SG47967A1 - N-phenyi-n-(4-piperidinyi) amides useful as analgesics - Google Patents
N-phenyi-n-(4-piperidinyi) amides useful as analgesicsInfo
- Publication number
- SG47967A1 SG47967A1 SG1996005735A SG1996005735A SG47967A1 SG 47967 A1 SG47967 A1 SG 47967A1 SG 1996005735 A SG1996005735 A SG 1996005735A SG 1996005735 A SG1996005735 A SG 1996005735A SG 47967 A1 SG47967 A1 SG 47967A1
- Authority
- SG
- Singapore
- Prior art keywords
- lower alkyl
- group
- alkoxy
- member selected
- carbonyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31131189A | 1989-02-15 | 1989-02-15 | |
| US07/448,497 US5019583A (en) | 1989-02-15 | 1989-12-11 | N-phenyl-N-(4-piperidinyl)amides useful as analgesics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG47967A1 true SG47967A1 (en) | 1998-04-17 |
Family
ID=26977841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG1996005735A SG47967A1 (en) | 1989-02-15 | 1990-02-14 | N-phenyi-n-(4-piperidinyi) amides useful as analgesics |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5019583A (nl) |
| EP (1) | EP0383579B1 (nl) |
| JP (1) | JP2895145B2 (nl) |
| KR (1) | KR0160979B1 (nl) |
| AT (1) | ATE140451T1 (nl) |
| AU (1) | AU636330B2 (nl) |
| CA (1) | CA2010011C (nl) |
| CY (1) | CY2002A (nl) |
| CZ (1) | CZ402591A3 (nl) |
| DE (2) | DE19675028I2 (nl) |
| DK (1) | DK0383579T3 (nl) |
| ES (1) | ES2088961T4 (nl) |
| GR (1) | GR3020719T3 (nl) |
| HK (1) | HK78297A (nl) |
| IE (1) | IE77156B1 (nl) |
| LU (1) | LU90011I2 (nl) |
| MX (1) | MX9203024A (nl) |
| NL (1) | NL960030I2 (nl) |
| NZ (1) | NZ232542A (nl) |
| PT (1) | PT93137B (nl) |
| SG (1) | SG47967A1 (nl) |
| SK (1) | SK402591A3 (nl) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5214148A (en) * | 1990-12-18 | 1993-05-25 | Glaxo Inc. | Analgesic N-phenyl-N-(3-OR1 -3-ME-4-piperidinyl)amides |
| US5130321A (en) * | 1990-12-18 | 1992-07-14 | Glaxo Inc. | Analgesic n-phenyl-n-(3-or 1-3-me-4-piperidinyl)amides |
| GB9316863D0 (en) * | 1993-08-13 | 1993-09-29 | Glaxo Group Ltd | Chemical process |
| US5466700A (en) * | 1993-08-30 | 1995-11-14 | Glaxo Wellcome Inc. | Anesthetic use of N-phenyl-N-(4-piperidinyl)amides |
| US5866591A (en) * | 1996-09-11 | 1999-02-02 | Glaxo Wellcome Inc. | Stable formulations of remifentanil |
| ZA9811842B (en) * | 1997-12-24 | 2000-06-23 | Ortho Mcneil Pharm Inc | 4-[aryl(piperidin-4-yl)]aminobenzamides. |
| US6858018B1 (en) | 1998-09-28 | 2005-02-22 | Vyteris, Inc. | Iontophoretic devices |
| US6436959B1 (en) | 1998-12-23 | 2002-08-20 | Ortho-Mcneil Pharmaceutical, Inc. | 4-[aryl(piperidin-4-yl)]aminobenzamides |
| ATE340159T1 (de) * | 1999-12-06 | 2006-10-15 | Mallinckrodt Inc | Verfahren zur herstellung von alfentanil, sufentanil und remifentanil |
| AU2001238690A1 (en) | 2000-03-14 | 2001-09-24 | Sepracor, Inc. | 3-substituted piperidines comprising urea functionality, and methods of use thereof |
| AU2001281746C1 (en) * | 2000-07-31 | 2010-09-09 | ISTITUTO GENTILI S.r.l. | Fentanyl composition for nasal administration |
| US6686377B2 (en) | 2001-04-03 | 2004-02-03 | Aryx Therapeutics | Ultrashort-acting opioids for transdermal application |
| EP1455784A1 (en) * | 2001-12-17 | 2004-09-15 | Aryx Therapeutics | Analgesic delivery systems and methods of use |
| JPWO2005030722A1 (ja) * | 2003-09-29 | 2006-12-07 | 日本ケミファ株式会社 | Ｎ−置換−ｎ−（４−ピペリジニル）アミド誘導体 |
| JP2008502651A (ja) | 2004-06-18 | 2008-01-31 | ノイロサーチ アクティーゼルスカブ | モノアミン神経伝達物質再取込み阻害剤としての、新規アルキル置換ピペリジン誘導体及びその使用 |
| US20090030041A1 (en) * | 2004-09-14 | 2009-01-29 | Toshihiro Takahashi | N-substituted N-(4-piperidinyl) Amide Derivative |
| EP1966140A1 (en) * | 2005-11-17 | 2008-09-10 | Mallinckrodt, Inc. | Process for synthesizing remifentanil |
| US20080312448A1 (en) * | 2006-01-24 | 2008-12-18 | Cheng Brian K | Process for Synthesizing Remifentanil |
| US20080319197A1 (en) * | 2006-02-03 | 2008-12-25 | Cheng Brian K | Crystalline Form of Remifentanil Hydrochloride |
| EP1867635A1 (en) * | 2006-06-15 | 2007-12-19 | Kern Pharma, S.L. | Process for preparing remifentanil, intermediates thereof, use of said intermediates and processes for their preparation |
| GB0613693D0 (en) * | 2006-07-10 | 2006-08-16 | Cenes Ltd | Benzodiazepine salts (3) |
| DK2081921T3 (da) | 2006-07-10 | 2011-01-03 | Paion Uk Ltd | Korttidsvirkende benzodiazepinsalte og deres polymorfe former |
| US20100099880A1 (en) * | 2006-10-05 | 2010-04-22 | Brian Cheng | Alternate Process for Remifentanil Preparation |
| WO2008066708A2 (en) * | 2006-11-29 | 2008-06-05 | Mallinckrodt Inc. | New process for remifentanil synthesis |
| EP3210976A1 (en) | 2008-03-31 | 2017-08-30 | The General Hospital Corporation | Etomidate analogues with improved pharmacokinetic and pharmacodynamic properties |
| US20110144346A1 (en) * | 2008-07-03 | 2011-06-16 | Cilag Ag | Method for producing n-phenyl-n-(4-piperidinyl) amide salts |
| WO2010053944A1 (en) * | 2008-11-04 | 2010-05-14 | Cambrex Charles City, Inc. | Improved method of making piperidine derivatives |
| JP5925121B2 (ja) | 2009-07-10 | 2016-05-25 | ザ ジェネラル ホスピタル コーポレイション | 副腎皮質ステロイド合成を阻害しないエトミデート類似体 |
| EP2450039A1 (en) | 2010-11-08 | 2012-05-09 | PAION UK Ltd. | Dosing regimen for sedation with CNS 7056 (Remimazolam) |
| SI2802325T1 (sl) | 2012-01-13 | 2017-04-26 | The General Hospital Corporation | Anestetične spojine in pripadajoči postopki za uporabo |
| KR20150065873A (ko) | 2012-10-08 | 2015-06-15 | 오클랜드 유니서비시즈 리미티드 | 케타민 유도체 |
| AR094963A1 (es) | 2013-03-04 | 2015-09-09 | Ono Pharmaceutical Co | Reacción de oxidación excelente en el índice de conversión |
| CN103728403B (zh) * | 2013-08-30 | 2015-10-07 | 宜昌人福药业有限责任公司 | 一种盐酸瑞芬太尼原料药中有关物质的检测方法 |
| ES2699636T3 (es) | 2016-01-29 | 2019-02-12 | Bioka S R O | Nuevo procedimiento para la preparación de derivados de N-fenil-N-(4-piperidinil) amida, como remifentanilo y carfentanilo |
| PT3643704T (pt) | 2018-10-26 | 2021-03-08 | Hameln Pharma Gmbh | Novos intermediários para a preparação de hidrocloreto de remifentanil |
| GB202010168D0 (en) * | 2020-07-02 | 2020-08-19 | Johnson Matthey Plc | Process for preparing remifentanil hydrochloride |
| CN114262320A (zh) * | 2021-12-28 | 2022-04-01 | 宜昌人福药业有限责任公司 | 一种利用连续流微通道反应器制备苯胺基哌啶类药物的合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL135583C (nl) * | 1961-10-10 | |||
| US3655675A (en) * | 1968-09-09 | 1972-04-11 | Sterling Drug Inc | N-(n-heteryl)-acylanilides |
| US3998834A (en) * | 1975-03-14 | 1976-12-21 | Janssen Pharmaceutica N.V. | N-(4-piperidinyl)-n-phenylamides and -carbamates |
| US4179569A (en) * | 1975-03-14 | 1979-12-18 | Janssen Pharmaceutica N.V. | N-(4-piperidinyl)-N-phenylamides |
| US4167574A (en) * | 1978-03-13 | 1979-09-11 | Janssen Pharmaceutica, N.V. | N-phenyl-N-(4-piperidinyl)amides |
| US4584303A (en) * | 1984-04-09 | 1986-04-22 | The Boc Group, Inc. | N-aryl-N-(4-piperidinyl)amides and pharmaceutical compositions and method employing such compounds |
| US4801721A (en) * | 1984-08-16 | 1989-01-31 | Ryan James W | Stereospecific synthesis of carboxyalkyl peptides |
| CA1317940C (en) * | 1987-09-25 | 1993-05-18 | Georges H. P. Van Daele | Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides |
-
1989
- 1989-12-11 US US07/448,497 patent/US5019583A/en not_active Expired - Lifetime
-
1990
- 1990-02-14 DK DK90301586.5T patent/DK0383579T3/da active
- 1990-02-14 KR KR1019900001796A patent/KR0160979B1/ko not_active IP Right Cessation
- 1990-02-14 JP JP2031680A patent/JP2895145B2/ja not_active Expired - Lifetime
- 1990-02-14 DE DE1996175028 patent/DE19675028I2/de active Active
- 1990-02-14 DE DE69027794T patent/DE69027794T2/de not_active Expired - Lifetime
- 1990-02-14 PT PT93137A patent/PT93137B/pt not_active IP Right Cessation
- 1990-02-14 EP EP90301586A patent/EP0383579B1/en not_active Expired - Lifetime
- 1990-02-14 CA CA002010011A patent/CA2010011C/en not_active Expired - Fee Related
- 1990-02-14 IE IE53290A patent/IE77156B1/en not_active IP Right Cessation
- 1990-02-14 ES ES90301586T patent/ES2088961T4/es not_active Expired - Lifetime
- 1990-02-14 NZ NZ232542A patent/NZ232542A/en unknown
- 1990-02-14 SG SG1996005735A patent/SG47967A1/en unknown
- 1990-02-14 AT AT90301586T patent/ATE140451T1/de active
- 1990-02-14 AU AU49731/90A patent/AU636330B2/en not_active Expired
-
1991
- 1991-12-23 CZ CS914025A patent/CZ402591A3/cs unknown
- 1991-12-23 SK SK4025-91A patent/SK402591A3/sk unknown
-
1992
- 1992-06-19 MX MX9203024A patent/MX9203024A/es unknown
-
1996
- 1996-08-02 GR GR960402083T patent/GR3020719T3/el unknown
- 1996-11-21 NL NL960030C patent/NL960030I2/nl unknown
-
1997
- 1997-01-24 LU LU90011C patent/LU90011I2/fr unknown
- 1997-06-12 HK HK78297A patent/HK78297A/xx not_active IP Right Cessation
- 1997-12-05 CY CY200297A patent/CY2002A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0383579B1 (en) | 1996-07-17 |
| JPH02300167A (ja) | 1990-12-12 |
| DE69027794D1 (de) | 1996-08-22 |
| KR0160979B1 (ko) | 1998-12-01 |
| LU90011I2 (fr) | 1997-03-11 |
| JP2895145B2 (ja) | 1999-05-24 |
| SK402591A3 (en) | 2000-09-12 |
| PT93137A (pt) | 1990-08-31 |
| IE77156B1 (en) | 1997-12-03 |
| DE19675028I2 (de) | 2002-11-07 |
| HK78297A (en) | 1997-06-20 |
| AU4973190A (en) | 1990-08-23 |
| ATE140451T1 (de) | 1996-08-15 |
| ES2088961T4 (es) | 1996-12-01 |
| ES2088961T3 (es) | 1996-10-01 |
| AU636330B2 (en) | 1993-04-29 |
| DE69027794T2 (de) | 1997-01-02 |
| PT93137B (pt) | 1996-02-29 |
| NL960030I2 (nl) | 1997-05-01 |
| CA2010011C (en) | 1997-12-02 |
| GR3020719T3 (en) | 1996-11-30 |
| KR900012906A (ko) | 1990-09-03 |
| EP0383579A1 (en) | 1990-08-22 |
| IE900532L (en) | 1990-08-15 |
| NZ232542A (en) | 1992-06-25 |
| MX9203024A (es) | 1992-07-01 |
| US5019583A (en) | 1991-05-28 |
| NL960030I1 (nl) | 1997-02-03 |
| CY2002A (en) | 1997-12-05 |
| CZ402591A3 (en) | 1993-04-14 |
| DK0383579T3 (da) | 1996-10-14 |
| CA2010011A1 (en) | 1990-08-15 |
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