DE60105221D1 - Verfahren zur Herstellung vom Mesylat Salz des Trihydrats des 1-(4-Hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanols und Zwischenprodukte für dieses Verfahren - Google Patents

Verfahren zur Herstellung vom Mesylat Salz des Trihydrats des 1-(4-Hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanols und Zwischenprodukte für dieses Verfahren

Info

Publication number
DE60105221D1
DE60105221D1 DE60105221T DE60105221T DE60105221D1 DE 60105221 D1 DE60105221 D1 DE 60105221D1 DE 60105221 T DE60105221 T DE 60105221T DE 60105221 T DE60105221 T DE 60105221T DE 60105221 D1 DE60105221 D1 DE 60105221D1
Authority
DE
Germany
Prior art keywords
phenylpiperidin
trihydrate
hydroxyphenyl
intermediates
propanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60105221T
Other languages
English (en)
Other versions
DE60105221T2 (de
Inventor
Joseph Philip Rainville
Terry Gene Sinay Jr
Stanley Walter Walinsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Application granted granted Critical
Publication of DE60105221D1 publication Critical patent/DE60105221D1/de
Publication of DE60105221T2 publication Critical patent/DE60105221T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE60105221T 2000-04-28 2001-04-24 Verfahren zur Herstellung vom Mesylat Salz des Trihydrats des 1-(4-Hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanols und Zwischenprodukte für dieses Verfahren Expired - Fee Related DE60105221T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20041700P 2000-04-28 2000-04-28
US200417P 2000-04-28

Publications (2)

Publication Number Publication Date
DE60105221D1 true DE60105221D1 (de) 2004-10-07
DE60105221T2 DE60105221T2 (de) 2005-09-15

Family

ID=22741639

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60105221T Expired - Fee Related DE60105221T2 (de) 2000-04-28 2001-04-24 Verfahren zur Herstellung vom Mesylat Salz des Trihydrats des 1-(4-Hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanols und Zwischenprodukte für dieses Verfahren

Country Status (26)

Country Link
US (1) US6570018B2 (de)
EP (1) EP1149831B1 (de)
JP (1) JP2001354650A (de)
KR (1) KR100432841B1 (de)
CN (1) CN1211366C (de)
AR (1) AR028377A1 (de)
AT (1) ATE275130T1 (de)
AU (1) AU781715B2 (de)
BR (1) BR0101611A (de)
CA (1) CA2345286C (de)
CZ (1) CZ20011472A3 (de)
DE (1) DE60105221T2 (de)
DK (1) DK1149831T3 (de)
ES (1) ES2225425T3 (de)
HK (1) HK1040514B (de)
HU (1) HUP0101725A3 (de)
ID (1) ID30012A (de)
IL (1) IL142706A0 (de)
IN (1) IN191534B (de)
PL (1) PL347299A1 (de)
PT (1) PT1149831E (de)
RU (1) RU2192415C1 (de)
SI (1) SI1149831T1 (de)
TW (1) TWI222440B (de)
YU (1) YU27801A (de)
ZA (1) ZA200103321B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743921B2 (en) 2002-01-24 2004-06-01 Dsm Catalytica Pharmaceuticals, Inc. Process for the preparation of nonracemic syn-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol compounds
CN105037221B (zh) * 2015-06-18 2017-05-10 吉林大学珠海学院 一种具有神经保护作用的化合物及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69620191T2 (de) 1995-08-11 2002-07-18 Pfizer Inc., New York (1s,2s)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol-methansulfonat trihydrat
TW450807B (en) * 1995-09-15 2001-08-21 Pfizer Pharmaceutical compositions for treating tinnitus comprising neuroprotective agents

Also Published As

Publication number Publication date
AU3889701A (en) 2001-12-13
IN191534B (de) 2003-12-06
DE60105221T2 (de) 2005-09-15
HK1040514B (zh) 2005-10-28
HUP0101725A2 (hu) 2002-02-28
CN1322716A (zh) 2001-11-21
RU2192415C1 (ru) 2002-11-10
AR028377A1 (es) 2003-05-07
HUP0101725A3 (en) 2003-04-28
JP2001354650A (ja) 2001-12-25
YU27801A (sh) 2003-04-30
EP1149831B1 (de) 2004-09-01
CZ20011472A3 (cs) 2001-12-12
IL142706A0 (en) 2002-03-10
BR0101611A (pt) 2002-01-15
HU0101725D0 (en) 2001-07-30
CA2345286A1 (en) 2001-10-28
TWI222440B (en) 2004-10-21
ES2225425T3 (es) 2005-03-16
US20020016466A1 (en) 2002-02-07
KR100432841B1 (ko) 2004-05-24
US6570018B2 (en) 2003-05-27
ZA200103321B (en) 2002-10-24
PT1149831E (pt) 2004-11-30
CA2345286C (en) 2004-11-09
ATE275130T1 (de) 2004-09-15
AU781715B2 (en) 2005-06-09
KR20010098924A (ko) 2001-11-08
SI1149831T1 (en) 2005-02-28
EP1149831A1 (de) 2001-10-31
DK1149831T3 (da) 2004-12-06
ID30012A (id) 2001-11-01
PL347299A1 (en) 2001-11-05
CN1211366C (zh) 2005-07-20
HK1040514A1 (en) 2002-06-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee