ATE340159T1 - Verfahren zur herstellung von alfentanil, sufentanil und remifentanil - Google Patents
Verfahren zur herstellung von alfentanil, sufentanil und remifentanilInfo
- Publication number
- ATE340159T1 ATE340159T1 AT00988013T AT00988013T ATE340159T1 AT E340159 T1 ATE340159 T1 AT E340159T1 AT 00988013 T AT00988013 T AT 00988013T AT 00988013 T AT00988013 T AT 00988013T AT E340159 T1 ATE340159 T1 AT E340159T1
- Authority
- AT
- Austria
- Prior art keywords
- remifentanil
- alfentanil
- sufentanil
- producing
- synthesizing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16873999P | 1999-12-06 | 1999-12-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE340159T1 true ATE340159T1 (de) | 2006-10-15 |
Family
ID=22612741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00988013T ATE340159T1 (de) | 1999-12-06 | 2000-12-04 | Verfahren zur herstellung von alfentanil, sufentanil und remifentanil |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7074935B2 (de) |
| EP (1) | EP1246801B1 (de) |
| JP (1) | JP2003515588A (de) |
| AT (1) | ATE340159T1 (de) |
| AU (1) | AU2427201A (de) |
| BR (1) | BR0016063A (de) |
| CA (1) | CA2393559C (de) |
| DE (1) | DE60030883T2 (de) |
| ES (1) | ES2272354T3 (de) |
| WO (1) | WO2001040184A2 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10141650C1 (de) | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
| AU2004287815B2 (en) * | 2003-10-29 | 2009-05-28 | Mallinckrodt Inc. | Industrial method for separation and purification of fentanyl by reverse phase preparative chromatography |
| JP2008519837A (ja) * | 2004-11-10 | 2008-06-12 | ベーリンガー インゲルハイム ケミカルズ インコーポレイテッド | フェンタニル中間体の生成方法 |
| GB0509276D0 (en) * | 2005-05-06 | 2005-06-15 | Univ Cranfield | Synthetic receptor |
| CN101312949A (zh) * | 2005-11-17 | 2008-11-26 | 马林克罗特公司 | 合成瑞芬太尼的方法 |
| US8252328B2 (en) * | 2006-01-06 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
| US8357114B2 (en) | 2006-01-06 | 2013-01-22 | Acelrx Pharmaceuticals, Inc. | Drug dispensing device with flexible push rod |
| US8865743B2 (en) | 2006-01-06 | 2014-10-21 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
| US8753308B2 (en) | 2006-01-06 | 2014-06-17 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
| US8535714B2 (en) | 2006-01-06 | 2013-09-17 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
| US8202535B2 (en) | 2006-01-06 | 2012-06-19 | Acelrx Pharmaceuticals, Inc. | Small-volume oral transmucosal dosage forms |
| US9289583B2 (en) | 2006-01-06 | 2016-03-22 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
| US8252329B2 (en) | 2007-01-05 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
| US9066847B2 (en) * | 2007-01-05 | 2015-06-30 | Aceirx Pharmaceuticals, Inc. | Storage and dispensing devices for administration of oral transmucosal dosage forms |
| JP2009525329A (ja) * | 2006-02-03 | 2009-07-09 | マリンクロッド・インコーポレイテッド | レミフェンタニル塩酸塩の結晶形 |
| US20070260491A1 (en) * | 2006-05-08 | 2007-11-08 | Pamela Palmer | System for delivery and monitoring of administration of controlled substances |
| EP1867635A1 (de) * | 2006-06-15 | 2007-12-19 | Kern Pharma, S.L. | Verfahren zur Herstellung von Remifentanil, seine Zwischenprodukte, die Verwendung von diesen Zwischenprodukten und das Verfahren zur deren Herstellung |
| US20070299687A1 (en) * | 2006-06-23 | 2007-12-27 | Pamela Palmer | Inpatient system for patient-controlled delivery of oral transmucosal medications dosed as needed |
| WO2008045192A2 (en) * | 2006-10-05 | 2008-04-17 | Mallinckrodt Inc. | Alternate process for remifentanil preparation |
| CA2670704A1 (en) * | 2006-11-29 | 2008-06-05 | Mallinckrodt Inc. | New process for remifentanil synthesis |
| JP2011526257A (ja) * | 2008-07-03 | 2011-10-06 | シラグ アーゲー | Ｎ−フェニル−ｎ−（４−ピペリジニル）アミド塩の製造方法 |
| WO2010027770A1 (en) * | 2008-09-04 | 2010-03-11 | Mallinckrodt Inc. | Crystalline forms of sufentanil citrate |
| US8299258B2 (en) | 2008-11-04 | 2012-10-30 | Cambrex Charles City | Method of making piperidine derivatives |
| US8945592B2 (en) * | 2008-11-21 | 2015-02-03 | Acelrx Pharmaceuticals, Inc. | Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same |
| ES2664801T3 (es) * | 2010-09-17 | 2018-04-23 | Mallinckrodt Llc | Proceso mejorado para la preparación de un precursor de sufentanilo base |
| EP2455377B1 (de) | 2010-11-11 | 2014-07-09 | hameln rds gmbh | Synthese von Fentanyl Analoga |
| CN102060753B (zh) * | 2010-12-29 | 2013-01-09 | 宜昌人福药业有限责任公司 | 一种4-苯胺基哌啶类镇痛药的精制方法 |
| CN103044398B (zh) * | 2012-12-12 | 2015-09-16 | 宜昌人福药业有限责任公司 | 一种盐酸阿芬太尼的晶型 |
| US8742111B1 (en) * | 2013-02-21 | 2014-06-03 | The United States Of America As Represented By The Secretary Of The Army | Synthesis of intermediate anilino methyl esters used in the production of synthetic opioid analgesics |
| EP3183232B1 (de) * | 2014-08-22 | 2023-05-03 | The Arizona Board of Regents on behalf of The University of Arizona | Substituierte 1-arylethyl-4-acylaminopiperidin-derivate als opioid-/alpha-adrenorezeptor-modulatoren und verfahren zu deren herstellung |
| EP3233799B1 (de) | 2014-12-19 | 2021-05-19 | The Broad Institute, Inc. | Dopamin-d2-rezeptor-liganden |
| EP3233077A4 (de) | 2014-12-19 | 2018-08-08 | The Broad Institute Inc. | Dopamin-d2-rezeptor-liganden |
| ES2806631T3 (es) | 2015-05-27 | 2021-02-18 | SpecGx LLC | Preparación de citrato de sufentanilo y base de sufentanilo |
| SI3199523T1 (sl) | 2016-01-29 | 2018-12-31 | Bioka S.R.O. | Nov postopek za pridobivanje n-fenil-n-(4-piperinidil)amidnih derivatov kot sta remifentanil in karfentanil |
| WO2017180659A1 (en) * | 2016-04-11 | 2017-10-19 | Arizona Board Of Regents On Behalf Of University Of Arizona | Opioid receptor modulators |
| US9650338B1 (en) | 2016-07-29 | 2017-05-16 | VDM Biochemicals, Inc. | Opioid antagonist compounds and methods of making and using |
| WO2022195497A1 (en) * | 2021-03-16 | 2022-09-22 | Ami Organics Ltd. | A process for the preparation of 4-piperidone hcl hydrate |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3161644A (en) | 1962-06-22 | 1964-12-15 | Res Lab Dr C Janssen N V | 1-benzyl-4-substituted piperidines |
| US3998834A (en) * | 1975-03-14 | 1976-12-21 | Janssen Pharmaceutica N.V. | N-(4-piperidinyl)-n-phenylamides and -carbamates |
| FR2389622B1 (de) * | 1977-05-05 | 1982-05-21 | Janssen Pharmaceutica Nv | |
| US4167574A (en) | 1978-03-13 | 1979-09-11 | Janssen Pharmaceutica, N.V. | N-phenyl-N-(4-piperidinyl)amides |
| US5019583A (en) | 1989-02-15 | 1991-05-28 | Glaxo Inc. | N-phenyl-N-(4-piperidinyl)amides useful as analgesics |
| US5461147A (en) | 1993-09-27 | 1995-10-24 | Schering Corporation | Process for preparing benzazepine intermediates for the synthesis of D1 antagonists |
| US5489689A (en) | 1993-09-30 | 1996-02-06 | Mallinckrodt Chemical, Inc. | Preparation of piperidine derivatives |
-
2000
- 2000-12-04 DE DE60030883T patent/DE60030883T2/de not_active Expired - Fee Related
- 2000-12-04 CA CA002393559A patent/CA2393559C/en not_active Expired - Fee Related
- 2000-12-04 WO PCT/US2000/032882 patent/WO2001040184A2/en active IP Right Grant
- 2000-12-04 AU AU24272/01A patent/AU2427201A/en not_active Abandoned
- 2000-12-04 BR BR0016063-6A patent/BR0016063A/pt not_active Application Discontinuation
- 2000-12-04 EP EP00988013A patent/EP1246801B1/de not_active Expired - Lifetime
- 2000-12-04 ES ES00988013T patent/ES2272354T3/es not_active Expired - Lifetime
- 2000-12-04 AT AT00988013T patent/ATE340159T1/de not_active IP Right Cessation
- 2000-12-04 US US10/130,324 patent/US7074935B2/en not_active Expired - Fee Related
- 2000-12-04 JP JP2001541870A patent/JP2003515588A/ja not_active Withdrawn
-
2006
- 2006-02-24 US US11/362,498 patent/US7208604B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20040138461A1 (en) | 2004-07-15 |
| US7208604B2 (en) | 2007-04-24 |
| AU2427201A (en) | 2001-06-12 |
| US20060149071A1 (en) | 2006-07-06 |
| EP1246801B1 (de) | 2006-09-20 |
| CA2393559C (en) | 2009-05-26 |
| DE60030883D1 (de) | 2006-11-02 |
| ES2272354T3 (es) | 2007-05-01 |
| WO2001040184B1 (en) | 2002-01-31 |
| DE60030883T2 (de) | 2007-09-06 |
| BR0016063A (pt) | 2002-08-06 |
| EP1246801A2 (de) | 2002-10-09 |
| CA2393559A1 (en) | 2001-06-07 |
| US7074935B2 (en) | 2006-07-11 |
| JP2003515588A (ja) | 2003-05-07 |
| WO2001040184A3 (en) | 2002-01-03 |
| WO2001040184A2 (en) | 2001-06-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |