SG4890G - 1-pyrimidinyloxy-3-hetarylalkylamino-2-propanols preparation and uses - Google Patents

1-pyrimidinyloxy-3-hetarylalkylamino-2-propanols preparation and uses

Info

Publication number
SG4890G
SG4890G SG48/90A SG4890A SG4890G SG 4890 G SG4890 G SG 4890G SG 48/90 A SG48/90 A SG 48/90A SG 4890 A SG4890 A SG 4890A SG 4890 G SG4890 G SG 4890G
Authority
SG
Singapore
Prior art keywords
hetarylalkylamino
pyrimidinyloxy
propanols
preparation
propanols preparation
Prior art date
Application number
SG48/90A
Other languages
English (en)
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of SG4890G publication Critical patent/SG4890G/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
SG48/90A 1983-05-09 1990-01-19 1-pyrimidinyloxy-3-hetarylalkylamino-2-propanols preparation and uses SG4890G (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/493,124 US4517188A (en) 1983-05-09 1983-05-09 1-Pyrimidinyloxy-3-hetaryl-alkylamino-2-propanols

Publications (1)

Publication Number Publication Date
SG4890G true SG4890G (en) 1990-07-13

Family

ID=23958998

Family Applications (1)

Application Number Title Priority Date Filing Date
SG48/90A SG4890G (en) 1983-05-09 1990-01-19 1-pyrimidinyloxy-3-hetarylalkylamino-2-propanols preparation and uses

Country Status (25)

Country Link
US (1) US4517188A (it)
JP (1) JPS59206364A (it)
KR (1) KR900005015B1 (it)
AT (1) AT392966B (it)
AU (1) AU576761B2 (it)
BE (1) BE899608A (it)
CA (1) CA1279064C (it)
CH (1) CH659247A5 (it)
CY (1) CY1522A (it)
DE (1) DE3416976A1 (it)
DK (1) DK166583C (it)
ES (3) ES8604529A1 (it)
FI (1) FI80268C (it)
FR (1) FR2545825B1 (it)
GB (1) GB2139623B (it)
GR (1) GR81557B (it)
HK (1) HK17590A (it)
IE (1) IE57410B1 (it)
IT (1) IT1175492B (it)
LU (1) LU85354A1 (it)
NL (1) NL8401450A (it)
PT (1) PT78570A (it)
SE (1) SE466309B (it)
SG (1) SG4890G (it)
ZA (1) ZA843378B (it)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4598149A (en) * 1984-03-02 1986-07-01 Merck & Co., Inc. 3-amino-2-hydroxypropyl of pyrimidin-4-one useful as antihypertensive, cardioprotective, antiarrythmic, and antianginal agents
US5177215A (en) * 1984-11-12 1993-01-05 Yamanouchi Pharmaceutical Co., Ltd. Heterocyclic compounds and pharmaceutical use thereof
PH22520A (en) * 1984-11-12 1988-10-17 Yamanouchi Pharma Co Ltd Heterocyclic compounds having 4-lover alkyl-3-hydroxy-2-lower alkyl phenoxy-lower alkylene-y-group, and process of producing them
JPS6242974A (ja) * 1985-08-20 1987-02-24 Ube Ind Ltd ピリミジニルオキシアルカン酸アミド誘導体および除草剤
US5030640A (en) * 1989-01-05 1991-07-09 Merck & Co., Inc. Novel β-adrenergic agonists and pharmaceutical compositions thereof
IL126458A (en) 1996-04-09 2004-06-20 Nps Pharma Inc Calcium receptor inhibiting calcilytic compounds
US6818660B2 (en) 1996-04-09 2004-11-16 Nps Pharmaceuticals, Inc. Calcilytic compounds
TW483881B (en) 1996-12-03 2002-04-21 Nps Pharma Inc Calcilytic compounds
US7202261B2 (en) 1996-12-03 2007-04-10 Nps Pharmaceuticals, Inc. Calcilytic compounds
US7037916B2 (en) 1999-07-15 2006-05-02 Pharmacopeia Drug Discovery, Inc. Pyrimidine derivatives as IL-8 receptor antagonists
PL365643A1 (en) * 2000-10-25 2005-01-10 Smithkline Beecham Corporation Calcilytic compounds
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
AU2004273057C1 (en) 2003-09-08 2011-06-30 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Non-peptide agonists and antagonists of adrenomedullin and gastrin releasing peptide
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
TWI556839B (zh) 2009-05-06 2016-11-11 研究室護膚股份有限公司 包含活性劑－磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL300886A (it) * 1962-11-23
US4193995A (en) * 1972-05-05 1980-03-18 Merck Sharp & Dohme (I.A.) Corp. 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazine compounds and compositions
US4042586A (en) * 1972-05-05 1977-08-16 Merck Sharp & Dohme (I.A.) Corporation 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazines
US4195090A (en) * 1973-02-20 1980-03-25 Ciba-Geigy Corporation 2-(3-Amino-2-hydroxy-propoxy)pyridine derivatives and pharmaceutical compositions therewith
CH584209A5 (en) * 1973-02-20 1977-01-31 Ciba Geigy Ag 3-amino-2-hydroxypropoxy substd. diazines and pyridines - with beta-adrenergic blocking or stimulating activity
AR206801A1 (es) * 1973-02-20 1976-08-23 Ciba Geigy Ag Procedimiento para la elaboracion de derivados del 1-pirid loxi-2-hidroxi-3-amino-propano
CH567484A5 (it) * 1973-04-05 1975-10-15 Sandoz Ag
JPS5839832B2 (ja) * 1974-02-20 1983-09-01 チバ ガイギ− アクチエンゲゼルシヤフト 新規ピラジン化合物の製法
US4139623A (en) * 1974-05-14 1979-02-13 C-G Corp. Cyclic-substituted derivatives of 1-amino-2-propanol
CH588308A5 (it) * 1975-02-18 1977-05-31 Escher Wyss Ag
GB1585950A (en) * 1976-08-02 1981-03-11 Ici Ltd Pyrimidine compoudns and their use as herbicides
IT1165040B (it) * 1979-04-23 1987-04-22 Isf Spa Alcossialchilidenidrazinopiridazione e procedimento per la loro preparazione
JPS55151570A (en) * 1979-05-15 1980-11-26 Takeda Chem Ind Ltd Pyrimidine derivatives, their preparation and antimicrobial for agriculture
US4312398A (en) * 1979-09-28 1982-01-26 The Boeing Company Method of forming fiber and metal composite structures
US4400201A (en) * 1980-12-15 1983-08-23 Sandoz Ltd. Novel pyrimidinyl ethers, their use as herbicides, herbicidal compositions comprising said pyrimidinyl ethers and processes for the preparation thereof
US4321398A (en) * 1981-05-07 1982-03-23 Mead Johnson & Company Thienyl and benzothienyl-tertiary butylaminophenoxypropanols

Also Published As

Publication number Publication date
IE841137L (en) 1984-11-09
GR81557B (it) 1984-12-11
KR900005015B1 (ko) 1990-07-16
IE57410B1 (en) 1992-08-26
ZA843378B (en) 1984-12-24
ES8704154A1 (es) 1987-03-16
FI80268B (fi) 1990-01-31
HK17590A (en) 1990-03-16
PT78570A (en) 1984-06-01
DK166583B (da) 1993-06-14
US4517188A (en) 1985-05-14
NL8401450A (nl) 1984-12-03
ES8702372A1 (es) 1986-12-16
FR2545825A1 (fr) 1984-11-16
AU2779284A (en) 1984-11-15
IT8420841A0 (it) 1984-05-08
FI841841A0 (fi) 1984-05-08
ES545198A0 (es) 1987-03-16
SE8402476D0 (sv) 1984-05-08
AU576761B2 (en) 1988-09-08
ES532282A0 (es) 1986-02-01
ATA152284A (de) 1990-12-15
CH659247A5 (de) 1987-01-15
SE466309B (sv) 1992-01-27
KR840008798A (ko) 1984-12-19
JPS59206364A (ja) 1984-11-22
DK227884A (da) 1984-11-10
IT1175492B (it) 1987-07-01
GB2139623A (en) 1984-11-14
SE8402476L (sv) 1984-11-10
IT8420841A1 (it) 1985-11-08
GB8411636D0 (en) 1984-06-13
DE3416976A1 (de) 1984-11-15
DK166583C (da) 1993-10-25
FI80268C (fi) 1990-05-10
ES8604529A1 (es) 1986-02-01
CY1522A (en) 1990-11-16
GB2139623B (en) 1987-01-21
FR2545825B1 (fr) 1987-10-09
AT392966B (de) 1991-07-25
DK227884D0 (da) 1984-05-08
LU85354A1 (fr) 1985-03-21
FI841841A (fi) 1984-11-10
BE899608A (fr) 1984-11-08
CA1279064C (en) 1991-01-15
ES551966A0 (es) 1986-12-16

Similar Documents

Publication Publication Date Title
DE3464100D1 (en) Electric-cable structure and its application
NZ210135A (en) 2-pyridylmethyl-thio and sulphinyl-benzimidazole derivatives
SG4890G (en) 1-pyrimidinyloxy-3-hetarylalkylamino-2-propanols preparation and uses
IL71658A (en) 17-sulfonylmethylene-steroids and their preparation
ZA842202B (en) Phenylaminobenzenealkanols and preparation
DE3367089D1 (en) 3-phenoxy-1-azetidinecarboxamides and their use and preparation
IL73876A0 (en) Acylamino-mitosanes and their preparation
DE3471652D1 (en) Diurethane-diureas and use
GB2146329B (en) Naphthalenylimidazopyridine and derivatives and their preparation
GB2117757B (en) Alkylspectinomycins and their preparation
ZA846610B (en) Novel pyrazolylsulfonylureas and isoxazolylsulfonylureas
GB2126230B (en) Substituted 1-pyridyloxy-3-indolylalkylamino-2-propanols preparation and use thereof
GB8428144D0 (en) Hydrophilic-film-forming preparation
PH21682A (en) Dihydroindenothiadiazinone and dihydronaphthothiadiazinone derivatives
GB8323796D0 (en) Preparation of haloacetals and halodioxolanes
GB2141121B (en) 1-phenoxy-3-hydroxyindolyl-alkylamino-3-propanols and preparation
DE3472250D1 (en) Novel halonitriles and their preparation
DE3463048D1 (en) Furan-3-hydroxamates and their use
GB2138803B (en) 2-guanidino-4-hydroxymethylthiazole and derivatives thereof
GR82496B (en) Compounds and use
DE3163316D1 (en) Diacyloxyalkadienes and their preparation
IL81484A0 (en) Fluoroazolylketones and their preparation
SU1150294A2 (en) Debris-trapping and fish-protecting arrangement
IL68484A0 (en) Sulfonamidobenzophenones and their preparation
PL240667A2 (en) Washing-disinfecting preparation