコン処理された支持体層の使用。
- オルガノポリシロキサン層がシリコン処理によってその上にしっかりと固定される、請求項13に記載の支持体層の使用。
- マイクロ・リザーバと、そこに溶解した少なくとも1つの活性成分と、また少なくとも1つのシリコーン接着剤とを含むシステムのポリマー層がオルガノポリシロキサン層に自己粘着的に接着している、請求項14に記載の支持体層の使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004044578.8 | 2004-09-13 | ||
DE102004044578A DE102004044578A1 (de) | 2004-09-13 | 2004-09-13 | Transdermales therapeutisches System mit einer Haftschicht, Verfahren zum Silikonisieren einer Rückschicht des Systems und Verwendung der Rückschicht |
PCT/EP2005/009547 WO2006029740A2 (de) | 2004-09-13 | 2005-09-06 | Transdermales therapeutisches system mit einer haftschicht, verfahren zum silikonisieren einer rückschicht des systems und verwendung der rückschicht |
Publications (3)
Publication Number | Publication Date |
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JP2008512411A true JP2008512411A (ja) | 2008-04-24 |
JP2008512411A5 JP2008512411A5 (ja) | 2008-10-09 |
JP4921371B2 JP4921371B2 (ja) | 2012-04-25 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2007530634A Active JP4921371B2 (ja) | 2004-09-13 | 2005-09-06 | 接着剤層を含む経皮治療システム、このシステムの支持層をシリコン処理する方法およびこの支持層の使用 |
Country Status (24)
Country | Link |
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US (2) | US9226903B2 (ja) |
EP (2) | EP1791533B1 (ja) |
JP (1) | JP4921371B2 (ja) |
KR (1) | KR101297903B1 (ja) |
CN (2) | CN102755305A (ja) |
AR (1) | AR050621A1 (ja) |
AU (1) | AU2005284436B2 (ja) |
BR (1) | BRPI0515270B8 (ja) |
CA (1) | CA2578534C (ja) |
CY (2) | CY1113997T1 (ja) |
DE (1) | DE102004044578A1 (ja) |
DK (2) | DK2529732T3 (ja) |
ES (2) | ES2634439T3 (ja) |
IL (1) | IL181337A (ja) |
LT (1) | LT2529732T (ja) |
MX (1) | MX2007002966A (ja) |
NZ (1) | NZ553485A (ja) |
PL (2) | PL1791533T3 (ja) |
PT (2) | PT1791533E (ja) |
RU (1) | RU2398567C2 (ja) |
SI (2) | SI2529732T1 (ja) |
TW (1) | TWI383811B (ja) |
WO (1) | WO2006029740A2 (ja) |
ZA (1) | ZA200701138B (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017511174A (ja) * | 2014-03-19 | 2017-04-20 | エルテーエス ローマン テラピー−ジステーメ アーゲー | 改善された適合性(compatibility)および長い接着期間を有するオーバーパッチ(over−patch)、ならびに前記オーバーパッチを製造するための方法 |
KR101850161B1 (ko) | 2012-05-17 | 2018-04-19 | 도레이첨단소재 주식회사 | 경피흡수제에 적합하게 사용될 수 있는 릴리즈 라이너 및 그 제조방법 |
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US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
US7780981B2 (en) | 2004-09-13 | 2010-08-24 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery |
US20070259930A1 (en) * | 2006-04-10 | 2007-11-08 | Knopp Neurosciences, Inc. | Compositions and methods of using r(+) pramipexole |
US8518926B2 (en) * | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
PL2026803T3 (pl) * | 2006-05-16 | 2012-05-31 | Knopp Neurosciences Inc | Kompozycje R(+) i S(-) pramipeksolu i sposoby ich zastosowania |
US8524695B2 (en) * | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
CA2681110A1 (en) * | 2007-03-14 | 2008-09-18 | Knopp Neurosciences, Inc. | Synthesis of chirally purified substituted benzothiazole diamines |
CA2734491A1 (en) * | 2008-08-19 | 2010-02-25 | Knopp Neurosciences, Inc. | Compositions and methods of using (r)-pramipexole |
EP2442655A4 (en) * | 2009-06-19 | 2013-04-03 | Knopp Neurosciences Inc | COMPOSITIONS AND METHODS FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
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WO2013096816A1 (en) | 2011-12-22 | 2013-06-27 | Biogen Idec Ma Inc. | Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
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