SG173186A1 - Carba-nucleoside analogs for antiviral treatment - Google Patents

Info

Publication number

SG173186A1

SG173186A1 SG2011054798A SG2011054798A SG173186A1 SG 173186 A1 SG173186 A1 SG 173186A1 SG 2011054798 A SG2011054798 A SG 2011054798A SG 2011054798 A SG2011054798 A SG 2011054798A SG 173186 A1 SG173186 A1 SG 173186A1

Authority

SG

Singapore

Prior art keywords

substituted

alkyl

independently

compound

formula

Prior art date

2009-02-10

Links

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• 238000011282 treatment Methods 0.000 title claims abstract description 20
• 239000002777 nucleoside Substances 0.000 title claims description 34
• 230000000840 anti-viral effect Effects 0.000 title claims description 23
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• 239000000203 mixture Substances 0.000 claims abstract description 173
• -1 furo[3,4-d]pyrimidin-7-yl ribosides Chemical class 0.000 claims abstract description 159
• 238000000034 method Methods 0.000 claims abstract description 107
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• 125000000217 alkyl group Chemical group 0.000 claims description 226
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• 125000003118 aryl group Chemical group 0.000 claims description 112
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• 241000711549 Hepacivirus C Species 0.000 claims description 92
• 125000004432 carbon atom Chemical group C* 0.000 claims description 88
• 150000003839 salts Chemical class 0.000 claims description 88
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• 150000002367 halogens Chemical class 0.000 claims description 56
• 239000003814 drug Substances 0.000 claims description 55
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• 125000003710 aryl alkyl group Chemical group 0.000 claims description 49
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• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 30
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• 125000001072 heteroaryl group Chemical group 0.000 claims description 26
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