SG155236A1 - Improved modalities for the treatment of degenerative diseases of the retina - Google Patents

Improved modalities for the treatment of degenerative diseases of the retina

Info

Publication number
SG155236A1
SG155236A1 SG200905546-8A SG2009055468A SG155236A1 SG 155236 A1 SG155236 A1 SG 155236A1 SG 2009055468 A SG2009055468 A SG 2009055468A SG 155236 A1 SG155236 A1 SG 155236A1
Authority
SG
Singapore
Prior art keywords
retina
treatment
degenerative diseases
improved modalities
retinal
Prior art date
Application number
SG200905546-8A
Other languages
English (en)
Inventor
Irina V Klimanskaya
Robert Lanza
Original Assignee
Advanced Cell Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Cell Tech Inc filed Critical Advanced Cell Tech Inc
Publication of SG155236A1 publication Critical patent/SG155236A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/062—Sensory transducers, e.g. photoreceptors; Sensory neurons, e.g. for hearing, taste, smell, pH, touch, temperature, pain
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/33—Insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acoustics & Sound (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Molecular Biology (AREA)
SG200905546-8A 2004-01-23 2005-01-24 Improved modalities for the treatment of degenerative diseases of the retina SG155236A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53896404P 2004-01-23 2004-01-23

Publications (1)

Publication Number Publication Date
SG155236A1 true SG155236A1 (en) 2009-09-30

Family

ID=34807248

Family Applications (4)

Application Number Title Priority Date Filing Date
SG10201606441SA SG10201606441SA (en) 2004-01-23 2005-01-24 Improved modalities for the treatment of degenerative diseases of the retina
SG10201912182UA SG10201912182UA (en) 2004-01-23 2005-01-24 Improved modalities for the treatment of degenerative diseases of the retina
SG200905546-8A SG155236A1 (en) 2004-01-23 2005-01-24 Improved modalities for the treatment of degenerative diseases of the retina
SG2013009170A SG188122A1 (en) 2004-01-23 2005-01-24 Improved modalities for the treatment of degenerative diseases of the retina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SG10201606441SA SG10201606441SA (en) 2004-01-23 2005-01-24 Improved modalities for the treatment of degenerative diseases of the retina
SG10201912182UA SG10201912182UA (en) 2004-01-23 2005-01-24 Improved modalities for the treatment of degenerative diseases of the retina

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG2013009170A SG188122A1 (en) 2004-01-23 2005-01-24 Improved modalities for the treatment of degenerative diseases of the retina

Country Status (15)

Country Link
US (6) US7736896B2 (zh)
EP (8) EP2438814A3 (zh)
JP (10) JP2007522131A (zh)
KR (3) KR101258292B1 (zh)
CN (3) CN102204930B (zh)
AU (6) AU2005207042B2 (zh)
BR (1) BRPI0507074A (zh)
CA (2) CA2555370C (zh)
ES (1) ES2721174T3 (zh)
HK (3) HK1216068A1 (zh)
IL (3) IL177015B (zh)
MX (2) MX343606B (zh)
NZ (1) NZ548929A (zh)
SG (4) SG10201606441SA (zh)
WO (1) WO2005070011A2 (zh)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8043614B2 (en) * 2004-03-09 2011-10-25 Ahlfors Jan-Eric W Autogenic living scaffolds and living tissue matrices: methods and uses thereof
US7794704B2 (en) 2004-01-23 2010-09-14 Advanced Cell Technology, Inc. Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration
EP2438814A3 (en) * 2004-01-23 2012-10-03 Advanced Cell Technology, Inc. Improved modalities for the treatment of degenerative diseases of the retina
US7893315B2 (en) 2004-11-04 2011-02-22 Advanced Cell Technology, Inc. Derivation of embryonic stem cells and embryo-derived cells
EP2479256A1 (en) 2004-11-04 2012-07-25 Advanced Cell Technology, Inc. Derivation of embryonic stem cells
CN1966080B (zh) * 2005-11-17 2011-06-08 李凌松 一种治疗老年痴呆症、帕金森病的神经干细胞注射液
US7541186B2 (en) * 2006-02-22 2009-06-02 University Of Washington Method of generating human retinal progenitors from embryonic stem cells
WO2007130664A2 (en) 2006-05-03 2007-11-15 Advanced Cell Technology, Inc. Derivation of embryonic stem cells and embryo-derived cells
JP5441099B2 (ja) * 2007-01-18 2014-03-12 独立行政法人理化学研究所 視細胞への分化誘導方法
CN101679942A (zh) 2007-02-23 2010-03-24 先进细胞技术公司 重编程分化细胞和从重编程的细胞产生动物和胚胎干细胞的高效方法
AU2008242106B2 (en) * 2007-04-18 2013-05-16 Hadasit Medical Research Services And Development Ltd. Stem cell-derived retinal pigment epithelial cells
US8574567B2 (en) 2007-05-03 2013-11-05 The Brigham And Women's Hospital, Inc. Multipotent stem cells and uses thereof
EP2155860B1 (en) 2007-05-03 2014-08-27 The Brigham and Women's Hospital, Inc. Multipotent stem cells and uses thereof
US20090028831A1 (en) * 2007-07-23 2009-01-29 University Of Kentucky Research Foundation Stem cell regulator, compositions and methods of use
AU2015201435B2 (en) * 2007-10-12 2017-02-02 Astellas Institute For Regenerative Medicine Improved methods of producing RPE cells and compositions of RPE cells
CA2702386C (en) * 2007-10-12 2018-07-24 Advanced Cell Technology, Inc. Improved methods of producing rpe cells and compositions of rpe cells
EP2279247B1 (en) * 2008-04-22 2019-01-02 Regenerative Research Foundation Retinal pigment epithelial stem cells
JP6166900B2 (ja) * 2009-08-24 2017-07-19 ウイスコンシン アラムナイ リサーチ ファウンデーシヨンＷｉｓｃｏｎｓｉｎ Ａｌｕｍｎｉ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ 実質的に純粋なヒト網膜前駆細胞培養物、前脳前駆細胞培養物、網膜色素上皮細胞培養物、及び、それらの製造方法
KR102073730B1 (ko) * 2009-11-17 2020-02-05 아스텔라스 인스티튜트 포 리제너러티브 메디슨 인간 ｒｐｅ 세포의 생산 방법 및 인간 ｒｐｅ 세포의 제약 제제
JP5876045B2 (ja) 2010-07-12 2016-03-02 ユニバーシティー オブ サザン カリフォルニア 幹細胞と標的組織の相互接続を促進する生体適合性基材およびそれを埋め込む方法
JP6184865B2 (ja) 2010-07-23 2017-08-23 アステラス インスティテュート フォー リジェネレイティブ メディシン 細胞の稀少なサブ集団を検出するための方法及び細胞の高度に精製された組成物
WO2013015835A1 (en) 2011-07-22 2013-01-31 Seven Networks, Inc. Mobile application traffic optimization
JP2012231786A (ja) * 2011-04-18 2012-11-29 Kyushu Univ 標的遺伝子の発現変化による食品機能成分及び医薬品感受性評価方法
WO2012149468A2 (en) 2011-04-29 2012-11-01 University Of Southern California Instruments and methods for the implantation of cell-seeded substrates
US8877489B2 (en) 2011-12-05 2014-11-04 California Institute Of Technology Ultrathin parylene-C semipermeable membranes for biomedical applications
EP2707479B1 (en) 2011-05-13 2018-01-10 The United States of America, as represented by The Secretary, Department of Health and Human Services Use of zscan4 and zscan4-dependent genes for direct reprogramming of somatic cells
CA2835215C (en) 2011-05-18 2023-10-10 The Regents Of The University Of California Non-immortal human retinal cell compositions, method for preparing them, and their use for treating retinal diseases
CN103007355B (zh) * 2011-09-20 2014-08-13 同济大学 一种水凝胶-纳米纤维膜及其制备方法和用途
TWI719277B (zh) * 2011-11-14 2021-02-21 美商安斯泰來再生醫藥協會 人類rpe細胞之醫藥組合物及其用途
US8961956B2 (en) 2011-11-30 2015-02-24 Ocata Therapeutics, Inc. Mesenchymal stromal cells and uses related thereto
DK2785359T3 (en) 2011-11-30 2018-10-29 Astellas Inst For Regenerative Medicine MESENKYMAL STROMACELLES AND APPLICATIONS RELATED
US9248013B2 (en) 2011-12-05 2016-02-02 California Institute Of Technology 3-Dimensional parylene scaffold cage
EP2814947B1 (en) * 2012-02-17 2018-11-21 Schepens Eye Research Institute Phenotype profile of human retinal progenitor cells
US10519422B2 (en) 2012-02-29 2019-12-31 Riken Method of producing human retinal pigment epithelial cells
CN104755611A (zh) * 2012-08-24 2015-07-01 独立行政法人理化学研究所 用于生产视网膜色素上皮细胞片层的方法
CN105378070A (zh) 2013-03-15 2016-03-02 奥卡塔治疗公司 由多能干细胞产生的光感受器和光感受器祖细胞
US11241460B2 (en) 2013-03-15 2022-02-08 Astellas Institute For Regenerative Medicine Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
EP2980207B1 (en) * 2013-03-25 2018-12-05 Foundation for Biomedical Research and Innovation at Kobe Cell sorting method
EP2796545A1 (en) * 2013-04-26 2014-10-29 Université Pierre et Marie Curie (Paris 6) Methods for obtaining retinal progenitors, retinal pigmented epithelial cells and neural retinal cells
RU2704984C1 (ru) 2013-11-27 2019-11-01 Киото Прифекчурал Паблик Юниверсити Корпорэйшн Применение ламинина в культуре клеток эндотелия роговицы
AU2014363032A1 (en) 2013-12-11 2016-06-09 Pfizer Limited Method for producing retinal pigment epithelial cells
CA2965770C (en) 2014-10-31 2024-02-13 Kyoto Prefectural Public University Corporation Treatment of cornea using laminin
US11918630B2 (en) 2014-10-31 2024-03-05 Kyoto Prefectural Public University Corporation Treatment of retina and nerve using laminin
US11422125B2 (en) 2015-03-23 2022-08-23 Astellas Institute For Regenerative Medicine Assays for potency of human retinal pigment epithelium (RPE) cells and photoreceptor progenitors
KR20230058544A (ko) 2015-08-18 2023-05-03 아스텔라스 인스티튜트 포 리제너러티브 메디슨 임상 제제
EP3347456B1 (en) 2015-09-08 2023-12-27 The United States of America, as represented by The Secretary, Department of Health and Human Services Method for reproducible differentiation of clinical-grade retinal pigment epithelium cells
CN108291206B (zh) 2015-09-08 2022-07-08 富士胶片细胞动力公司 干细胞来源的视网膜色素上皮的基于macs的纯化
ES2922475T3 (es) 2015-09-08 2022-09-15 Sumitomo Pharma Co Ltd Método para producir células epiteliales pigmentarias de la retina
KR102669318B1 (ko) 2015-10-20 2024-05-28 후지필름 셀룰러 다이내믹스, 인코포레이티드 유전자 프로그래밍에 의한 다중-계통 조혈 전구 세포 생산
CN106609257B (zh) * 2015-10-22 2020-04-10 同济大学 高效分离体外诱导的rpe细胞和rpc的方法
CN106609255B (zh) * 2015-10-22 2019-11-05 同济大学 含pj34和视网膜色素上皮细胞的细胞悬液及其应用
CN106609256B (zh) * 2015-10-22 2020-04-07 同济大学 体外诱导人胚胎干细胞分化为视网膜色素上皮细胞的方法
CN106609263B (zh) * 2015-10-22 2020-04-07 同济大学 高效诱导多能干细胞向视网膜色素上皮细胞分化的方法
CN106282096A (zh) * 2016-10-19 2017-01-04 江苏艾尔康生物医药科技有限公司 一种人类视网膜色素上皮细胞层的分离培养方法
US11618883B2 (en) 2017-03-08 2023-04-04 Sumitomo Pharma Co., Ltd. Method for producing retinal pigment epithelial cells
EP3595687A1 (en) * 2017-03-16 2020-01-22 Lineage Cell Therapeutics, Inc. Methods for measuring therapeutic effects of retinal disease therapies
CA3075883A1 (en) * 2017-09-14 2019-03-21 Riken Method for amplifying cone photoreceptors or rod photoreceptors using dorsalization signal transmitter or ventralization signal transmitter
CR20200210A (es) 2017-11-15 2020-09-23 Friedrich Miescher Institute For Biomedical Res Promotor especìfico de las cèlulas del epitelio pigmentario retinal en primates
CN108029638B (zh) * 2017-12-04 2020-04-21 四川省人民医院 一种视网膜色素变性疾病动物模型的构建方法及应用
WO2019177936A1 (en) * 2018-03-12 2019-09-19 Nxcell Inc. Method for generating multiple cellular products from single pluripotent cell source
US20220249572A1 (en) * 2019-04-26 2022-08-11 Riken Composite Including Neural Retina, Retinal Pigment Epithelial Cells, and Hydrogel, and Method for Producing Same
MX2022005134A (es) 2019-10-30 2022-05-30 Astellas Inst For Regenerative Medicine Metodos para producir celulas del epitelio pigmentario retiniano.
RU2730937C1 (ru) * 2019-11-01 2020-08-26 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр глазных болезней имени Гельмгольца" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ГБ им. Гельмгольца" Миндрава России) Способ трансплантации клеток ретинального пигментного эпителия (РПЭ), дифференцированных из индуцированных плюрипотентных стволовых клеток человека, при атрофии ретинального пигментного эпителия
WO2022191216A1 (ja) 2021-03-09 2022-09-15 国立研究開発法人理化学研究所 低免疫原性網膜色素上皮細胞の製造方法
JPWO2023090427A1 (zh) 2021-11-19 2023-05-25
WO2023176906A1 (ja) 2022-03-16 2023-09-21 住友ファーマ株式会社 移植用媒体
US20230377685A1 (en) 2022-04-15 2023-11-23 Aspen Neuroscience, Inc. Methods of classifying the differentiation state of cells and related compositions of differentiated cells

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994025569A1 (en) 1993-04-30 1994-11-10 Photogenesis, Incorporated Retinal pigment epithelium transplantation
US6878544B2 (en) 1996-04-19 2005-04-12 Neurotech Sa Retinal cell lines with extended life-span and their applications
US20040086494A1 (en) * 1996-10-07 2004-05-06 John Constance Mary Immune privileged cells for delivery of proteins and peptides
JP2001508302A (ja) 1997-01-10 2001-06-26 ライフ テクノロジーズ，インコーポレイテッド 胚性幹細胞血清置換
US6331406B1 (en) * 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
CA2317115A1 (en) 1998-01-02 1999-07-15 Titan Pharmaceuticals, Inc. Use of pigmented retinal epithelial cells for creation of an immune privilege site
AU2884499A (en) 1998-03-02 1999-09-20 Compucyte Corp. Selective cell analysis
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
MXPA02004233A (es) 1999-10-28 2004-02-17 Univ Massachusetts Produccion ginogenetica o androgenetica de celulas pluripotentes y lineas celulares, y uso de las mismas para producir celulas diferenciadas y tejidos.
JP3454206B2 (ja) * 1999-11-10 2003-10-06 三菱電機株式会社 雑音抑圧装置及び雑音抑圧方法
WO2001050848A2 (en) * 2000-01-07 2001-07-19 Oregon Health And Science University Clonal propagation of primate offspring by embryo splitting
US6602711B1 (en) * 2000-02-21 2003-08-05 Wisconsin Alumni Research Foundation Method of making embryoid bodies from primate embryonic stem cells
US20030084471A1 (en) * 2000-03-16 2003-05-01 David Beach Methods and compositions for RNA interference
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
CA2456008A1 (en) 2000-08-19 2002-02-28 Axordia Limited Stem cell differentiation
US6576464B2 (en) 2000-11-27 2003-06-10 Geron Corporation Methods for providing differentiated stem cells
DK1339438T3 (da) 2000-11-29 2006-02-13 Allergan Inc Forebyggelse af transplantatafvisning i ojet
DE10108412B4 (de) * 2001-02-21 2006-03-09 Cevec Pharmaceuticals Gmbh Pigmentepithelzelle des Auges, ihre Herstellung und Verwendung in der Therapie einer Augen- oder Nervenerkrankung
CA2447015A1 (en) 2001-05-15 2002-11-21 Rappaport Family Institute For Research In The Medical Sciences Insulin producing cells derived from human embryonic stem cells
KR101073411B1 (ko) 2001-07-12 2011-10-17 제론 코포레이션 인간 다분화능 줄기 세포로부터 제조된 심근 세포 계통의 세포
AU2002360424A1 (en) * 2001-11-26 2003-06-10 Advanced Cell Technology, Inc. Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells
EP1463531B1 (en) 2001-12-11 2011-09-28 Fibrogen, Inc. Methods for inhibiting ocular processes
CA2482903A1 (en) 2002-04-18 2003-10-23 Lynkeus Biotech Gmbh Means and methods for the specific inhibition of genes in cells and tissue of the cns and/or eye
US7422736B2 (en) * 2002-07-26 2008-09-09 Food Industry Research And Development Institute Somatic pluripotent cells
WO2004033635A2 (en) * 2002-10-04 2004-04-22 Tissuetech, Inc. Retinal pigment epithelial cell cultures on amniotic membrane and transplantation
WO2004034734A1 (ja) * 2002-10-08 2004-04-22 Nec Corporation アレイ装置および携帯端末
US20040138558A1 (en) * 2002-11-14 2004-07-15 Dunki-Jacobs Robert J Methods and devices for detecting tissue cells
US20050032126A1 (en) * 2003-03-03 2005-02-10 Coombs James H. Methods and apparatus for use in detection and quantitation of various cell types and use of optical bio-disc for performing same
US7794704B2 (en) * 2004-01-23 2010-09-14 Advanced Cell Technology, Inc. Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration
EP2438814A3 (en) * 2004-01-23 2012-10-03 Advanced Cell Technology, Inc. Improved modalities for the treatment of degenerative diseases of the retina
EP2479256A1 (en) 2004-11-04 2012-07-25 Advanced Cell Technology, Inc. Derivation of embryonic stem cells
CN102220280A (zh) 2005-02-11 2011-10-19 新加坡科技研究局 增殖干细胞的方法
KR100832592B1 (ko) 2006-08-17 2008-05-27 박현숙 폴리머 막을 이용한 줄기세포와 피더세포의 공배양방법
AU2008242106B2 (en) 2007-04-18 2013-05-16 Hadasit Medical Research Services And Development Ltd. Stem cell-derived retinal pigment epithelial cells
JP2008307007A (ja) * 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
CA2702386C (en) * 2007-10-12 2018-07-24 Advanced Cell Technology, Inc. Improved methods of producing rpe cells and compositions of rpe cells
HU0700675D0 (en) 2007-10-15 2007-12-28 Mta Tamogatott Kutatohelyek Ir Method for monitoring stem cell differentiation
US20090233324A1 (en) * 2008-03-11 2009-09-17 Kopf-Sill Anne R Methods for Diagnosing Cancer Using Samples Collected From A Central Vein Location or an Arterial Location
US8652123B2 (en) * 2008-09-02 2014-02-18 Geoffrey C. GURTNER Methods and devices for improving the appearance of tissue
KR102073730B1 (ko) 2009-11-17 2020-02-05 아스텔라스 인스티튜트 포 리제너러티브 메디슨 인간 ｒｐｅ 세포의 생산 방법 및 인간 ｒｐｅ 세포의 제약 제제
JP6184865B2 (ja) * 2010-07-23 2017-08-23 アステラス インスティテュート フォー リジェネレイティブ メディシン 細胞の稀少なサブ集団を検出するための方法及び細胞の高度に精製された組成物
EP2702135B1 (en) 2011-04-29 2019-04-17 University of Southern California Method of cryopreservation of stem cell-derived retinal pigment epithelial cells on polymeric substrate
TWI719277B (zh) 2011-11-14 2021-02-21 美商安斯泰來再生醫藥協會 人類rpe細胞之醫藥組合物及其用途
US9850463B2 (en) 2012-02-01 2017-12-26 The Regents Of The University Of California Methods of culturing retinal pigmented epithelium cells, including xeno-free production, RPE enrichment, and cryopreservation
EP2882846B1 (en) 2012-06-05 2018-09-05 The Regents of the University of California Methods and compositions for the rapid production of retinal pigmented epithelial cells from pluripotent cells

Also Published As

Publication number Publication date
EP1708575A4 (en) 2009-07-01
SG10201912182UA (en) 2020-02-27
EP2929782A1 (en) 2015-10-14
US9649340B2 (en) 2017-05-16
EP4248751A3 (en) 2023-11-01
EP4269561A2 (en) 2023-11-01
AU2021200601A1 (en) 2021-03-04
JP2014079650A (ja) 2014-05-08
JP2022153630A (ja) 2022-10-12
WO2005070011A3 (en) 2005-10-13
JP2015096556A (ja) 2015-05-21
AU2005207042A1 (en) 2005-08-04
EP4248752A2 (en) 2023-09-27
JP2007522131A (ja) 2007-08-09
US9730962B2 (en) 2017-08-15
WO2005070011A2 (en) 2005-08-04
HK1207821A1 (zh) 2016-02-12
CN1968608B (zh) 2011-06-29
EP2438815A2 (en) 2012-04-11
US9040770B2 (en) 2015-05-26
ES2721174T3 (es) 2019-07-29
EP2438816A2 (en) 2012-04-11
SG10201606441SA (en) 2016-09-29
CN102204930B (zh) 2014-12-03
HK1216068A1 (zh) 2016-10-14
EP1708575A2 (en) 2006-10-11
JP2020146575A (ja) 2020-09-17
BRPI0507074A (pt) 2007-06-19
CN102204930A (zh) 2011-10-05
AU2010249263B2 (en) 2013-04-18
CA2555370C (en) 2024-02-06
CN104434979A (zh) 2015-03-25
AU2013201791B2 (en) 2016-08-18
JP2019217356A (ja) 2019-12-26
EP2438816A3 (en) 2012-10-03
AU2019200513A1 (en) 2019-02-14
EP2438816B1 (en) 2019-03-27
US20110117062A1 (en) 2011-05-19
EP2438815A3 (en) 2012-10-03
KR20120051754A (ko) 2012-05-22
JP2016195862A (ja) 2016-11-24
IL291162A (en) 2022-05-01
US20150328261A1 (en) 2015-11-19
AU2016259323A1 (en) 2016-12-01
KR101398356B1 (ko) 2014-05-23
IL177015B (en) 2019-06-30
CA2937099A1 (en) 2005-08-04
HK1162931A1 (zh) 2012-09-07
US7736896B2 (en) 2010-06-15
EP4269561A3 (en) 2024-01-03
NZ548929A (en) 2010-10-29
IL177015A0 (en) 2006-12-10
US7795025B2 (en) 2010-09-14
KR20070069087A (ko) 2007-07-02
EP4248752A3 (en) 2024-01-03
JP2024038460A (ja) 2024-03-19
US20060018886A1 (en) 2006-01-26
US20180064761A1 (en) 2018-03-08
IL267126B (en) 2022-04-01
IL267126A (en) 2019-08-29
KR101258292B1 (ko) 2013-04-25
AU2005207042B2 (en) 2010-09-09
CA2555370A1 (en) 2005-08-04
SG188122A1 (en) 2013-03-28
US20070031386A1 (en) 2007-02-08
AU2016259323B2 (en) 2019-01-31
MX2020009456A (es) 2020-10-12
MX343606B (es) 2016-11-11
AU2010249263A1 (en) 2011-01-06
AU2013201791A1 (en) 2013-04-11
US20100299765A1 (en) 2010-11-25
EP2438814A3 (en) 2012-10-03
JP2012148085A (ja) 2012-08-09
EP4248751A2 (en) 2023-09-27
JP2018086274A (ja) 2018-06-07
KR20130025953A (ko) 2013-03-12
CN1968608A (zh) 2007-05-23
EP2438814A2 (en) 2012-04-11

Similar Documents

Publication Publication Date Title
SG155236A1 (en) Improved modalities for the treatment of degenerative diseases of the retina
WO2006080952A3 (en) Improved modalities for the treatment of degenerative diseases of the retina
WO2008157791A3 (en) Methods and compositions for stimulating neurogenesis and inhibiting neuronal degeneration using isothiazolopyrimidinones
WO2006044204A3 (en) Neuronal progenitors from feeder-free human embryonic stem cell culture
WO2019070891A8 (en) Gene therapies for lysosomal disorders
MX2009006685A (es) Antagonistas del dr6 y usos de los mismos en el tratamiento de trastornos neurologicos.
WO2010048332A3 (en) Compounds for treating ophthalmic diseases and disorders
MX2010008206A (es) Metodos y composiciones que utilizan polipeptidos de fusion de klotho-fgf.
WO2008029276A3 (en) Compositions and methods for the treatment of ophthalmic disease
WO2005112981A3 (en) Compositions and methods for the stimulation or enhancement of bone formation and the self-renewal of cells
MX2013000908A (es) Producción de una n-acetilgalactosamina-6-sulfatasa humana activa altamente fosforilada y sus usos.
WO2011096728A3 (en) Method for proliferating stem cells by activating c-met/hgf signaling and notch signaling
WO2007035722A3 (en) Methods and compositions for stimulating neurogenesis and inhibiting neuronal degeneration
HK1157814A1 (en) Materials and methods relating to cell based therapies
DE502005008759D1 (de) In vitro aus knochenmarkstammzellen differenzierteerwendung
MY153738A (en) Sulphur-linked compounds for treating ophthalmic diseases and disorders.
NZ602479A (en) Pharmaceutical composition for the treatment of dry eye and/or corneal and conjunctival lesion
AU2016204146A1 (en) Methods of Increasing Neuronal Differentiation Using Antibodies to Lysophoshatidic Acid
SG11201900986YA (en) Alleviation and treatment of ischemia reperfusion-induced lung injury using pluripotent stem cells
WO2010062905A3 (en) Lateral ventricle cell compositions and use for treating neural degenerative diseases
WO2011045383A3 (en) 2, 6 -diaminopyridine compounds for treating diseases associated with amyloid proteins or for treating ocular diseases
WO2011005523A3 (en) Galectin-immunoglobulin chimeric molecules
WO2010101301A9 (en) Prophylaxis and treatment of macular degeneration and retinopathy using a prdx protein
WO2011133566A3 (en) Repairing bruch's membrane with hydrogels
WO2013067076A3 (en) Methods and compositions for neuroprotection