SG194822A1 - Pyrazole derivatives useful as aldosterone synthase inhibitors - Google Patents
Pyrazole derivatives useful as aldosterone synthase inhibitors Download PDFInfo
- Publication number
- SG194822A1 SG194822A1 SG2013082367A SG2013082367A SG194822A1 SG 194822 A1 SG194822 A1 SG 194822A1 SG 2013082367 A SG2013082367 A SG 2013082367A SG 2013082367 A SG2013082367 A SG 2013082367A SG 194822 A1 SG194822 A1 SG 194822A1
- Authority
- SG
- Singapore
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- mmol
- compounds
- Prior art date
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- 229940123338 Aldosterone synthase inhibitor Drugs 0.000 title abstract description 12
- 150000003217 pyrazoles Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract description 39
- 150000001875 compounds Chemical class 0.000 claims description 196
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 29
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 16
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- JSDRRTOADPPCHY-HSQYWUDLSA-N quinapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 JSDRRTOADPPCHY-HSQYWUDLSA-N 0.000 description 1
- IBBLRJGOOANPTQ-JKVLGAQCSA-N quinapril hydrochloride Chemical compound Cl.C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 IBBLRJGOOANPTQ-JKVLGAQCSA-N 0.000 description 1
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- CWCSCNSKBSCYCS-UHFFFAOYSA-M sodium;2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetate Chemical compound [Na+].CCC(=C)C(=O)C1=CC=C(OCC([O-])=O)C(Cl)=C1Cl CWCSCNSKBSCYCS-UHFFFAOYSA-M 0.000 description 1
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- WRECIMRULFAWHA-UHFFFAOYSA-N trimethyl borate Chemical compound COB(OC)OC WRECIMRULFAWHA-UHFFFAOYSA-N 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161496657P | 2011-06-14 | 2011-06-14 | |
| US201161506349P | 2011-07-11 | 2011-07-11 | |
| PCT/US2012/041212 WO2012173849A1 (en) | 2011-06-14 | 2012-06-07 | Pyrazole derivatives useful as aldosterone synthase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG194822A1 true SG194822A1 (en) | 2013-12-30 |
Family
ID=46317515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2013082367A SG194822A1 (en) | 2011-06-14 | 2012-06-07 | Pyrazole derivatives useful as aldosterone synthase inhibitors |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US8778984B2 (https=) |
| EP (1) | EP2721009B1 (https=) |
| JP (1) | JP5890012B2 (https=) |
| KR (1) | KR101555119B1 (https=) |
| CN (1) | CN103596930B (https=) |
| AR (1) | AR086665A1 (https=) |
| AU (1) | AU2012271023A1 (https=) |
| BR (1) | BR112013031873A2 (https=) |
| CA (1) | CA2836804C (https=) |
| CL (1) | CL2013003536A1 (https=) |
| CO (1) | CO6821955A2 (https=) |
| CR (1) | CR20130601A (https=) |
| CY (1) | CY1116687T1 (https=) |
| DK (1) | DK2721009T3 (https=) |
| DO (1) | DOP2013000284A (https=) |
| EA (1) | EA201391655A1 (https=) |
| EC (1) | ECSP13013080A (https=) |
| ES (1) | ES2548210T3 (https=) |
| GT (1) | GT201300307A (https=) |
| HR (1) | HRP20150939T1 (https=) |
| HU (1) | HUE026461T2 (https=) |
| IL (1) | IL229485A0 (https=) |
| ME (1) | ME02223B (https=) |
| MX (1) | MX336042B (https=) |
| PE (1) | PE20140606A1 (https=) |
| PH (1) | PH12013502597A1 (https=) |
| PL (1) | PL2721009T3 (https=) |
| PT (1) | PT2721009E (https=) |
| RS (1) | RS54269B1 (https=) |
| SG (1) | SG194822A1 (https=) |
| SI (1) | SI2721009T1 (https=) |
| TW (1) | TWI518073B (https=) |
| WO (1) | WO2012173849A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6596417B2 (ja) * | 2014-07-04 | 2019-10-23 | 日本たばこ産業株式会社 | インドール化合物の製造方法 |
| CN108586221B (zh) * | 2018-06-26 | 2021-03-02 | 常州制药厂有限公司 | 用于制备替卡格雷的中间体及其制备方法 |
| CN112409432B (zh) * | 2020-11-16 | 2023-07-07 | 陕西理工大学 | 一种依西美坦的合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57165369A (en) | 1981-04-06 | 1982-10-12 | Teijin Ltd | Pyrazole derivative and its preparation |
| US4617307A (en) * | 1984-06-20 | 1986-10-14 | Ciba-Geigy Corporation | Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors |
| US5057521A (en) | 1988-10-26 | 1991-10-15 | Ciba-Geigy Corporation | Use of bicyclic imidazole compounds for the treatment of hyperaldosteronism |
| GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
| WO2007111175A1 (ja) | 2006-03-17 | 2007-10-04 | Ngk Insulators, Ltd. | 目封止ハニカム構造体の製造方法 |
| ES2472446T3 (es) | 2009-11-30 | 2014-07-01 | Novartis Ag | Derivados de imidazol como inhibidores de aldosterona sintasa |
| JP5602250B2 (ja) | 2010-01-14 | 2014-10-08 | ノバルティス アーゲー | 副腎ホルモン修飾剤の使用 |
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2012
- 2012-06-04 AR ARP120101967A patent/AR086665A1/es unknown
- 2012-06-04 TW TW101120004A patent/TWI518073B/zh not_active IP Right Cessation
- 2012-06-07 RS RS20150619A patent/RS54269B1/sr unknown
- 2012-06-07 SG SG2013082367A patent/SG194822A1/en unknown
- 2012-06-07 ES ES12727984.2T patent/ES2548210T3/es active Active
- 2012-06-07 PH PH1/2013/502597A patent/PH12013502597A1/en unknown
- 2012-06-07 JP JP2014515877A patent/JP5890012B2/ja not_active Expired - Fee Related
- 2012-06-07 PT PT127279842T patent/PT2721009E/pt unknown
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