SG193291A1 - Alkyne substituted quinazoline compound and methods of use - Google Patents

Alkyne substituted quinazoline compound and methods of use Download PDF

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Publication number
SG193291A1
SG193291A1 SG2013066352A SG2013066352A SG193291A1 SG 193291 A1 SG193291 A1 SG 193291A1 SG 2013066352 A SG2013066352 A SG 2013066352A SG 2013066352 A SG2013066352 A SG 2013066352A SG 193291 A1 SG193291 A1 SG 193291A1
Authority
SG
Singapore
Prior art keywords
compound
cancer
alkyl
chloro
salt
Prior art date
Application number
SG2013066352A
Other languages
English (en)
Inventor
Wang Shen
Aimin Zhang
Jack Maung
Xiaoling Zheng
Original Assignee
Newgen Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Newgen Therapeutics Inc filed Critical Newgen Therapeutics Inc
Publication of SG193291A1 publication Critical patent/SG193291A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG2013066352A 2011-03-04 2012-03-02 Alkyne substituted quinazoline compound and methods of use SG193291A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161449088P 2011-03-04 2011-03-04
PCT/US2012/027614 WO2012122058A2 (en) 2011-03-04 2012-03-02 Alkyne substituted quinazoline compound and methods of use

Publications (1)

Publication Number Publication Date
SG193291A1 true SG193291A1 (en) 2013-10-30

Family

ID=46798728

Family Applications (3)

Application Number Title Priority Date Filing Date
SG2013066352A SG193291A1 (en) 2011-03-04 2012-03-02 Alkyne substituted quinazoline compound and methods of use
SG10201601711SA SG10201601711SA (en) 2011-03-04 2012-03-02 Alkyne Substituted Quinazoline Compound And Methods Of Use
SG10201913982WA SG10201913982WA (en) 2011-03-04 2012-03-02 Alkyne Substituted Quinazoline Compound And Methods Of Use

Family Applications After (2)

Application Number Title Priority Date Filing Date
SG10201601711SA SG10201601711SA (en) 2011-03-04 2012-03-02 Alkyne Substituted Quinazoline Compound And Methods Of Use
SG10201913982WA SG10201913982WA (en) 2011-03-04 2012-03-02 Alkyne Substituted Quinazoline Compound And Methods Of Use

Country Status (14)

Country Link
US (5) US9090588B2 (OSRAM)
EP (1) EP2680850B1 (OSRAM)
JP (1) JP6006242B2 (OSRAM)
KR (4) KR20210043016A (OSRAM)
CN (1) CN103998040B (OSRAM)
AU (3) AU2012225693A1 (OSRAM)
BR (1) BR112013022552B1 (OSRAM)
CA (1) CA2828713C (OSRAM)
IL (1) IL228072A (OSRAM)
MX (1) MX344302B (OSRAM)
RU (1) RU2013144571A (OSRAM)
SG (3) SG193291A1 (OSRAM)
TW (1) TWI617556B (OSRAM)
WO (1) WO2012122058A2 (OSRAM)

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CN103254156B (zh) * 2013-05-10 2015-08-26 苏州明锐医药科技有限公司 阿法替尼中间体的制备方法
CN103254183B (zh) * 2013-05-10 2015-11-11 苏州明锐医药科技有限公司 阿法替尼的制备方法
CN108430972B (zh) 2015-12-24 2022-12-27 协和麒麟株式会社 α,β不饱和酰胺化合物
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US11083492B2 (en) * 2018-06-06 2021-08-10 Lifetech Scientific (Shenzhen) Co., Ltd Method for implanting an interventional medical device
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BR112021005513A2 (pt) 2018-09-25 2021-06-22 Black Diamond Therapeutics, Inc. derivados de quinazolina como inibidor de tirosina quinase, composições, métodos de fabricação e uso dos mesmos
MX2022001952A (es) * 2019-08-15 2022-06-02 Black Diamond Therapeutics Inc Compuestos de alquinil quinazolina.
CN113527215B (zh) * 2020-04-17 2023-12-05 北京赛特明强医药科技有限公司 一种喹唑啉类化合物、制备方法及其应用
WO2021209039A1 (zh) * 2020-04-17 2021-10-21 北京赛特明强医药科技有限公司 一种喹唑啉类化合物、制备方法及其应用
EP4236954A1 (en) * 2020-11-02 2023-09-06 Black Diamond Therapeutics, Inc. Method of treating cancers with alkyne substituted quinazoline derivatives
CN120769850A (zh) * 2023-03-02 2025-10-10 江苏康缘药业股份有限公司 一种炔基取代的喹唑啉化合物的晶型、其制备方法和应用

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Also Published As

Publication number Publication date
AU2018267622B2 (en) 2020-05-14
KR20200003933A (ko) 2020-01-10
TW201249835A (en) 2012-12-16
WO2012122058A3 (en) 2014-04-24
WO2012122058A2 (en) 2012-09-13
US20160031860A1 (en) 2016-02-04
RU2013144571A (ru) 2015-04-10
KR20210043016A (ko) 2021-04-20
US20180093975A1 (en) 2018-04-05
US9090588B2 (en) 2015-07-28
KR20220031732A (ko) 2022-03-11
CA2828713C (en) 2022-08-16
MX344302B (es) 2016-12-13
KR20140020955A (ko) 2014-02-19
US20140128417A1 (en) 2014-05-08
IL228072A (en) 2016-08-31
US20190382382A1 (en) 2019-12-19
CN103998040B (zh) 2017-03-29
EP2680850A4 (en) 2015-01-28
MX2013010016A (es) 2013-11-20
CA2828713A1 (en) 2012-09-13
BR112013022552B1 (pt) 2021-11-23
SG10201913982WA (en) 2020-03-30
US11524956B2 (en) 2022-12-13
AU2012225693A1 (en) 2013-09-19
SG10201601711SA (en) 2016-04-28
CN103998040A (zh) 2014-08-20
TWI617556B (zh) 2018-03-11
KR102061743B1 (ko) 2020-01-03
US20210047303A1 (en) 2021-02-18
AU2018267622A1 (en) 2018-12-13
JP2014518544A (ja) 2014-07-31
BR112013022552A2 (pt) 2016-12-06
AU2017200984A1 (en) 2017-03-02
EP2680850A2 (en) 2014-01-08
IL228072A0 (en) 2013-09-30
JP6006242B2 (ja) 2016-10-12
EP2680850B1 (en) 2018-05-23

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