SI1149831T1 - Process for the preparation of the mesylate salt trihydrate of 1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol and intermediates useful therefor - Google Patents

Process for the preparation of the mesylate salt trihydrate of 1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol and intermediates useful therefor

Info

Publication number
SI1149831T1
SI1149831T1 SI200130185T SI200130185T SI1149831T1 SI 1149831 T1 SI1149831 T1 SI 1149831T1 SI 200130185 T SI200130185 T SI 200130185T SI 200130185 T SI200130185 T SI 200130185T SI 1149831 T1 SI1149831 T1 SI 1149831T1
Authority
SI
Slovenia
Prior art keywords
phenylpiperidin
hydroxyphenyl
propanol
hydroxy
preparation
Prior art date
Application number
SI200130185T
Other languages
Unknown language ( )
English (en)
Slovenian (sl)
Inventor
Joseph Philip Rainville
Terry Gene Sinay Jr.
Stanley Walter Walinsky
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of SI1149831T1 publication Critical patent/SI1149831T1/

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SI200130185T 2000-04-28 2001-04-24 Process for the preparation of the mesylate salt trihydrate of 1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol and intermediates useful therefor SI1149831T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20041700P 2000-04-28 2000-04-28
EP01303713A EP1149831B1 (en) 2000-04-28 2001-04-24 Process for the preparation of the mesylate salt trihydrate of 1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol and intermediates useful therefor

Publications (1)

Publication Number Publication Date
SI1149831T1 true SI1149831T1 (en) 2005-02-28

Family

ID=22741639

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200130185T SI1149831T1 (en) 2000-04-28 2001-04-24 Process for the preparation of the mesylate salt trihydrate of 1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol and intermediates useful therefor

Country Status (26)

Country Link
US (1) US6570018B2 (ja)
EP (1) EP1149831B1 (ja)
JP (1) JP2001354650A (ja)
KR (1) KR100432841B1 (ja)
CN (1) CN1211366C (ja)
AR (1) AR028377A1 (ja)
AT (1) ATE275130T1 (ja)
AU (1) AU781715B2 (ja)
BR (1) BR0101611A (ja)
CA (1) CA2345286C (ja)
CZ (1) CZ20011472A3 (ja)
DE (1) DE60105221T2 (ja)
DK (1) DK1149831T3 (ja)
ES (1) ES2225425T3 (ja)
HK (1) HK1040514B (ja)
HU (1) HUP0101725A3 (ja)
ID (1) ID30012A (ja)
IL (1) IL142706A0 (ja)
IN (1) IN191534B (ja)
PL (1) PL347299A1 (ja)
PT (1) PT1149831E (ja)
RU (1) RU2192415C1 (ja)
SI (1) SI1149831T1 (ja)
TW (1) TWI222440B (ja)
YU (1) YU27801A (ja)
ZA (1) ZA200103321B (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743921B2 (en) * 2002-01-24 2004-06-01 Dsm Catalytica Pharmaceuticals, Inc. Process for the preparation of nonracemic syn-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol compounds
CN105037221B (zh) * 2015-06-18 2017-05-10 吉林大学珠海学院 一种具有神经保护作用的化合物及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1615861A (zh) 1995-08-11 2005-05-18 美国辉瑞有限公司 （1s，2s）－1－（4－羟基苯基）－2－（4－羟基－4－苯基哌啶－1－基）－1－丙醇甲磺酸盐三水合物
TW450807B (en) * 1995-09-15 2001-08-21 Pfizer Pharmaceutical compositions for treating tinnitus comprising neuroprotective agents

Also Published As

Publication number Publication date
YU27801A (sh) 2003-04-30
IN191534B (ja) 2003-12-06
ATE275130T1 (de) 2004-09-15
AU3889701A (en) 2001-12-13
ZA200103321B (en) 2002-10-24
CN1211366C (zh) 2005-07-20
DE60105221D1 (de) 2004-10-07
RU2192415C1 (ru) 2002-11-10
TWI222440B (en) 2004-10-21
HUP0101725A2 (hu) 2002-02-28
ID30012A (id) 2001-11-01
DE60105221T2 (de) 2005-09-15
CZ20011472A3 (cs) 2001-12-12
HUP0101725A3 (en) 2003-04-28
ES2225425T3 (es) 2005-03-16
CN1322716A (zh) 2001-11-21
AR028377A1 (es) 2003-05-07
PL347299A1 (en) 2001-11-05
CA2345286C (en) 2004-11-09
KR20010098924A (ko) 2001-11-08
EP1149831A1 (en) 2001-10-31
JP2001354650A (ja) 2001-12-25
EP1149831B1 (en) 2004-09-01
CA2345286A1 (en) 2001-10-28
KR100432841B1 (ko) 2004-05-24
AU781715B2 (en) 2005-06-09
HK1040514B (zh) 2005-10-28
HU0101725D0 (en) 2001-07-30
US6570018B2 (en) 2003-05-27
HK1040514A1 (en) 2002-06-14
IL142706A0 (en) 2002-03-10
US20020016466A1 (en) 2002-02-07
DK1149831T3 (da) 2004-12-06
PT1149831E (pt) 2004-11-30
BR0101611A (pt) 2002-01-15

Similar Documents

Publication Publication Date Title
HK1048232A1 (en) Method for improving the skin and coat of pets
HUP0101723A3 (en) Process for the preparation of the meylate salt trihydrate of 1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol and intermediates useful therefor
SI1149831T1 (en) Process for the preparation of the mesylate salt trihydrate of 1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol and intermediates useful therefor
GB9921936D0 (en) Ultrasonic surgical tool
IL133760A0 (en) Composition for the treatment of dandruff
HK1042484A1 (en) Processes for the preparation of (r)-a-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)-4-piperidinemethanol
HUP0001558A3 (en) Process for the preparation of pirlindole hydrochloride
HUP0004503A3 (en) Process for the preparation of paroxetine hydrochloride
AU6481799A (en) Process for the preparation of paroxetine hydrochloride
EP1242362A4 (en) METHOD FOR PRODUCING FLUOXETINE HYDROCHLORIDE
GB9922410D0 (en) Shower head
HUP0202145A3 (en) The use of r(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol for the treatment of sleep disorders
TW501526U (en) Improved structure for hanger of hand tool
HU0004052D0 (en) Improved process for the preparation of 1-(3'-chloro-2-tertier-butylamino)-propiophenone
AU6580800A (en) Process for the preparation of paroxetine hydrochloride
EP1398054A4 (en) METHOD OF ACCELERATING THE IMPROVEMENT OF THE SKIN BARRIER FUNCTION
GB9922409D0 (en) Shower head
AU1396600A (en) Process for the preparation of paroxetine hydrochloride
GB0125119D0 (en) Process of preparing paroxetine and intermediates for use therein
AU2003207409A1 (en) Process for the preparation of nonracemic syn-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol compounds
HRP960445B1 (en) New process for the preparation of ropivacaine hydrochloride monohydrate
TW365846U (en) Improved structure for shower head
GB9912214D0 (en) Head doctor
AU146987S (en) Corner broom head
TW401847U (en) Improved shower head structure