SG55069A1 - Compounds with growth hormone releasing properties - Google Patents
Compounds with growth hormone releasing propertiesInfo
- Publication number
- SG55069A1 SG55069A1 SG1996004604A SG1996004604A SG55069A1 SG 55069 A1 SG55069 A1 SG 55069A1 SG 1996004604 A SG1996004604 A SG 1996004604A SG 1996004604 A SG1996004604 A SG 1996004604A SG 55069 A1 SG55069 A1 SG 55069A1
- Authority
- SG
- Singapore
- Prior art keywords
- growth hormone
- compounds
- hormone releasing
- releasing properties
- pct
- Prior art date
Links
- 102000018997 Growth Hormone Human genes 0.000 title abstract 2
- 108010051696 Growth Hormone Proteins 0.000 title abstract 2
- 239000000122 growth hormone Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 230000003578 releasing effect Effects 0.000 title 1
- 230000001817 pituitary effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurosurgery (AREA)
- Zoology (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK143993A DK143993D0 (de) | 1993-12-23 | 1993-12-23 | |
| DK12194 | 1994-01-28 | ||
| DK119194 | 1994-10-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG55069A1 true SG55069A1 (en) | 1998-12-21 |
Family
ID=27220421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG1996004604A SG55069A1 (en) | 1993-12-23 | 1994-12-22 | Compounds with growth hormone releasing properties |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5767085A (de) |
| EP (1) | EP0736039B1 (de) |
| JP (1) | JP3181918B2 (de) |
| KR (1) | KR100354897B1 (de) |
| CN (1) | CN1052731C (de) |
| AT (1) | ATE197158T1 (de) |
| AU (1) | AU689181B2 (de) |
| BR (1) | BR9408377A (de) |
| CA (1) | CA2179597A1 (de) |
| CZ (1) | CZ293113B6 (de) |
| DE (1) | DE69426206T2 (de) |
| DK (1) | DK0736039T3 (de) |
| ES (1) | ES2153469T3 (de) |
| FI (1) | FI962584A (de) |
| GR (1) | GR3035150T3 (de) |
| HU (1) | HU224345B1 (de) |
| IL (1) | IL112112A (de) |
| MX (1) | MX9500072A (de) |
| NO (1) | NO315561B1 (de) |
| NZ (1) | NZ277486A (de) |
| PL (1) | PL181280B1 (de) |
| PT (1) | PT736039E (de) |
| RO (1) | RO115635B1 (de) |
| SG (1) | SG55069A1 (de) |
| SK (1) | SK281963B6 (de) |
| UA (1) | UA42747C2 (de) |
| WO (1) | WO1995017423A1 (de) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0730578A4 (de) * | 1993-11-24 | 1997-10-08 | Merck & Co Inc | Indolyl-gruppen enthaltende verbindungen und deren verwendung zur förderung der freisetzung von wachstumshormonen |
| IL112111A (en) * | 1993-12-23 | 2000-07-16 | Novo Nordisk As | Peptides having growth hormone releasing properties and pharmaceutical compositions containing them |
| US5798337A (en) * | 1994-11-16 | 1998-08-25 | Genentech, Inc. | Low molecular weight peptidomimetic growth hormone secretagogues |
| US20020111461A1 (en) * | 1999-05-21 | 2002-08-15 | Todd C. Somers | Low molecular weight peptidomimetic growth hormone secretagogues |
| PL186511B1 (pl) * | 1995-01-27 | 2004-01-30 | Novo Nordisk As | Nowe związki peptydowe, kompozycje farmaceutycznedo pobudzania uwalniania hormonu wzrostu i zastosowanie tych związków do wytwarzania leku do pobudzania uwalniania hormonu wzrostu |
| IL122371A0 (en) * | 1995-06-22 | 1998-06-15 | Novo Nordisk As | Compounds with growth hormone releasing properties |
| JP3798024B2 (ja) | 1995-12-13 | 2006-07-19 | メルク エンド カンパニー インコーポレーテッド | 成長ホルモン分泌促進物質レセプターアッセイ |
| US6531314B1 (en) | 1996-12-10 | 2003-03-11 | Merck & Co., Inc. | Growth hormone secretagogue receptor family |
| GB2308362A (en) * | 1995-12-19 | 1997-06-25 | Lilly Industries Ltd | Pharmaceutical indole derivatives |
| EP0869974B1 (de) * | 1995-12-22 | 2009-03-04 | Novo Nordisk A/S | Verbindungen mit wachstumshormon-freisetzenden eigenschaften |
| US6451970B1 (en) | 1996-02-21 | 2002-09-17 | Novo Nordisk A/S | Peptide derivatives |
| US5919777A (en) * | 1996-04-24 | 1999-07-06 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| EP0907643B1 (de) * | 1996-04-24 | 2003-01-15 | Novo Nordisk A/S | Verbindungen mit wachtumshormon freisetzenden eigenschaften |
| DE69734215T2 (de) * | 1996-07-22 | 2006-06-29 | Novo Nordisk A/S | Verbindungen mit Wachstumshormon-freisetzenden Eigenschaften |
| WO1998008492A1 (en) * | 1996-08-29 | 1998-03-05 | Novo Nordisk A/S | Transdermal delivery of peptides |
| US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
| US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
| US6127341A (en) * | 1997-06-20 | 2000-10-03 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| AU7906998A (en) | 1997-06-20 | 1999-01-04 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| DE69921611T2 (de) | 1998-01-16 | 2005-11-03 | Novo Nordisk A/S | Verbindungen mit wachstumshormon-freisetzenden eigenschaften |
| US6919315B1 (en) | 1998-06-30 | 2005-07-19 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| US6682908B1 (en) | 1998-07-10 | 2004-01-27 | Merck & Co., Inc. | Mouse growth hormone secretagogue receptor |
| CA2333857A1 (en) | 1998-07-13 | 2000-01-20 | Merck & Co., Inc. | Growth hormone secretagogue related receptors and nucleic acids |
| EP1112282A4 (de) | 1998-08-10 | 2002-10-31 | Merck & Co Inc | Rezeptor des wachstumshormon-sekretionsförderers aus dem hund |
| US6696063B1 (en) * | 1998-12-30 | 2004-02-24 | Applied Research Systems Ars Holding N.V. | Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy |
| ATE284415T1 (de) | 1999-01-06 | 2004-12-15 | Genentech Inc | Mutierte variante des insulin-ähnlichen wachstumsfaktor-i (igf-i) |
| KR100699404B1 (ko) | 1999-02-18 | 2007-03-23 | 가켄 세야쿠 가부시키가이샤 | 성장 호르몬 분비촉진제로서의 신규 아미드 유도체 |
| JP2003501394A (ja) * | 1999-06-04 | 2003-01-14 | ノボ ノルディスク アクティーゼルスカブ | 延長された重度の疾患の異化状態の処理のための組成物 |
| DE60133271T2 (de) | 2000-05-16 | 2009-04-23 | Genentech, Inc., South San Francisco | Behandlung von knorpelerkrankungen |
| EP1159964B1 (de) | 2000-05-31 | 2009-10-28 | Pfizer Products Inc. | Verwendung von Wachstumshormonsekretagoga zur Förderung der Beweglichkeit des Verdauungstrakts |
| TWI331922B (en) | 2002-08-09 | 2010-10-21 | Ipsen Pharma Sas | Growth hormone releasing peptides |
| EA008572B1 (ru) * | 2003-05-19 | 2007-06-29 | Уорнер-Ламберт Компани Ллс | Твёрдая желатиновая капсула, содержащая оксид титана с контролируемым размером частиц, и способ её получения |
| US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
| EP1667521B1 (de) | 2003-09-12 | 2011-12-07 | Tercica, Inc. | Verfahren zur behandlung von igf-1 (insulin-like growth factor 1)-mangel |
| WO2005027913A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a growth hormone secretagogue |
| CA2565324A1 (en) * | 2004-03-30 | 2005-10-20 | Sapphire Therapeutics, Inc. | Method of reducing c-reactive protein using growth hormone secretagogues |
| UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| AU2005272598B2 (en) * | 2004-08-12 | 2011-11-17 | Helsinn Therapeutics (U.S.), Inc. | Method of stimulating the motility of the gastrointestinal system using growth hormone secretagogues |
| CU23558A1 (es) | 2006-02-28 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento |
| US8536120B2 (en) * | 2006-04-28 | 2013-09-17 | The Administrators Of The Tulane Educational Fund | Ghrelin/growth hormone releasing peptide/growth hormone secretatogue receptor antagonists and uses thereof |
| AU2008241532A1 (en) | 2007-02-09 | 2008-10-30 | Tranzyme Pharma, Inc. | Macrocyclic ghrelin receptor modulators and methods of using the same |
| KR20090112720A (ko) * | 2007-02-13 | 2009-10-28 | 헬신 세라퓨틱스 (유.에스.) 인크. | 성장 호르몬 분비촉진제를 이용한 세포 증식 질환의 치료방법 |
| TWI429436B (zh) * | 2007-04-10 | 2014-03-11 | Helsinn Therapeutics Us Inc | 使用生長激素促泌素治療或預防嘔吐之方法 |
| US20100099640A1 (en) | 2007-05-04 | 2010-04-22 | Joannes Geuns | Tissue degeneration protection |
| EP2225226B1 (de) | 2007-12-26 | 2016-08-17 | Critical Outcome Technologies, Inc. | Verbindungen und ihre verwending in einem verfahren zur behandlung von krebs |
| CA2730890C (en) | 2008-07-17 | 2018-05-15 | Critical Outcome Technologies Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
| UA105657C2 (uk) | 2009-02-27 | 2014-06-10 | Хелсінн Терапьютікс (Ю.Ес.), Інк. | Поліпшені способи лікування мігрені на основі анамореліну |
| US9724381B2 (en) | 2009-05-12 | 2017-08-08 | The Administrators Of The Tulane Educational Fund | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof |
| SG176717A1 (en) * | 2009-06-12 | 2012-01-30 | Helsinn Therapeutics Us Inc | Ipamorelin diacetate injection and infusion solutions |
| EP2552915B1 (de) | 2010-04-01 | 2017-07-19 | Critical Outcome Technologies Inc. | Verbindungen zur behandlung von hiv |
| WO2013190520A2 (en) | 2012-06-22 | 2013-12-27 | The General Hospital Corporation | Gh-releasing agents in the treatment of vascular stenosis and associated conditions |
| US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
| US10328082B2 (en) | 2014-05-30 | 2019-06-25 | Pfizer Inc. | Methods of use and combinations |
| WO2017075535A1 (en) | 2015-10-28 | 2017-05-04 | Oxeia Biopharmaceuticals, Inc. | Methods of treating neurodegenerative conditions |
| WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4228156A (en) * | 1979-03-30 | 1980-10-14 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
| US4223020A (en) * | 1979-03-30 | 1980-09-16 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
| US4223019A (en) * | 1979-03-30 | 1980-09-16 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
| US4410512A (en) * | 1981-12-28 | 1983-10-18 | Beckman Instruments, Inc. | Combinations having synergistic pituitary growth hormone releasing activity |
| WO1983002272A1 (en) * | 1981-12-28 | 1983-07-07 | Beckman Instruments Inc | Synthetic peptides having pituitary growth hormone releasing activity |
| US4803261A (en) * | 1986-06-27 | 1989-02-07 | The Administrators Of The Tulane Educational Fund | Method for synthesizing a peptide containing a non-peptide |
| IL98910A0 (en) * | 1990-07-24 | 1992-07-15 | Polygen Holding Corp | Polypeptide compounds having growth hormone releasing activity and pharmaceutical compositions containing them |
| US5663146A (en) * | 1991-08-22 | 1997-09-02 | Administrators Of The Tulane Educational Fund | Polypeptide analogues having growth hormone releasing activity |
| WO1994007519A1 (en) * | 1992-09-25 | 1994-04-14 | Smithkline Beecham Corporation | Growth hormone releasing peptides |
| EP0730578A4 (de) * | 1993-11-24 | 1997-10-08 | Merck & Co Inc | Indolyl-gruppen enthaltende verbindungen und deren verwendung zur förderung der freisetzung von wachstumshormonen |
-
1994
- 1994-12-22 PL PL94315113A patent/PL181280B1/pl not_active IP Right Cessation
- 1994-12-22 WO PCT/DK1994/000485 patent/WO1995017423A1/en active IP Right Grant
- 1994-12-22 PT PT95903774T patent/PT736039E/pt unknown
- 1994-12-22 BR BR9408377A patent/BR9408377A/pt not_active Application Discontinuation
- 1994-12-22 KR KR1019960703336A patent/KR100354897B1/ko not_active IP Right Cessation
- 1994-12-22 CN CN94194590A patent/CN1052731C/zh not_active Expired - Fee Related
- 1994-12-22 SG SG1996004604A patent/SG55069A1/en unknown
- 1994-12-22 EP EP95903774A patent/EP0736039B1/de not_active Expired - Lifetime
- 1994-12-22 CZ CZ19961834A patent/CZ293113B6/cs not_active IP Right Cessation
- 1994-12-22 JP JP51710995A patent/JP3181918B2/ja not_active Expired - Lifetime
- 1994-12-22 SK SK820-96A patent/SK281963B6/sk unknown
- 1994-12-22 HU HU9501947A patent/HU224345B1/hu not_active IP Right Cessation
- 1994-12-22 UA UA96062486A patent/UA42747C2/uk unknown
- 1994-12-22 AU AU12724/95A patent/AU689181B2/en not_active Ceased
- 1994-12-22 AT AT95903774T patent/ATE197158T1/de not_active IP Right Cessation
- 1994-12-22 IL IL11211294A patent/IL112112A/xx not_active IP Right Cessation
- 1994-12-22 ES ES95903774T patent/ES2153469T3/es not_active Expired - Lifetime
- 1994-12-22 NZ NZ277486A patent/NZ277486A/en unknown
- 1994-12-22 RO RO96-01293A patent/RO115635B1/ro unknown
- 1994-12-22 DK DK95903774T patent/DK0736039T3/da active
- 1994-12-22 DE DE69426206T patent/DE69426206T2/de not_active Expired - Lifetime
- 1994-12-22 US US08/448,623 patent/US5767085A/en not_active Expired - Lifetime
- 1994-12-22 CA CA002179597A patent/CA2179597A1/en not_active Abandoned
-
1995
- 1995-01-02 MX MX9500072A patent/MX9500072A/es unknown
-
1996
- 1996-06-20 FI FI962584A patent/FI962584A/fi not_active IP Right Cessation
- 1996-06-21 NO NO19962665A patent/NO315561B1/no not_active IP Right Cessation
-
2000
- 2000-12-27 GR GR20000402838T patent/GR3035150T3/el not_active IP Right Cessation
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