SG152900A1 - 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives - Google Patents

4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives

Info

Publication number
SG152900A1
SG152900A1 SG200405552-1A SG2004055521A SG152900A1 SG 152900 A1 SG152900 A1 SG 152900A1 SG 2004055521 A SG2004055521 A SG 2004055521A SG 152900 A1 SG152900 A1 SG 152900A1
Authority
SG
Singapore
Prior art keywords
phenyl
piperazinyl
piperidinyl
bond
formula
Prior art date
Application number
SG200405552-1A
Other languages
English (en)
Inventor
Benny Bang-Andersen
Jan Kehler
Jakob Felding
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of SG152900A1 publication Critical patent/SG152900A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG200405552-1A 1999-12-30 2000-12-22 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives SG152900A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA199901887 1999-12-30

Publications (1)

Publication Number Publication Date
SG152900A1 true SG152900A1 (en) 2009-06-29

Family

ID=8108820

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200405552-1A SG152900A1 (en) 1999-12-30 2000-12-22 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives

Country Status (32)

Country Link
US (2) US7074796B2 (de)
EP (2) EP1464641B1 (de)
JP (1) JP2003519225A (de)
KR (2) KR100792186B1 (de)
CN (2) CN1244577C (de)
AR (1) AR029461A1 (de)
AT (2) ATE395333T1 (de)
AU (2) AU783786B2 (de)
BG (1) BG106960A (de)
BR (1) BR0016953A (de)
CA (1) CA2395869C (de)
CZ (1) CZ20022603A3 (de)
DE (2) DE60038911D1 (de)
DK (2) DK1464641T3 (de)
EA (2) EA008627B1 (de)
ES (2) ES2302992T3 (de)
HK (1) HK1055960A1 (de)
HR (1) HRP20020567A2 (de)
HU (1) HUP0203839A3 (de)
IL (3) IL150366A0 (de)
IS (1) IS6432A (de)
MX (1) MXPA02006590A (de)
NO (2) NO323401B1 (de)
NZ (2) NZ530137A (de)
PL (1) PL355502A1 (de)
PT (2) PT1246817E (de)
SG (1) SG152900A1 (de)
SK (1) SK11072002A3 (de)
TR (2) TR200402408T4 (de)
UA (1) UA73756C2 (de)
WO (1) WO2001049679A1 (de)
ZA (1) ZA200205019B (de)

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ES2311012T3 (es) * 2000-03-27 2009-02-01 ABBOTT GMBH & CO. KG Ligandos del receptor d3 de la dopamina para el tratamiento de la adiccion.
GB0117577D0 (en) * 2001-02-16 2001-09-12 Aventis Pharm Prod Inc Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands
FR2831166B1 (fr) * 2001-10-18 2004-02-27 Sanofi Synthelabo Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant
US7307075B2 (en) * 2001-12-28 2007-12-11 Acadia Pharmaceuticals Inc. Tetrahydroquinoline analogues as muscarinic agonists
US7550459B2 (en) * 2001-12-28 2009-06-23 Acadia Pharmaceuticals, Inc. Tetrahydroquinoline analogues as muscarinic agonists
RS50589B (sr) 2003-12-23 2010-05-07 H. Lundbeck A/S. 2-(1h-indolilsulfanil)-benzil amin derivati kao ssri
DE102004027358A1 (de) * 2004-06-04 2005-12-29 Abbott Gmbh & Co. Kg Pyrimidinverbindungen und ihre Verwendung
AR052308A1 (es) 2004-07-16 2007-03-14 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto
FR2878524B1 (fr) * 2004-12-01 2007-01-19 Bioprojet Soc Civ Ile Nouveaux derives d'arylpiperazine
AR054393A1 (es) 2005-06-17 2007-06-20 Lundbeck & Co As H Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos.
US7629473B2 (en) 2005-06-17 2009-12-08 H. Lundbeck A/S 2-(1H-indolylsulfanyl)-aryl amine derivatives
EP1870405A1 (de) * 2006-06-22 2007-12-26 Bioprojet Carbonylierte (Aza)cyclohexane als Dopamin D3 Rezeptorliganden
EP3027607B1 (de) 2013-07-29 2020-08-26 Sunshine Lake Pharma Co., Ltd. Substituierte heteroarylverbindungen und verfahren zur verwendung davon
CN104725359B (zh) 2013-12-20 2017-05-03 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
US10316025B2 (en) 2015-06-03 2019-06-11 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof

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GB944443A (de) * 1959-09-25 1900-01-01
US3468882A (en) * 1966-10-07 1969-09-23 Sterling Drug Inc Phenylhydrazone derivatives as intermediates for preparing indoles
DE2138865A1 (de) * 1970-08-15 1973-02-22 Sumitomo Chemical Co 3-indolylpiperazine, verfahren zu ihrer herstellung und arzneimittel
FR2635104B1 (fr) * 1988-08-03 1992-04-30 Synthelabo Derives d'indolone, leur preparation et leur application en therapeutique
US4950664A (en) * 1988-09-16 1990-08-21 Rugby-Darby Group Companies, Inc. Nasal administration of benzodiazepine hypnotics
DE4101686A1 (de) * 1991-01-22 1992-07-23 Merck Patent Gmbh Indolderivate
US5556857A (en) * 1991-05-08 1996-09-17 Otsuka Pharmaceutical Co., Ltd. Disturbance-of-consciousness improving agent
IT1255178B (it) * 1992-06-26 1995-10-20 Pierrel Spa N(eter0)-aril-n(etero)-tetralinalchil piperazine aventi attivita' serotoninergica,dopaminergica e adrenergica
US5814644A (en) * 1993-04-15 1998-09-29 Merck Sharp & Dohme, Ltd. Indole derivatives as dopamine D4 antagonists
EP1738753B1 (de) * 1993-06-28 2008-04-23 Wyeth Neue Behandlungsmethoden durch Verwendung von Phenethylaminderivaten
WO1996017831A1 (de) * 1994-12-07 1996-06-13 Byk Gulden Lomberg Chemische Fabrik Gmbh Uracilderivate
WO1998008816A1 (fr) * 1996-08-26 1998-03-05 Meiji Seika Kaisha, Ltd. Derives d'indoxyle et psychotropes
JP2002536291A (ja) * 1997-08-15 2002-10-29 ファイザー・プロダクツ・インク ２−（４−アリール又はヘテロアリール−ピペラジン−１−イルメチル）−１ｈ−インドール誘導体
US6355644B1 (en) * 1999-06-14 2002-03-12 Neurogen Corporation Benzylpiperazinyl-indolinylethanones
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HENNING BOTTCHER ET AL.: 'Synthesis and dopaminergic activity of some 3-(1,2,3,6-tetrahydro 1-pyridylalkyl)indoles. A novel conformational model to explain structure-activity relationships' J. MED. CHEM. vol. 35, no. 22, 1992, pages 4020 - 4026 *
MOKROSZ M J ET AL: "5-HT1A AND 5-HT2A RECEPTOR AFFINITY AND FUNCTIONAL PROFILE OF SOME N-3-(4-ARYL-1-PIPERAZINYL)PROPYL DERIVATIVES OF INDOLIN-2(1H) -ONE, QUINOLIN-2(1H)-ONE, AND ISOQUINOLIN-1(2H)-ONE PART 30: STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF CNS AGENTS STRUKTUR-WIRKUNGS-BEZIEHUNGEN ZNS-WIRKSAMER SUBSTANZEN," PHARMAZIE, VEB VERLAG VOLK UND GESUNDHEIT. BERLIN, DD, vol. 52, no. 6, 1997, pages 423-428 *

Also Published As

Publication number Publication date
US7223765B2 (en) 2007-05-29
IL150366A0 (en) 2002-12-01
WO2001049679A1 (en) 2001-07-12
HUP0203839A2 (hu) 2003-02-28
MXPA02006590A (es) 2002-12-13
NZ519740A (en) 2004-03-26
KR100729536B1 (ko) 2007-06-18
NO20023151D0 (no) 2002-06-28
TR200201690T2 (tr) 2002-11-21
CN1244577C (zh) 2006-03-08
TR200402408T4 (tr) 2004-12-21
NO20023151L (no) 2002-08-02
HUP0203839A3 (en) 2004-07-28
AR029461A1 (es) 2003-07-02
CA2395869C (en) 2006-07-25
DE60038911D1 (de) 2008-06-26
DE60011817D1 (de) 2004-07-29
BG106960A (bg) 2003-04-30
US7074796B2 (en) 2006-07-11
AU783786B2 (en) 2005-12-08
AU2006201000A1 (en) 2006-04-06
JP2003519225A (ja) 2003-06-17
BR0016953A (pt) 2003-02-25
IS6432A (is) 2002-06-19
SK11072002A3 (sk) 2003-03-04
US20060148815A1 (en) 2006-07-06
DK1464641T3 (da) 2008-08-18
NO20065681L (no) 2002-08-02
CN1434819A (zh) 2003-08-06
CN1803784A (zh) 2006-07-19
ATE269857T1 (de) 2004-07-15
KR20070014234A (ko) 2007-01-31
EP1246817B1 (de) 2004-06-23
EA008627B1 (ru) 2007-06-29
KR20020063285A (ko) 2002-08-01
DK1246817T3 (da) 2004-10-18
DE60011817T2 (de) 2005-07-14
CA2395869A1 (en) 2001-07-12
ZA200205019B (en) 2003-09-22
CZ20022603A3 (cs) 2002-10-16
EP1464641B1 (de) 2008-05-14
EA200200729A1 (ru) 2002-12-26
EA200400641A1 (ru) 2004-10-28
HK1055960A1 (en) 2004-01-30
ES2223628T3 (es) 2005-03-01
US20030027832A1 (en) 2003-02-06
IL186954A0 (en) 2009-02-11
HRP20020567A2 (en) 2005-04-30
EP1464641A1 (de) 2004-10-06
PT1464641E (pt) 2008-07-01
IL150366A (en) 2008-06-05
ES2302992T3 (es) 2008-08-01
NZ530137A (en) 2005-09-30
NO323401B1 (no) 2007-04-23
AU2152701A (en) 2001-07-16
EA005013B1 (ru) 2004-10-28
UA73756C2 (en) 2005-09-15
ATE395333T1 (de) 2008-05-15
PT1246817E (pt) 2004-11-30
KR100792186B1 (ko) 2008-01-08
EP1246817A1 (de) 2002-10-09
PL355502A1 (en) 2004-05-04

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