SI1737962T1 - Univerzalni signalni peptid GAS1 - Google Patents

Univerzalni signalni peptid GAS1

Info

Publication number
SI1737962T1
SI1737962T1 SI200531167T SI200531167T SI1737962T1 SI 1737962 T1 SI1737962 T1 SI 1737962T1 SI 200531167 T SI200531167 T SI 200531167T SI 200531167 T SI200531167 T SI 200531167T SI 1737962 T1 SI1737962 T1 SI 1737962T1
Authority
SI
Slovenia
Prior art keywords
heavy chain
chain variable
variable domain
immunoglobulin heavy
domain polypeptide
Prior art date
Application number
SI200531167T
Other languages
English (en)
Slovenian (sl)
Inventor
Wildt Rudolph M T De
Original Assignee
Domantis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Domantis Ltd filed Critical Domantis Ltd
Publication of SI1737962T1 publication Critical patent/SI1737962T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/055—Fusion polypeptide containing a localisation/targetting motif containing a signal for localisation to secretory granules (for exocytosis)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Gas Separation By Absorption (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SI200531167T 2004-03-24 2005-03-24 Univerzalni signalni peptid GAS1 SI1737962T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55576404P 2004-03-24 2004-03-24
PCT/GB2005/001180 WO2005093074A1 (en) 2004-03-24 2005-03-24 Gas1 universal leader
EP05729650A EP1737962B1 (en) 2004-03-24 2005-03-24 Gas1 universal leader

Publications (1)

Publication Number Publication Date
SI1737962T1 true SI1737962T1 (sl) 2011-01-31

Family

ID=34963448

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200531167T SI1737962T1 (sl) 2004-03-24 2005-03-24 Univerzalni signalni peptid GAS1

Country Status (11)

Country Link
US (1) US7846721B2 (pl)
EP (2) EP2172553A1 (pl)
AT (1) ATE479760T1 (pl)
CY (1) CY1111063T1 (pl)
DE (1) DE602005023291D1 (pl)
DK (1) DK1737962T3 (pl)
ES (1) ES2351509T3 (pl)
PL (1) PL1737962T3 (pl)
PT (1) PT1737962E (pl)
SI (1) SI1737962T1 (pl)
WO (1) WO2005093074A1 (pl)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101128487B (zh) 2004-12-02 2012-10-10 杜门蒂斯有限公司 靶向血清白蛋白和glp-1或pyy的双特异性结构域抗体
CA2688434A1 (en) 2007-06-06 2008-12-11 Domantis Limited Polypeptides, antibody variable domains and antagonists
SG194383A1 (en) 2008-12-05 2013-11-29 Glaxo Group Ltd Methods for selecting protease resistant polypeptides
PE20120170A1 (es) 2009-02-19 2012-03-21 Glaxo Group Ltd Variantes de union a anti-albumina de suero mejoradas
EP3330287B1 (en) 2009-02-19 2019-12-18 Glaxo Group Limited Improved anti-serum albumin binding variants
WO2010094720A2 (en) 2009-02-19 2010-08-26 Glaxo Group Limited Improved anti-tnfr1 polypeptides, antibody variable domains & antagonists
CA2768460A1 (en) 2009-07-16 2011-01-20 Glaxo Group Limited Antagonists, uses & methods for partially inhibiting tnfr1
BR112012001681A2 (pt) 2009-07-16 2019-09-24 Graxo Group Ltd domínios variáveis de ligação de anti-albumina sérica aperfeiçoados
KR20120063475A (ko) 2009-07-29 2012-06-15 글락소 그룹 리미티드 항-ｔｇｆ-베타 수용체 타입 ⅱ 단일 도메인 항체
EP2523686A2 (en) 2010-01-14 2012-11-21 Glaxo Group Limited Liver targeting domain antibodies
WO2011131659A2 (en) 2010-04-21 2011-10-27 Glaxo Group Limited Binding domains
JP2013529080A (ja) 2010-05-20 2013-07-18 グラクソ グループ リミテッド 改良された抗血清アルブミン結合変異体
US20120077191A1 (en) * 2010-08-11 2012-03-29 Celula, Inc. Genotyping dna
US9012609B2 (en) 2010-08-13 2015-04-21 Glaxosmithkline Intellectual Property Development Limited Anti-serum albumin binding variants
BR112013003899A2 (pt) 2010-08-20 2016-06-07 Glaxosmithkline Ip Dev Ltd domínio variável único da imunoglobina anti-albumina sérica (sa), ligando multiespecífico, proteína de fusão, composição, ácido nucleico, vetor, célula hospedeira isolada, e, método de tratar ou previnir uma doença ou distúrbio em um paciente
ES2627299T3 (es) 2011-01-06 2017-07-27 Glaxo Group Limited Ligandos que se unen al receptor II del TGF-beta
US20130310281A1 (en) 2011-02-02 2013-11-21 Glaxo Group Limited Novel antigen binding proteins
US9475879B2 (en) 2011-04-21 2016-10-25 Bristol-Myers Squibb Company Antibody polypeptides that antagonize CD40
CN110042114B (zh) * 2012-07-05 2024-09-10 弗·哈夫曼-拉罗切有限公司 表达和分泌系统
WO2015134988A1 (en) 2014-03-07 2015-09-11 Bristol-Myers Squibb Company Method of using antibody polypeptides that antagonize cd40 to treat ibd

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9400600A (pt) * 1994-02-17 1995-10-24 Finep Financiadora De Estudos Processos para produção de uma protéina recombinante e/ou de glicosilfosfatidilinositol (GPI) em células de microorganismos eucariontes e para a obtenção de leveduras de S. cerevisae; célula de levedura sequência de nucleotídios; meio de cultura; medicamento ou vacina; e produto dos ditos processos
US6555310B1 (en) * 1997-04-04 2003-04-29 Biosite Diagnostics, Inc. Polyclonal libraries
US7094579B2 (en) * 2002-02-13 2006-08-22 Xoma Technology Ltd. Eukaryotic signal sequences for prokaryotic expression

Also Published As

Publication number Publication date
EP1737962A1 (en) 2007-01-03
DK1737962T3 (da) 2010-12-13
WO2005093074A1 (en) 2005-10-06
PL1737962T3 (pl) 2011-02-28
EP1737962B1 (en) 2010-09-01
DE602005023291D1 (de) 2010-10-14
PT1737962E (pt) 2010-12-03
EP2172553A1 (en) 2010-04-07
US20070026462A1 (en) 2007-02-01
US7846721B2 (en) 2010-12-07
ATE479760T1 (de) 2010-09-15
CY1111063T1 (el) 2015-06-11
ES2351509T3 (es) 2011-02-07

Similar Documents

Publication Publication Date Title
SI1737962T1 (sl) Univerzalni signalni peptid GAS1
NZ734307A (en) Antibodies specific for claudin 6 (cldn6)
BRPI0519766A2 (pt) proteases Ácidas féngicas
NZ603037A (en) Fusion constructs and use of same to produce antibodies with increased fc receptor binding affinity and effector function
WO2004099376A3 (en) Assays using amyloid precursor proteins with modified beta-secretase cleavage sites to monitor beta-secretase activity
ATE503009T1 (de) Polypeptide mit lipase-aktivität und diese kodierende polynukleotide
HK1097855A1 (en) Method of detecting probnp with a monoclonal antibody binding to the amino acid 41-46
WO2008005847A3 (en) Method of producing factor viii proteins by recombinant methods
HK1070902A1 (en) Recombinant production of mixtures of antibodies
EP2395092A3 (en) Plants having enhanced yield-related traits and a method for making the same
MX337991B (es) Metodo para detectar cancer.
ATE402267T1 (de) Verfahren zur herstellung von monoklonalen antikörpern
ATE454455T1 (de) Leitsequenzen zur anleitung von polypeptidsekretion und verfahren zur herstellung
ATE424458T1 (de) Eg-vegf nukleinsäuren und polypeptide und verfahren zur deren verwendung
WO2003004622A3 (en) Human secreted proteins
DE502006009060D1 (de) Verfahren zur fermentativen Herstellung von Antikörpern
DK1616878T3 (da) Udskilte og membranspændende polypeptider samt nukleinsyrer kodende for disse
WO2003000865A3 (en) Human secreted proteins
ATE539163T1 (de) Auf der verwendung von mva beruhende impfstoffe
WO2009028531A1 (ja) ドックリンポリペプチドおよびそれを利用した組換え融合タンパク質の精製方法
ATE320484T1 (de) Histone-deacetylase-8 proteine, nukleinsäuren und methoden zur verwendung
WO2007019064A3 (en) ANTI-TNFα ANTIBODIES AND METHODS OF USE
ATE444370T1 (de) Expressionsvektor zur sekretion eines antikörperfragments unter verwendung einer e.coli-signalsequenz sowie verfahren zur massenproduktion des antikörperfragments
WO2006013462A3 (en) Growth factors nsg28, nsg30, and nsg32
WO2008079705A3 (en) Acyl-transferase