SG70587G - Novel antihistamines, process for their preparation and pharmaceutical compositions containing them - Google Patents

Novel antihistamines, process for their preparation and pharmaceutical compositions containing them

Info

Publication number
SG70587G
SG70587G SG705/87A SG70587A SG70587G SG 70587 G SG70587 G SG 70587G SG 705/87 A SG705/87 A SG 705/87A SG 70587 A SG70587 A SG 70587A SG 70587 G SG70587 G SG 70587G
Authority
SG
Singapore
Prior art keywords
antihistamines
novel
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
SG705/87A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22578489&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG70587(G) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of SG70587G publication Critical patent/SG70587G/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SG705/87A 1980-06-19 1987-08-27 Novel antihistamines, process for their preparation and pharmaceutical compositions containing them SG70587G (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06160795 US4282233B1 (en) 1980-06-19 1980-06-19 Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines

Publications (1)

Publication Number Publication Date
SG70587G true SG70587G (en) 1988-02-19

Family

ID=22578489

Family Applications (1)

Application Number Title Priority Date Filing Date
SG705/87A SG70587G (en) 1980-06-19 1987-08-27 Novel antihistamines, process for their preparation and pharmaceutical compositions containing them

Country Status (25)

Country Link
US (1) US4282233B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0042544B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS5735586A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR850000744B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE9695T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU543054B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1160230A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CY (1) CY1405A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3166441D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK169817B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES8300779A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI70213C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HK (1) HK94387A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU186774B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE51303B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL63122A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KE (1) KE3758A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU88359I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MY (1) MY8700761A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL930094I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ197435A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH19252A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT73200B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SG (1) SG70587G (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA814062B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU195800B (en) * 1983-10-13 1988-07-28 Sandoz Ltd Process for producing 4h-benzo/4,5/cylopenta/1,2-b/ thiofene derivatives and pharmaceutical compositions containing them
JPS61501205A (ja) * 1984-02-15 1986-06-19 シェリング・コ−ポレ−ション ８↓−クロル↓−６，１１↓−ジヒドロ↓−１１↓−（４↓−ピペリジリデン）↓−５Ｈ↓−ベンゾ〔５，６〕シクロヘプタ〔１，２−ｂ〕ピリジンおよびその塩、これらの化合物の製造方法、ならびにこれらの化合物を含有する医薬組成物
EP0208855B1 (en) * 1985-05-13 1991-03-06 Schering Corporation process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof, compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions
US4804666A (en) * 1985-08-14 1989-02-14 Schering Corporation Antiallergic 6,11-dihydro-11-(4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US5665726A (en) * 1986-10-31 1997-09-09 Schering Corporation Benzo[5,6]cycloheptapyridines, compositions and methods of use
US5438062A (en) * 1986-10-31 1995-08-01 Schering Corporation Benzo(5,6)cycloheptapyridines, compositions and methods of use
AU635400B2 (en) * 1986-10-31 1993-03-18 Schering Corporation Intermediates for producing benzo(5,6)cycloheptapyridines
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
CA1341044C (en) * 1988-04-28 2000-07-04 Frank J. Villani Benzopyrido piperidine, piperidylidene and peperazine compounds, compositions, methods of manufacture and methods of use
US4912222A (en) * 1988-06-17 1990-03-27 Fisons Corporation Antihistamines related to cyproheptadine
US4863931A (en) * 1988-09-15 1989-09-05 Schering Corporation Antihistaminic fluoro substituted benzocycloheptapyridines
US4990535A (en) * 1989-05-03 1991-02-05 Schering Corporation Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine
CA2038417A1 (en) * 1990-04-11 1991-10-12 Yasuo Ito Piperidine compounds, method for preparation thereof, and a pharmaceutical composition comprising the same
NZ238629A (en) * 1990-06-22 1993-09-27 Schering Corp Bis-benzo- or benzopyrido-cyclohepta (where z is c, o, s or n) piperidine, piperidylidene or piperazine compounds, medicaments and methods of preparation
US5393753A (en) * 1990-10-10 1995-02-28 Schering Corporation Substituted imidazobenzazepines
JPH05506249A (ja) * 1990-10-10 1993-09-16 シェリング・コーポレーション ビスーベンゾシクロヘプタピペリジリデン、ピペリジンおよびピペラジン化合物、組成物および使用法
EP0563134B1 (en) * 1990-12-18 1996-06-19 The Wellcome Foundation Limited Agents for potentiating the effects of antitumor agents and combating multiple drug resistance
JPH0676403B2 (ja) * 1991-01-18 1994-09-28 エスエス製薬株式会社 新規なベンゾ［５，６ シクロヘプタ［１，２−ｂ ピリジン誘導体及びこれを含有する抗アレルギー剤
AU2028892A (en) * 1991-05-23 1992-12-30 Schering Corporation Novel benzopyrido piperidylidene compounds, compositions, methods of manufacture and methods of use
CA2114009A1 (en) * 1991-07-23 1993-02-04 Jesse K. Wong Novel benzopyrido piperidylidene compounds, compositions, methods of manufacture and methods of use
ES2040177B1 (es) * 1992-03-06 1994-05-16 S A Tamarang Procedimiento para la sintesis de la 8-cloro-6, 11-dihidro-11, (1-etoxicarbonil-4-piperidiliden) -5h-benzo (5,6) ciclohepta-(1,2-b) piridina.
ES2102026T3 (es) * 1992-03-27 1997-07-16 Schering Corp Derivados de bis-aril-carbinol puenteados, composiciones y metodos de uso.
US5679692A (en) * 1992-03-27 1997-10-21 Schering Corporation Unbridged bis-aryl carbinol derivatives, compositions and methods of use
ES2042421B1 (es) * 1992-05-22 1994-08-01 Uriach & Cia Sa J Procedimiento para la obtencion de la 8-cloro-11-*1-*(5-metil-3-piridil)metil*-4-piperidiliden*-6,11-dihidro-5h-benzo*5,6*ciclohepta*1,2-b*piridina.
US5314697A (en) * 1992-10-23 1994-05-24 Schering Corporation Stable extended release oral dosage composition comprising loratadine and pseudoephedrine
US6129930A (en) * 1993-09-20 2000-10-10 Bova; David J. Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night
US6746691B2 (en) 1993-09-20 2004-06-08 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
US6080428A (en) * 1993-09-20 2000-06-27 Bova; David J. Nicotinic acid compositions for treating hyperlipidemia and related methods therefor
US6676967B1 (en) 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
US6818229B1 (en) 1993-09-20 2004-11-16 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia
US5721236A (en) * 1993-10-15 1998-02-24 Schering Corporation Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5661152A (en) * 1993-10-15 1997-08-26 Schering Corporation Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
NZ274749A (en) * 1993-10-15 1998-05-27 Schering Corp Tricyclic carbamate derivatives useful for inhibition of g-protein function and for treating proliferative diseases, medicaments
US6075025A (en) 1993-10-15 2000-06-13 Schering Corporation Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL111257A0 (en) * 1993-10-15 1994-12-29 Schering Corp Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US6365588B1 (en) 1993-10-15 2002-04-02 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US7211582B1 (en) * 1994-12-30 2007-05-01 Sepracor Inc. Methods for treating urticaria using descarboethoxyloratadine
US7214683B1 (en) 1994-12-30 2007-05-08 Sepracor Inc. Compositions of descarboethoxyloratadine
US5595997A (en) 1994-12-30 1997-01-21 Sepracor Inc. Methods and compositions for treating allergic rhinitis and other disorders using descarboethoxyloratadine
US5700806A (en) * 1995-03-24 1997-12-23 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5684013A (en) * 1995-03-24 1997-11-04 Schering Corporation Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5801175A (en) * 1995-04-07 1998-09-01 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5712280A (en) * 1995-04-07 1998-01-27 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
US5891872A (en) * 1995-04-07 1999-04-06 Schering Corporation Tricyclic compounds
JP3779349B2 (ja) * 1995-04-24 2006-05-24 興和株式会社 ピペリジン誘導体
JP3383499B2 (ja) 1995-11-30 2003-03-04 富士写真フイルム株式会社 ハロゲン化銀カラー写真感光材料
JPH09152696A (ja) 1995-11-30 1997-06-10 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
US5874442A (en) * 1995-12-22 1999-02-23 Schering-Plough Corporation Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease
CZ248798A3 (cs) * 1996-02-08 1999-01-13 Merck And Co., Inc. Farmaceutický prostředek
JP3882224B2 (ja) * 1996-05-31 2007-02-14 旭硝子株式会社 パロキセチンの製造方法
ID22002A (id) * 1996-09-13 1999-08-19 Schering Corp Derivatif benzosikloheptapiridin tersubstitusi yang berguna untuk penghalangan transferase protein farnesil
US5945429A (en) * 1996-09-13 1999-08-31 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US5900421A (en) * 1997-02-11 1999-05-04 Sepracor Inc. Methods and compositions for treating allergic asthma and dermatitis using descarboethoxyloratadine
US5939426A (en) * 1997-02-28 1999-08-17 Sepracor Inc. Methods for treating urinary incontinence using descarboethoxyloratadine
SE509618C2 (sv) 1997-03-06 1999-02-15 Goeran Blomqvist Farmaceutisk komposition för behandling av s k restless legs
US5998620A (en) * 1997-03-25 1999-12-07 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
US6506767B1 (en) 1997-07-02 2003-01-14 Schering Corporation 8-chloro-6,11-dihydro-11-(4-piperidylidine)-5H-benzo[5,6]cyclohepta[1-2-b] pyridine
US5869479A (en) * 1997-08-14 1999-02-09 Schering Corporation Treatment of upper airway allergic responses
US6335347B1 (en) * 1997-10-10 2002-01-01 Schering Corporation Ethyl 4-(8-chloro-5,6-dihydro-11 H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidene carboxylate polymorph
JP2001519428A (ja) * 1997-10-10 2001-10-23 シェーリング コーポレイション エチル４−（８−クロロ−５，６−ジヒドロ−１１Ｈ−ベンゾ［５，６］シクロヘプタ［１，２−ｂ］ピリジン−１１−イリデン）−１−ピペリデンカルボキシレート多形物
DK0968715T3 (da) * 1998-06-30 2004-12-27 Pfizer Prod Inc Loratadin til anvendelse som et antiarytmikum
US6423721B1 (en) 1998-09-10 2002-07-23 Schering Corporation Methods and compositions for treating sinusitis, otitis media and other related disorders using antihistamines
EP1131296A2 (en) 1998-11-20 2001-09-12 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
US6372909B1 (en) 1998-11-20 2002-04-16 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
US6271378B1 (en) 1998-12-18 2001-08-07 Schering Corporation Process for preparing tricyclic compounds having antihistaminic activity
EP1140899B1 (en) * 1998-12-18 2003-09-10 Schering Corporation Process for preparing tricyclic compounds having antihistaminic activity
US6894059B1 (en) 1999-03-26 2005-05-17 Ucb S.A. Compounds and methods for treatment of asthma, allergy and inflammatory disorders
PE20001566A1 (es) 1999-03-26 2001-02-05 Ucb Sa Piperazinas 1,4-sustituidas, piperidinas 1,4-sustituidas y 4-alquilidenilpiperidinas 1-sustituidas
US6686502B1 (en) 1999-03-26 2004-02-03 Ucb S.A. Compounds and methods for treatment of asthma, allergy and inflammatory disorders
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US6100274A (en) * 1999-07-07 2000-08-08 Schering Corporation 8-chloro-6,11-dihydro-11- ](4-piperidylidine)-5H-benzo[5,6]cyclohepta[1,2-bpyridine oral compositions
US6475493B1 (en) 1999-09-02 2002-11-05 Norstrum Pharmaceuticals, Inc. Controlled release pellet formulation
US6267986B1 (en) 1999-09-24 2001-07-31 Ranbaxy Laboratories Limited Process for the preparation of a controlled drug delivery system containing pseudoephedrine and a long acting antihistamine
US6114346A (en) * 1999-10-22 2000-09-05 Schering Corporation Treating sleep disorders using desloratadine
AU2276801A (en) 1999-12-20 2001-07-03 Schering Corporation Extended release oral dosage composition
WO2001045668A2 (en) 1999-12-20 2001-06-28 Schering Corporation Stable extended release oral dosage composition comprising pseudoephedrine and desloratadine
US7405223B2 (en) 2000-02-03 2008-07-29 Schering Corporation Treating allergic and inflammatory conditions
US6492519B2 (en) 2000-04-18 2002-12-10 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
RU2164796C1 (ru) * 2000-05-25 2001-04-10 Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" Противогистаминное средство и способ его получения
RU2165255C1 (ru) * 2000-07-14 2001-04-20 Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" Антигистаминная композиция
WO2002036077A2 (en) * 2000-11-06 2002-05-10 Andrx Pharmaceuticals, Inc. Once a day antihistamine and decongestant formulation
HU226998B1 (en) 2000-11-23 2010-04-28 Richter Gedeon Nyrt Desloratadine hemisulphate, process for the preparation thereof and pharmaceutical compositions containing the same
US6599913B1 (en) * 2001-06-29 2003-07-29 Schering Corporation Treating allergic and inflammatory conditions
US6720002B2 (en) 2001-07-20 2004-04-13 R.P. Scherer Technologies, Inc. Antihistamine formulations for soft capsule dosage forms
US20030004179A1 (en) * 2002-05-21 2003-01-02 Affrime Melton B Treating allergic and inflammatory conditions
US20040033257A1 (en) * 2002-05-30 2004-02-19 Strides Inc. Pharmaceutical formulation in a drug delivery system and process for preparing the same
TW200400816A (en) * 2002-06-26 2004-01-16 Lilly Co Eli Tricyclic steroid hormone nuclear receptor modulators
US20040001885A1 (en) * 2002-06-27 2004-01-01 Unchalee Kositprapa Rapidly disintegrating antihistamine formulation
US20040101563A1 (en) * 2002-07-18 2004-05-27 Kundu Subhas C. Storage stable antihistaminic syrup formulations
US8092831B2 (en) * 2002-11-08 2012-01-10 Andrx Pharmaceuticals, Llc Antihistamine and decongestant system
US6635654B1 (en) 2003-01-09 2003-10-21 Allergan, Inc. Ophthalmic compositions containing loratadine
US20040229896A1 (en) * 2003-03-12 2004-11-18 Toth Zoltan G. Stable pharmaceutical compositions of desloratadine
US20050026890A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease
JP3881640B2 (ja) * 2003-08-08 2007-02-14 塩野義製薬株式会社 ロラタジンを含むドライシロップ剤
MX2007001561A (es) * 2004-08-04 2007-04-16 Schering Corp Formulacion farmaceutica que comprende pleconaril para tratamiento de enfermedades de vias aereas.
US20060154948A1 (en) * 2005-01-12 2006-07-13 Schering Corporation Treating allergic and inflammatory conditions
US20060240101A1 (en) * 2005-04-22 2006-10-26 Shubha Chungi Orally disintegrating pharmaceutical tablet formulations of olanzapine
US8603523B2 (en) 2005-06-17 2013-12-10 Aft Pharmaceuticals Limited Pharmaceutical composition and its use in a method for treatment of patients with upper respiratory mucosal congestion
US20080194823A1 (en) * 2006-04-04 2008-08-14 Mayur Devjibhai Khunt Preparation of loratadine form i
MX2008015358A (es) * 2006-06-01 2009-03-06 Schering Corp Composiciones farmaceuticas para liberacion sostenida de fenilefrina.
NZ573174A (en) 2006-06-01 2012-01-12 Msd Consumer Care Inc Sustained release pharmaceutical dosage form containing phenylephrine
ES2391585T3 (es) 2006-06-01 2012-11-28 Msd Consumer Care, Inc. Formulación farmacéutica de liberación sostenida que comprende fenilefrina
EP2023957A2 (en) * 2006-06-07 2009-02-18 Morton Grove Pharmaceuticals, Inc. Oral liquid loratadine formulations and methods
JP5383514B2 (ja) * 2007-03-12 2014-01-08 ウェルズ ファーゴ バンク ナショナル アソシエイション オリゴマー−抗ヒスタミン複合体
US20090082385A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched desloratidine
WO2010021681A2 (en) * 2008-08-18 2010-02-25 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
MX2011013679A (es) 2009-06-16 2012-01-20 Schering Corp Esteroides de heteroarilo [3.2-c] novedosos como agonistas de receptor de glucocorticoide composiciones y uso de los mismos.
US20110130711A1 (en) * 2009-11-19 2011-06-02 Follica, Inc. Hair growth treatment
CA2690490C (en) 2010-01-19 2012-06-26 Accucaps Industries Limited Pharmaceutical formulations of loratadine for encapsulation and combinations thereof
EP2762141A4 (en) 2011-09-29 2015-03-25 Shionogi & Co THERAPEUTIC PHARMACEUTICAL PRODUCT AGAINST ALLERGIC RHINITIS COMPRISING A PGD2 ANTAGONIST AND A HISTAMINE ANTAGONIST
US10525057B2 (en) 2013-09-24 2020-01-07 Otsuka Pharmaceutical Co., Ltd. Method of providing aripiprazole to patients having impaired CYP2D6 or CYP3A4 enzyme function
CN106478595B (zh) * 2016-09-18 2019-05-21 西安交通大学 氯雷他定晶型及其制备方法和用途
CN110845473B (zh) * 2019-10-08 2023-04-07 深圳市南山区人民医院 一种抗金黄色葡萄球菌毒力和生物被膜形成的抑制剂Lo-乙酸乙酯及其用途
CN110818685A (zh) * 2019-10-08 2020-02-21 深圳市南山区人民医院 一种抗金黄色葡萄球菌毒力和生物被膜形成的抑制剂Lo-异己基及其用途
CN110818684B (zh) * 2019-10-08 2023-04-07 深圳市南山区人民医院 一种抗金黄色葡萄球菌毒力和生物被膜形成的抑制剂Lo-SH及其用途
MX2022005102A (es) * 2019-10-31 2022-05-30 Jd Bioscience Inc Compuesto triciclico y uso farmaceutico del mismo.
KR102242382B1 (ko) 2020-02-28 2021-04-20 삼익제약주식회사 용해성, 안정성 및 쓴맛이 개선된 로라타딘 함유 시럽 조성물
JP2023549381A (ja) 2020-11-18 2023-11-24 バイオファーマ・シナジーズ，エス．エル． 抗ヒスタミン活性化合物を含む口内分散性粉末組成物
CN112645928A (zh) * 2020-12-23 2021-04-13 常州大学 一种连续流制备氯雷他定ⅱ晶型的方法
CN113135893B (zh) * 2021-06-21 2022-02-11 北京鑫开元医药科技有限公司 苯并环庚烷并吡啶化合物、其制备方法及其用途
CN115778924A (zh) * 2022-12-22 2023-03-14 河北三禾实创生物科技有限公司 一种氯雷他定制剂及其制备方法
CN116496259B (zh) * 2023-04-24 2025-08-29 黑龙江珍宝岛药业股份有限公司 一种富马酸卢帕他定的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL132137C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1963-04-24
US3419565A (en) * 1963-04-24 1968-12-31 Schering Corp Aza-dibenzocycloheptenes
US3264342A (en) * 1963-05-24 1966-08-02 Geigy Chem Corp Derivatives of 5h-dibenzo[a, d] cycloheptene
US3491103A (en) * 1963-12-19 1970-01-20 Sandoz Ag Certain 4h-benzo(4,5)cyclohepta-(1,2-b) thiophenes
US3464983A (en) * 1964-02-04 1969-09-02 Sandoz Ag 4h-benzo(4,5)cyclohepta(1,2-b)thiophenes
US3435073A (en) * 1966-04-19 1969-03-25 Colgate Palmolive Co 5-(n-benzyl-n-lower alkylaminoalkylene)-5h-dibenzo(a,d)cycloheptenes
US3513201A (en) * 1966-10-25 1970-05-19 Merck & Co Inc Process for preparing 5-(3-alkylaminopropyl)-5h-dibenzo(a,d)cycloheptenes
US3917669A (en) * 1966-11-08 1975-11-04 Hoffmann La Roche Intermediates for tricyclic amines
ES356805A1 (es) * 1967-08-03 1970-05-01 Hoffmann La Roche Procedimiento para la preparacion de compuestos tricicli- cos.
US3952017A (en) * 1968-05-03 1976-04-20 Hoffmann-La Roche Inc. Tricyclic compounds
CH531000A (de) * 1970-03-11 1972-11-30 Sandoz Ag Verfahren zur Herstellung neuer Benzocycloheptathiophene
GB1329733A (en) * 1970-12-02 1973-09-12 Science Union & Cie Derivatives of isonipecotic acid and a process for their prepa- ration

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CY1405A (en) 1988-04-22
HU186774B (en) 1985-09-30
AU543054B2 (en) 1985-03-28
ZA814062B (en) 1982-07-28
DK169817B1 (da) 1995-03-06
EP0042544A2 (en) 1981-12-30
DE3166441D1 (en) 1984-11-08
JPS6355513B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1988-11-02
MY8700761A (en) 1987-12-31
KR830006218A (ko) 1983-09-20
PT73200A (en) 1981-07-01
ATE9695T1 (de) 1984-10-15
KR850000744B1 (ko) 1985-05-24
EP0042544B1 (en) 1984-10-03
US4282233A (en) 1981-08-04
IE811328L (en) 1981-12-19
IE51303B1 (en) 1986-11-26
FI811878L (fi) 1981-12-20
ES503085A0 (es) 1982-11-01
ES8300779A1 (es) 1982-11-01
NZ197435A (en) 1984-03-30
AU7186281A (en) 1981-12-24
IL63122A (en) 1985-06-30
PT73200B (en) 1983-04-26
US4282233B1 (en) 2000-09-05
LU88359I2 (fr) 1994-05-04
NL930094I1 (nl) 1993-10-01
FI70213B (fi) 1986-02-28
CA1160230A (en) 1984-01-10
NL930094I2 (nl) 1994-12-01
JPS5735586A (en) 1982-02-26
HK94387A (en) 1987-12-18
KE3758A (en) 1987-10-02
FI70213C (fi) 1986-09-15
EP0042544A3 (en) 1982-04-07
PH19252A (en) 1986-02-17
DK263481A (da) 1981-12-20

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