SI1147103T1 - Fenantridin-N-oksidi s PDE-IV inhibicijsko aktivnostjo - Google Patents

Fenantridin-N-oksidi s PDE-IV inhibicijsko aktivnostjo

Info

Publication number
SI1147103T1
SI1147103T1 SI200030713T SI200030713T SI1147103T1 SI 1147103 T1 SI1147103 T1 SI 1147103T1 SI 200030713 T SI200030713 T SI 200030713T SI 200030713 T SI200030713 T SI 200030713T SI 1147103 T1 SI1147103 T1 SI 1147103T1
Authority
SI
Slovenia
Prior art keywords
oxides
phenantrhridine
pde
inhibiting activity
compounds
Prior art date
Application number
SI200030713T
Other languages
English (en)
Inventor
Dieter Flockerzi
Hermann Amschler
Armin Hatzelmann
Daniela Bundschuh
Rolf Beume
Hildegard Boss
Hans-Peter Kley
Beate Schmidt
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of SI1147103T1 publication Critical patent/SI1147103T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Junction Field-Effect Transistors (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI200030713T 1999-01-15 2000-01-13 Fenantridin-N-oksidi s PDE-IV inhibicijsko aktivnostjo SI1147103T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99100693 1999-01-15
EP00901539A EP1147103B1 (en) 1999-01-15 2000-01-13 Phenantrhridine-n-oxides with pde-iv inhibiting activity
PCT/EP2000/000192 WO2000042034A1 (en) 1999-01-15 2000-01-13 Phenanthridine-n-oxides with pde-iv inhibiting activity

Publications (1)

Publication Number Publication Date
SI1147103T1 true SI1147103T1 (sl) 2005-10-31

Family

ID=8237350

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200030713T SI1147103T1 (sl) 1999-01-15 2000-01-13 Fenantridin-N-oksidi s PDE-IV inhibicijsko aktivnostjo

Country Status (12)

Country Link
US (1) US6534519B1 (sl)
EP (1) EP1147103B1 (sl)
JP (1) JP2003502278A (sl)
AT (1) ATE294793T1 (sl)
AU (1) AU2290000A (sl)
CA (1) CA2359449A1 (sl)
DE (1) DE60019894T2 (sl)
DK (1) DK1147103T3 (sl)
ES (1) ES2241571T3 (sl)
PT (1) PT1147103E (sl)
SI (1) SI1147103T1 (sl)
WO (1) WO2000042034A1 (sl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL144026A0 (en) * 1999-01-15 2002-04-21 Byk Gulden Lomberg Chem Fab Phenylphenanthridine derivatives and pharmaceutical compostions containing the same
DE60133879D1 (de) 2000-01-11 2008-06-19 Nycomed Gmbh Phenanthridin -n- oxide
ES2236288T3 (es) 2000-07-14 2005-07-16 Altana Pharma Ag 6-heteroarilfenantridinas.
ATE348616T1 (de) * 2002-08-29 2007-01-15 Altana Pharma Ag 2-hydroxy-6-phenylphenanthridine als pde-4-hemmer
CA2496459C (en) 2002-08-29 2013-06-25 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
CA2533636A1 (en) * 2003-07-31 2005-02-10 Altana Pharma Ag Novel 6-phenylphenanthridines
WO2005012252A1 (en) * 2003-07-31 2005-02-10 Altana Pharma Ag Novel 6-phenylphenantridines
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
US7776893B2 (en) 2003-09-05 2010-08-17 Nycomed Gmbh Use of PDE4 inhibitors for the treatment of diabetes mellitus
WO2005077906A1 (en) 2004-02-18 2005-08-25 Altana Pharma Ag Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
RS52916B (en) 2004-03-03 2014-02-28 Takeda Gmbh NEW HYDROXY-6-HETEROARYLPHENANTRIDINES AND THEIR USE AS PDE4 INHIBITORS
US20070185149A1 (en) * 2004-03-10 2007-08-09 Altana Pharma Ag Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibtors
SI1856093T1 (sl) 2005-03-02 2010-03-31 Nycomed Gmbh Hidrokloridna sol R aR bR dimetoksipiridin il etoksi metoksi a b heksahidrofenantridin ola
CA2599376C (en) 2005-03-08 2014-05-13 Nycomed Gmbh Roflumilast for the treatment of diabetes mellitus
ES2460897T3 (es) 2007-10-04 2014-05-14 F. Hoffmann-La Roche Ag Derivados de ciclopropil aril amida y usos de los mismos
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455252A (en) * 1993-03-31 1995-10-03 Syntex (U.S.A.) Inc. Optionally substituted 6,8-quinolines
US5475003A (en) * 1994-03-03 1995-12-12 Syntex (U.S.A.) Inc. 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives
US5466697A (en) * 1994-07-13 1995-11-14 Syntex (U.S.A.) Inc. 8-phenyl-1,6-naphthyridin-5-ones
CZ289340B6 (cs) * 1996-01-31 2002-01-16 Byk Gulden Lomberg Chemische Fabrik Gmbh Fenanthridinové deriváty a farmaceutický prostředek s jejich obsahem
US6127378A (en) 1996-03-26 2000-10-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridines substituted in the 6 position
DK0889886T5 (da) * 1996-03-26 2003-02-24 Altana Pharma Ag Hidtil ukendte, i 6-stilling substituerede phenanthridiner
GB9622386D0 (en) * 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
CA2270964C (en) 1996-11-11 2007-07-31 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridines as bronchial therapeutics
GB9626643D0 (en) 1996-12-21 1997-02-12 Astra Pharma Prod Compounds
DK0968211T3 (da) 1997-03-07 2003-12-08 Altana Pharma Ag Tetrazolderivater
SI0988302T1 (sl) 1997-06-03 2003-08-31 Altana Pharma Ag Benzonafthiridini
PL190685B1 (pl) 1997-07-25 2005-12-30 Altana Pharma Ag Nowe pochodne tetrazolu, środek farmaceutyczny oraz zastosowanie
CA2342245A1 (en) 1998-08-31 2000-03-09 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity

Also Published As

Publication number Publication date
EP1147103A1 (en) 2001-10-24
DE60019894T2 (de) 2006-01-12
DE60019894D1 (de) 2005-06-09
AU2290000A (en) 2000-08-01
PT1147103E (pt) 2005-08-31
DK1147103T3 (da) 2005-08-29
ES2241571T3 (es) 2005-11-01
WO2000042034A1 (en) 2000-07-20
CA2359449A1 (en) 2000-07-20
ATE294793T1 (de) 2005-05-15
US6534519B1 (en) 2003-03-18
JP2003502278A (ja) 2003-01-21
EP1147103B1 (en) 2005-05-04

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