SG177990A1 - Methods, systems, and apparatuses for heat treatment for treating meibomian gland dysfunction - Google Patents
Methods, systems, and apparatuses for heat treatment for treating meibomian gland dysfunction Download PDFInfo
- Publication number
- SG177990A1 SG177990A1 SG2012003638A SG2012003638A SG177990A1 SG 177990 A1 SG177990 A1 SG 177990A1 SG 2012003638 A SG2012003638 A SG 2012003638A SG 2012003638 A SG2012003638 A SG 2012003638A SG 177990 A1 SG177990 A1 SG 177990A1
- Authority
- SG
- Singapore
- Prior art keywords
- eyelid
- heat
- controller
- force
- patient
- Prior art date
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0001—Body part
- A61F2007/0002—Head or parts thereof
- A61F2007/0004—Eyes or part of the face surrounding the eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0086—Heating or cooling appliances for medical or therapeutic treatment of the human body with a thermostat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/007—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00718—Restoration of lid function
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Thermal Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Massaging Devices (AREA)
- Percussion Or Vibration Massage (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88085007P | 2007-01-17 | 2007-01-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG177990A1 true SG177990A1 (en) | 2012-02-28 |
Family
ID=39636379
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2012003638A SG177990A1 (en) | 2007-01-17 | 2008-01-17 | Methods, systems, and apparatuses for heat treatment for treating meibomian gland dysfunction |
| SG2012003646A SG177991A1 (en) | 2007-01-17 | 2008-01-17 | Methods, systems, and apparatuses for heat treatment for treating meibomian gland dysfunction |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2012003646A SG177991A1 (en) | 2007-01-17 | 2008-01-17 | Methods, systems, and apparatuses for heat treatment for treating meibomian gland dysfunction |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP3434313A1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP5406728B2 (cg-RX-API-DMAC10.html) |
| CN (3) | CN103181837B (cg-RX-API-DMAC10.html) |
| BR (1) | BRPI0806635A2 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2692434T3 (cg-RX-API-DMAC10.html) |
| IL (1) | IL199920A0 (cg-RX-API-DMAC10.html) |
| SG (2) | SG177990A1 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2008089327A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070060988A1 (en) | 2005-07-18 | 2007-03-15 | Grenon Stephen M | Melting meibomian gland obstructions |
| US8083787B2 (en) | 2005-07-18 | 2011-12-27 | Tearscience, Inc. | Method and apparatus for treating meibomian gland dysfunction |
| WO2013003594A2 (en) | 2011-06-28 | 2013-01-03 | Tearscience, Inc. | Methods and systems for treating meibomian gland dysfunction using radio-frequency energy |
| US7981145B2 (en) | 2005-07-18 | 2011-07-19 | Tearscience Inc. | Treatment of meibomian glands |
| US7981095B2 (en) | 2005-07-18 | 2011-07-19 | Tearscience, Inc. | Methods for treating meibomian gland dysfunction employing fluid jet |
| US8950405B2 (en) | 2006-05-15 | 2015-02-10 | Tearscience, Inc. | Treatment of obstructive disorders of the eye or eyelid |
| US20080114423A1 (en) | 2006-05-15 | 2008-05-15 | Grenon Stephen M | Apparatus for inner eyelid treatment of meibomian gland dysfunction |
| US20090043365A1 (en) | 2005-07-18 | 2009-02-12 | Kolis Scientific, Inc. | Methods, apparatuses, and systems for reducing intraocular pressure as a means of preventing or treating open-angle glaucoma |
| US8137390B2 (en) | 2006-05-15 | 2012-03-20 | Tearscience, Inc. | System for providing heat treatment and heat loss reduction for treating meibomian gland dysfunction |
| US8128673B2 (en) | 2006-05-15 | 2012-03-06 | Tearscience, Inc. | System for inner eyelid heat and pressure treatment for treating meibomian gland dysfunction |
| US9314369B2 (en) | 2006-05-15 | 2016-04-19 | Tearscience, Inc. | System for inner eyelid treatment of meibomian gland dysfunction |
| US8128674B2 (en) | 2006-05-15 | 2012-03-06 | Tearscience, Inc. | System for outer eyelid heat and pressure treatment for treating meibomian gland dysfunction |
| CN103251375B (zh) | 2009-04-01 | 2016-09-28 | 眼泪科学公司 | 用于成像和测量泪液膜层一个或多个厚度的仪器 |
| US9642520B2 (en) | 2009-04-01 | 2017-05-09 | Tearscience, Inc. | Background reduction apparatuses and methods of ocular surface interferometry (OSI) employing polarization for imaging, processing, and/or displaying an ocular tear film |
| US9888839B2 (en) | 2009-04-01 | 2018-02-13 | Tearscience, Inc. | Methods and apparatuses for determining contact lens intolerance in contact lens wearer patients based on dry eye tear film characteristic analysis and dry eye symptoms |
| US9510972B2 (en) * | 2012-01-04 | 2016-12-06 | Sight Sciences, Inc. | Dry eye treatment systems |
| WO2013114127A1 (en) * | 2012-02-03 | 2013-08-08 | Anant Sharma | Eye Massage Device |
| US10842670B2 (en) | 2012-08-22 | 2020-11-24 | Johnson & Johnson Vision Care, Inc. | Apparatuses and methods for diagnosing and/or treating lipid transport deficiency in ocular tear films, and related components and devices |
| US9339177B2 (en) | 2012-12-21 | 2016-05-17 | Tearscience, Inc. | Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography |
| US9763827B2 (en) | 2013-04-30 | 2017-09-19 | Tear Film Innovations, Inc. | Systems and methods for the treatment of eye conditions |
| WO2014179795A2 (en) * | 2013-05-03 | 2014-11-06 | Tearscience, Inc. | Eyelid illumination systems and methods for imaging meibomian glands for meibomian gland analysis |
| US9795290B2 (en) | 2013-11-15 | 2017-10-24 | Tearscience, Inc. | Ocular tear film peak detection and stabilization detection systems and methods for determining tear film layer characteristics |
| WO2016070134A1 (en) * | 2014-10-30 | 2016-05-06 | Tear Film Innovations, Inc. | Systems and methods for the treatment of eye conditions |
| CN105520805B (zh) * | 2016-02-04 | 2017-11-07 | 张晨明 | 赶压式睑板腺功能障碍治疗装置 |
| US10974063B2 (en) | 2016-06-30 | 2021-04-13 | Alcon Inc. | Light therapy for eyelash growth |
| TWI772314B (zh) * | 2016-07-12 | 2022-08-01 | 德商得瑪法公司 | 用於瘙癢症的高熱治療之裝置 |
| LT3308752T (lt) * | 2016-10-11 | 2020-07-27 | Dermapharm Ag | Niežėjimo gydymo hiperterminiu būdų prietaisas |
| EP3618783B1 (en) | 2017-05-05 | 2023-07-05 | Craig Litherland | Devices for treating eyelids |
| WO2019033339A1 (en) * | 2017-08-17 | 2019-02-21 | Xinova, LLC | DISPOSABLE CONTACT LENS FOR OPTICAL PROCESSING SYSTEMS |
| US20200179168A1 (en) * | 2018-12-06 | 2020-06-11 | Alcon Inc. | Systems and methods for the treatment of eye conditions |
| WO2020130176A1 (ko) * | 2018-12-19 | 2020-06-25 | 부산대학교 산학협력단 | 안구 건조증 치료용 장치 |
| CN109771127A (zh) * | 2019-02-27 | 2019-05-21 | 浙江花园润嘉医疗器械有限公司 | 干眼症治疗仪及其控制方法 |
| CN111658305A (zh) * | 2020-05-21 | 2020-09-15 | 李秀岩 | 一种带眼压传感器的温控眼压感应眼加热电热膜 |
| CN115957067A (zh) * | 2021-10-09 | 2023-04-14 | 上海臻复医疗科技有限公司 | 眼部冷敷装置 |
| CN114081716B (zh) * | 2022-01-22 | 2022-04-12 | 南方医科大学深圳医院 | 用于向睑板腺递送药物的装置 |
| CN117562733A (zh) * | 2022-08-08 | 2024-02-20 | 上海臻复医疗科技有限公司 | 眼杯以及眼部治疗装置 |
| KR20250103563A (ko) * | 2023-12-26 | 2025-07-07 | 주식회사 옵트로쓰 | 온열 시스템을 구비하는 스마트 콘택트렌즈 |
| WO2025199573A1 (en) * | 2024-03-27 | 2025-10-02 | Nthalmic Holding Pty Ltd | Smart wearable device to treat meibomian gland deficiencies |
| CN118304085A (zh) * | 2024-04-11 | 2024-07-09 | 沪湾生物科技(上海)有限公司 | 睑板腺治疗装置 |
| CN119235542B (zh) * | 2024-10-31 | 2025-07-29 | 华创视康(深圳)医疗科技有限公司 | 眼睑热敷装置 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3140390A (en) | 1963-06-12 | 1964-07-07 | Smith Percy | Therapeutic appliance |
| US5958912A (en) | 1992-04-21 | 1999-09-28 | The Schepens Eye Research Institute, Inc. | Ocular therapy in keratoconjunctivitis sicca using topically applied androgens of TGF-β |
| US6107289A (en) | 1992-04-21 | 2000-08-22 | The Schepens Eye Research Institute, Inc. | Ocular therapy in keratoconjunctivitis sicca using topically applied androgens or TGF-β |
| JPH06269473A (ja) * | 1993-03-19 | 1994-09-27 | Santen Pharmaceut Co Ltd | 携帯式眼部加温器 |
| WO1997020578A1 (en) | 1995-12-04 | 1997-06-12 | University Of Miami | Non-preserved topical corticosteroid for treatment of dry eye, filamentary keratitis, and delayed tear clearance |
| JPH11221247A (ja) * | 1997-08-25 | 1999-08-17 | Seputo:Kk | 温熱付眼鏡 |
| DK1676579T3 (da) | 1998-05-08 | 2009-03-16 | Univ Miami | Anvendelse af sub-antimikrobielle tetracykliner til behandling af okulær rosacea |
| TW539564B (en) * | 1999-05-25 | 2003-07-01 | Iomed Inc | Methods and apparatus for ocular iontophoresis |
| JP3613634B2 (ja) * | 2001-11-06 | 2005-01-26 | 得一郎 長谷川 | 視力矯正装置 |
| GB2384430B (en) * | 2002-01-24 | 2003-12-03 | John Robert Fuller | Therapeutic eye and eyelid cover |
| GB0225795D0 (en) * | 2002-11-05 | 2002-12-11 | Guillon Michael | Wipes |
| US7513893B2 (en) * | 2004-03-12 | 2009-04-07 | Abraham Ebbie Soroudi | Device and method for treatment of eyelid diseases |
| DE602005026978D1 (de) * | 2004-11-23 | 2011-04-28 | Timothy L Lee | Medizinische vorrichtung zur temperaturregelung und behandlung des auges sowie des umgebenden gewebes |
| JP2006198249A (ja) * | 2005-01-21 | 2006-08-03 | Rohto Pharmaceut Co Ltd | ドライアイ治療用具 |
| WO2008024100A2 (en) * | 2006-08-21 | 2008-02-28 | Tearscience, Inc. | Method and apparatus for treating gland dysfunction |
| US8083787B2 (en) | 2005-07-18 | 2011-12-27 | Tearscience, Inc. | Method and apparatus for treating meibomian gland dysfunction |
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2008
- 2008-01-17 BR BRPI0806635-3A patent/BRPI0806635A2/pt not_active Application Discontinuation
- 2008-01-17 EP EP18192086.9A patent/EP3434313A1/en not_active Withdrawn
- 2008-01-17 JP JP2009546506A patent/JP5406728B2/ja not_active Expired - Fee Related
- 2008-01-17 CN CN201310017761.3A patent/CN103181837B/zh not_active Expired - Fee Related
- 2008-01-17 ES ES08727830.5T patent/ES2692434T3/es active Active
- 2008-01-17 CN CN2008800087417A patent/CN101663064B/zh active Active
- 2008-01-17 CN CN201310017764.7A patent/CN103083131B/zh active Active
- 2008-01-17 WO PCT/US2008/051309 patent/WO2008089327A1/en not_active Ceased
- 2008-01-17 SG SG2012003638A patent/SG177990A1/en unknown
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| JP2014087649A (ja) | 2014-05-15 |
| JP2010516343A (ja) | 2010-05-20 |
| JP5406728B2 (ja) | 2014-02-05 |
| CN103181837B (zh) | 2015-04-22 |
| WO2008089327A1 (en) | 2008-07-24 |
| EP2121109A4 (en) | 2013-01-23 |
| CN101663064B (zh) | 2013-03-06 |
| CN103181837A (zh) | 2013-07-03 |
| SG177991A1 (en) | 2012-02-28 |
| EP3434313A1 (en) | 2019-01-30 |
| EP2121109A1 (en) | 2009-11-25 |
| CN103083131B (zh) | 2015-07-22 |
| CN101663064A (zh) | 2010-03-03 |
| BRPI0806635A2 (pt) | 2011-09-06 |
| EP2121109B1 (en) | 2018-09-05 |
| CN103083131A (zh) | 2013-05-08 |
| IL199920A0 (en) | 2010-04-15 |
| ES2692434T3 (es) | 2018-12-03 |
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