SI1147087T1 - Fenantridni-N-oksidi s PDE-IV inhibicijsko aktivnostjo - Google Patents

Fenantridni-N-oksidi s PDE-IV inhibicijsko aktivnostjo

Info

Publication number
SI1147087T1
SI1147087T1 SI200030717T SI200030717T SI1147087T1 SI 1147087 T1 SI1147087 T1 SI 1147087T1 SI 200030717 T SI200030717 T SI 200030717T SI 200030717 T SI200030717 T SI 200030717T SI 1147087 T1 SI1147087 T1 SI 1147087T1
Authority
SI
Slovenia
Prior art keywords
oxides
phenanthridine
pde
inhibiting activity
compounds
Prior art date
Application number
SI200030717T
Other languages
English (en)
Inventor
Dieter Flockerzi
Hermann Di Amschler
Armin Hatzelmann
Daniela Bundschuh
Rolf Beume
Hildegard Boss
Hans-Peter Kley
Beate Gutterer
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of SI1147087T1 publication Critical patent/SI1147087T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
SI200030717T 1999-01-15 2000-01-12 Fenantridni-N-oksidi s PDE-IV inhibicijsko aktivnostjo SI1147087T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99100707 1999-01-15
EP00901089A EP1147087B1 (en) 1999-01-15 2000-01-12 Phenanthridine-n-oxides with pde-iv inhibiting activity
PCT/EP2000/000150 WO2000042017A1 (en) 1999-01-15 2000-01-12 Phenanthridine-n-oxides with pde-iv inhibiting activity

Publications (1)

Publication Number Publication Date
SI1147087T1 true SI1147087T1 (sl) 2005-10-31

Family

ID=8237354

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200030717T SI1147087T1 (sl) 1999-01-15 2000-01-12 Fenantridni-N-oksidi s PDE-IV inhibicijsko aktivnostjo

Country Status (12)

Country Link
US (1) US6538005B2 (sl)
EP (1) EP1147087B1 (sl)
JP (1) JP2002534505A (sl)
AT (1) ATE295352T1 (sl)
AU (1) AU2107700A (sl)
CA (1) CA2359404A1 (sl)
DE (1) DE60020079T2 (sl)
DK (1) DK1147087T3 (sl)
ES (1) ES2242594T3 (sl)
PT (1) PT1147087E (sl)
SI (1) SI1147087T1 (sl)
WO (1) WO2000042017A1 (sl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL144026A0 (en) * 1999-01-15 2002-04-21 Byk Gulden Lomberg Chem Fab Phenylphenanthridine derivatives and pharmaceutical compostions containing the same
DE60133879D1 (de) 2000-01-11 2008-06-19 Nycomed Gmbh Phenanthridin -n- oxide
WO2002006239A1 (en) * 2000-07-14 2002-01-24 Altana Pharma Ag Phenanthridine n-oxides
ES2236288T3 (es) 2000-07-14 2005-07-16 Altana Pharma Ag 6-heteroarilfenantridinas.
CA2496459C (en) 2002-08-29 2013-06-25 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
WO2005077906A1 (en) 2004-02-18 2005-08-25 Altana Pharma Ag Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
RS52916B (en) 2004-03-03 2014-02-28 Takeda Gmbh NEW HYDROXY-6-HETEROARYLPHENANTRIDINES AND THEIR USE AS PDE4 INHIBITORS
US20070185149A1 (en) * 2004-03-10 2007-08-09 Altana Pharma Ag Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibtors
US7589205B2 (en) * 2004-09-08 2009-09-15 Nycomed Gmbh 3-thia-10-aza-phenanthrene derivatives
SI1856093T1 (sl) 2005-03-02 2010-03-31 Nycomed Gmbh Hidrokloridna sol R aR bR dimetoksipiridin il etoksi metoksi a b heksahidrofenantridin ola
JP2008532980A (ja) * 2005-03-09 2008-08-21 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング アミド置換された６−フェニルフェナントリジン
ES2460897T3 (es) 2007-10-04 2014-05-14 F. Hoffmann-La Roche Ag Derivados de ciclopropil aril amida y usos de los mismos
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455252A (en) * 1993-03-31 1995-10-03 Syntex (U.S.A.) Inc. Optionally substituted 6,8-quinolines
US5475003A (en) * 1994-03-03 1995-12-12 Syntex (U.S.A.) Inc. 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives
US5466697A (en) * 1994-07-13 1995-11-14 Syntex (U.S.A.) Inc. 8-phenyl-1,6-naphthyridin-5-ones
CZ289340B6 (cs) * 1996-01-31 2002-01-16 Byk Gulden Lomberg Chemische Fabrik Gmbh Fenanthridinové deriváty a farmaceutický prostředek s jejich obsahem
US6127378A (en) 1996-03-26 2000-10-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridines substituted in the 6 position
DK0889886T5 (da) * 1996-03-26 2003-02-24 Altana Pharma Ag Hidtil ukendte, i 6-stilling substituerede phenanthridiner
GB9622386D0 (en) * 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
CA2270964C (en) 1996-11-11 2007-07-31 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridines as bronchial therapeutics
GB9626643D0 (en) 1996-12-21 1997-02-12 Astra Pharma Prod Compounds
DK0968211T3 (da) 1997-03-07 2003-12-08 Altana Pharma Ag Tetrazolderivater
SI0988302T1 (sl) * 1997-06-03 2003-08-31 Altana Pharma Ag Benzonafthiridini
PL190685B1 (pl) 1997-07-25 2005-12-30 Altana Pharma Ag Nowe pochodne tetrazolu, środek farmaceutyczny oraz zastosowanie
JP2001510827A (ja) * 1997-07-25 2001-08-07 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 置換６−フェニルフェナントリジン
CA2342245A1 (en) 1998-08-31 2000-03-09 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity

Also Published As

Publication number Publication date
CA2359404A1 (en) 2000-07-20
ES2242594T3 (es) 2005-11-16
PT1147087E (pt) 2005-09-30
DK1147087T3 (da) 2005-09-05
EP1147087A1 (en) 2001-10-24
EP1147087B1 (en) 2005-05-11
US6538005B2 (en) 2003-03-25
US20020183350A1 (en) 2002-12-05
AU2107700A (en) 2000-08-01
ATE295352T1 (de) 2005-05-15
WO2000042017A1 (en) 2000-07-20
DE60020079D1 (de) 2005-06-16
JP2002534505A (ja) 2002-10-15
DE60020079T2 (de) 2006-01-19

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