SI1002792T1 - 2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same - Google Patents
2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the sameInfo
- Publication number
- SI1002792T1 SI1002792T1 SI9830698T SI9830698T SI1002792T1 SI 1002792 T1 SI1002792 T1 SI 1002792T1 SI 9830698 T SI9830698 T SI 9830698T SI 9830698 T SI9830698 T SI 9830698T SI 1002792 T1 SI1002792 T1 SI 1002792T1
- Authority
- SI
- Slovenia
- Prior art keywords
- compound
- same
- aminopropane
- intermediates
- synthesizing
- Prior art date
Links
- KJJPLEZQSCZCKE-UHFFFAOYSA-N 2-aminopropane-1,3-diol Chemical class OCC(N)CO KJJPLEZQSCZCKE-UHFFFAOYSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 230000002194 synthesizing effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 238000010322 bone marrow transplantation Methods 0.000 abstract 1
- 239000003937 drug carrier Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001629 suppression Effects 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/16—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same carbon atom of an acyclic carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
- C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/34—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton and at least one hydroxy group bound to another carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C223/00—Compounds containing amino and —CHO groups bound to the same carbon skeleton
- C07C223/02—Compounds containing amino and —CHO groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8625597 | 1997-04-04 | ||
| EP98911211A EP1002792B1 (de) | 1997-04-04 | 1998-04-03 | 2-aminopropan-1,3-diol-verbindungen, ihre medizinische anwendung und zwischenprodukte zu ihrer synthese |
| PCT/JP1998/001571 WO1998045249A1 (fr) | 1997-04-04 | 1998-04-03 | Composes 2-aminopropane-1,3-diol, leur utilisation pharmaceutique, et intermediaires servant a leur synthese |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1002792T1 true SI1002792T1 (en) | 2004-12-31 |
Family
ID=13881722
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9830698T SI1002792T1 (en) | 1997-04-04 | 1998-04-03 | 2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same |
| SI9830785T SI1319651T1 (en) | 1997-04-04 | 1998-04-03 | 2-Aminopropane-1,3-diol compound, pharmaceutical use thereof and synthetic intermediates therefor |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9830785T SI1319651T1 (en) | 1997-04-04 | 1998-04-03 | 2-Aminopropane-1,3-diol compound, pharmaceutical use thereof and synthetic intermediates therefor |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US6214873B1 (de) |
| EP (2) | EP1002792B1 (de) |
| JP (1) | JP4045364B2 (de) |
| KR (1) | KR100551931B1 (de) |
| CN (2) | CN1137086C (de) |
| AT (2) | ATE298740T1 (de) |
| AU (1) | AU735853B2 (de) |
| BR (1) | BR9808481A (de) |
| CA (1) | CA2286315C (de) |
| DE (2) | DE69825056T2 (de) |
| DK (2) | DK1002792T3 (de) |
| ES (2) | ES2226110T3 (de) |
| IL (3) | IL132208A (de) |
| NZ (1) | NZ500713A (de) |
| PT (2) | PT1319651E (de) |
| RU (1) | RU2198162C2 (de) |
| SI (2) | SI1002792T1 (de) |
| WO (1) | WO1998045249A1 (de) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6861442B1 (en) * | 1998-12-30 | 2005-03-01 | Sugen, Inc. | PYK2 and inflammation |
| US6515117B2 (en) * | 1999-10-12 | 2003-02-04 | Bristol-Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
| CA2415678A1 (en) | 2000-07-13 | 2003-01-10 | Sankyo Company Limited | Amino alcohol derivatives |
| AU2001296536A1 (en) | 2000-10-03 | 2002-04-15 | University Of Virginian Patent Foundation | Novel lysophosphatidic acid receptor agonists and antagonists |
| US20040241211A9 (en) * | 2000-11-06 | 2004-12-02 | Fischell Robert E. | Devices and methods for reducing scar tissue formation |
| US6534693B2 (en) * | 2000-11-06 | 2003-03-18 | Afmedica, Inc. | Surgically implanted devices having reduced scar tissue formation |
| EP1383778B1 (de) | 2001-01-30 | 2009-10-21 | University Of Virginia Patent Foundation | Agonisten und antagonisten von sphingosin-1-phosphatrezeptoren |
| EP1368015B1 (de) * | 2001-02-22 | 2006-08-09 | Novartis AG | Verwendung von beschleunigten lymphozyten zielansteuernden wirkstoffen zur herstellung eines medikaments für die behandlung der verzögertern transplantat-funktion |
| US20030072717A1 (en) * | 2001-02-23 | 2003-04-17 | Vapotronics, Inc. | Inhalation device having an optimized air flow path |
| DK1377593T3 (da) | 2001-03-26 | 2006-04-10 | Novartis Ag | 2-Amino-propanolderivater |
| CA2448022C (en) * | 2001-05-21 | 2013-11-12 | Injet Digital Aerosols Limited | Compositions for protein delivery via the pulmonary route |
| GB0117921D0 (en) * | 2001-07-23 | 2001-09-12 | Novartis Ag | Organic compounds |
| DE60235900D1 (de) | 2001-09-27 | 2010-05-20 | Kyorin Seiyaku Kk | Osuppressivum |
| DE60223699T2 (de) * | 2001-09-27 | 2008-10-30 | Kyorin Pharmaceutical Co., Ltd. | Diarylsulfidderivat, dessen additionssalz und immunsuppressivum |
| GB0125443D0 (en) * | 2001-10-23 | 2001-12-12 | Novartis Ag | Organic Compounds |
| PT1471054E (pt) | 2002-01-11 | 2009-09-23 | Daiichi Sankyo Co Ltd | Derivado de aminoálcool ou derivado de ácido fosfónico e composição medicinal que os contém |
| US6797722B2 (en) * | 2002-05-03 | 2004-09-28 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Use of 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole for the treatment of autoimmune diseases |
| CN1652757B (zh) | 2002-05-16 | 2012-02-08 | 诺瓦提斯公司 | Edg受体结合剂在癌症中的应用 |
| GB0217152D0 (en) | 2002-07-24 | 2002-09-04 | Novartis Ag | Organic compounds |
| EP1539674A1 (de) * | 2002-09-13 | 2005-06-15 | Novartis AG | Aminopropanol-derivate |
| TWI376363B (en) * | 2002-09-24 | 2012-11-11 | Novartis Ag | Pharmaceutical combination for treating demyelinating disease |
| AU2008200368B2 (en) * | 2003-04-08 | 2011-04-28 | Mitsubishi Tanabe Pharma Corporation | Solid pharmaceutical compositions comprising a S1P receptor agonist and a sugar alcohol |
| PE20130200A1 (es) * | 2003-04-08 | 2013-03-09 | Novartis Ag | Composicion farmaceutica que contiene un agonista del receptor s1p y un alcohol de azucar |
| AU2011205050B2 (en) * | 2003-04-08 | 2014-01-30 | Mitsubishi Tanabe Pharma Corporation | Solid pharmaceutical compositions comprising a S1P receptor agonist and a sugar alcohol |
| JP4603531B2 (ja) * | 2003-04-30 | 2010-12-22 | ノバルティス アーゲー | スフィンゴシン−１−ホスフェートレセプターモジュレーターとしての、アミノプロパノール誘導体 |
| MY150088A (en) | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
| EP1484057A1 (de) * | 2003-06-06 | 2004-12-08 | Aventis Pharma Deutschland GmbH | Verwendung von 2-amino-1,3-propandiolderivaten zur herstrllung eines medikaments zur behandlung von bestimmten schmerzen |
| US7524887B2 (en) | 2003-06-06 | 2009-04-28 | Sanofi-Aventis Deutschland Gmbh | 2-amino-1,3-propanediol compounds for the treatment of acute pain |
| US20040265238A1 (en) * | 2003-06-27 | 2004-12-30 | Imtiaz Chaudry | Inhalable formulations for treating pulmonary hypertension and methods of using same |
| GB0320638D0 (en) | 2003-09-03 | 2003-10-01 | Novartis Ag | Organic compounds |
| GB0324210D0 (en) * | 2003-10-15 | 2003-11-19 | Novartis Ag | Organic compounds |
| GB0329498D0 (en) | 2003-12-19 | 2004-01-28 | Novartis Ag | Organic compounds |
| GB0500020D0 (en) | 2005-01-04 | 2005-02-09 | Novartis Ag | Organic compounds |
| KR20110136901A (ko) | 2004-02-24 | 2011-12-21 | 상꾜 가부시키가이샤 | 아미노 알코올 화합물 |
| JP2007536310A (ja) * | 2004-05-03 | 2007-12-13 | ノバルティス アクチエンゲゼルシャフト | Ｓ１ｐ受容体アゴニストおよびｊａｋ３キナーゼ阻害剤を含む、組合せ剤 |
| EP1750722A4 (de) | 2004-05-06 | 2010-03-10 | Univ Virginia | Neue lysophosphatidsäure-rezeptorselektive antagonisten |
| GB0411929D0 (en) * | 2004-05-27 | 2004-06-30 | Novartis Ag | Organic compounds |
| US20110104186A1 (en) | 2004-06-24 | 2011-05-05 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
| JP4917433B2 (ja) | 2004-07-16 | 2012-04-18 | 杏林製薬株式会社 | 効果的な医薬の使用法及び副作用発現の防御に関する方法 |
| JP4919374B2 (ja) * | 2004-07-29 | 2012-04-18 | 第一三共株式会社 | 免疫抑制剤としての医薬組成物 |
| TW200611687A (en) * | 2004-07-29 | 2006-04-16 | Sankyo Co | Pharmaceutical compositions used for immunosuppressant |
| AU2005266449B2 (en) | 2004-07-30 | 2009-10-08 | Novartis Ag | Compound formulations of 2-amino-1,3-propanediol compounds |
| US20060223866A1 (en) * | 2004-08-13 | 2006-10-05 | Praecis Pharmaceuticals, Inc. | Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity |
| EP1781595A1 (de) * | 2004-08-13 | 2007-05-09 | Praecis Pharmaceuticals Inc. | Verfahren und zusammensetzungen zur modulation von sphingosin-1-phosphat-rezeptoraktivität |
| PT2511262T (pt) * | 2004-10-12 | 2017-03-30 | Kyorin Seiyaku Kk | Processo para a produção de cloridrato de 2-amino-2-[2-[4-(3- benziloxi-feniltio)-2-clorofenil[etil]-1,3-propanodiol |
| MX2007006373A (es) | 2004-11-29 | 2007-06-20 | Novartis Ag | Regimen de dosificacion de un agonista del receptor s1p. |
| CA2595960A1 (en) * | 2005-02-08 | 2006-08-17 | Novartis Ag | Antilymphocyte antibody induction by combination of an s1p receptor agonist/modulator and of immunosuppressive drugs |
| GB0504544D0 (en) | 2005-03-04 | 2005-04-13 | Novartis Ag | Organic compounds |
| TW200702326A (en) * | 2005-05-31 | 2007-01-16 | Mitsubishi Pharma Corp | 2-aminobutanol compound and its pharmaceutical use |
| TWI418350B (zh) * | 2005-06-24 | 2013-12-11 | Sankyo Co | 含有ｐｐａｒ調節劑之醫藥組成物的用途 |
| GT200600350A (es) * | 2005-08-09 | 2007-03-28 | Formulaciones líquidas | |
| EP1932522B1 (de) * | 2005-10-07 | 2012-05-23 | Kyorin Pharmaceutical Co., Ltd. | Therapeutisches Mittel gegen Lebererkrankungen mit einem 2-Amino-1,3-propandiol-Derivat als Wirkstoff |
| TWI389683B (zh) * | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
| RU2448976C2 (ru) | 2006-04-11 | 2012-04-27 | Новартис Аг | Ингибиторы hcv/вич и их применение |
| GB0612721D0 (en) | 2006-06-27 | 2006-08-09 | Novartis Ag | Organic compounds |
| TW200815600A (en) | 2006-08-04 | 2008-04-01 | Daiichi Sankyo Co Ltd | An enzyme for phosphorizing a medicine |
| RS53080B (en) * | 2006-08-08 | 2014-06-30 | Kyorin Pharmaceutical Co. Ltd. | AMINOPHOSPHORIC ACID ETHAR DERIVATIVE AND S1P RECEPTOR MODULATOR CONTAINING THE SAME AS THE ACTIVE INGREDIENT |
| WO2008018447A1 (fr) * | 2006-08-08 | 2008-02-14 | Kyorin Pharmaceutical Co., Ltd. | Dérivé d'aminoalcool et immunodépresseur le contenant en tant que principe actif |
| PL3103448T3 (pl) | 2006-09-26 | 2019-12-31 | Novartis Ag | Kompozycje farmaceutyczne zawierające modulator S1P |
| WO2008121709A1 (en) * | 2007-03-30 | 2008-10-09 | Transport Pharmaceuticals, Inc. | Pharmaceutical formulations for iontophoretic delivery of an anti-fungal drug |
| KR101161498B1 (ko) | 2007-06-14 | 2012-06-29 | 미쓰비시 타나베 파마 코퍼레이션 | 아민 화합물 및 그 의약 용도 |
| DE102007039954A1 (de) * | 2007-08-23 | 2009-02-26 | Henkel Ag & Co. Kgaa | Reduktive Entfärbung keratinhaltiger Fasern |
| WO2009048993A2 (en) | 2007-10-12 | 2009-04-16 | Novartis Ag | Compositions comprising sphingosine 1 phosphate (s1p) receptor modulators |
| TW200946105A (en) | 2008-02-07 | 2009-11-16 | Kyorin Seiyaku Kk | Therapeutic agent or preventive agent for inflammatory bowel disease containing amino alcohol derivative as active ingredient |
| US20110182850A1 (en) | 2009-04-10 | 2011-07-28 | Trixi Brandl | Organic compounds and their uses |
| US8512690B2 (en) | 2009-04-10 | 2013-08-20 | Novartis Ag | Derivatised proline containing peptide compounds as protease inhibitors |
| EA201390532A1 (ru) | 2010-10-08 | 2013-09-30 | Новартис Аг | Композиции сульфамидых ингибиторов ns3, содержащие витамин е |
| JO3177B1 (ar) | 2011-04-01 | 2018-03-08 | Novartis Ag | تركيبات تتالف من 2-أمينو-2- [ 2- ( 4- أكتيل فينيل ) إثيل ] بروبان - 3, 1- ديول |
| EP2842937B1 (de) | 2012-04-23 | 2018-01-17 | Mitsubishi Tanabe Pharma Corporation | Aminverbindung und verwendung davon für medizinische zwecke |
| CN110862409B (zh) * | 2019-12-04 | 2021-08-20 | 江南大学 | 一种制备含二元醇结构的硅烷类化合物及其改性水性聚氨酯的方法 |
| US20220153684A1 (en) * | 2020-11-13 | 2022-05-19 | Shivalik Rasayan Limited | Process for preparation of fingolimod hydrochloride |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3660488A (en) * | 1965-07-16 | 1972-05-02 | Phillips Petroleum Co | 2-halo-alkylene- and -cyclopentylene-2-amino-propane 1 3-diols |
| DE122011100012I1 (de) * | 1992-10-21 | 2011-10-20 | Mitsubishi Tanabe Pharma Corp | 2-Amino-1, 3-propandiolverbindung und immunosuppressium. |
| DE69524962T4 (de) * | 1994-08-22 | 2003-08-28 | Mitsubishi Pharma Corp., Osaka | Benzolderivate und deren medizinische verwendung |
-
1998
- 1998-04-03 NZ NZ500713A patent/NZ500713A/xx not_active IP Right Cessation
- 1998-04-03 DE DE69825056T patent/DE69825056T2/de not_active Expired - Lifetime
- 1998-04-03 BR BR9808481-0A patent/BR9808481A/pt active Search and Examination
- 1998-04-03 IL IL13220898A patent/IL132208A/xx not_active IP Right Cessation
- 1998-04-03 DE DE69830756T patent/DE69830756T2/de not_active Expired - Lifetime
- 1998-04-03 CN CNB988058804A patent/CN1137086C/zh not_active Expired - Fee Related
- 1998-04-03 AU AU65230/98A patent/AU735853B2/en not_active Ceased
- 1998-04-03 DK DK98911211T patent/DK1002792T3/da active
- 1998-04-03 CN CNB03136893XA patent/CN1290819C/zh not_active Expired - Fee Related
- 1998-04-03 IL IL15506698A patent/IL155066A/en not_active IP Right Cessation
- 1998-04-03 AT AT03003623T patent/ATE298740T1/de active
- 1998-04-03 ES ES98911211T patent/ES2226110T3/es not_active Expired - Lifetime
- 1998-04-03 AT AT98911211T patent/ATE271028T1/de active
- 1998-04-03 US US09/402,375 patent/US6214873B1/en not_active Ceased
- 1998-04-03 KR KR1019997009082A patent/KR100551931B1/ko not_active IP Right Cessation
- 1998-04-03 CA CA002286315A patent/CA2286315C/en not_active Expired - Fee Related
- 1998-04-03 JP JP54259298A patent/JP4045364B2/ja not_active Expired - Fee Related
- 1998-04-03 EP EP98911211A patent/EP1002792B1/de not_active Expired - Lifetime
- 1998-04-03 PT PT03003623T patent/PT1319651E/pt unknown
- 1998-04-03 RU RU99123047/04A patent/RU2198162C2/ru not_active IP Right Cessation
- 1998-04-03 US US10/410,387 patent/USRE39072E1/en not_active Expired - Lifetime
- 1998-04-03 EP EP03003623A patent/EP1319651B1/de not_active Expired - Lifetime
- 1998-04-03 DK DK03003623T patent/DK1319651T3/da active
- 1998-04-03 WO PCT/JP1998/001571 patent/WO1998045249A1/ja active IP Right Grant
- 1998-04-03 SI SI9830698T patent/SI1002792T1/xx unknown
- 1998-04-03 ES ES03003623T patent/ES2240868T3/es not_active Expired - Lifetime
- 1998-04-03 SI SI9830785T patent/SI1319651T1/xx unknown
- 1998-04-03 IL IL15506598A patent/IL155065A/en not_active IP Right Cessation
- 1998-04-03 PT PT98911211T patent/PT1002792E/pt unknown
Also Published As
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| Publication | Publication Date | Title |
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